CN101472584B - 用作组胺h4受体调节剂的吲哚类和苯并咪唑类 - Google Patents

用作组胺h4受体调节剂的吲哚类和苯并咪唑类 Download PDF

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Publication number
CN101472584B
CN101472584B CN200780021127XA CN200780021127A CN101472584B CN 101472584 B CN101472584 B CN 101472584B CN 200780021127X A CN200780021127X A CN 200780021127XA CN 200780021127 A CN200780021127 A CN 200780021127A CN 101472584 B CN101472584 B CN 101472584B
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ketone
indole
pyrrolidin
methylamino
octahydro
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Expired - Fee Related
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Chinese (zh)
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CN101472584A (zh
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J·P·爱德华兹
B·M·萨瓦尔
C·R·沙
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
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  • Obesity (AREA)
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  • Pain & Pain Management (AREA)
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  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200780021127XA 2006-04-07 2007-03-30 用作组胺h4受体调节剂的吲哚类和苯并咪唑类 Expired - Fee Related CN101472584B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79042106P 2006-04-07 2006-04-07
US60/790,421 2006-04-07
PCT/US2007/008218 WO2007117401A2 (en) 2006-04-07 2007-03-30 Indoles and benzoimidazoles as modulators of the histamine h4 receptor

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CN101472584A CN101472584A (zh) 2009-07-01
CN101472584B true CN101472584B (zh) 2013-04-24

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CN200780021127XA Expired - Fee Related CN101472584B (zh) 2006-04-07 2007-03-30 用作组胺h4受体调节剂的吲哚类和苯并咪唑类

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US (1) US7544698B2 (https=)
EP (1) EP2010172B1 (https=)
JP (1) JP5132673B2 (https=)
CN (1) CN101472584B (https=)
AU (1) AU2007235578B2 (https=)
WO (1) WO2007117401A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117399A2 (en) 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
WO2007120690A2 (en) * 2006-04-10 2007-10-25 Janssen Pharmaceutica N.V. Combination histamine h1r and h4r antagonist therapy for treating pruritus
DK2354124T3 (da) 2006-12-19 2013-03-11 Hoffmann La Roche Heteroarylpyrrolidinyl og piperidinylketonderivater
WO2009023179A2 (en) * 2007-08-10 2009-02-19 Genelabs Technologies, Inc. Nitrogen containing bicyclic chemical entities for treating viral infections
BRPI0915526A2 (pt) * 2008-06-12 2016-01-26 Janssen Pharmaceutica Nv uso de um antagonista da histamina h4 para o tratamento de aderências pós-operatórias
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
US8436008B2 (en) 2008-12-22 2013-05-07 Incyte Corporation Substituted heterocyclic compounds
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US8481732B2 (en) 2009-03-20 2013-07-09 Incyte Corporation Substituted heterocyclic compounds
US20120277238A1 (en) * 2009-07-31 2012-11-01 Shionogi & Co., Ltd Pharmaceutical composition containing fused hetero-ring derivative
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
WO2011092290A1 (en) 2010-02-01 2011-08-04 Novartis Ag Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
EP3378476A1 (en) 2012-06-08 2018-09-26 Sensorion H4 receptor inhibitors for treating tinnitus
AR092211A1 (es) * 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung Derivados de hidropirrolopirrol
PT2964229T (pt) 2013-03-06 2020-03-23 Janssen Pharmaceutica Nv Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina
EP3746430A4 (en) * 2018-02-02 2021-11-03 Padforward LLC INHIBITORS OF PROTEIN ARGININE DEIMINASES
AR133293A1 (es) * 2023-07-18 2025-09-17 Muna Therapeutics Aps Antagonistas del canal de potasio kv1.3
TW202527931A (zh) * 2023-11-08 2025-07-16 美商奧科坦特公司 視紫質的藥理校正劑及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2592611A1 (en) * 2005-01-12 2006-07-20 Dainippon Sumitomo Pharma Co., Ltd. 2-(cyclic aminocarbonyl)indoline derivative and medicinal composition containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072548A2 (en) 2001-03-09 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Heterocyclic compounds and their use as histamine h4 ligands.
WO2004022060A2 (en) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders
EP1505064A1 (en) 2003-08-05 2005-02-09 Bayer HealthCare AG 2-Aminopyrimidine derivatives
WO2005054239A1 (en) 2003-12-05 2005-06-16 Bayer Healthcare Ag 2-aminopyrimidine derivatives
US20060111416A1 (en) 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
CA2682483A1 (en) * 2007-03-29 2008-10-09 Novartis Ag 3-imidazolyl-indoles for the treatment of proliferative diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2592611A1 (en) * 2005-01-12 2006-07-20 Dainippon Sumitomo Pharma Co., Ltd. 2-(cyclic aminocarbonyl)indoline derivative and medicinal composition containing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nalan Terzioglu et al..Synthesis and structure–activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists.《Bioorganic & Medicinal Chemistry Letters》.2004,第14卷(第21期),p.5251-5256. *

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Publication number Publication date
WO2007117401A2 (en) 2007-10-18
EP2010172B1 (en) 2012-08-29
US7544698B2 (en) 2009-06-09
AU2007235578A1 (en) 2007-10-18
WO2007117401A3 (en) 2008-06-26
AU2007235578B2 (en) 2011-07-14
EP2010172A2 (en) 2009-01-07
US20070238771A1 (en) 2007-10-11
JP2009533343A (ja) 2009-09-17
HK1125034A1 (en) 2009-07-31
CN101472584A (zh) 2009-07-01
JP5132673B2 (ja) 2013-01-30
EP2010172A4 (en) 2010-03-31

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