CN101468145A - (Sugar-free type) granule medicament containing figwort, ophiopogon root, liquorice and ballonflower, and method for preparing the same - Google Patents
(Sugar-free type) granule medicament containing figwort, ophiopogon root, liquorice and ballonflower, and method for preparing the same Download PDFInfo
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- CN101468145A CN101468145A CNA2008100701650A CN200810070165A CN101468145A CN 101468145 A CN101468145 A CN 101468145A CN A2008100701650 A CNA2008100701650 A CN A2008100701650A CN 200810070165 A CN200810070165 A CN 200810070165A CN 101468145 A CN101468145 A CN 101468145A
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Abstract
The invention discloses a new medicine capable of reducing fever, nourishing body's essential fluid, eliminating sputum and relieving sore-throat, also relates to a preparation method thereof, composed of figwort, lilyturf root, glycyrrhiza and balloonflower as raw material and dextrin as adjuvant. The medicine is made into granules prepared by extraction and refining using the modern pharmaceutical technology. The formula and preparation method of the medicine are special and suitable for wider population and has obvious curative effect.
Description
Technical field
The present invention relates to the medicine of a kind of heat clearing away YIN nourishing, dispelling phlegm and relieving sore-throat.Be the Chinese patent medicine of feedstock production specifically, the invention still further relates to and the preparation method of this medicine with the Chinese crude drug.
Background technology
Pharyngolaryngitis, respiratory tract disease are commonly encountered diseases, frequently-occurring disease clinically.Particularly influenza, pharyngolaryngitis endanger very big to the people's life, work.Motherland pharmaceutically people also accumulated comparatively rich experience and treated and prevented this kind disease, but because granules medicine contains sucrose mostly, and sugar part proportion is bigger.This brings difficulty to diabetics.Diabetics surpasses more than 100,000,000 people in the world at present, and China is near 2,000 ten thousand, and the trend that increases is year by year arranged.Case fatality rate is only second to acute tumor and cardiovascular diseases, is to jeopardize one of the third-largest disease of human life.Therefore, these granules all are not suitable for the diabetics use.
Summary of the invention
Purpose of the present invention: the one, be to provide a kind of and have enhancing human body immunity, antiinflammatory and resisting pathogenic microbes, eliminate the phlegm, antitussive, a kind of suitable crowd of the antipyretic granules medicine of wide (particularly diabetics); Two provide the preparation method that the treatment respiratory tract is suitable for the wider medicine of crowd.
The side is a principal agent with Radix Scrophulariae, grows lung and contains the moon, removing pathogenic heat from blood and toxic substance from the body; Be aided with lung-yin nourishing Radix Ophiopogonis, lung moistening is dry; A left side is with the Radix Platycodonis dispelling phlegm and relieving sore-throat; Radix Glycyrrhizae is in harmonious proportion the crude drug relieving cough and resolving phlegm of holding concurrently for making.Four medicine adapteds have the effect of heat clearing away YIN nourishing, dispelling phlegm and relieving sore-throat.
Medicine of the present invention is the medicine of being made by the following weight proportion raw material:
Radix Scrophulariae 140～160 Radix Platycodoniss, 140～160 Radix Glycyrrhizaes 140～160,140～160 Radix Ophiopogonis
The weight proportion of preferential each raw material of this prescription is:
Radix Scrophulariae 145～455 Radix Platycodoniss, 145～155 Radix Glycyrrhizaes 145～155,145～155 Radix Ophiopogonis
The weight proportion of best each raw material of the present invention is:
Radix Scrophulariae 148.1 Radix Platycodoniss, 148.1 Radix Glycyrrhizaes 148.1,148.1 Radix Ophiopogonis
Preparation method when above-mentioned each component is made the drug solvent of heat clearing away YIN nourishing, dispelling phlegm and relieving sore-throat is:
1. Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis, Radix Glycyrrhizae are cleaned respectively, run through.
2. Radix Platycodonis, Radix Glycyrrhizae are cut sheet 2～4mm, Radix Scrophulariae shave 1～2mm.
3. the medicine that will clean and cut decocts with water three times, adds drinking water at every turn and is respectively 1000 liters, 800 liters, 800 liters, and decocting time was respectively 1.5 hours, 1 hour, 1 hour, merged three times decocting liquid, filters.
4. filtrate was left standstill 12 hours.
5. be concentrated into the extractum of relative density 1.32～1.35 (70～80 ℃) with the energy-conservation concentrator of triple effect.
6. utilize one-step-granulating method that extractum is sprayed into suitable dextrin and make granule, drying, granulate gets final product.
Acute toxicity test of the present invention: get each 10 of large and small white mouse, fasting experimentized after 24 hours, with the dosage gastric infusion of 5g/kg, pressed the 5g/kg dosed administration more once every 6 hours respectively, totally four times.Observed seven days continuously, none is only dead.This illustrates that the medicine of this invention does not have the obvious toxic and side effects reaction.
Long term toxicity test of the present invention: get 60 of white mice, be divided into high and low dose group and blank group at random.High dose group is pressed the 5g/kg dosed administration every day, and low dose group is pressed the 2.5g/kg dosed administration every day, oral three times of every day, observes for 16 weeks continuously.The result shows: to main histopathologic examination, and no abnormality seen and pathological change.
The particulate acute experiment of sugared type Xuanmai Ganju is arranged: get each 10 of large and small white mouse, fasting experimentized after 24 hours, respectively with the dosage gastric infusion of 10g/kg, divided in 24 hours and gavaged for for four times large and small Mus.Observed seven days continuously, none is only dead.Do not see toxic reaction.Can think the LD of this product
5010g/kg, be equivalent to more than 1000 times of clinical consumption.
The particulate long term toxicity test of sugared Xuanmai Ganju is arranged: will have the Xuanmai Ganju granule of sugar to gavage 2.5g/kg, 5g/kg respectively, and observe for 16 weeks continuously to rat.The result shows: to main histopathologic examination, and no abnormality seen and pathological change.
The specific embodiment:
Take by weighing raw material (unit: kg) by following proportioning
Radix Scrophulariae 148.1 Radix Glycyrrhizaes, 148.1 Radix Platycodoniss 148.1,148.1 Radix Ophiopogonis
Production method is as follows:
Earlier Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Platycodonis are cleaned respectively, run through.Again Radix Platycodonis, Radix Glycyrrhizae are cut sheet 2～4mm, Radix Scrophulariae shave 1～2mm decocts with water three times with the medical material of cleaning and cut then, add drinking water at every turn and be respectively 1000 liters, 800 liters, 800 liters, three times decocting time was respectively 1.5 hours, 1 hour, 1 hour.Merge three times decocting liquid, filter, filtrate was left standstill 12 hours, was concentrated into the extractum that relative density is 1.32～1.35 (70～80 ℃) with the energy-conservation concentrator of triple effect.Utilize one-step-granulating method that extractum is sprayed in an amount of dextrin, make granule, drying, granulate is promptly.
Claims (6)
1. heat clearing away YIN nourishing, the medicine of dispelling phlegm and relieving sore-throat is characterized in that it is the medicament of being made by following weight proportioning raw material:
Radix Scrophulariae 140～160g 140～160g Radix Ophiopogonis Radix Platycodonis 140～160g Radix Glycyrrhizae 140～160g.
2. heat clearing away YIN nourishing according to claim 1, the medicine of dispelling phlegm and relieving sore-throat, wherein the weight proportion of each raw material is:
Radix Scrophulariae 145～155g 145～155g Radix Ophiopogonis Radix Platycodonis 145～155g Radix Glycyrrhizae 145～155g.
3. heat clearing away YIN nourishing according to claim 2, the medicine of dispelling phlegm and relieving sore-throat, wherein the weight proportion of each raw material is:
Radix Scrophulariae 148.1g 148.1g Radix Ophiopogonis Radix Platycodonis 148.1g Radix Glycyrrhizae 148.1g.
4. according to claim 1,2 or 3 described heat clearing away YIN nourishing, the medicine of dispelling phlegm and relieving sore-throat larynx is characterized in that said medicament is that drug weight with above-mentioned four flavor Chinese medicines decoct with water, said dosage form on a kind of pharmaceutics of producing with modern processing technique.
5. heat clearing away YIN nourishing according to claim 4, the medicine of dispelling phlegm and relieving sore-throat larynx is characterized in that said medicament is a granule.
6. heat clearing away YIN nourishing according to claim 5, the preparation method of dispelling phlegm and relieving sore-throat medicine is characterized in that:
A. Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Platycodonis are cleaned respectively, run through.
B. Radix Platycodonis, Radix Glycyrrhizae are cut sheet 2～4mm, Radix Scrophulariae shave 1～2mm.
C. the medicine that will clean and cut decocts with water three times, adds drinking water at every turn and is respectively 1000 liters, 800 liters, 800 liters, and decocting time was respectively 1.5 hours, 1 hour, 1 hour, merged three times decoction liquor, filters.
D. filtrate was left standstill 12 hours.
E. be concentrated into suitable concentrated solution with the energy-conservation concentrator of triple effect, reuse concentrating under reduced pressure pot is concentrated into the extractum of relative density 1.32～1.35 (70～80 ℃).
F. make granule with adding dextrin in the extractum, drying, granulate gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100701650A CN101468145A (en) | 2008-08-25 | 2008-08-25 | (Sugar-free type) granule medicament containing figwort, ophiopogon root, liquorice and ballonflower, and method for preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100701650A CN101468145A (en) | 2008-08-25 | 2008-08-25 | (Sugar-free type) granule medicament containing figwort, ophiopogon root, liquorice and ballonflower, and method for preparing the same |
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| CN101468145A true CN101468145A (en) | 2009-07-01 |
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| CNA2008100701650A Pending CN101468145A (en) | 2008-08-25 | 2008-08-25 | (Sugar-free type) granule medicament containing figwort, ophiopogon root, liquorice and ballonflower, and method for preparing the same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638289A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Figwort-creeping liriope-licorice root-balloonflower root extract preparation method |
| CN103636857A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Herbaceous plant cool tea and preparation method thereof |
| CN104258281A (en) * | 2014-09-23 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Sugar-free granules with effect of clearing heat from throat and preparation method thereof |
| CN104510895A (en) * | 2013-09-27 | 2015-04-15 | 李三济 | Prescription of traditional Chinese medicine for treating children's cold |
| CN106511745A (en) * | 2016-11-25 | 2017-03-22 | 神威药业集团有限公司 | Xuanmaiganju composition (composition consisting of radix scrophulariae, radix ophiopogonis, liquorice root and radix platycodonis) and preparation method of composition |
| CN113144103A (en) * | 2021-05-07 | 2021-07-23 | 潘畅 | Traditional Chinese medicine composition for clearing heat from throat and benefiting throat and application thereof |
-
2008
- 2008-08-25 CN CNA2008100701650A patent/CN101468145A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510895A (en) * | 2013-09-27 | 2015-04-15 | 李三济 | Prescription of traditional Chinese medicine for treating children's cold |
| CN103638289A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Figwort-creeping liriope-licorice root-balloonflower root extract preparation method |
| CN103636857A (en) * | 2013-11-21 | 2014-03-19 | 宁夏多维药业有限公司 | Herbaceous plant cool tea and preparation method thereof |
| CN104258281A (en) * | 2014-09-23 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Sugar-free granules with effect of clearing heat from throat and preparation method thereof |
| CN106511745A (en) * | 2016-11-25 | 2017-03-22 | 神威药业集团有限公司 | Xuanmaiganju composition (composition consisting of radix scrophulariae, radix ophiopogonis, liquorice root and radix platycodonis) and preparation method of composition |
| CN106511745B (en) * | 2016-11-25 | 2020-06-16 | 神威药业集团有限公司 | Xuanmai Ganju composition and preparation method thereof |
| CN113144103A (en) * | 2021-05-07 | 2021-07-23 | 潘畅 | Traditional Chinese medicine composition for clearing heat from throat and benefiting throat and application thereof |
| CN113144103B (en) * | 2021-05-07 | 2022-06-21 | 潘畅 | Traditional Chinese medicine composition for clearing throat and application thereof |
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Open date: 20090701 |