CN101467039B - 散乱蛋白pdz调节剂 - Google Patents

散乱蛋白pdz调节剂 Download PDF

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Publication number
CN101467039B
CN101467039B CN2007800216108A CN200780021610A CN101467039B CN 101467039 B CN101467039 B CN 101467039B CN 2007800216108 A CN2007800216108 A CN 2007800216108A CN 200780021610 A CN200780021610 A CN 200780021610A CN 101467039 B CN101467039 B CN 101467039B
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CN
China
Prior art keywords
polypeptide
peptide
dvl
pdz
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2007800216108A
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English (en)
Chinese (zh)
Other versions
CN101467039A (zh
Inventor
迈克·科斯塔
萨克德夫·S·西德休
张映楠
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Genentech Inc
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Genentech Inc
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Priority to CN201310261484.0A priority Critical patent/CN103351425B/zh
Publication of CN101467039A publication Critical patent/CN101467039A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
CN2007800216108A 2006-04-10 2007-04-09 散乱蛋白pdz调节剂 Expired - Fee Related CN101467039B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310261484.0A CN103351425B (zh) 2006-04-10 2007-04-09 散乱蛋白pdz调节剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79067306P 2006-04-10 2006-04-10
US60/790,673 2006-04-10
PCT/US2007/066267 WO2007121147A2 (en) 2006-04-10 2007-04-09 Disheveled pdz modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201310261484.0A Division CN103351425B (zh) 2006-04-10 2007-04-09 散乱蛋白pdz调节剂

Publications (2)

Publication Number Publication Date
CN101467039A CN101467039A (zh) 2009-06-24
CN101467039B true CN101467039B (zh) 2013-11-06

Family

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Family Applications (2)

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CN2007800216108A Expired - Fee Related CN101467039B (zh) 2006-04-10 2007-04-09 散乱蛋白pdz调节剂
CN201310261484.0A Expired - Fee Related CN103351425B (zh) 2006-04-10 2007-04-09 散乱蛋白pdz调节剂

Family Applications After (1)

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CN201310261484.0A Expired - Fee Related CN103351425B (zh) 2006-04-10 2007-04-09 散乱蛋白pdz调节剂

Country Status (8)

Country Link
US (2) US7695928B2 (enExample)
EP (2) EP2002259B1 (enExample)
JP (1) JP5290148B2 (enExample)
CN (2) CN101467039B (enExample)
AU (1) AU2007238186B2 (enExample)
CA (1) CA2648322C (enExample)
ES (2) ES2385261T3 (enExample)
WO (1) WO2007121147A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI494319B (zh) * 2007-02-21 2015-08-01 Oncotherapy Science Inc 表現腫瘤相關抗原之癌症的胜肽疫苗
KR101278073B1 (ko) * 2008-08-04 2013-06-24 연세대학교 산학협력단 Ｉｄｂｆ의 신규 용도
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
EP2812350B1 (en) 2012-02-11 2019-04-03 F.Hoffmann-La Roche Ag R-spondin translocations and methods using the same
GB201220901D0 (en) 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived peptides for treating pancreatic cancer
GB201220891D0 (en) 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived peptides for treating breast cancers
TWI658049B (zh) 2013-03-12 2019-05-01 腫瘤療法 科學股份有限公司 Ｋｎｔｃ２胜肽及含此胜肽之疫苗
US9520180B1 (en) 2014-03-11 2016-12-13 Hypres, Inc. System and method for cryogenic hybrid technology computing and memory
GB201421647D0 (en) 2014-12-05 2015-01-21 Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0134986A2 (de) * 1983-07-13 1985-03-27 FARMITALIA CARLO ERBA S.r.l. Biologisch aktive Heptapeptide, Mittel, die diese enthalten und Anwendungsverfahren
EP0183245A2 (en) * 1984-11-30 1986-06-04 FARMITALIA CARLO ERBA S.r.l. Animal growth promotant
WO2002090544A2 (en) * 2001-05-04 2002-11-14 Hybrigenics Protein-protein interactions in adipocyte cells (3)
US20030148264A1 (en) * 2001-07-06 2003-08-07 Genentech, Inc. Phage displayed PDZ domain ligands

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US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
ATE189526T1 (de) 1988-10-28 2000-02-15 Genentech Inc Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
US5688936A (en) * 1992-06-11 1997-11-18 The Regents Of The University Of California Vesicle membrane transport proteins
ES2151541T3 (es) 1992-12-02 2001-01-01 Alkermes Inc Microesferas que contienen hormona del crecimiento de liberacion prolongada.
WO1994029351A2 (en) 1993-06-16 1994-12-22 Celltech Limited Antibodies
BR9509201A (pt) 1994-09-09 1997-12-30 Takeda Chemical Industries Ltd Preparação de liberação sustemtada uso de um sal de metal polivalente insolúvel em água ou ligeiramente solúvel em água e processo para produzir uma preparação de liberação sustentada
EP0831787B1 (en) 1995-06-07 2001-08-22 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of human growth hormone
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
US6294330B1 (en) 1997-01-31 2001-09-25 Odyssey Pharmaceuticals Inc. Protein fragment complementation assays for the detection of biological or drug interactions
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
DE69937291T2 (de) 1998-04-02 2008-07-10 Genentech, Inc., South San Francisco Antikörpervarianten und fragmente davon
EP1100890A2 (en) 1998-07-27 2001-05-23 Genentech, Inc. Improved transformation efficiency in phage display through modification of a coat protein
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
CA2501235A1 (en) 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
EP1781609A4 (en) * 2004-07-01 2009-07-29 Univ California INHIBITION OF A PDZ DOMAIN INTERACTION BY SMALL MOLECULES

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0134986A2 (de) * 1983-07-13 1985-03-27 FARMITALIA CARLO ERBA S.r.l. Biologisch aktive Heptapeptide, Mittel, die diese enthalten und Anwendungsverfahren
EP0183245A2 (en) * 1984-11-30 1986-06-04 FARMITALIA CARLO ERBA S.r.l. Animal growth promotant
WO2002090544A2 (en) * 2001-05-04 2002-11-14 Hybrigenics Protein-protein interactions in adipocyte cells (3)
US20030148264A1 (en) * 2001-07-06 2003-08-07 Genentech, Inc. Phage displayed PDZ domain ligands

Also Published As

Publication number Publication date
HK1131438A1 (en) 2010-01-22
US7977064B2 (en) 2011-07-12
CN101467039A (zh) 2009-06-24
ES2385261T3 (es) 2012-07-20
JP2009533465A (ja) 2009-09-17
JP5290148B2 (ja) 2013-09-18
CN103351425A (zh) 2013-10-16
WO2007121147A2 (en) 2007-10-25
CA2648322C (en) 2017-11-28
ES2487637T3 (es) 2014-08-22
EP2002259B1 (en) 2012-05-16
AU2007238186A1 (en) 2007-10-25
EP2002259A2 (en) 2008-12-17
US20100136580A1 (en) 2010-06-03
EP2343551B1 (en) 2014-05-28
CN103351425B (zh) 2016-01-20
EP2343551A1 (en) 2011-07-13
AU2007238186B2 (en) 2014-01-09
US7695928B2 (en) 2010-04-13
CA2648322A1 (en) 2007-10-25
US20080167386A1 (en) 2008-07-10
WO2007121147A3 (en) 2008-01-10

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