CN101463050A - Modification method of humic acid, product obtained therefrom, and use thereof in skin-protection health products or medicaments preparation - Google Patents
Modification method of humic acid, product obtained therefrom, and use thereof in skin-protection health products or medicaments preparation Download PDFInfo
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Abstract
The invention discloses a modification method of humic acid. The method comprises the following steps: (1) under ultrasonic wave, activating and oxidating and degrading a pulverized raw materials containing the humic acid or the humic acid in water in the presence of basic copper salt and alkali to prepare a humic acid degradation product; and (2) allowing the humic acid degradation product obtained in the step (1) to react with urea to prepare a modified humic acid substance. The invention further relates to the modified humic acid substance prepared by the method and application thereof to preparing skincare health products or skincare medicines. The modified humic acid substance has better efficacies on caring skin, resisting cracking, enhancing cutin softening and promoting skin lesions extinction and healing, has higher application value and simple preparation method, and is applicable to industrialized production.
Description
Technical field
The present invention relates to a kind of method of modifying and products obtained therefrom and the application in preparation skin-protection health products or medicine thereof of humic acids.
Background technology
Humic acids (Humic Acid writes a Chinese character in simplified form HA) is the animals and plants remains, mainly is the remains of plant, through decomposition and the conversion of microorganism, and a series of chemical process and a type organic matter that accumulates.It has functions such as good physiologically active and absorption, complexing, exchange by the polymeric organic acid that aromatic series and multiple functional group thereof constitute.Humic acids extensively is present in soil, lake, river, ocean, and in peat (claiming the peat composed of rotten mosses again), brown coal and the weathered coal etc.According to solvability in solvent and color classification, humic acids can be divided into xanthohumic acid, ulmic acid and Ulmic acids etc.
Human research to humic acids obtained existing 214 years history first from soil from 1786.If with " coal looses " of enrolling in the famous medical scholar's LI Shi-Zhen Compendium of Material Medica works of China " medicine sage " Ming Dynasty is an example, existing more than 400 year of that Application humic.At present, humic acids is as organic matter raw material, has been widely used in farming, woods, herds, every field such as oil, chemical industry, building materials, medicine, health, environmental protection.China's resource of humic acid is very abundant, and its reserves is big, and it is wide to distribute, and grade is good.According to the pertinent data statistics, 124.8 hundred million tons in peat is arranged, occupy the 4th in the world; 1,265 hundred million tons in brown coal also have a large amount of weathered coals.Therefore, the research and development to resource of humic acid have great development prospect.
At present, in the application of field of medicaments, find that humic acids has blood coagulation, hematostatic effect, and effect is similar to Yunnan white powder.In the application in skin care field, find that it has similar Unidasa and catalatic metabolism.(" coal looses " power-assist skin care product go back to nature Huang Liangcai, humic acids, 2004,5:30-31) think, humic acids has effects such as the blood circulation of enhancing, hemostasis and pain-relieving, antiulcer agent, exudation resistance and promotion wound healing, itself and the skin moisture-keeping factor etc. are mixed with the protective skin cream (the happy U.S. frost of skin) that is used to prevent and treat chapped skin, skin pruritus and pernio etc., good relieving itching and eliminating swelling is arranged, promote effects such as little wound healing is fast.Xu Chuanzhong, Zhu Yaqin (patent publication No.: CN1213665) with natural peat and sodium hydroxide effect salify, and through dissolved deliming patent medicine grade peat sodium fulvic acids such as ethanol or hydrochloric acid.This finished product molecular-weight average is little, and multiple biologically active gene is arranged, and oral administration or external application are mainly as the Chinese medicine additive of broad-spectrum antimicrobial.
Summary of the invention
Technical problem to be solved by this invention is for a kind of new application approach of humic acids is provided, and provide a kind of method of modifying of humic acids, and preparedly have preferable promotion cutin softening, skin care anticracking, promote skin to decrease to disappear the modified humic acid substance of healing effect, and the application in preparation skin-protection health products or medicine by this method.
Method of the present invention comprises the steps:
(1) raw material that contains humic acids or the humic acids that will pulverize, in water, under the ultrasonic wave, in the presence of alkali type nantokite and alkali, activated oxidative degradation makes humic acid degradation product.
Wherein, the described raw material that contains humic acids is the existing natural matter that contains humic acids, as contains peat, brown coal or the weathered coal etc. of humic acids.The abundant natural peat of preferred resources among the present invention, especially preferred natural low moor pat.Described natural low moor pat is to be grown by the place of low-lying place, seasonal ponding or long-term ponding, need the more plant of nutrient inorganic salt, as each kind of plant the broken branches and fallen leaves that sedge belongs to, reed belongs to and alluviation is got off, peat through accumulation formation for many years, its general degree of decomposition is higher, acidity is lower, and ash oontent is higher.The preferred humic acids total content of the present invention is the natural low moor pat of 35～65wt%.Natural low moor pat has a large amount of distributions in China southwest, Central China, North China and northeast, the natural low moor pat of the preferred Yunnan of the present invention stone screen.Described humic acids is by humic acids that extracts in the above-mentioned various natural matters or artificial humic acids, preferably the humic acids that extracts from natural low moor pat.
Wherein, the raw material that contains humic acids of described pulverizing or the particle diameter of humic acids are advisable more fully can realize the active oxidation degraded, and that preferable is 20～100nm, and that better is 20～50nm.The method of pulverizing can adopt the conventional breaking method in this area, and preferable for to pulverize in the ultra-high speed pulverizer, that the linear speed of ultra-high speed pulverizer is preferable is 100～250m/s, and that better is 150～200m/s.Pulverize preferable carrying out under 30～80 ℃, better carries out under 50～60 ℃.
Preferable, will use behind described raw material that contains humic acids or the air-dry removal moisture of humic acids, effect is better.Air-dryly adopt natural air drying or artificial drying, preferable condition is: under 15～35 ℃ temperature, through 5～10 days natural air dryings, perhaps in thermostatic drying chamber, under 50～75 ℃ the temperature, through oven dry in 1～3 hour, under 60～70 ℃ the temperature that better is, through oven dry in 2 hours.
Wherein, described raw material or the humic acids that contains humic acids, with the mass volume ratio of water preferable be 1g/30～70ml, that better is 1g/50ml.That described alkali type nantokite is preferable is Cu
2(NO
3) (OH)
3And/or Cu
2CO
3(OH)
2What described alkali was preferable is mineral alkali, and as potassium hydroxide, sodium hydroxide and ammoniacal liquor etc., preferable is potassium hydroxide and/or sodium hydroxide.What the total concn of described alkali type nantokite and alkali was preferable is mass percent 5～20%, and better is mass percent 10～15%.That the mass ratio of described alkali type nantokite and alkali is preferable is 1:5～1:20, and that better is 1:8～1:12, and that best is 1:9.
That wherein, described frequency of ultrasonic is preferable is 50～100KHZ.What the temperature of described active oxidation degraded was preferable is 20～100 ℃, and better is 30～80 ℃.Described active oxidation degradation time is generally 10～40min, and that preferable is 20～30min.
Active oxidation degraded can directly be carried out the next step after finishing, and the also available alcoholic solvent aqueous solution or ketones solvent aqueous solution extraction are got organic phase, carry out the next step again behind dry the solid.
(2) under the microwave condition, humic acid degradation product and urea reaction with step (1) makes promptly make modified humic acid substance.
Wherein, that the frequency of described microwave is preferable is 915～2450MHz, and that the power of microwave is preferable is 350～500W.That the time of described reaction is preferable is 5～25min, and that better is 10～20min.Most preferred reaction conditions is: microwave frequency 2450MHz, microwave power 500W, time 10～20min.
Wherein, the consumption of described urea is preferable is 1.5～2.5 times of humic acid degradation product molar weight, and better is 2 times.Among the present invention, the molar weight of described humic acid degradation product is calculated with following formula: humic acid degrading amount ÷ humic acid degradation product molecular-weight average; Described humic acid degradation product molecular-weight average can be measured (concrete grammar reference: Li Shanxiang with dark type viscometer or ebullioscopic method, humic acids product analysis and standard, Chemical Industry Press, in September, 2007, p110～112, p112～113), generally recording the humic acid degradation product molecular-weight average is 130～320.
If the active oxidation DeR of step (1) finishes the back without aftertreatment, directly carry out the reaction of step (2), then do not need solubilizing agent again.After aftertreatment gets the humic acid degradation product solid if the active oxidation DeR of step (1) finishes, carry out the reaction of step (2) again, then need add solvent.Solvent can be the mixed solvent of this area alcoholic solvent commonly used, the ketones solvent aqueous solution, water or above-mentioned solvent, preferred alcohol, acetone or water, and the consumption of solvent is advisable to obtain semi-solid, is generally 1g/3～5g humic acid degradation product solid.
After the end of step (2) reaction, gained modified humic acid substance convection drying can be used, can be used for preparing pulvis usually.Also the gained modified humic acid substance with the aqueous solution of alcoholic solvent or the aqueous solution extraction of ketones solvent, can be got organic phase,, can be directly used in the preparation liquid preparation, also can be used to prepare pulvis after the drying with further purification.Described alcoholic solvent or ketones solvent are this area alcohols commonly used or organic solvent of ketone, preferred alcohol or acetone.
In the method for modifying of the present invention, but the optimum condition arbitrary combination of above steps promptly obtains each preferred embodiments of the present invention.
The invention still further relates to the modified humic acid substance that makes by aforesaid method.This modified humic acid substance has preferable skin care, anticracking, promotion cutin softening, promotes skin to decrease the effect that disappears and heal.
Therefore, the invention further relates to the application of modified humic acid substance of the present invention in preparation skin-protection health products or skin care medicine.As required, modified humic acid substance of the present invention can be mixed with skin-protection and health-care field or the acceptable various conventional auxiliary materials of pharmaceutical field, make the product of various formulations, as paste, liquid agent or pulvis etc.
Agents useful for same of the present invention and raw material are all commercially available to be got.
Positive progressive effect of the present invention is: modified humic acid substance of the present invention has preferable skin care, anticracking, promotion cutin softening, promotes skin to decrease the effect that disappears and heal, and than the common drug humic acids, have stronger pharmacological, the more single-minded characteristics of action target spot, using value is higher.In addition, its preparation method is simple, is easy to suitability for industrialized production.The present invention provides new way for making full use of humic acids.
Embodiment
Further specify the present invention with embodiment below, but the present invention is not limited.
In following examples, natural low moor pat is provided by Shiping County, Yunnan science and technology office, and its humic acids content is 57wt%.
In following examples, the humic acid degradation product molecular-weight average is measured (concrete reference: Li Shanxiang, humic acids product analysis and standard, Chemical Industry Press, in September, 2007, p112～113) by ebullioscopic method.
Embodiment 1
100g through 5 days natural low moor pat of 30 ℃ of natural air dryings, under 50 ℃, in the ultra-high speed pulverizer of linear velocity 200m/s, is ground into the particulate of 20～30nm.Afterwards, containing Cu
2(NO
3) (OH)
3With (5000ml, total concn is 10wt%, Cu in the aqueous solution of potassium hydroxide
2(NO
3) (OH)
3With the potassium hydroxide mass ratio be 1:20), under the ultrasonic wave of 100KHz, 65 ℃ of temperature, activated oxidative degradation, the reaction 20min, promptly make natural low moor pat humic acid degradation product.
Get the urea of above-mentioned natural low moor pat humic acid degradation product (molecular-weight average 280) that makes of 3080g (11mol) and 1320g (22mol), be microwave frequency 2450MHz, under the microwave power 500W, react, behind the reaction 12min, promptly get natural low moor pat modified humic acid substance.Again through the aqueous ethanolic solution of 50wt% under 10～35 ℃ normal temperature, behind the extraction 25min, get organic phase, at 25～45 ℃ of dry 60min down, get final product the natural low moor pat modified humic acid substance solid of purifying.
Embodiment 2
100g through 10 days natural low moor pat of 15 ℃ of natural air dryings, under 30 ℃, in the ultra-high speed pulverizer of linear velocity 250m/s, is ground into the particulate of 70～80nm.Afterwards, containing Cu
2(CO
3) (OH)
2With (6000ml, total concn is 20wt%, Cu in the aqueous solution of potassium hydroxide
2(CO
3) (OH)
2With the potassium hydroxide mass ratio be 1:10), under the ultrasonic wave of 50KHz, 100 ℃ of temperature, activated oxidative degradation, the reaction 23min, make natural low moor pat humic acid degradation product.
Get the urea of above-mentioned natural low moor pat humic acid degradation product (molecular-weight average 220) that makes of 3200g (14.5mol) and 1740g (29mol), at microwave frequency 2450MHz, under the microwave power 500W, react, the reaction 20min after, get final product natural low moor pat modified humic acid substance solid.
Embodiment 3
100g through 8 days natural low moor pat of 35 ℃ of natural air dryings, under 80 ℃, in the ultra-high speed pulverizer of linear velocity 150m/s, is ground into the particulate of 80～100nm.Afterwards, containing Cu
2(NO
3) (OH)
3With (7000ml, total concn is 15wt%, Cu in the aqueous solution of sodium hydroxide
2(NO
3) (OH)
3With the sodium hydroxide mass ratio be 1:5), under the ultrasonic wave of 80KHz, 30 ℃ of temperature, activated oxidative degradation, the reaction 10min, make natural low moor pat humic acid degradation product.
Get the urea of above-mentioned natural low moor pat humic acid degradation product (molecular-weight average 320) that makes of 3200g (10mol) and 900g (15mol), at microwave frequency 2450MHz, under the microwave power 500W, react, behind the reaction 10min, promptly get natural low moor pat modified humic acid substance.Again through the aqueous propanol solution of 50wt% under 10～35 ℃ normal temperature, behind the extraction 15min, get organic phase, at 25～45 ℃ of dry 30min down, get final product the natural low moor pat modified humic acid substance solid of purifying.
Embodiment 4
100g through 3 hours natural low moor pat of 50 ℃ of oven dry of thermostatic drying chamber, under 60 ℃, in the ultra-high speed pulverizer of linear velocity 100m/s, is ground into the particulate of 50～60nm.Afterwards, containing Cu
2(CO
3) (OH)
2With (4000ml, total concn is 5wt%, Cu in the aqueous solution of sodium hydroxide
2(CO
3) (OH)
2With the sodium hydroxide mass ratio be 1:8), under the ultrasonic wave of 60KHz, 80 ℃ of temperature, activated oxidative degradation, the reaction 32min, make natural low moor pat humic acid degradation product.
Get the urea of above-mentioned natural low moor pat humic acid degradation product (molecular-weight average 160) that makes of 3200g (20mol) and 3000g (50mol), at microwave frequency 915MHz, under the microwave power 500W, react, behind the reaction 25min, promptly get natural low moor pat modified humic acid substance.Again through 50% aqueous ethanolic solution under 10～35 ℃ normal temperature, behind the extraction 20min, get organic phase, at 25～45 ℃ of dry 50min down,, get final product the natural low moor pat modified humic acid substance solid of purifying.
Embodiment 5
100g through 1 hour natural low moor pat of 75 ℃ of oven dry of thermostatic drying chamber, under 70 ℃, in the ultra-high speed pulverizer of linear velocity 200m/s, is ground into the particulate of 60～70nm.Afterwards, containing Cu
2(NO
3) (OH)
3With (3000ml, total concn is 12wt%, Cu in the aqueous solution of potassium hydroxide
2(NO
3) (OH)
3With the potassium hydroxide mass ratio be 1:12), under the ultrasonic wave of 100KHz, 20 ℃ of temperature, activated oxidative degradation, the reaction 28min, make natural low moor pat humic acid degradation product.
Get the urea of above-mentioned natural low moor pat humic acid degradation product (molecular-weight average 210) that makes of 3150g (15mol) and 1800g (30mol), at microwave frequency 2450MHz, under the microwave power 500W, react, behind the reaction 5min, promptly get natural low moor pat modified humic acid substance.Again through 50% aqueous ethanolic solution under 10～35 ℃ normal temperature, behind the extraction 25min, get organic phase, at 25～45 ℃ of dry 60min down, get final product the natural low moor pat modified humic acid substance solid of purifying.
Embodiment 6
100g through 2 hours natural low moor pat of 65 ℃ of oven dry of thermostatic drying chamber, under 40 ℃, in the ultra-high speed pulverizer of linear velocity 250m/s, is ground into the particulate of 20～30nm.Afterwards, containing Cu
2(NO
3) (OH)
3With (5000ml, total concn is 10wt%, Cu in the aqueous solution of potassium hydroxide
2(NO
3) (OH)
3With the potassium hydroxide mass ratio be 1:9), under the ultrasonic wave of 100KHz, 65 ℃ of temperature, activated oxidative degradation, the reaction 30min, make natural low moor pat humic acid degradation product.
Get the urea of above-mentioned natural low moor pat humic acid degradation product (molecular-weight average 189) that makes of 3213g (17mol) and 1980g (33mol), at microwave frequency 2450MHz, under the microwave power 350W, react, behind the reaction 12min, promptly get natural low moor pat modified humic acid substance.Again through the aqueous ethanolic solution of 50wt% under 10～35 ℃ normal temperature, behind the extraction 20min, get organic phase, at 25～45 ℃ of dry 60min down, get final product the natural low moor pat modified humic acid substance solid of purifying.
Embodiment 7
100g without air-dry natural low moor pat, under 45 ℃, in the ultra-high speed pulverizer of linear velocity 200m/s, is ground into the particulate of 20～30nm.Afterwards, containing Cu
2(NO
3) (OH)
3With (5000ml, total concn is 10wt%, Cu in the aqueous solution of potassium hydroxide
2(NO
3) (OH)
3With the potassium hydroxide mass ratio be 1:8), under the ultrasonic wave of 100KHz, 70 ℃ of temperature, activated oxidative degradation, the reaction 40min, make natural low moor pat humic acid degradation product.Again through the aqueous ethanolic solution of 50wt% under 10～35 ℃ normal temperature, behind the extraction 20min, get organic phase, at 25～45 ℃ of dry 60min down, get final product the natural low moor pat humic acid degradation product solid of purifying.
Get the urea of above-mentioned natural low moor pat humic acid degradation product (molecular-weight average 139) that makes of 3200g (23mol) and 2760g (46mol), at microwave frequency 2450MHz, under the microwave power 500W, react, behind the reaction 12min, promptly get natural low moor pat modified humic acid substance.Again through 50% aqueous ethanolic solution under 10～35 ℃ normal temperature, behind the extraction 20min, get organic phase, at 25～45 ℃ of dry 60min down, get final product the natural low moor pat modified humic acid substance solid of purifying.
Embodiment 8
Get the natural low moor pat modified humic acid substance 150g that embodiment 1 makes, whiteruss 100g, stearic acid 50g, glycerine 50g, add the 150ml deionized water dissolving, mixing is heated to 75 ℃, keep 15min, condensation cooling again gets 500g humic acid in peat modifier cold cream.
Effect embodiment
Following effect experiment is carried out in Quanzhou institute of traditional Chinese medicine.The humic acid in peat modifier cold cream that respectively embodiment 8 is made, wallantoin cold cream (sending auspicious specialization worker company limited available from Changzhou) and common drug are with humic acids (refining humic acids, Hami Handilong humic acids company limited) be coated with usefulness for each patient that 10 routine keratinization skins decrease, evenly be applied to keratinization skin damage place, be coated with outside the part 2 every day, 2 weeks of the course of treatment.The result is as shown in table 1.
The anti-keratinization skin of table 1 modified humic acid substance cold cream decreases effect
| Title | Skin decreases area minification % | Keratinization epidermal thickness/mm |
| The blank group | / | 0.232～0.235 |
| The common drug humic acids | 15 | 0.235～0.242 |
| The wallantoin cold cream | 80 | 0.233～0.236 |
| The modified humic acid substance cold cream | 80 | 0.232～0.236 |
By table 1 result as seen, modified humic acid substance of the present invention has the effect of significant promotion cutin softening, skin care anticracking, and than the common drug humic acids, have stronger pharmacological, the more single-minded characteristics of action target spot, can travel in conjunction with top grade, health facility exploitation series product.
Claims (13)
1, a kind of method of modifying of humic acids, it comprises the steps:
(1) raw material that contains humic acids or the humic acids that will pulverize, in water, under the ultrasonic wave, in the presence of alkali type nantokite and alkali, activated oxidative degradation makes humic acid degradation product;
(2) under the microwave condition, humic acid degradation product and urea reaction with step (1) makes promptly make modified humic acid substance.
2, the method for claim 1 is characterized in that: in the step (1), the described raw material that contains humic acids is peat, brown coal or the weathered coal that contains humic acids.
3, method as claimed in claim 2 is characterized in that: in the step (1), described peat is the natural low moor pat of mass percent 35～65% for the humic acids total content, or originates from the natural low moor pat of Yunnan stone screen.
4, the method for claim 1 is characterized in that: in the step (1), the raw material that contains humic acids of described pulverizing or the particle diameter of humic acids are 20～100nm.
5, the method for claim 1 is characterized in that: in the step (1), will use behind described raw material that contains humic acids or the air-dry removal moisture of humic acids.
6, the method for claim 1 is characterized in that: in the step (1), described raw material or the humic acids that contains humic acids, with the mass volume ratio of water be 1g/30～70ml.
7, the method for claim 1 is characterized in that: in the step (1), described alkali type nantokite is Cu
2(NO
3) (OH)
3And/or Cu
2CO
3(OH)
2Described alkali is potassium hydroxide and/or sodium hydroxide.
8, the method for claim 1 is characterized in that: in the step (1), the total concn of described alkali type nantokite and alkali is a mass percent 5～20%; The mass ratio of described alkali type nantokite and alkali is 1:5～1:20.
9, the method for claim 1 is characterized in that: in the step (1), described frequency of ultrasonic is 50～100KHZ; The temperature of described active oxidation degraded is 30～80 ℃; Described active oxidation degradation time is 10～40min.
10, the method for claim 1 is characterized in that: in the step (2), the frequency of described microwave is 915～2450MHz, and the power of microwave is 350～500W, and the time of described reaction is 5～25min.
11, the method for claim 1 is characterized in that: in the step (2), the consumption of described urea is 1.5～2.5 times of humic acid degradation product molar weight; The molar weight of described humic acid degradation product is calculated with following formula: humic acid degrading amount ÷ humic acids molecular-weight average.
12, the modified humic acid substance that makes as each described method of claim 1～11.
13, the application of modified humic acid substance as claimed in claim 12 in preparation skin-protection health products or skin care medicine.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102070375A (en) * | 2010-12-22 | 2011-05-25 | 山东农大肥业科技有限公司 | Manufacturingmethod of active humic acid controlled-release fertilizer |
| CN105997768A (en) * | 2016-07-29 | 2016-10-12 | 济宁医学院 | Mild moistening amino acid facial cleanser |
| CN107541367A (en) * | 2017-09-08 | 2018-01-05 | 东北师范大学 | A kind of soap base acid-base neutralization auxiliary agent and its preparation method |
| CN108576058A (en) * | 2018-05-31 | 2018-09-28 | 中国矿业大学 | The extracting method of regenerated xanthohumic acid in a kind of low metamorphic lignite |
| CN112641708A (en) * | 2021-02-05 | 2021-04-13 | 东晟源研究院(广州)有限公司 | Formula and preparation method of humic acid essence for promoting wound healing |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009131717A2 (en) * | 2008-04-22 | 2009-10-29 | Phibro Wood, LLC | Composition and method for incorporating colorant into wood |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297631C (en) * | 2005-04-04 | 2007-01-31 | 师进 | Composite moisture holding agent of humic acid and preparation method |
-
2008
- 2008-12-30 CN CN 200810205101 patent/CN101463050B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009131717A2 (en) * | 2008-04-22 | 2009-10-29 | Phibro Wood, LLC | Composition and method for incorporating colorant into wood |
Non-Patent Citations (1)
| Title |
|---|
| 李兆君 等: "腐殖酸尿素的制造及其增产作用机理的研究近况", 《土壤通报》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102070375A (en) * | 2010-12-22 | 2011-05-25 | 山东农大肥业科技有限公司 | Manufacturingmethod of active humic acid controlled-release fertilizer |
| CN102070375B (en) * | 2010-12-22 | 2013-07-24 | 山东农大肥业科技有限公司 | Manufacturing method of active humic acid controlled-release fertilizer |
| CN105997768A (en) * | 2016-07-29 | 2016-10-12 | 济宁医学院 | Mild moistening amino acid facial cleanser |
| CN107541367A (en) * | 2017-09-08 | 2018-01-05 | 东北师范大学 | A kind of soap base acid-base neutralization auxiliary agent and its preparation method |
| CN108576058A (en) * | 2018-05-31 | 2018-09-28 | 中国矿业大学 | The extracting method of regenerated xanthohumic acid in a kind of low metamorphic lignite |
| CN112641708A (en) * | 2021-02-05 | 2021-04-13 | 东晟源研究院(广州)有限公司 | Formula and preparation method of humic acid essence for promoting wound healing |
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| CN101463050B (en) | 2013-06-05 |
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