CN101448829A - 4-氨基-吡啶并[3,2-e]吡嗪类，其作为磷酸二酯酶10的抑制剂的用途以及制备它们的方法 - Google Patents
4-氨基-吡啶并[3,2-e]吡嗪类，其作为磷酸二酯酶10的抑制剂的用途以及制备它们的方法 Download PDFInfo
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- CN101448829A CN101448829A CNA2007800178341A CN200780017834A CN101448829A CN 101448829 A CN101448829 A CN 101448829A CN A2007800178341 A CNA2007800178341 A CN A2007800178341A CN 200780017834 A CN200780017834 A CN 200780017834A CN 101448829 A CN101448829 A CN 101448829A
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Landscapes
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| BR (1) | BRPI0711857A2 (enExample) |
| CA (1) | CA2653412A1 (enExample) |
| CL (1) | CL2007001555A1 (enExample) |
| MX (1) | MX2008015308A (enExample) |
| PE (1) | PE20080266A1 (enExample) |
| TW (1) | TW200815436A (enExample) |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104684912A (zh) * | 2012-08-17 | 2015-06-03 | 艾伯维德国有限责任两合公司 | 磷酸二酯酶10a型的抑制剂化合物 |
| CN104703987A (zh) * | 2011-10-10 | 2015-06-10 | H.隆德贝克有限公司 | 具有咪唑并吡嗪酮骨架的pde9抑制剂 |
| US9434733B2 (en) | 2012-01-26 | 2016-09-06 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone |
| US10513524B2 (en) | 2015-07-07 | 2019-12-24 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| US12006319B2 (en) | 2018-05-25 | 2024-06-11 | Cardurion Pharmaceuticals, Inc. | Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one |
| US12213975B2 (en) | 2018-08-31 | 2025-02-04 | Cardurion Pharmaceuticals, Inc. | PDE9 inhibitors for treating sickle cell disease |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2599054T3 (es) * | 2006-12-13 | 2017-01-31 | Aska Pharmaceutical Co., Ltd. | Derivados de quinoxalina |
| WO2009070583A1 (en) * | 2007-11-30 | 2009-06-04 | Wyeth | Pyrido[3,2-e]pyrazines, process for preparing the same, and their use as inhibitors of phosphodiesterase 10 |
| WO2009068246A2 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Methods of treating obesity and metabolic disorders |
| US7875618B2 (en) * | 2007-11-30 | 2011-01-25 | Wyeth | Substituted imidazo[1,5-a]quinoxalines useful as inhibitors of phosphodiesterase 10 for the treatment of neurological and other disorders |
| US20100120763A1 (en) * | 2008-11-07 | 2010-05-13 | Wyeth | Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases |
| NZ705135A (en) * | 2010-05-26 | 2017-10-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| DE102010042833B4 (de) | 2010-10-22 | 2018-11-08 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Neue Halogenalkoxychinazoline, deren Herstellung und Verwendung |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
| SG192839A1 (en) | 2011-02-18 | 2013-09-30 | Allergan Inc | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| EP2763989A1 (en) * | 2011-09-09 | 2014-08-13 | H. Lundbeck A/S | Pyridine compounds and uses thereof |
| MX2014005705A (es) | 2011-11-09 | 2014-09-04 | Abbvie Deutschland | Carboxamidas heterociclicas utiles como inhibidores de fosfodiesterasa del tipo 10a. |
| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| MX361539B (es) | 2012-04-25 | 2018-12-10 | Takeda Pharmaceuticals Co | Compuesto heterociclico nitrogenado. |
| EP2861596B1 (en) * | 2012-06-19 | 2019-03-20 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| WO2014010732A1 (ja) | 2012-07-13 | 2014-01-16 | 武田薬品工業株式会社 | 複素環化合物 |
| US20140045856A1 (en) * | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| RU2015114331A (ru) | 2012-09-17 | 2016-11-10 | Эббви Дойчланд Гмбх Унд Ко. Кг | Новые соединения в качестве ингибиторов фосфодиэстеразы типа 10а |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9790203B2 (en) | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| US9200005B2 (en) | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
| JP6280912B2 (ja) | 2013-03-14 | 2018-02-14 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2016510788A (ja) | 2013-03-14 | 2016-04-11 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | ホスホジエステラーゼ１０ａ型の新規な阻害剤化合物 |
| WO2015002231A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2015002230A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | アミド化合物 |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| CN103980281B (zh) * | 2014-05-27 | 2016-06-08 | 天津市斯芬克司药物研发有限公司 | 一种咪唑吡嗪化合物及其制备方法 |
| WO2020065583A1 (en) | 2018-09-28 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Balipodect for treating or preventing autism spectrum disorders |
| CN114524808B (zh) * | 2022-02-21 | 2023-10-24 | 深圳市儿童医院 | 一种吡唑衍生物及其作为pde10抑制剂的用途 |
| CN114524806B (zh) * | 2022-02-22 | 2024-09-03 | 深圳市儿童医院 | 一种三氮唑衍生物及其作为pde10抑制剂的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE430149T1 (de) * | 1998-03-04 | 2009-05-15 | Bristol Myers Squibb Co | Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren |
| JPH11292878A (ja) * | 1998-04-09 | 1999-10-26 | Yamanouchi Pharmaceut Co Ltd | イミダゾナフチリジン誘導体 |
| US20030032579A1 (en) * | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| IL149106A0 (en) * | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
| TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
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2007
- 2007-05-18 TW TW096117904A patent/TW200815436A/zh unknown
- 2007-05-24 US US11/753,260 patent/US20070299079A1/en not_active Abandoned
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- 2007-05-30 PE PE2007000675A patent/PE20080266A1/es not_active Application Discontinuation
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104703987B (zh) * | 2011-10-10 | 2017-05-03 | H.隆德贝克有限公司 | 具有咪唑并吡嗪酮骨架的pde9抑制剂 |
| CN104703987A (zh) * | 2011-10-10 | 2015-06-10 | H.隆德贝克有限公司 | 具有咪唑并吡嗪酮骨架的pde9抑制剂 |
| US9993477B2 (en) | 2011-10-10 | 2018-06-12 | H. Lundbeck A/S | Substituted imidazo[1,5-a]pyrazines as PDE9 inhibitors |
| US9643970B2 (en) | 2011-10-10 | 2017-05-09 | H. Lundbeck A/S | Substituted imidazo [1,5-a]pyrazines as PDE9 inhibitors |
| US9850249B2 (en) | 2012-01-26 | 2017-12-26 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone |
| US9533992B2 (en) | 2012-01-26 | 2017-01-03 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone |
| US9434733B2 (en) | 2012-01-26 | 2016-09-06 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone |
| CN104684912A (zh) * | 2012-08-17 | 2015-06-03 | 艾伯维德国有限责任两合公司 | 磷酸二酯酶10a型的抑制剂化合物 |
| US10513524B2 (en) | 2015-07-07 | 2019-12-24 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| US11608342B2 (en) | 2015-07-07 | 2023-03-21 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| US12006319B2 (en) | 2018-05-25 | 2024-06-11 | Cardurion Pharmaceuticals, Inc. | Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one |
| US12466832B2 (en) | 2018-05-25 | 2025-11-11 | Cardurion Pharmaceuticals, Inc. | Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one |
| US12213975B2 (en) | 2018-08-31 | 2025-02-04 | Cardurion Pharmaceuticals, Inc. | PDE9 inhibitors for treating sickle cell disease |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070299079A1 (en) | 2007-12-27 |
| CA2653412A1 (en) | 2007-12-06 |
| AU2007267391A1 (en) | 2007-12-06 |
| EP2021341A1 (en) | 2009-02-11 |
| WO2007137819A1 (en) | 2007-12-06 |
| JP2009538852A (ja) | 2009-11-12 |
| PE20080266A1 (es) | 2008-04-10 |
| CL2007001555A1 (es) | 2008-01-18 |
| MX2008015308A (es) | 2008-12-12 |
| BRPI0711857A2 (pt) | 2011-12-13 |
| AR060984A1 (es) | 2008-07-23 |
| TW200815436A (en) | 2008-04-01 |
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