CN101439055A - Use of aqueous extract of Trametes robiniophila Murr. in preparing medicament - Google Patents
Use of aqueous extract of Trametes robiniophila Murr. in preparing medicament Download PDFInfo
- Publication number
- CN101439055A CN101439055A CNA2007101705866A CN200710170586A CN101439055A CN 101439055 A CN101439055 A CN 101439055A CN A2007101705866 A CNA2007101705866 A CN A2007101705866A CN 200710170586 A CN200710170586 A CN 200710170586A CN 101439055 A CN101439055 A CN 101439055A
- Authority
- CN
- China
- Prior art keywords
- carcinoma
- cancer
- trametes robiniophila
- water
- robiniophila murr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a usage of Jew ear fungal aqueous extract in the preparation of a drug for curing tumors, wherein, the tumors include cervical cancer, ovarian cancer, carcinoma of endometrium, vulva cancer, prostate cancer, parotid gland, thyroid cancer, salivary gland cancer, skin cancer, nasopharyngeal carcinoma, tongue cancer, oral cavity cancer, carcinoma of larynx, encephaloma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, testicular cancer, penile cancer, multiple myeloma and/or malignant melanoma.
Description
Technical field
The present invention relates to the plant extract field, relate in particular to the new purposes of Trametes robiniophila Murr. water extract.
Background technology
The Auricularia Sophorae granule is by medical material Trametes robiniophila Murr. (authentication code: the granule (electuary) that is prepared from through the water extraction accurate word Z20000108 of traditional Chinese medicines).The Auricularia Sophorae granule has strengthening the body resistance, the invigorate blood circulation effect of Xiao Disorder, be mainly used in the treatment of hepatocarcinoma, other has the application report aspect human primary gastrointestinal cancers, breast carcinoma, pulmonary carcinoma, treatment of pancreatic cancer, but for not appearing in the newspapers in the application facet of treatment cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma, malignant melanoma.
Summary of the invention
The present invention aims to provide the new purposes of Trametes robiniophila Murr. water extract aspect the treatment tumor.
In a first aspect of the present invention, the purposes of a kind of Trametes robiniophila Murr. water extract in the medicine of preparation treatment tumor is provided, wherein, described tumor is selected from cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma and/or malignant melanoma.
In another preference, described tumor is selected from carcinoma of endometrium, carcinoma vulvae, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis and/or multiple myeloma.
In a second aspect of the present invention, a kind of purposes of compositions in the medicine of preparation treatment tumor that contains the Trametes robiniophila Murr. water extract is provided, wherein, described tumor is selected from cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma and/or malignant melanoma, wherein
Described compositions contains following composition:
0.1-99 parts by weight Trametes robiniophila Murr. water extracts; With
The pharmaceutically acceptable carrier of 1-99 parts by weight.
In another preference, described compositions contains:
10-40 parts by weight Trametes robiniophila Murr. water extracts; With
The pharmaceutically acceptable carrier of 30-70 parts by weight.
In another preference, described compositions is powder, granule, pill, oral liquid, tablet or capsule.
In another preference, described Trametes robiniophila Murr. water extract obtains with water extraction.
In another preference, described water extraction comprises Trametes robiniophila Murr. and 2-12 times of water are mixed and boils 1-6 times, boils 3-9 hours at every turn, obtains the Trametes robiniophila Murr. water extract.
In another preference, Trametes robiniophila Murr. and water mixing are boiled 2-4 times, boiled 5-7 hours at every turn, obtain the Trametes robiniophila Murr. water extract.
In another preference, described Trametes robiniophila Murr. water extract is obtained by following step:
(a) Trametes robiniophila Murr. and 3-12 times of water gagings mixing were boiled 3-9 hours, filter and obtain extracting solution and filtering residue for the first time for the first time;
(b) filtering residue and 2-10 times of water gagings mixing were boiled 3-9 hours for the first time, filtered and obtained extracting solution and filtering residue for the second time for the second time;
(c) filtering residue and 2-10 times of water gagings mixing were boiled 3-9 hours for the second time, filtered and obtained extracting solution for the third time;
(d) three extracting solution merging are obtained the Trametes robiniophila Murr. water extract.
In another preference, also comprise step (e) after the step (d) of described acquisition Trametes robiniophila Murr. water extract: the Trametes robiniophila Murr. water extract simmer down to relative density that step (d) is obtained is the clear paste of 1.2-1.6 (55 ℃).
In view of the above, the invention provides the new purposes of Trametes robiniophila Murr. water extract aspect the treatment tumor.
The specific embodiment
The inventor is surprised to find that through extensive and deep research the Trametes robiniophila Murr. water extract can be used for treating tumors such as cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma, malignant melanoma.
For the ease of understanding the present invention, the inventor proposes the possible mechanism of purposes of the present invention.Be to be noted that claim scope of the present invention is not subjected to any restriction of this mechanism.Mechanism of the present invention is as follows:
Chinese medicine thinks that the weakened body resistance and domination of pathogen is the reason of pathogenesis of cancer, and is pointed as " Required Readings for Medical Professionals gathers a piece of writing ": " then pathogen is crouched it for long-pending one-tenth person, positive QI-insufficiency." just because of plain body weakness, by heresy is suffered from, the stagnation of QI, expectorant coagulate, congestion, evil malicious strongly fragrant of a specified duration, check meridians, with the passing of time become disease, the hematozemia of feeling frustrated checks mechanism of qi, and can follow outside causing heresy and scurry, and is that disease is very grave.
Cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma, the generation development of various tumors such as malignant melanoma also is the process of a vital QI being weakened and pathogen being violent, be that whole body belongs to void, local true a kind of wasting diseases, strengthening the body resistance is the fundamental law of treatment, blood circulation promoting and blood stasis dispelling, the softening the hard mass abdominal mass of loosing, strengthening the body resistance is started with, attack and just do not hinder, the removing food stagnancy tumor takes a turn for the better patient's clinical symptoms and disappearance.The Auricularia Sophorae granule has strengthening the body resistance, the effect of the Xiao Disorder that invigorates blood circulation, and QI invigorating and do not stay the stasis of blood, removing blood stasis and not feeling frustrated, thus reaching strengthening the body resistance, the purpose of removing blood stasis dispersing tumor treating both the principal and secondary aspects of a disease is applicable to each stage of above-mentioned oncotherapy.
As used herein, Auricularia Sophorae (Chinese scholartree moth) is a medicinal fungi, and formal name used at school is TrametesrobiniophilaMurr., and it only grows in the old-age group on the Chinese scholar tree Sophorajaponica trunk.Press categorizing systems in 1973 such as Ainsworth, belong to Basidiomycotina Basidiomycotina, Polyporaceae Polyporaceae, Trametes.
As used herein, Trametes robiniophila Murr. is natural Auricularia Sophorae artificial culture thing.
As used herein, term " pharmaceutically acceptable carrier " refers to be used for the treatment of the carrier of agent administration, comprises various excipient, stabilizing agent, fluidizer and diluent.This term refers to some medicament carriers like this: they itself are not necessary active component, and do not have undue toxicity after using.Suitable carriers is well known to those of ordinary skill in the art.(MackPub.Co. can find discussing fully about pharmaceutically acceptable excipient in N.J.1991) at Remington ' sPharmaceuticalSciences.Acceptable carrier can contain liquid on combination of Chinese medicine is learned, as water, saline, glycerol and ethanol.In addition, also may there be complementary material in these carriers, as wetting agent or emulsifying agent, pH buffer substance etc.Other inessential compositions (for example other complementary medical materials) are also included within the definition of pharmaceutically acceptable carrier.
The present invention uses Auricularia Sophorae granule therapy tumor, and described Auricularia Sophorae granule is a kind of compositions, wherein contains 0.1-99 parts by weight Trametes robiniophila Murr. water extracts; Pharmaceutically acceptable carrier with 1-99 parts by weight.
Trametes robiniophila Murr. water extract provided by the invention can be with the mixture boiled of Trametes robiniophila Murr. and water, filtration and is obtained.
The present invention uses Auricularia Sophorae granule therapy cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma, malignant melanoma, available usual manner is used, and is for example oral.When using the Auricularia Sophorae granule, gross weight by the Trametes robiniophila Murr. water extract, usually every day, dosage was at least about 15 grams/60 kg body weight, and in most of the cases was no more than about 150 grams/60 kg body weight, and preferably this dosage is about 30 grams/60 kg body weight-Yue 90 grams/60 kg body weight; Divide 1-3 time oral, serve on 20-40 days.Certainly, concrete dosage also should be considered factors such as route of administration, patient health situation, and these all are within the skilled practitioners skill.
Auricularia Sophorae granule therapy cervical cancer provided by the invention, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma, malignant melanoma, have evident in efficacy, conditions of patients is stable, improve patient's life quality, increase patient's body weight, improve patient's immunologic function, advantages such as drug safety.
The above-mentioned feature that the present invention mentions, or the feature that embodiment mentions can combination in any.All features that this case description is disclosed can with any composition forms and usefulness, each feature that is disclosed in the description can anyly provide the alternative characteristics of identical, impartial or similar purpose to replace.Therefore removing has special instruction, and the feature that is disclosed only is the general example of equalization or similar features.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, usually according to normal condition, or the condition of advising according to manufacturer.In an embodiment, percentage ratio is weight percentage, and umber is parts by weight, unless stated otherwise.
Embodiment 1
Extractum is extracted in preparation
(1) get Trametes robiniophila Murr. 1100g, decoct with water, add 7 times of water gagings for the first time, boiled 6 hours, filter, extracting solution is standby;
(2) second and third time adds 5 times of water gagings respectively, boils 6 hours, filters;
(3) merge three extracting solution, being evaporated to relative density is the clear paste of 1.35-1.40 (55 ℃).
Embodiment 2
Preparation Auricularia Sophorae granule
With clear paste and an amount of mixing of sucrose, dextrin, soluble starch and correctives that embodiment 1 obtains, to granulate, drying is sieved, and makes Auricularia Sophorae granule 1000g.
Embodiment 3
Clinical trial
1 materials and methods
1.1 be subjected to the reagent thing:
1, embodiment 2 prepared Auricularia Sophorae granules.
2, the employed medicine of matched group:
Medicine available from
Carboplatin Yangzijiang Pharmaceutical Group Co., Ltd
Cisplatin Jiangsu Haosen Pharmaceutical Co., Ltd
Bleomycin A5 Haizheng Medicine Stock Co., Ltd., Zhejiang Prov
Bleomycin Haizheng Medicine Stock Co., Ltd., Zhejiang Prov
Amycin (daunorubicin) Haizheng Medicine Stock Co., Ltd., Zhejiang Prov
Mitomycin Haizheng Medicine Stock Co., Ltd., Zhejiang Prov
Epirubicin Pfizer (Wuxi) company limited
Vincristine sulfate Yangzhou Olympic Competition health pharmaceutcal corporation, Ltd
Vindesine sulfate Hangzhou Minsheng Pharmaceutical Group Co
Methotrexate Hualian Pharmaceutical Factory of Shanghai Pharmaceuticals Holding Co., Ltd.
Paclitaxel Yangzijiang Pharmaceutical Group Co., Ltd
Cyclophosphamide Daping Pharmaceutical Factory, Huashi Pharmaceutical Co., Ltd., Shanghai
Ifosfamide Hengrui Medicine Co., Ltd., Jiangsu Prov.
Prednisone Chifeng Meng Xin pharmaceutcal corporation, Ltd
Phosphoric acid estramustine PhamaciaItaliaS.p.A
Etoposide Hengrui Medicine Co., Ltd., Jiangsu Prov.
5-fluorouracil (5-FU) Hainan Pulin Pharmaceutical Co., Ltd
Dacarbazine Nanjing Pharmaceutical Factory Co., Ltd.
Interferon a Beijing KaiYin Bioisystech Co., Ltd
Interleukin II Egen Corp.
The teniposide Beijing Double-Crane Modern Medicine Technologies Limited Liability Company
Floxuridine Haizheng Medicine Stock Co., Ltd., Zhejiang Prov
Etoposide (Lastet) Nippon Kayaku Co., Ltd.
Mesnaum (mesna) Hengrui Medicine Co., Ltd., Jiangsu Prov.
L-Sarcolysinum Ge Lansu company
Carmustine (carmustine) Hualian Pharmaceutical Co., Ltd., Shanghai
Tamoxifen (tamoxifen) Yangzijiang Pharmaceutical Group Co., Ltd
1.2 main agents, instrument and assessment method
Curative effect determinate standard
1) the tcm syndrome semidefinite quantize standards of grading (be regardless of disease kind, be primarily aimed at through put, tumor patient after the chemotherapy)
Main symptom:
Fatigue and weakness, it is indigestion and loss of appetite to breathe hard, have a dizzy spell, soreness of the waist and knees, score by following standard:
Initiatively tell when the patient goes to a doctor and respectively remember 3 fens
After doctor's inquiry, tell and respectively remember 2 fens
Through doctor prompting or question closely and tell and respectively remember 1 fen
Inferior card:
Lustreless complexion, alopecia is scored by following standard:
Note 1 minute is arranged
There is not note 0 minute
Picture of the tongue:
Unusual body of the tongue and tongue fur note 1 minute
Normal body of the tongue and tongue fur note 0 minute
Pulse condition:
Unusual pulse condition note 1 minute
Normal pulse condition note 0 minute
2) tcm syndrome curative effect judging standard
Produce effects: transference cure or obviously alleviate, syndrome are kept the score and are reduced by 2/3 above person.
Effectively: syndrome alleviates or alleviates, and syndrome is kept the score and reduced greater than 1/3, less than 2/3.
Invalid: as not improve or the syndrome minimizing deficiency of keeping the score with relatively having before the treatment.
Life quality: physical situation score standard (Karnofsky grading scheme)
| The muscle power situation | Keep the score |
| All are normal, do not have uncomfortable disease | 100 |
| Can carry out normal activity, slight disease is arranged | 90 |
| Can carry out normal activity reluctantly, some Sxs are arranged | 80 |
| Life can be taken care of oneself, but can not keep normal activity or heavy work | 70 |
| Life can most ofly be taken care of oneself, but needs others to help once in a while | 60 |
| Need others more to help, and often need medical treatment and nursing | 50 |
| Lose viability, need special the treatment and help | 40 |
| Seriously lose viability, need to be in hospital, but do not have death threats temporarily | 30 |
| Seriously ill, need to be in hospital and positive Supporting Therapy | 20 |
| Critically ill | 10 |
| Dead | 0 |
Evaluation criterion:
(1) tcm syndrome:
Produce effects: treatment back integration reduces more than 2/3 (〉=2/3) than treatment is preceding.
Effectively: treatment back integration reduces more than 1/3 than treatment is preceding, but less than 2/3.
Invalid: integration reduces less than 1/3 than before treating after the treatment, even increase (≤1/3).
(2) life quality:, be chosen as reduction, stablize, improve three grades with the Ka Shi point system.Treat the back than increase by 10 fens before treating or above person for improving, reduces 10 fens or above person for reducing, the no change person stablizes.
(3) body weight: treating 1 kilogram of back weight increase or above person be " increase ", and reducing by 1 kilogram or above person is that " decline " variation is " stablizing " less than 1 kilogram of person.
(4) immunologic function:
Every indexs such as T cell subsets, NK cell compare before treating, after treating
Improve: be lower than before the treatment normally, recover normal after the treatment or treat the back than raising 〉=10% before treating;
Descend: be lower than before the treatment normally, treat the back and treat preceding decline 〉=10%, normal before the treatment, be lower than after the treatment normally.
Stable: as to be lower than before the treatment normally, to treat the preceding rising of treatment of back, decline deficiency.All normal before and after the treatment.
Method, reagent and the instrument of every indexs such as T cell subsets, NK cell:
Method: flow cytometry
Instrument: flow cytometer
Reagent: special measuring test kit (T Lymphocyte Subsets Determination test kit, NK raji cell assay Raji test kit)
1.3 test method
The Auricularia Sophorae granule therapy cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma, the malignant melanoma that make with embodiment 2.Above-mentioned patient is divided into treatment group and matched group according to the disease kind, is one group with 60-70 people and goes into to organize medication at random, matched group only carries out chemotherapy, and the treatment group is taken the Auricularia Sophorae granule therapy on the chemotherapy basis.Oral Auricularia Sophorae granule, everyone every day 3 times, each 20 grams.Be 2 chemotherapy cycles, totally 6 weeks the course of treatment.
1.4 statistical analysis technique
Statistical analysis adopts the SPSS10.0 statistical analysis software to calculate.
All statistical test all adopt two-sided test, and the P value is less than or equal to 0.05 difference that will be considered to be checked statistical significance.
The measurement data that each time prescription on individual diagnosis is organized in different treatments will adopt mean ± standard deviation to carry out descriptive statistics.Compare with screening phase basic value, adopt front and back difference in the paired t-test comparable group.The variation of two groups of treatment front and back adopts two sample mean t check, variance analysis (ANOVA) and Wilcoxon rank test to compare.
The enumeration data that each time prescription on individual diagnosis is organized in different treatments adopts frequency (constituent ratio) to carry out descriptive statistics.X is adopted in the variation of two groups of treatment front and back
2Check or non parametric tests.
Analysis comes off: two groups of total expulsion rates and since adverse events and expulsion rate relatively will adopt x
2Check.
The harmony analysis of basic value: adopt variance analysis or x2 to check comparison demography data and other basic value index, how to weigh two groups of harmonies.
Efficiency analysis: adopt two sample mean t check, variance analysis (ANOVA), x
2Check, CMHx
2Check, Wilcoxon rank test compare analysis.The influence of center effect to curative effect index will be considered.
Safety analysis: x
2Relatively two groups of adverse events incidence rates are adopted in check, and the adverse events that this test is taken place is described in tabulation; Lab test results normal/abnormal situation of change and when abnormal change takes place and the relation of trial drug before and after test.
2 result of the tests
After the treatment of 6 weeks, carry out statistical analysis, the result is as follows:
3 conclusion (of pressure testing)s
Above-mentioned tumor patient is after the process treatment, and Syndrome in TCM marquis's test group effective percentage is 92.38%, and the matched group effective percentage is 42.56%, treats back symptom analysis test group significantly better than matched group, P＜0.05.
The life quality evaluation (physical situation score) of treatment back, test group raising rate 64.84%, matched group raising rate 18.87%, test group be significantly better than matched group, P＜0.05.
The body weight evaluation of treatment back, test group raising rate 58.75%, matched group raising rate 17.02%, test group be significantly better than matched group, P＜0.05.
The immunologic function evaluation of treatment back, NK test cell line group raising rate 56.12%, matched group raising rate 16.51%, test group be significantly better than matched group, P＜0.05; CD4+/CD8+ test group raising rate 54.36%, matched group raising rate 15.40%, test group be significantly better than matched group, P＜0.05.
Do not observe the variation of this medicine safety aspect.
The result shows that Auricularia Sophorae granule provided by the invention can improve the symptom of tumor patient, improves patient's life quality, increase patient's body weight, improves patient's immunologic function.
Simultaneously, Auricularia Sophorae granule provided by the invention medication is fool proof, no serious adverse effects.Be the tumor patient chance that provides more choices.
Embodiment 4
Control and test for example
1, Wang, the woman 36 years old, is diagnosed as cervical cancer, pathological diagnosis in May, 2005: squamous cell carcinoma, clinical stages: the IIb phase, patient's purplish tongue, few tongue, tongue body are fat slightly, nervous, poor appetite, deficient pulse is unable, spiritlessness and weakness, deficiency of QI with disinclination to talk.The patient is carried out chemotherapy cooperate the Auricularia Sophorae granule therapy, per 3 weeks are one-period, carry out the treatment in 2 cycles.Significantly improve through 6 week treatment back patient's Syndrome in TCM marquis, nervous, poor appetite, unable, the spiritlessness and weakness of deficient pulse, deficiency of QI with disinclination to talk is clearly better, weight increase 3.5kg, immunologic function improves.The patient feels good, and adheres to taking after leaving hospital, and patient's symptom is stable so far.
2, Liu, the woman, 45 years old, be diagnosed as ovarian cancer in October, 2004, carries out full uterus double accessory and omentum resection, simultaneously systemic chemotherapy.Find relapse and metastasis in April, 2005, carried out the 2nd operation, and postoperative patient lower abdomen pain is weighed down the discomfort that expands, and complexion is dark dim, emaciated physique, and spiritlessness and weakness, indigestion and loss of appetite, two is not just smooth, and dimly purple tongue has ecchymosis, thready and hesitant pulse.The patient is carried out chemotherapy take the Auricularia Sophorae granule therapy simultaneously, through the treatment in 6 weeks, the patient demonstrate,proves Hou Xianzhu and improves, spiritlessness and weakness, indigestion and loss of appetite being clearly better, and abdominal part weighs down uncomfortable disappearance of expanding, and two is just smooth, body weight gain 2kg, immunologic function significantly improves.CT examination shows: recurrence kitchen range tumor is obviously dwindled the metastasis complete obiteration.
3, Zhang, the woman 56 years old, is diagnosed as carcinoma of endometrium, pathological diagnosis in February, 2005: middle differentiation cancer, clinical stages: III phase, the patient is hospitalized for treatment, patient's soreness of waist Mental fatigue before treating, and shortness of breath and palpitation, lower abdomen weighs down pain, and is indigestion and loss of appetite, dreaminess, big loose stool, body of the tongue is light red, white and greasy fur, deep-thready pulse.The patient is carried out 2 cycle chemotherapy take the Auricularia Sophorae granule therapy simultaneously, through the treatment in 6 weeks, the patient demonstrate,proves Hou Xianzhu and improves, and lower abdomen weighs down pain, indigestion and loss of appetite being clearly better, soreness of waist Mental fatigue, and shortness of breath and palpitation disappears, body weight gain 3.3kg.CT examination shows: tumor is obviously dwindled.
4, Xing, the man, 64 years old, be diagnosed as malignant melanoma (right side nasal cavity) in February, 2005, the treatment that undergos surgery in 2 cycles of postoperative PBDV scheme chemotherapy, is taken the Auricularia Sophorae granule therapy simultaneously.Have a medical check-up before the treatment, weight in patients 67.2kg, physical situation scoring 70 minutes, weak, chest is vexed tired, side of body rib distension, the belch acid regurgitation, nasal cavity distending pain, stringy and hesitant pulse or string are floating, and the tip of the tongue stasis of blood is dim.Through the treatment in 6 weeks, patient's symptom is significantly improved, and weak, chest is vexed to be tired of, to coerce rib distension, the disappearance of nasal cavity distending pain, weight increase to 70.6kg, physical situation scoring 90 minutes, and every inspection is normal, is left hospital.
5, Hangzhoupro, the man, 44 years old, be diagnosed as carcinoma of gallbladder in March, 2004, right hypochondrial region persistence dull pain is off one's feed, and becomes thin.The patient receives treatment in local hospital, combination therapy of Chinese and western, but unsatisfactory curative effect.The doctor advises operative treatment, but the patient is reluctant to perform the operation.Went to a doctor in the monthly income the court in 2005 2, patient's two side of body distending pains, and stomach discomfort, backache, the singultus belch, anorexia, refreshing tired weak, body weight 56.4kg, physical situation scoring 70 minutes.According to conditions of patients, give the Auricularia Sophorae granule therapy.The patient takes two recoveries from illness course of treatment of Auricularia Sophorae granule.Treat refreshing tired weak, the singultus belch transference cure of back patient, body weight 61.2kg, physical situation scoring 90 minutes, two side of body distending pains, stomach discomfort degree alleviate, and appetite increases, and does not have other discomforts.Leave hospital.Phone is followed up a case by regular visits to, and does not see recurrence.
6, Bai, the woman, 30 years old, patient's renal carcinoma was made a definite diagnosis the back and is accepted 3 cycle VFH scheme chemotherapies.Patient's fatigue and weak, spontaneous sweating, lusterless complexion is done during hematuria, lumbago abdominal distention, anemia is become thin, the action tachypnea, the time cough companion's low grade fever is arranged, xerostomia, red tongue, dim purple has ecchymosis, thready and rapid pulse is reluctant to continue chemotherapy.According to conditions of patients, take the Auricularia Sophorae granule and carry out the right supporting anticancer treatment.Behind the Auricularia Sophorae granule therapy through 2 courses of treatment, the lab testing renal biopsy shows that cancerous cell does not shift, and patient's symptom is significantly improved, weak disappearance, weight increase is after the patient leaves hospital, every half a year, accept one-period injection chemotherapy, adhere to taking the Auricularia Sophorae granule.So far do not see recurrence and transfer in 2 years.
7, Qiu, man, 65 years old.Patient's what in December, 2003, conscious health heating, the lower abdomen discomfort, urine is discharged unable and drop is not well, is diagnosed as on inspection: carcinoma of prostate.Conclusive evidence back chemotherapy twice is because of the patient is difficult to stand to chemotherapy, so stop chemotherapy.In February, 2004, my institute accepted Chinese traditional treatment.Examine and see that patient's spirit is poor, urinary obstruction, pale complexion, the waist knee joint is cold and sluggish, pale tongue, tongue is white, a little less than the deep-thready pulse.Take the Auricularia Sophorae granule therapy, after taking medicine 10 days, urine can smooth and easyly be discharged, can be free movable after taking medicine 20 days, General Symptoms greatly takes on a new look, and continues to take medicine one month, and the patient leaves hospital, and continues to take the Auricularia Sophorae granule, phone is visited, and life is handled fully, and healthy.
8, grandson, man, 35 years old.There is the ellipse lump in left side, patient throat, is increase tendency gradually, and lobus sinister tuberosity position is developed unclear, is radial damaged.Through pathological diagnosis is thyroid malignancy, and the doctor advises excision.The patient is reluctant operation and changes Chinese traditional treatment.The left front cervical region of patient has one 4.0cm * 2.5cm * 2.5cm lump on inspection, and matter is hard, is uneven, and tenderness is arranged, and color of the leather is no abnormal, and degree of excursion is little.Patient's inappetence, spirit is poor, weak, red tongue, white and thin fur, moderate pulse, the yellowish complexion body is thin.Take the Auricularia Sophorae granule after 20 days, the throat lump begins to dwindle that (2cm * 1.5cm * 1.5cm), matter is soft slightly, and appetite is promoted, weight increase 2kg.After continuing the treatment one and a half months, it is big that the throat lump has been contracted to Semen Viciae fabae, spirit, and appetite is as usual.Treat after 2 months, neck region lump all disappears, and symptom all disappears, and drug withdrawal was observed 1 year, and all are normal.
9, the week certain, woman, 30 years old.First visit in October, 2004.Patient's headache, ophthalmic bloated, feel sick, blurred vision, finger increase slightly nearly 4 years of poor appetite gradually.Be diagnosed as pituitary tumor through the inspection of head sheet.The head sheet shows: the sella turcica anteroposterior diameter has reached 25mm, and dark footpath is 16mm.Disease is seen chronic facies during prescription on individual diagnosis, and lusterless complexion, face, lip and extremity acra are obviously loose, and enlarged tongue is big, white and thin fur, and root is thick greasy, and body of the tongue is light red, thready pulse.After treating 15 days, dizziness headache, blurred vision takes a turn for the better, and the ability of thinking and the mental status are also improved, and appetite increases.Continued to take 3 months, and continued to take to consolidate curative effect after leaving hospital.Check head sheet: the sella turcica anteroposterior diameter is reduced into 22mm, and dark footpath is 10mm.Take an evident turn for the better with former head sheet contrast.The all diseases of patient disappear substantially, and in adhering to, night job.Back drug withdrawal more than 1 year is got well and is visited so far not recurrence.
10, the flood certain, man, 49 years old.The former nasopharyngeal carcinoma that is diagnosed as, several years posterior nasopharynx local recurrence of radiotherapy.Biopsy pathology is a squamous cell carcinoma III level, patient's expectorant blood, and cervicodynia, Hiccough and deaf, right side headache, the red tongue tongue is white, and rolling pulse is thin, and the nasopharynx inspection finds, and the right side knuckle finds to have the cauliflower-like thing 1cm * 1cm that swells, and carries out chemotherapy in conjunction with the Auricularia Sophorae granule therapy.The swollen thing of posterior nasopharynx began to dwindle in 2 months, and symptom takes a turn for the better.Obviously swollen thing is not seen in posterior nasopharynx inspection in 3 months.Adhere to taking the Auricularia Sophorae granule, patient's symptom fades away.Cancerous cell is not found in the biopsy of 1 year posterior nasopharynx portion.
11, the week certain, man, 45 years old.The patient is owing to occur hoarseness suddenly, and the companion coughs, and the expectorant Huang is swallowed malaise symptoms, the commentaries on classics of not getting better in 10 days, hospital admission through laryngoscopy, finds that there is the neoplasm of a diameter 0.5cm at preceding 1/3 place of vocal cords, left side, local vocal cords limitation of movement, the surface is uneven, and becomes the ulcer shape.The focus biopsy is " well-differentiated squamous carcinoma ".The patient is reluctant to perform the operation, and carries out the radiotherapy combined Chinese traditional treatment.Disease is seen hoarseness, cough, expectorant Huang, and is mute, and the self-induction dry laryngopharynx is swallowed discomfort, and dry when half congealed during stool, tongue is little deep red, and tongue is yellowish, stringy and thready pulse.Patient's radiotherapy combined is taken the Auricularia Sophorae granule therapy.Treat after 30 days and check that neoplasm is obviously dwindled, being clearly better appears in each symptom.Continue to take the Auricularia Sophorae granule and check preceding 1/3 place of left vocal cord after 2 months and do not see neoplasm, pharynx and vocal cords epidermis, it is fair to move.Conclusion is: " high differentiation squamous cell is almost recovered ".Continue to take the Auricularia Sophorae granule, to consolidate curative effect.
The above only is preferred embodiment of the present invention, be not in order to limit essence technology contents scope of the present invention, essence technology contents of the present invention is broadly to be defined in the claim scope of application, any technology entity or method that other people finish, if it is defined identical with the claim scope of application, also or a kind of change of equivalence, all will be regarded as being covered by among this claim scope.
Claims (10)
1. the Trametes robiniophila Murr. water extract purposes in the medicine of preparation treatment tumor, wherein, described tumor is selected from cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma and/or malignant melanoma.
2. purposes as claimed in claim 1, it is characterized in that described tumor is selected from carcinoma of endometrium, carcinoma vulvae, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis and/or multiple myeloma.
3. the purposes of a compositions that contains the Trametes robiniophila Murr. water extract in the medicine of preparation treatment tumor, wherein, described tumor is selected from cervical cancer, ovarian cancer, carcinoma of endometrium, carcinoma vulvae, carcinoma of prostate, carcinoma of parotid gland, thyroid carcinoma, salivary-gland carcinoma, skin carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, oral cancer, laryngeal carcinoma, cerebroma, carcinoma of gallbladder, renal carcinoma, gingival carcinoma, carcinoma of testis, carcinoma of penis, multiple myeloma and/or malignant melanoma, wherein
Described compositions contains following composition:
0.1-99 parts by weight Trametes robiniophila Murr. water extracts; With
The pharmaceutically acceptable carrier of 1-99 parts by weight.
4. purposes as claimed in claim 3 is characterized in that, described compositions contains:
10-40 parts by weight Trametes robiniophila Murr. water extracts; With
The pharmaceutically acceptable carrier of 30-70 parts by weight.
5. as the arbitrary described purposes of claim 1-4, it is characterized in that described compositions is powder, granule, pill, oral liquid, tablet or capsule.
6. as the arbitrary described purposes of claim 1-4, it is characterized in that described Trametes robiniophila Murr. water extract obtains with water extraction.
7. purposes as claimed in claim 6 is characterized in that, described water extraction comprises Trametes robiniophila Murr. and 2-12 times of water are mixed and boils 1-6 times, boils 3-9 hours at every turn, obtains the Trametes robiniophila Murr. water extract.
8. purposes as claimed in claim 7 is characterized in that, Trametes robiniophila Murr. and water mixing are boiled 2-4 times, boils 5-7 hours at every turn, obtains the Trametes robiniophila Murr. water extract.
9. as the arbitrary described purposes of claim 1-4, it is characterized in that described Trametes robiniophila Murr. water extract is obtained by following step:
(a) Trametes robiniophila Murr. and 3-12 times of water gagings mixing were boiled 3-9 hours, filter and obtain extracting solution and filtering residue for the first time for the first time;
(b) filtering residue and 2-10 times of water gagings mixing were boiled 3-9 hours for the first time, filtered and obtained extracting solution and filtering residue for the second time for the second time;
(c) filtering residue and 2-10 times of water gagings mixing were boiled 3-9 hours for the second time, filtered and obtained extracting solution for the third time;
(d) three extracting solution merging are obtained the Trametes robiniophila Murr. water extract.
10. purposes as claimed in claim 9 is characterized in that, also comprises step (e) after the step (d) of described acquisition Trametes robiniophila Murr. water extract: the Trametes robiniophila Murr. water extract simmer down to relative density that step (d) is obtained is 1.2-1.6 clear paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101705866A CN101439055B (en) | 2007-11-19 | 2007-11-19 | Use of aqueous extract of Trametes robiniophila Murr. in preparing medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101705866A CN101439055B (en) | 2007-11-19 | 2007-11-19 | Use of aqueous extract of Trametes robiniophila Murr. in preparing medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101439055A true CN101439055A (en) | 2009-05-27 |
| CN101439055B CN101439055B (en) | 2011-08-24 |
Family
ID=40723753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101705866A Active CN101439055B (en) | 2007-11-19 | 2007-11-19 | Use of aqueous extract of Trametes robiniophila Murr. in preparing medicament |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101439055B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623438B (en) * | 2009-07-28 | 2011-12-28 | 启东盖天力药业有限公司 | Application of Huaiqihuang particle compound preparation in kidney disease treatment |
| CN102621260A (en) * | 2011-01-31 | 2012-08-01 | 启东盖天力药业有限公司 | Sophora fungus mycoplasma extract identification and detection method |
| CN103316051A (en) * | 2013-05-14 | 2013-09-25 | 三峡大学 | New functions and applications of trametes lactinea(Berk.)Pat. or extractives and trametenloic acid B |
| CN107670041A (en) * | 2015-02-12 | 2018-02-09 | 中国医科大学附属第医院 | A kind of method for configuring zirconium dioxide composite nano materials dispersion liquid |
-
2007
- 2007-11-19 CN CN2007101705866A patent/CN101439055B/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623438B (en) * | 2009-07-28 | 2011-12-28 | 启东盖天力药业有限公司 | Application of Huaiqihuang particle compound preparation in kidney disease treatment |
| CN102621260A (en) * | 2011-01-31 | 2012-08-01 | 启东盖天力药业有限公司 | Sophora fungus mycoplasma extract identification and detection method |
| CN103316051A (en) * | 2013-05-14 | 2013-09-25 | 三峡大学 | New functions and applications of trametes lactinea(Berk.)Pat. or extractives and trametenloic acid B |
| CN103316051B (en) * | 2013-05-14 | 2015-07-22 | 三峡大学 | New functions and applications of trametes lactinea(Berk.)Pat. or extractives and trametenloic acid B |
| CN107670041A (en) * | 2015-02-12 | 2018-02-09 | 中国医科大学附属第医院 | A kind of method for configuring zirconium dioxide composite nano materials dispersion liquid |
| CN107812191A (en) * | 2015-02-12 | 2018-03-20 | 中国医科大学附属第医院 | Configuration dispersion liquid that is a kind of while being imaged for chemotherapy, microwave heat therapeutic and CT |
| CN107812191B (en) * | 2015-02-12 | 2020-07-31 | 中国医科大学附属第一医院 | A dispersion for chemotherapy, microwave thermotherapy and CT imaging |
| CN107670041B (en) * | 2015-02-12 | 2020-07-31 | 中国医科大学附属第一医院 | Method for preparing zirconium dioxide composite nano material dispersion liquid |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101439055B (en) | 2011-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101439055B (en) | Use of aqueous extract of Trametes robiniophila Murr. in preparing medicament | |
| CN102579840B (en) | Chinese medicinal composition with effects of reducing intraocular pressure and protecting optic nerves and preparation method thereof | |
| CN100381143C (en) | Chinese-medicine cataplasma for treating cervical vertebra disease and preparing method | |
| CN102846802B (en) | Capsule for treating urinary system diseases and preparation method thereof | |
| CN102836250B (en) | Medicine for regulating blood pressure | |
| CN102008688B (en) | Medicament for treating periodic psychosis | |
| CN100546611C (en) | A kind of Chinese medicine preparation for the treatment of acquired immune deficiency syndrome (AIDS) | |
| CN100488496C (en) | Medicine for treating lung cancer | |
| CN104623605A (en) | Traditional Chinese medicine capable of treating breast cancer | |
| CN115105576B (en) | Traditional Chinese medicine composition for treating ovarian cancer, traditional Chinese medicine preparation and application thereof | |
| CN1330358C (en) | Concurrent medicine for cancer in late stage or chemotherapy | |
| CN103784554B (en) | A kind of treat damp and hot accumulate kidney card renal tuberculosis Chinese medicine composition | |
| CN105596687A (en) | Traditional Chinese medicine for treating perimenopausal syndrome | |
| CN105412319A (en) | Traditional Chinese medicine preparation for treating chronic kidney failure and preparation method and application thereof | |
| CN107837360A (en) | A kind of navel plaster, navel paster, preparation method and application method for treating chronic gastritis | |
| CN101732563A (en) | Application of composite from trametes robinioplila murr, wolfberry and sealwort | |
| CN107320662A (en) | Traditional Chinese medicine composition for treating nasopharyngeal carcinoma and cooperating with nasopharyngeal carcinoma chemoradiotherapy | |
| CN106420889A (en) | Traditional Chinese medicine composition containing royal jelly as well as preparation and application of traditional Chinese medicine composition | |
| CN105833220A (en) | Traditional Chinese medicine composition for assistant treatment of gynecologic malignant tumors | |
| CN104306796A (en) | Traditional Chinese medicine combination for relieving thyroid cancer postoperative liver depression phlegm stagnation syndrome | |
| CN104689246B (en) | A kind of medicine for the treatment of gastric cancer | |
| CN104258303A (en) | Traditional Chinese medicine for treating dysmenorrhea | |
| CN103845499B (en) | A kind of Chinese medicine composition for the treatment of chronic prostatitis | |
| CN102670900B (en) | External medicament for treating vulvar dystrophy | |
| CN103495088B (en) | Pharmaceutical composition of a kind for the treatment of or auxiliary treatment carcinoma of prostate and its production and use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |