CN101433606B

CN101433606B - External-use agent for treating vitiligo

Info

Publication number: CN101433606B
Application number: CN2008101476151A
Authority: CN
Inventors: 王洪斌
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-11-20
Filing date: 2008-11-20
Publication date: 2012-06-27
Anticipated expiration: 2028-11-20
Also published as: CN101433606A

Abstract

The invention discloses an externally used medicament for treating leucoderma, which comprises effective components such as angelica dahurica, white paeony root, rhizome drynariae, lopseed, clematis root, peach kernel, sulfur, blue vitriol, goslarite, and the like. The preparation method comprises the following steps: crushing the effective components of Chinese herbal medicine and then extracting and separating out effective constituents; grinding minerals by glycerin and then pressurizing and filtering the minerals by a screen of 400 meshes; and respectively taking proper filtrate and mixing the filtrate by 50 percent ethanol into turbid suspension, or taking the filtrate according to certain proportion and then using cream to prepare the filtrate into ointment. The medicament has remarkable and unique curative effect for vitiligo and leucoderma diseases caused by depigmentation of skin, and has the advantages of safe use, short treatment course and high curative ratio.

Description

Treat leukodermic topical agent

Technical field

The present invention relates to treat dermopathic key areas.Be specifically related to the leukodermic medicine for external use of a kind of treatment

Background technology

Agent.

Summary of the invention

Vitiligo is a kind of pigmented dermatosis of common pilosity, and this disease is with local or general property depigmentation, and the formation white macula is a characteristic.Be due to the local skin pigment lacks, relevant with the melanin hyposecretion.Generation is all arranged all over the world, and India's sickness rate is the highest, and China has 1,200 ten thousand people morbidity approximately, and primary disease can involve all races, men and women's no marked difference of falling ill.In recent years sickness rate rises year by year, causes people's common concern.White macula, therapy for vitiligo always are the difficult point in the dermatosis field, particularly mucosa and leukoplakia vulvae, more show refractory.

The purpose of this invention is to provide a kind of white macula, vitiligo disease of treating due to the depigmentation of skin, safe in utilization, short treating period, the topical agent that cure rate is high.Particularly in the treatment of facial area, lip mucosa and leukoplakia vulvae, remarkable result is arranged more.

In order to achieve the above object and curative effect, the present invention is processed by following raw materials in weight portion:

The Radix Angelicae Dahuricae 15～25 Radix Paeoniae Albas 10～20 Rhizoma Drynariae 10～20 Herba speranskiae tuberculataes 5～15 Radix Clematidis 5～15

Semen Persicae 5～15 sulfur 5～15 Chalcanthitums 5～25 white vitriols 5～15

50% ethanol: 1000～2000

Glycerol: 500～1000

Frost base: sodium laurylsulfate 50～100.

Optimum weight part proportioning of medicine of the present invention is:

The Radix Angelicae Dahuricae 10 Radix Paeoniae Albas 15 Rhizoma Drynariae 15 Herba speranskiae tuberculataes 10 Radix Clematidis 10

Semen Persicae 10 sulfur 10 Chalcanthitums 15 white vitriols 10

50% ethanol: 1500

Glycerol: 800

Frost base: sodium laurylsulfate etc. 80

Making step of the present invention is following:

(1) Chinese herbal medicine is got and is carried: get the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Rhizoma Drynariae, Herba speranskiae tuberculatae, Radix Clematidis and Semen Persicae by said prescription proportioning and pulverize; Chinese drugs powder after pulverizing is added 50% alcohol solvent by the prescription proportioning, after fully stirring, leave standstill more than 72 hours (stir 2-3 every day).Use four layers of filtered through gauze then.Getting its filtrating A contains in the container bottle subsequent use.

(2) mineral grinds: said prescription proportioning is got sulfur, Chalcanthitum and white vitriol and is pulverized, and the mineral drug powder after pulverizing is pressed the prescription proportioning add the glycerol grinding, then with 400 sieve pressure filtrations.Getting its liquor B contains in the container bottle subsequent use.

(3) finished product:,, liquor B and an amount of 50% ethanol mixing are processed suspension commodity B1 so will filtrate A and an amount of 50% ethanol mixing are processed suspension commodity A1 because of these medicine characteristics are that fresh result of use is best.A1, B1 place the plastics colored bottle respectively.The A that will filtrate mixes to mix thoroughly with an amount of frost base and processes ointment commodity A2, with liquor B with an amount of white basic mix to mix thoroughly process ointment commodity B2.A2, B2 place wide-mouth coloured plastics material box respectively.Place 3-10 ℃ of refrigerator to preserve lucifuge.During use, by different proportion get commodity A1 and B1 mix thoroughly suspension, be coated with the part outward.Perhaps by different proportion get commodity A2 and B2 mix mix thoroughly ointment, be coated with the part outward.

The mechanism of action of the present invention: 1, through oxidation reaction, for local cells provides pigment.2, various trace elements is provided, supplies with cytotrophy.

The present invention becomes for vitiligo, white macula due to the local skin depigmentation, limit office sexually transmitted disease (STD), and medical history had significant especially curative effect in 5 years with interior person.Simultaneously treatment tinea versicolor etc. also there is certain effect.And select for use suspension or ointment to put the part outward on the skin to diseased region.As: the body surface white macula, select suspension for use.Time spent is mixed A1, two kinds of medicines of B1, shakes up, and with the open-minded chopsticks dipping affected part of bamboo let, must not repeatedly overflow in normal skin.Put on the skin 2-3 time every day outward, and it is only normal to become a full member to skin pigment.About medication 10 days, local white macula more whitening is a little, continues to put on the skin then blackening gradually.Facial area, lip mucosa are selected white fundamental mode ointment (white macula ointment) for use.Time spent is mixed A2, B2 two boxes, mixes thoroughly with bamboo let, is applied to affected part, and put on the skin 2-3 time every day outward, and it is only normal to become a full member to pigment.Must not repeatedly overflow in normal skin when being coated with, thickness of covering is opened thick for printing paper 3-5.Medicine generation grey black reaction under photosynthesis behind the coating.

Short treating period of the present invention, cure rate height, local no side reaction, safe in utilization, be fit to a plurality of age group and use, particularly child, teenager.Treatment facial area, lip mucosa, leukoplakia vulvae have significant curative effect, and the patient is prone to grasp use.Its manufacturing process is simple, and dosage form is stable, and cost is more honest and cleaner, but mass production.

Model case

1, Zhao, woman, 4 years old.Left front volume 2cm * 5cm white macula is to scalp, a handful of poliosis on the white macula, and medical history 2 years is diagnosed as vitiligo to various big hospitals such as Chengdu; Fail to respond to any medical treatment, come to go to a doctor, adopt the externally applied liquid treatment on JIUYUE 24th, 20058; Pigmentation was arranged in 3 months, and to recovery from illness in 12 months, poliosis transferred hair color to.

2, for certain, man, 28 years old.Bottom right jaw leukoderma, medical history 4 years is a vitiligo to other hospital diagnosis, comes to go to a doctor on May 25th, 2006.With the externally applied liquid treatment, cured in 12 months.

3, Lee, woman, 20 years old.Place, right forelock border white macula, right hand palmar and refer to a plurality of white maculas came to go to a doctor on July 5th, 2007.Hospital of a few family goes to control repeatedly to the Leshan in readme, and is invalid.Adopt medicament ointment of the present invention to put forehead outward on the skin, every day 3 times.Hand getting is with treatments such as " refining melanoma liquids ".Forehead had pigmentation in three month, and skin pigment was often become a full member in 8 months, and hand was cured in 11 months.

4, Zhang, woman, 15 years old.Two skin of upper extremity white maculas are vitiligo (medical history 5 years) to other hospital diagnosis, fail to respond to any medical treatment.Come to go to a doctor on August 1st, 2007, suspension is put on the skin outward, cures in 8 months.

5, Lu, the woman, 12 years old, facial area white macula many places were vitiligo to how tame hospital diagnosis such as Leshan, Chengdu, medical history 5 years is failed to respond to any medical treatment.Come to go to a doctor on October 13rd, 2007, with the outer liniment for treatment of ointment, skin recovers normal after 56 days.

6, Wang, woman, 37 years old.Right side lip membranous part white macula is a vitiligo to other hospital diagnosis, medical history 1 year.Come to go to a doctor on JIUYUE 6th, 2008.Put on the skin outward with ointment, lip mucosa pigment recovered normal in 52 days.

7, the hair certain, woman, 27 years old.The a plurality of white maculas of right side lower jaw to cervical region are vitiligo to other hospital diagnosis, and medical history 1 year came to go to a doctor on JIUYUE 10th, 2008, put on the skin outward with ointment, cured in 45 days.Specific embodiment

The present invention forms by following proportioning:

Semen Persicae 10 sulfur 10 Chalcanthitums 15 white vitriols 10

50% ethanol: 1500

Glycerol: 800

Frost base: sodium laurylsulfate etc. 80

The present invention makes by following making step:

Claims

1. treat leukodermic topical agent for one kind, it is characterized in that it is the medicament of being processed by the following weight parts proportion raw material:

Semen Persicae 5～15 sulfur 5～15 Chalcanthitums 5～25 white vitriols 5～15

50% ethanol: 1000～2000

Glycerol: 500～1000

Frost base: sodium laurylsulfate 50～100;

The making step of the leukodermic topical agent of said treatment is following:

(1) Chinese herbal medicine: get the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Rhizoma Drynariae, Herba speranskiae tuberculatae, Radix Clematidis and Semen Persicae by said prescription proportioning and pulverize; Chinese drugs powder after pulverizing is added 50% alcohol solvent by the prescription proportioning, after fully stirring, leave standstill more than 72 hours, stir 2-3 every day, uses four layers of filtered through gauze then, gets its filtrating A and contain in the container bottle subsequent use;

(2) mineral medicine: get sulfur, Chalcanthitum and white vitriol by said prescription proportioning and pulverize, the mineral drug powder after pulverizing is pressed the prescription proportioning add the glycerol grinding, with 400 sieve pressure filtrations, get its liquor B and contain in container bottle subsequent use then;

(3) allotment and finished product: because of these medicine characteristics are that fresh result of use is best; The A that will filtrate mixes to mix thoroughly with an amount of frost base and processes ointment commodity A2; Liquor B and an amount of frost base mixed to mix thoroughly process ointment commodity B2, A2, B2 place wide-mouth coloured plastics material box respectively, during use; By different proportion get commodity A2 and B2 mix mix thoroughly ointment, be coated with the part outward.

2. treat leukodermic topical agent for one kind, wherein the weight portion proportioning of each raw material is:

Semen Persicae 10 sulfur 10 Chalcanthitums 15 white vitriols 10

50% ethanol: 1500

Glycerol: 800

Frost base: sodium laurylsulfate 80;