CN104257781A - External preparation for treating vitiligo - Google Patents

External preparation for treating vitiligo Download PDF

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CN104257781A
CN104257781A CN201410504899.0A CN201410504899A CN104257781A CN 104257781 A CN104257781 A CN 104257781A CN 201410504899 A CN201410504899 A CN 201410504899A CN 104257781 A CN104257781 A CN 104257781A
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radix
external preparation
treatment
fructus
parts
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王生学
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K2236/30—Extraction of the material
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention relates to a traditional Chinese medicine for treating vitiligo and belongs to the field of traditional Chinese medicines. In particular, the traditional Chinese medicine for treating vitiligo is prepared from the following Chinese medicinal raw materials in parts by weight: 9-18 parts of trichosanthes palmate, 9-18 parts of tribulusterrestris, 9-18 parts of mulberry fruit, 9-18 parts of lithospermum, 6-12 parts of fructus cnidii, 6-12 parts of glossy privet fruit, 6-10 parts of radices sileris, 2-6 parts of moutan bark, 2-6 parts of radix clematidis and 1-5 parts of borneol. The invention aims at achieving the technical effects that the external preparation for treating vitiligo is good in treatment effect on vitiligo, high in effective rate, short in treatment course and low in price.

Description

A kind of external preparation for the treatment of vitiligo
Technical field
The present invention relates to a kind of Chinese medicine compound, be specifically related to one and treat leukodermic external preparation and preparation method thereof.
Background technology
Vitiligo is a kind of agnogenic depigmentation dermatoses, though without sufferings, multiple at human body exsertion part, and the large stretch of white macula particularly in head, face, neck, item, wrist, for fear of appearance, can bring heavy mental burden to people.
Traditional Chinese medical science medical science is referred to as " vitiligo " or " vitiligo ".Chinese medicine is thought, leukodermic Etiological pathogenesis is stagnation of QI due to depression of the liver, deficiency of the liver and kindey, stagnation of QI-blood.Exopathogen is taken advantage of a weak point in opponent's defence and is attacked, and visitor enters flesh table, and meridians are obstructed, coagulation of QI-blood, and fur space between skin and muscles loses supports and the speckle that turns white.12 meridians, eight extra-channel all can be invaded by pathogenic factor, and all can fall ill in any position of body surface, have bilateral symmetric property characteristics of incidence, the how double congestion of course of disease elder.Lung governing qi, at body and skin, its Hua Mao.Have Xuan Fawei gas, semen deposition is in physiological functions such as furs.Chinese traditional treatment pathogensis of vitiligo vulgaris many employings tonifying liver lung kidney, regulate the flow of vital energy and blood, invigorating striae of the skin method for the treatment of.
Current doctor trained in Western medicine has following several to vitiligo method: 1. Drug therapy.Psoralen and derivatives for treatment thereof: such as add ultraviolet radiation as methoxsalen is oral.Megavitamin is treated, and such as vitamin B complex, vitamin C, Citrin long-term, high-dose are taken.The treatment such as the medicine of useful cupric is as oral in 0.5% copper-bath.Immunomodulator is treated, and such as levamisole is oral, lyophilized bacillus calmette-guerin vaccine (BCG) intramuscular injection, oral Bovine Placenta etc.Treatment is embrocated in skin irritant local makes skin be inflamed reaction, and impel pigment hypertrophy, dust head has 30% psoralea tincture, chlormethine ethanol, phenol (pure carbolic acid), 25% ~ 50% trichloroacetic acid, Mylabris tincture etc.This method is only applicable to small pieces skin lesion, and after being coated with, skin lesion place can occur bulla.Corticosteroid treatment, various corticosteroid hormone is as local package treatments such as propanoic acid beclometasone ointment, halometasone cream, omcilon carbamide ointments, and this method side effect is very large.2. operative treatment.AUTOEPIDERMIC GRAFTING is performed the operation.3. decolouring therapy.Be applicable to skin lesion area large, exceed body surface area person over half, put on the skin outside available 3% ~ 20% hydroquinone list methyl phenyl ethers anisole frost.4. physiotherapy, adopts narrow ripple ultraviolet, long wave ultraviolet or 308nm excimer laser treatment.
Chinese traditional treatment medicine mainly contains: the painted soup of Lignum Sappan, TONGQIAOHUOXUE Decoction, YIN nourishing Tongluo Decoction, refrigerant yin-nourishing soup, Fructus Tribuli Lagerstroemia indica L. soup, Radix Bupleuri resolving depression soup, compound recipe SIWU TANG etc. tens of kinds.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of good to vitiligo therapeutic effect, and effective percentage is high, short treating period, the leukodermic Chinese medicine composition of cheap treatment.
The present invention mainly adopts following technical scheme to realize:
One treats leukodermic external preparation, is made up of following raw material of Chinese medicine:
Radix Stephaniae Cepharanthae, Fructus Atriplicis Sibiricae, Fructus Mori, Radix Arnebiae (Radix Lithospermi), Fructus Cnidii, Fructus Ligustri Lucidi, Radix Saposhnikoviae, Cortex Moutan, Radix Clematidis, Borneolum Syntheticum.
As preferably, the present invention treats leukodermic Chinese medicine composition, is made up of the raw material of Chinese medicine of following parts by weight:
Radix Stephaniae Cepharanthae 9-18, Fructus Atriplicis Sibiricae 9-18, Fructus Mori 9-18, Radix Arnebiae (Radix Lithospermi) 9-18, Fructus Cnidii 6-12, Fructus Ligustri Lucidi 6-12, Radix Saposhnikoviae 6-10, Cortex Moutan 2-6, Radix Clematidis 2-6, Borneolum Syntheticum 1-5.
As preferably, the present invention treats leukodermic external preparation, is made up of the raw material of Chinese medicine of following parts by weight:
Radix Stephaniae Cepharanthae 16, Fructus Atriplicis Sibiricae 16, Fructus Mori 12, Radix Arnebiae (Radix Lithospermi) 12, Fructus Cnidii 8, Fructus Ligustri Lucidi 8, Radix Saposhnikoviae 6, Cortex Moutan 3, Radix Clematidis 3, Borneolum Syntheticum 2.
External preparation of the present invention can add appropriate adjuvant as required, such as antiseptic, dispersant, suspending agent, thickening agent, cosolvent, wetting agent, buffer agent, emulsifying agent, stabilizing agent, transdermal enhancer etc.
As preferably, external preparation of the present invention is preferably ointment, gel or liniment.
Present invention also offers a kind of preparation method for the treatment of Leukoderma liniment, it is characterized in that comprising the following steps:
1) take above-mentioned each raw material, after grinder grinding, cross 100 mesh sieves, by weight portion mix homogeneously of the present invention, add the vegetable oil of 2-4 times amount, stir 1-3 hour, under room temperature, soak 7-14 days, filter, filtrate is for subsequent use;
2) in filtering residue, add the vegetable oil of 2-4 amount again, be heated to 100-130 degree Celsius, insulated and stirred 2-4 hour, filter, by for subsequent use near for filtrate room temperature;
3) merging filtrate, sterilizing, subpackage, obtains Chinese medicine composition composition liniment of the present invention.
Preferably, the vegetable oil described in above-mentioned preparation method is selected from one or more in Oleum sesami, Castor oil, soybean oil, Oleum Arachidis hypogaeae semen, olive oil.
Preferably, the vegetable oil described in above-mentioned preparation method most preferably is Oleum sesami.
It will be appreciated by persons skilled in the art that the present invention also according to existing Chinese medicine extraction technology, can be prepared into other external preparation.
In side of the present invention, the efficiency analysis of medical material used is as follows: Radix Stephaniae Cepharanthae: bitter, cold.Heat-clearing and toxic substances removing, cooling blood for hemostasis, pain relieving.Fructus Atriplicis Sibiricae: pungent, bitter, tepor; Slightly poisonous.Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.Fructus Mori: sweet; Acid; Cold in nature, nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening, having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation.Radix Arnebiae (Radix Lithospermi): sweet, salty, cold.Removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Fructus Cnidii: pungent, bitter, temperature; Slightly poisonous.Warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.Fructus Ligustri Lucidi: sweet, bitter, cold.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.Radix Saposhnikoviae: acrid, sweet, warm.Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.Cortex Moutan: bitter, pungent, is slightly cold.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.Radix Clematidis: pungent, salty, temperature.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx.Borneolum Syntheticum: pungent, bitter, is slightly cold.To have one's ideas straightened out refreshment, clearing away heat to alleviate pain.
The present invention treats leukodermic external preparation usage and dosage: smear affected part every day 3 times, and the morning, noon and afternoon, respectively once, after smearing, available preservative film covered, and effect more.30 days courses for the treatment of.Pungent, greasy and seafood is avoided during medication.
The present invention treats leukodermic external preparation, and preparation method is simple, and cost is low, and cure rate is high, short treating period, and crude drug source is extensive, and safe without toxic side effect, is applicable to promoting the use of.
Detailed description of the invention
Embodiment 1
The preparation of liniment of the present invention:
Prescription:
Radix Stephaniae Cepharanthae 16kg Fructus Atriplicis Sibiricae 16kg Fructus Mori 12kg Radix Arnebiae (Radix Lithospermi) 12kg Fructus Cnidii 8kg
Fructus Ligustri Lucidi 8kg Radix Saposhnikoviae 6kg Cortex Moutan 3 kg Radix Clematidis 3kg Borneolum Syntheticum 2kg
Preparation technology:
1) by above-mentioned prescription, take each raw material, after grinder grinding, cross 100 mesh sieves, mix homogeneously, adds the vegetable oil of 3 times amount, stirs 2 hours, soaks 7 days under room temperature, filters, obtains filtrate;
2) in filtering residue, add the Oleum sesami of 2 times amount, be heated to 105-110 degree Celsius, insulated and stirred 2 hours, filter, obtain filtrate;
3) merging filtrate, sterilizing, subpackage, obtains Chinese medicine composition composition liniment of the present invention.
Embodiment 2
The preparation of liniment of the present invention:
Prescription:
Radix Stephaniae Cepharanthae 18kg Fructus Atriplicis Sibiricae 18kg Fructus Mori 18kg Radix Arnebiae (Radix Lithospermi) 9kg Fructus Cnidii 6kg
Fructus Ligustri Lucidi 6kg Radix Saposhnikoviae 8kg Cortex Moutan 4kg Radix Clematidis 3kg Borneolum Syntheticum 3kg
Preparation technology:
1) by above-mentioned prescription, take each raw material, after grinder grinding, cross 100 mesh sieves, mix homogeneously, adds the vegetable oil of 3 times amount, stirs 2 hours, soaks 14 days under room temperature, filters, obtains filtrate;
2) in filtering residue, add the Oleum sesami of 3 times amount, be heated to 100-105 degree Celsius, insulated and stirred 2 hours, filter, obtain filtrate;
3) merging filtrate, sterilizing, subpackage, obtains Chinese medicine composition composition liniment of the present invention.
Embodiment 3
The preparation of liniment of the present invention:
Prescription:
Radix Stephaniae Cepharanthae 12kg Fructus Atriplicis Sibiricae 12kg Fructus Mori 12kg Radix Arnebiae (Radix Lithospermi) 18kg Fructus Cnidii 12kg
Fructus Ligustri Lucidi 12kg Radix Saposhnikoviae 6kg Cortex Moutan 2kg Radix Clematidis 6kg Borneolum Syntheticum 1kg
Preparation technology:
1) by above-mentioned prescription, take each raw material, after grinder grinding, cross 100 mesh sieves, mix homogeneously, adds the vegetable oil of 3 times amount, stirs 2 hours, soaks 14 days under room temperature, filters, obtains filtrate;
2) in filtering residue, add the Oleum sesami of 3 times amount, be heated to 100-105 degree Celsius, insulated and stirred 2 hours, filter, obtain filtrate;
3) merging filtrate, sterilizing, subpackage, obtains Chinese medicine composition composition liniment of the present invention.
Above embodiment is not restriction the present invention being made to other form, and the equivalence that any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as equivalent variations is implemented.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Clinical efficacy criterion and therapeutic outcome:
1, clinical data and diagnostic criteria
Clinical data: the present inventor in 2009 so far, carries out clinical observation treatment to 218 routine patients with vitiligo, wherein man 160 example, female 58 example, max age 56 years old, minimal ages 11 years old, 23.6 years old mean age.The course of disease is the shortest is 2 months, and the longest is 15 years.
Diagnostic criteria: speckle or the patch of the white of depigmentation appear in skin surface.Around normal skin.Decolouring speckle differs in size from several millimeters to several centimetres, and in progressive stage, skin lesion can expand gradually, and constantly has new decolouring speckle to occur.The patient that the colour of skin is more shallow, white macula can be not obvious, but dark-complexioned people, color contrast is then very distinct.Under wood lamp, vitiligo position and surrounding skin have obviously boundary.
2, Therapeutic Method
In affected part, every day smears the obtained liniment of the embodiment of the present invention 13 times, and the morning, noon and afternoon, respectively once 30 days courses for the treatment of, 2 courses for the treatment of were a treatment cycle.Pungent, greasy and seafood is avoided during medication.
3, curative effect judging standard:
Cure: white macula all disappears, recover normal skin tone;
Effective: white macula partial remission or reduce, recover normal skin tone, disappear or reduce that area accounts for skin lesion area more than 50%.
Effective: white macula partial remission or reduce;
Invalid: the regeneration of white macula non-pigment or expanded range.
4, therapeutic outcome:
After the treatment through 2 courses for the treatment of, cure 140 examples, cure rate is 64.2%; Effective 44 examples, obvious effective rate 20.2%; Effective 26 examples, effective percentage 11.9%; Invalid 8 examples; Total effective rate 96.3%.
Model case
1, poplar, man, 16 years old, suffer from vitiligo 2 years, face, the back of the hand, arm many places have vitiligo speckle, white macula sharpness of border.In February, 2012, carry out here treatment, after adopting 2 courses for the treatment of of medicine of the present invention, white macula all disappears, and normal skin tone is recovered at speckle place, continuing to strengthen 1 course for the treatment of of use, following up a case by regular visits to without recurring after 2 years.
2, season, female, 18 years old, suffer from vitiligo 6 months, there are white macula 2 square centimeters of irregular type vitiligo in cervical region position, white macula sharpness of border, in June, 2012, carry out here treatment, after adopting 2 courses for the treatment of of medicine of the present invention, white macula all disappears, and normal skin tone is recovered at speckle place, continue to strengthen 1 course for the treatment of of use, follow up a case by regular visits to after 2 years without recurrence.
3, Xing, man, 43 years old, suffer from vitiligo 4 years, facial, front abdomen, the back of the hand, the whole province's multiple locations such as upper limb, lower limb, biped all had the vitiligo speckle of different size, white macula sharpness of border.In April, 2013, carry out here treatment, after adopting 2 courses for the treatment of of medicine of the present invention, white macula all disappears, and normal skin tone is recovered at speckle place, continuing to strengthen 1 course for the treatment of of use, following up a case by regular visits to without recurring after 1 year.
4, Lee, female, 25 years old, suffer from vitiligo 6 years, face, the back of the hand, all there is the vitiligo speckle of different size at back, white macula sharpness of border.Once AUTOEPIDERMIC GRAFTING operation was done, poor effect.In June, 2013, carry out here treatment, after adopting 2 courses for the treatment of of medicine of the present invention, white macula all disappears, and normal skin tone is recovered at speckle place, continuing to strengthen 1 course for the treatment of of use, following up a case by regular visits to without recurring after 1 year.
5, season, man, 36 years old, suffer from vitiligo 4 years, face, the back of the hand, the healths such as the palm of the hand, back, leg all have the vitiligo speckle of different size, white macula sharpness of border.Once the AUTOEPIDERMIC GRAFTING operation of face was done, poor effect.In August, 2013, carry out here treatment, after adopting 2 courses for the treatment of of medicine of the present invention, white macula all disappears, and normal skin tone is recovered at speckle place, continuing to strengthen 1 course for the treatment of of use, following up a case by regular visits to without recurring after 1 year.

Claims (9)

1. treat a leukodermic external preparation, it is characterized in that, be made up of following raw material of Chinese medicine: Radix Stephaniae Cepharanthae, Fructus Atriplicis Sibiricae, mulberry, Radix Arnebiae (Radix Lithospermi), Fructus Cnidii, Fructus Ligustri Lucidi, Radix Saposhnikoviae, Cortex Moutan, Radix Clematidis, Borneolum Syntheticum.
2. treat a leukodermic external preparation, it is characterized in that, be made up of the raw material of Chinese medicine of following parts by weight:
Radix Stephaniae Cepharanthae 9-18, Fructus Atriplicis Sibiricae 9-18, Fructus Mori 9-18, Radix Arnebiae (Radix Lithospermi) 9-18, Fructus Cnidii 6-12, Fructus Ligustri Lucidi 6-12, Radix Saposhnikoviae 6-10, Cortex Moutan 2-6, Radix Clematidis 2-6, Borneolum Syntheticum 1-5.
3. treat a leukodermic external preparation, it is characterized in that, be made up of the raw material of Chinese medicine of following parts by weight:
Radix Stephaniae Cepharanthae 16, Fructus Atriplicis Sibiricae 16, Fructus Mori 12, Radix Arnebiae (Radix Lithospermi) 12, Fructus Cnidii 8, Fructus Ligustri Lucidi 8, Radix Saposhnikoviae 6, Cortex Moutan 3, Radix Clematidis 3, Borneolum Syntheticum 2.
4. the leukodermic external preparation for the treatment of as described in as arbitrary in claim 1-3, it is characterized in that, can also add pharmaceutically conventional adjuvant, described adjuvant is including but not limited to antiseptic, dispersant, suspending agent, thickening agent, cosolvent, wetting agent, buffer agent, emulsifying agent, stabilizing agent, transdermal enhancer.
5. the leukodermic external preparation for the treatment of as described in as arbitrary in claim 1-3, it is characterized in that, described external preparation is preferably ointment, gel or liniment.
6. the leukodermic external preparation for the treatment of as claimed in claim 5, it is characterized in that, described external preparation is liniment.
7. the leukodermic external preparation for the treatment of as claimed in claim 6, it is characterized in that, the preparation method of described liniment comprises the following steps:
1) take above-mentioned each raw material, after grinder grinding, cross 100 mesh sieves, by weight portion mix homogeneously of the present invention, add the vegetable oil of 2-4 times amount, stir 1-3 hour, under room temperature, soak 7-14 days, filter, filtrate is for subsequent use;
2) in filtering residue, add the vegetable oil of 2-4 amount again, be heated to 100-130 degree Celsius, insulated and stirred 2-4 hour, filter, by for subsequent use near for filtrate room temperature;
3) merging filtrate, sterilizing, subpackage, obtains Chinese medicine composition composition liniment of the present invention.
8. the leukodermic external preparation for the treatment of as claimed in claim 7, is characterized in that, step 1) and step 2) vegetable oil in described preparation method be selected from Oleum sesami, Castor oil, soybean oil, Oleum Arachidis hypogaeae semen, olive oil one or more.
9. the leukodermic external preparation for the treatment of as claimed in claim 8, is characterized in that, step 1) and step 2) vegetable oil in described preparation method is Oleum sesami.
CN201410504899.0A 2014-09-27 2014-09-27 External preparation for treating vitiligo Pending CN104257781A (en)

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Application publication date: 20150107