CN101428112B - Formulation for treating acne and preparation method thereof - Google Patents
Formulation for treating acne and preparation method thereof Download PDFInfo
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- CN101428112B CN101428112B CN2008101883726A CN200810188372A CN101428112B CN 101428112 B CN101428112 B CN 101428112B CN 2008101883726 A CN2008101883726 A CN 2008101883726A CN 200810188372 A CN200810188372 A CN 200810188372A CN 101428112 B CN101428112 B CN 101428112B
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Abstract
The invention relates to a preparation for treating acne vulgaris, and the preparation is prepared by the mixture of traditional Chinese medicines and alcohol solution according to the weight ratio of (1-3): (5-50); the mixture of the traditional Chinese medicines is prepared by the following raw materials by parts by weight: 50-150 parts of golden thread, 45-160 parts of amur corktree bark, 30-130 parts of herba violae, 65-175 parts of lightyellow sophora root, 40-130 parts of swordlike atractylodes rhizome, 60-170 parts of densefruit pittany root-bark and 65-160 parts of sinkiang arnebia root; and the alcohol concentration of the alcohol solution is 65 percent-80 percent. The preparation overcomes the shortcomings of the existing treatment method, has the effects of clearing heat, eliminating dampness, clearing fire, removing toxin, dispelling pathogenic wind and relieving itch and being characterized by ability of treating the acne vulgaris, rapid onset of action, great efficacy, low cost, no toxicity or side effects, etc.
Description
Technical field
The present invention relates to a kind of preparation for the treatment of comedo and preparation method thereof.
Background technology
The acne that " comedo " is exactly medically to be said, it is a kind of pilosebaceous chronic inflammation disease, thinks that mostly microorganism has substantial connection in its cause of disease and androgen, sebaceous gland and the hair follicle.Acne is that comedo is a kind of puzzlement adolescence men and women of regular meeting even adult men and women's a dermatosis; Endocrine disturbance, incoordination between the spleen and stomach, happiness food are pungent, zest or greasy food, drainage difficulty, lung-heat etc. all are the inducements occurred frequently of comedo; Comedo all may produce huge strike and torment to patient's spirit, psychology, emotion, also hinders its physical and mental health simultaneously.
The method and the deficiency thereof of existing treatment comedo: (1) Drug therapy, traditional Therapeutic Method such as local application or oral medicine exist the length course of treatment, unsatisfactory curative effect, take effect slowly, side effect greatly, the shortcoming that easily develops immunity to drugs; (2) existing acne-eliminating cosmetic, as cleansing milk, Whelk-eliminating paste etc., in the majority with hormones, life-time service can stimulate sebaceous hyperplasia and pigment cell's hypertrophy, stays the pigmentation spots that is difficult to eliminate or causes corticosteroid dermatitis; (3) laser therapy, the medical expense costliness, the rate that takes effect is low, easily waits repeatedly.
In the face of the deficiencies in the prior art, need just a kind of instant effect, curative effect good, have no side effect, low price, product easy to use, the original intention and the purpose of the present invention that Here it is (a kind of preparation for the treatment of comedo) preparation.
Summary of the invention
Technical problem to be solved by this invention provides a kind of preparation for the treatment of comedo and preparation method thereof, it overcomes the deficiency of present Therapeutic Method, effect with heat clearing and damp drying, eliminating fire and detoxication, dispelling wind for relieving itching has in treatment that instant effect, curative effect are good, with low cost, characteristics such as have no side effect aspect the comedo.
Technical problem to be solved by this invention is achieved through the following technical solutions
A kind of preparation for the treatment of comedo, be by Chinese medicine mixture and alcoholic solution by weight (1-3): the preparation that (5-50) is prepared from; Described Chinese medicine mixture is by the mixture that comprises that following weight portion raw material components is prepared from: Rhizoma Coptidis 50-150, Cortex Phellodendri 45-160, Rhizoma Paridis 30-130, Radix Sophorae Flavescentis 65-175, Rhizoma Atractylodis 40-130, Cortex Dictamni 60-170, Radix Arnebiae (Radix Lithospermi) 65-160; The concentration of described alcoholic solution is 65%-80%.
Described preparation be by Chinese medicine mixture and alcoholic solution by weight 1: the preparation that (8-15) is prepared from.
The concentration of described alcoholic solution is excellent to be 75%.
The weight portion of described Chinese medicine mixture is excellent to be: Rhizoma Coptidis 70-130, Cortex Phellodendri 60-120, Rhizoma Paridis 50-110, Radix Sophorae Flavescentis 80-140, Rhizoma Atractylodis 50-110, Cortex Dictamni 90-150, Radix Arnebiae (Radix Lithospermi) 80-140.
The present invention also provides a kind of preparation method for the treatment of the preparation of comedo, may further comprise the steps:
(1) takes by weighing above-mentioned Chinese medicine mixture by described weight portion, clean, after drying, place the pulverizer crushing screening, collect the Chinese medicine mix powder;
(2) measure alcoholic solution by the above-mentioned Chinese medicine mixture and the weight ratio of alcoholic solution, alcoholic solution and the Chinese medicine mix powder collected are put into glass container simultaneously or tradition is fired water vat, soaked 8-15 days under the state of sealing, gained filtrate is the preparation of treatment comedo.
Acne vulgaris is a kind of multifactor property disease, microorganism is the principal element of acne morbidity in the effect of endocrine disturbance, sebum, the hair follicle, " rosacea caused by lung-wind " put down in writing in it and the motherland's medical literature is similar, put down in writing as " doctor Song Jin mirror surgery heart method rosacea caused by lung-wind ": " this disease is formed by the lung meridian heat in blood; every is played broken pimple in the face nose, and shape such as broomcorn millet are considered to be worth doing; red complexion swells and ache, and break out white lead juice ".Its etiology and pathogenesis is many because of eating and drinking without temperance, and surfeit delicious food savoury causes stomach and large intestine intenseness of heat, attack on the pathogenic heat in lung, lung stomach Yun heat, on steam in face diseases caused by exogenous pathogenic factor poison heresy and be primary disease; Or because of depression of liver-QI, Gan Dan Yun heat, the anti-insult in lung attacked on the lung-heat in face, multiple sense poison heresy, QI and blood, noxious dampness stasis and to send out be primary disease.So use Rhizoma Coptidis, Cortex Phellodendri, Rhizoma Paridis, heat clearing and damp drying, eliminating fire and detoxication; Be equipped with Radix Sophorae Flavescentis, Rhizoma Atractylodis, the Cortex Dictamni dehumidifying is dispeled the wind, and detoxifying and relieving itching is with Zhi Qiyin; Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, its poison that becomes silted up that looses are to control its fruit.The effect of dampness detoxifcation, cooling blood and removing stasis, dispelling wind for relieving itching is played in all medicine cooperations altogether.
1, Rhizoma Coptidis: [function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.It mainly has the dampness heat clearing away among the present invention, the effect of eliminating fire and detoxication, and external can be treated the various skin disease, is particularly useful for the scorchingly hot flourishing phase
2, Cortex Phellodendri: [function cures mainly] heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.It mainly has heat clearing and damp drying among the present invention, and eliminating fire and detoxication is used for sore swollen toxin, eczema etc.
3, Radix Arnebiae (Radix Lithospermi): [function cures mainly] removing heat from blood, invigorate blood circulation the detoxifcation rash.Be used for that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood is used for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.It mainly has removing heat from blood and promoting blood circulation among the present invention, the function of detoxifcation rash, and external is used for Du Re Yun knot, the purpura due to the stagnation of QI-blood, erythema nodosum etc.
4, Radix Sophorae Flavescentis: [function cures mainly] heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.It mainly has with clearing away heat-damp and promoting diuresis and is good among the present invention, and the effect of removing pathogenic heat from blood and toxic substance from the body dispelling wind for relieving itching is arranged again.
5, Cortex Dictamni: [function cures mainly] heat clearing and damp drying, the detoxifcation of dispeling the wind.Be used for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine.It mainly has heat-clearing and toxic substances removing among the present invention, and the merit of expelling wind and removing dampness is the key medicine of treatment dermatosis.
6, Rhizoma Atractylodis: [function cures mainly]: drying damp and strengthening spleen, dispel the wind, cold expelling makes eye bright; Control wet the Sheng and be stranded spleen, the asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting is had loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Join Cortex Phellodendri, the power multiplication of dampness, Cortex Phellodendri gets Rhizoma Atractylodis, and is cold with temperature system, heat clearing away and unlikely damage sun, the two medicine mutual-assistances are made mutually, and the heat clearing and damp drying power is remarkable, is usually used in the sufficient knee joint red and swollen heat pain of damp-heat in lower-JIAO, flaccidity of the lower limbs is unable, or damp-heat vaginal discharge, and eczema is dripping and see diseases such as oliguria with reddish urine, yellowish fur.Among the present invention its mainly have drying damp and strengthening spleen, the merit of dispelling wind for relieving itching, external can be treated the cicatrix due to the wet resistance meridians skin, pimple, prurigo etc.
7, Rhizoma Paridis: [function cures mainly]: heat-clearing and toxic substances removing, antiasthmatic-antitussive, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.It mainly has heat-clearing and toxic substances removing among the present invention, the effect of detumescence pain relieving.
All medicines share, and play removing pathogenic heat from blood and toxic substance from the body altogether, the merit of mass dissipating and swelling eliminating.Be applicable to the acne vulgaris of Re Du Yun stagnation of QI blood clotting due to stagnating, this disease is more common in youth of both sexes face, the hair follicle of chest and back, and the chronic inflammatory disease of sebaceous gland, as acne, pimple, pustule, tuberosity, skin lesions such as cyst.
Compared with prior art, beneficial effect of the present invention is embodied in:
Characteristics such as 1, preparation of the present invention has heat clearing and damp drying, eliminating fire and detoxication, and the effect of dispelling wind for relieving itching is treated comedo and had instant effect, and curative effect is good;
2, compare with similar preparation, preparation of the present invention is with low cost, and is easy to use, has no side effect.
For proving above-mentioned advantage, it is that the proportioning preparation carries out clinical verification that preparation of the present invention has carried out with embodiment 1, evident in efficacy, as follows:
1. experimenter group
These test total number of persons 97 people, man 49 people wherein, woman 48 people, the range of age: 13 years old-19 years old 52 people, 20 years old-30 years old 27 people, 30 years old-40 years old 18 people.
2. verification method
Press embodiment 1 and be equipped with preparation, bottling divides and the experimenter, accounts for this preparation with cotton swab after the experimenter washes one's face every day and smears affected part, forbids using simultaneously with other cosmetics, and use 2-3 every day, and 3 is a course of treatment, does every day once and pays a return visit.
3. effect is summed up
This experiment, the follow-up investigation through 10 days, experimenter, press correct method and use, the result shows, uses after 1 day, the sense of patient's sufferings obviously alleviates, and uses after two days the part patients with mild, comedo obviously disappears, and uses after three days the part severe patient, affected part is existing obviously to be improved, and uses after 10 days, except that patient between 2 30-40 year, still have outside 1-2 place affected part still need continue to smear, all the other affected parts are all controlled.Through summing up obvious effective rate to 100%, effective percentage reaches 97.9%, and inefficiency is 0.
The case case is as follows:
1 of example so-and-so, man 23 years old, pimple appears in facial area, pustule is more than 2 years, through the county hospital department of dermatologry be diagnosed as " acne vulgaris ", through using Western medicine oral medicine and medicine for external use, the commentaries on classics of always not getting better, after the back was embrocated 2 days with the embodiment of the invention 1 proportioning preparation, skin lesion was obviously disappeared; All disappear after 7 days and the announcement recovery from illness, observed through 6 months and do not see recurrence.
Example 2: surplus so-and-so, woman 21 years old, being dispersed in property pustule appears in frons and two buccals, every time food pungent thing and increasing the weight of, once be diagnosed as to the city center hospital dermatology department: " acne vulgaris " and the commentaries on classics of after treatment, not getting better, after use the embodiment of the invention 1 proportioning preparation instead and embrocated for two weeks after, facial abscess disappears totally, does not see recurrence through long-term observation.
Example 3: Zhang, man 31 years old, face, being dispersed in property acne, pustule appear in cervical region, chest and back, can squeeze out white secretions shape such as white lead juice during every extruding, the time pruritus arranged, once bad during the multi-treatment fashion, skin lesion is not seen all the time and is eliminated after after the embodiment of the invention 1 proportioning preparation embrocated two weeks, skin lesion disappeared substantially, after using 10 again, face, cervical region, chest and back acne, abscess all disappears, as ordinary person.
The specific embodiment
Embodiment 1
Raw material (g): Rhizoma Coptidis 100, Cortex Phellodendri 90, Rhizoma Paridis 80, Radix Sophorae Flavescentis 110, Rhizoma Atractylodis 80, Cortex Dictamni 120, Radix Arnebiae (Radix Lithospermi) 110, concentration are that 75% the alcoholic solution and the weight ratio of Chinese medicine mixture are 1: 10
Preparation method:
(1) takes by weighing above-mentioned Chinese medicine mixture, clean, after drying, place the pulverizer crushing screening, collect the Chinese medicine mix powder;
(2) measure alcoholic solution by the weight ratio of Chinese medicine mixture and alcoholic solution, alcoholic solution and the Chinese medicine mix powder collected are put into glass container simultaneously or tradition is fired water vat, soaked 10 days under the state of sealing, gained filtrate is the preparation of treatment comedo.
Embodiment 2.
Raw material (g): Rhizoma Coptidis 50, Cortex Phellodendri 45, Rhizoma Paridis 30, Radix Sophorae Flavescentis 65, Rhizoma Atractylodis 40, Cortex Dictamni 60, Radix Arnebiae (Radix Lithospermi) 65, concentration are that 65% the alcoholic solution and the weight ratio of Chinese medicine mixture are 1: 5
Preparation method:
(1) takes by weighing above-mentioned Chinese medicine mixture, clean, after drying, place the pulverizer crushing screening, collect the Chinese medicine mix powder;
(2) measure alcoholic solution by the weight ratio of Chinese medicine mixture and alcoholic solution, alcoholic solution and the Chinese medicine mix powder collected are put into glass container simultaneously or tradition is fired water vat, soaked 8 days under the state of sealing, gained filtrate is the preparation of treatment comedo.
Embodiment 3.
Raw material (g): Rhizoma Coptidis 70, Cortex Phellodendri 60, Rhizoma Paridis 50, Radix Sophorae Flavescentis 80, Rhizoma Atractylodis 50, Cortex Dictamni 90, Radix Arnebiae (Radix Lithospermi) 80, concentration are that 70% the alcoholic solution and the weight ratio of Chinese medicine mixture are 1: 8
Preparation method:
(1) takes by weighing above-mentioned Chinese medicine mixture, clean, after drying, place the pulverizer crushing screening, collect the Chinese medicine mix powder;
(2) measure alcoholic solution by the weight ratio of Chinese medicine mixture and alcoholic solution, alcoholic solution and the Chinese medicine mix powder collected are put into glass container simultaneously or tradition is fired water vat, soaked 15 days under the state of sealing, gained filtrate is the preparation of treatment comedo.
Embodiment 4.
Raw material (g): Rhizoma Coptidis 130, Cortex Phellodendri 120, Rhizoma Paridis 110, Radix Sophorae Flavescentis 140, Rhizoma Atractylodis 110, Cortex Dictamni 150, Radix Arnebiae (Radix Lithospermi) 140, concentration are that 75% the alcoholic solution and the weight ratio of Chinese medicine mixture are 1: 15
Preparation method: with embodiment 1
Embodiment 5.
Raw material (g): Rhizoma Coptidis 150, Cortex Phellodendri 160, Rhizoma Paridis 130, Radix Sophorae Flavescentis 175, Rhizoma Atractylodis 130, Cortex Dictamni 170, Radix Arnebiae (Radix Lithospermi) 160, concentration are that 80% the alcoholic solution and the weight ratio of Chinese medicine mixture are 3: 50
Preparation method: with embodiment 1
Claims (4)
1. preparation for the treatment of comedo, be by Chinese medicine mixture and alcoholic solution by weight (1-3): the preparation that (5-50) is prepared from; Described Chinese medicine mixture is the mixture that is prepared from by following weight portion raw material components: Rhizoma Coptidis 50-150, Cortex Phellodendri 45-160, Rhizoma Paridis 30-130, Radix Sophorae Flavescentis 65-175, Rhizoma Atractylodis 40-130, Cortex Dictamni 60-170, Radix Arnebiae (Radix Lithospermi) 65-160; The concentration of described alcoholic solution is 65-80%.
2. a kind of preparation for the treatment of comedo according to claim 1, the concentration of described alcoholic solution is 75%.
3. a kind of preparation for the treatment of comedo according to claim 1, the weight portion of described Chinese medicine mixture is: Rhizoma Coptidis 70-130, Cortex Phellodendri 60-120, Rhizoma Paridis 50-110, Radix Sophorae Flavescentis 80-140, Rhizoma Atractylodis 50-110, Cortex Dictamni 90-150, Radix Arnebiae (Radix Lithospermi) 80-140.
4. the preparation method of the preparation of the described treatment comedo of one of claim 1-3 may further comprise the steps:
(1) takes by weighing described Chinese medicine mixture by the described weight portion of one of claim 1-3, clean, after drying, place the pulverizer crushing screening, collect the Chinese medicine mix powder;
(2) measure alcoholic solution by the weight ratio of described Chinese medicine mixture of one of claim 1-3 and alcoholic solution, alcoholic solution and the Chinese medicine mix powder collected are put into glass container simultaneously or tradition is fired water vat, soaked 8-15 days under the state of sealing, gained filtrate is the preparation of treatment comedo.
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101953973B (en) * | 2010-09-08 | 2012-09-05 | 王存银 | Traditional Chinese medicine for treating dermatitis |
| CN104225148B (en) * | 2014-09-19 | 2017-07-18 | 湖南康尔佳生物医药科技有限公司 | A kind of Chinese medicine composition of effective anti-acne |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772232A (en) * | 2005-10-27 | 2006-05-17 | 李文 | Medicine for treating teenage's acne |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1772232A (en) * | 2005-10-27 | 2006-05-17 | 李文 | Medicine for treating teenage's acne |
Non-Patent Citations (3)
| Title |
|---|
| 景录先 主编.金起凤教授学术思想及临床验案探析.《名医经验录》.中国医药科技出版社,1996,第316-318页. * |
| 李玉卿.中药酒酊治痤疮40例.《实践医学杂志》.2000,第13卷(第1期),第36-37页. * |
| 鲁美君，张友堂.中医药治疗痤疮的研究进展.《中医药信息》.2001,第18卷(第3期),第10-12页. * |
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