CN101426936A - 乙肝表面抗原的兔单克隆抗体及其应用方法 - Google Patents
乙肝表面抗原的兔单克隆抗体及其应用方法 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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Abstract
Description
样品 | 小鼠MAb试验 | 兔MAb试验 |
阳性对照 | 127.15 | 143.06 |
阴性对照 | 3.34 | 4.42 |
adw 0.5ng/ml | 327.62 | 334.99 |
ayw 0.5ng/ml | 299.61 | 302.06 |
G145R 1ng/ml | 167.36 | 145.65 |
S143L 1ng/ml | 33.59 | 39.67 |
P120Q 1ng/ml | 33.06 | 68.81 |
P142L 0.2ng/ml | 21.01 | 35.77 |
D144A 0.2ng/ml | 48.40 | 37.54 |
F134S 0.2ng/ml | 85.83 | 88.22 |
F134A 0.2ng/ml | 140.45 | 145.80 |
Y118K 1:9000 | 26.83 | 28.68 |
Y118S 1:9000 | 46.65 | 49.10 |
Y131A 1:9000 | 85.89 | 86.72 |
T126N(牛) | 156.28 | 166.39 |
Q129H(牛) | 222.93 | 291.02 |
M133D(牛) | 51.13 | 66.07 |
P142S(1:10稀释) | 41.48 | 223.58 |
D144N(1:600稀释) | 61.55 | 81.05 |
Claims (66)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57756104P | 2004-06-07 | 2004-06-07 | |
US60/577,561 | 2004-06-07 | ||
US58373404P | 2004-06-28 | 2004-06-28 | |
US60/583,734 | 2004-06-28 | ||
PCT/US2005/020254 WO2006085918A2 (en) | 2004-06-07 | 2005-06-07 | Rabbit monoclonal antibodies to hepatitis b surface antigens and methods of using the same |
Publications (2)
Publication Number | Publication Date |
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CN101426936A true CN101426936A (zh) | 2009-05-06 |
CN101426936B CN101426936B (zh) | 2013-03-20 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2005800182865A Expired - Fee Related CN101426936B (zh) | 2004-06-07 | 2005-06-07 | 乙肝表面抗原的兔单克隆抗体及其应用方法 |
Country Status (11)
Country | Link |
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US (2) | US7563873B2 (zh) |
EP (1) | EP1766098B1 (zh) |
JP (2) | JP5209309B2 (zh) |
KR (1) | KR101262732B1 (zh) |
CN (1) | CN101426936B (zh) |
CA (1) | CA2569561C (zh) |
ES (1) | ES2488849T3 (zh) |
MX (1) | MXPA06013933A (zh) |
PL (1) | PL1766098T3 (zh) |
PT (1) | PT1766098E (zh) |
WO (1) | WO2006085918A2 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101357228B (zh) * | 2007-07-30 | 2011-03-16 | 深圳市卫武光明生物制品有限公司 | 静脉注射用人乙型肝炎免疫球蛋白的制备方法 |
JP5800299B2 (ja) * | 2009-02-20 | 2015-10-28 | 国立大学法人 東京大学 | 新規モノクローナル抗体、並びにその使用 |
CN102286075A (zh) * | 2011-08-01 | 2011-12-21 | 中国人民解放军第三军医大学 | 乙肝病毒表面抗原的免疫显性hla-a*1101限制性ctl表位及其应用 |
CN103997691B (zh) * | 2014-06-02 | 2016-01-13 | 合一网络技术(北京)有限公司 | 视频交互的方法和系统 |
CN105132376B (zh) * | 2015-06-26 | 2018-02-09 | 南京红十字血液中心 | 一个能特异性识别HBsAg多个抗原表位的单克隆抗体及其应用 |
CN105017415A (zh) * | 2015-08-03 | 2015-11-04 | 中国人民解放军第二军医大学 | 针对乙肝表面蛋白全人源单克隆抗体的制备及其用途 |
CN105061591A (zh) * | 2015-08-03 | 2015-11-18 | 中国人民解放军第二军医大学 | 一种抗乙肝病毒表面抗原的全人源抗体及其用途 |
US10389646B2 (en) * | 2017-02-15 | 2019-08-20 | Mellanox Technologies Tlv Ltd. | Evading congestion spreading for victim flows |
CN113138276B (zh) * | 2020-01-19 | 2022-09-16 | 厦门万泰凯瑞生物技术有限公司 | 用于检测HBcAg的方法及抗体 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324513A (en) * | 1984-03-07 | 1994-06-28 | Institut Pasteur | Composition useful for the fabrication of vaccines |
US5098704A (en) * | 1984-06-18 | 1992-03-24 | Chiron Corporation | Hepatitis surface antigen particle vaccine |
US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
US4859595A (en) * | 1985-05-03 | 1989-08-22 | Strosberg Arthur D | Method for preparing rabbit monoclonal antibodies, the cell lines used therein and the antibodies produced thereby |
US4977081A (en) * | 1987-05-04 | 1990-12-11 | Adi Diagnostics, Inc. | Stable rabbit-mouse hybridomas and secretion products thereof |
US6306625B1 (en) * | 1988-12-30 | 2001-10-23 | Smithkline Beecham Biologicals, Sa | Method for obtaining expression of mixed polypeptide particles in yeast |
EP0583980A1 (en) * | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
WO1994021812A2 (en) | 1993-03-24 | 1994-09-29 | Imperial College Of Science, Technology & Medicine | Hepatitis b escape mutant specific binding molecules |
US6030616A (en) * | 1993-03-24 | 2000-02-29 | Imperial College Of Science, Technology & Medicine | Hepatitis B escape mutant specific binding molecules |
US5675063A (en) * | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
WO1997039029A2 (en) | 1996-04-18 | 1997-10-23 | Abbott Laboratories | An antigenic epitope of the a determinant of hepatitis b surface antigen and uses thereof |
GB9608626D0 (en) * | 1996-04-25 | 1996-07-03 | Univ College Of London | Hepatitis b monoclonal antibodies |
FR2815634B1 (fr) | 2000-10-20 | 2003-10-31 | Biomerieux Sa | Anticorps monoclonaux diriges contre des virus de l'hepatite b |
CA2492524A1 (en) * | 2002-08-15 | 2004-02-26 | Epitomics, Inc. | Humanized rabbit antibodies |
-
2005
- 2005-06-07 WO PCT/US2005/020254 patent/WO2006085918A2/en active Application Filing
- 2005-06-07 KR KR1020067026757A patent/KR101262732B1/ko active IP Right Grant
- 2005-06-07 JP JP2007527715A patent/JP5209309B2/ja not_active Expired - Fee Related
- 2005-06-07 PT PT58574484T patent/PT1766098E/pt unknown
- 2005-06-07 US US11/148,012 patent/US7563873B2/en active Active
- 2005-06-07 CA CA2569561A patent/CA2569561C/en not_active Expired - Fee Related
- 2005-06-07 EP EP05857448.4A patent/EP1766098B1/en active Active
- 2005-06-07 ES ES05857448.4T patent/ES2488849T3/es active Active
- 2005-06-07 MX MXPA06013933A patent/MXPA06013933A/es active IP Right Grant
- 2005-06-07 PL PL05857448T patent/PL1766098T3/pl unknown
- 2005-06-07 CN CN2005800182865A patent/CN101426936B/zh not_active Expired - Fee Related
-
2008
- 2008-10-27 US US12/290,096 patent/US8173375B2/en not_active Expired - Fee Related
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2012
- 2012-05-08 JP JP2012106831A patent/JP2012143251A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US8173375B2 (en) | 2012-05-08 |
CA2569561C (en) | 2014-08-12 |
CA2569561A1 (en) | 2006-08-17 |
US20090191536A1 (en) | 2009-07-30 |
KR101262732B1 (ko) | 2013-05-09 |
KR20070034505A (ko) | 2007-03-28 |
EP1766098A4 (en) | 2010-04-14 |
CN101426936B (zh) | 2013-03-20 |
PL1766098T3 (pl) | 2014-10-31 |
EP1766098B1 (en) | 2014-05-07 |
WO2006085918A2 (en) | 2006-08-17 |
EP1766098A2 (en) | 2007-03-28 |
JP2012143251A (ja) | 2012-08-02 |
ES2488849T3 (es) | 2014-08-29 |
JP2008507299A (ja) | 2008-03-13 |
US7563873B2 (en) | 2009-07-21 |
JP5209309B2 (ja) | 2013-06-12 |
PT1766098E (pt) | 2014-08-22 |
WO2006085918A3 (en) | 2009-04-23 |
MXPA06013933A (es) | 2007-01-26 |
US20060008798A1 (en) | 2006-01-12 |
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