CN101417780A - Aseptic half-adding stopper method - Google Patents
Aseptic half-adding stopper method Download PDFInfo
- Publication number
- CN101417780A CN101417780A CNA2008102044028A CN200810204402A CN101417780A CN 101417780 A CN101417780 A CN 101417780A CN A2008102044028 A CNA2008102044028 A CN A2008102044028A CN 200810204402 A CN200810204402 A CN 200810204402A CN 101417780 A CN101417780 A CN 101417780A
- Authority
- CN
- China
- Prior art keywords
- plug
- rubber plug
- outlet
- machine
- transhipment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000007599 discharging Methods 0.000 claims abstract description 20
- 230000001954 sterilising effect Effects 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 5
- 238000004140 cleaning Methods 0.000 claims description 27
- 238000011068 loading method Methods 0.000 claims description 19
- 238000004659 sterilization and disinfection Methods 0.000 claims description 17
- 230000004888 barrier function Effects 0.000 claims description 9
- 238000002955 isolation Methods 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 3
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract description 2
- 230000036512 infertility Effects 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 4
- 238000007730 finishing process Methods 0.000 abstract 1
- 238000003032 molecular docking Methods 0.000 abstract 1
- 238000005475 siliconizing Methods 0.000 abstract 1
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 description 5
- 238000010586 diagram Methods 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B1/00—Closing bottles, jars or similar containers by applying stoppers
- B67B1/03—Pretreatment of stoppers, e.g. cleaning, steaming, heating, impregnating or coating; Applying resilient rings to stoppers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/17—Combination with washing or cleaning means
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Sealing Of Jars (AREA)
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The invention relates to a sterile partially stoppering method, which is characterized by the following steps: the outside of the rubber plug washing machine outlet is provided with a sterile separating screen; the rubber plug is intruded into the rubber plug washing machine for finishing processes of washing, sterilizing, siliconizing, drying and the like; a transferring barrel sterilized by a dry hot sterilizing cabinet is placed under the discharging outlet of the rubber plug washing machine in the sterile separating screen to intrude the rubber plug, then moved to one side of a lifting machine for docking and locking, and then driven by the lifting machine to be lifted to the height above a feeding hopper, and a sterilized connecting soft pipe is connected with an outlet and a connecting head on a stoppering machine; the valve gate of the transferring barrel outlet is opened, the rubber plug in the transferring barrel falls on the feeding hopper on a partially stoppering machine automatically by the connecting soft pipe, and the stoppering of medicine bottles is carried out in the feeding hopper. The sterile partially stoppering method has the advantages of guaranteeing the whole partially stoppering process under the sterile protection state, having high sterility and meeting requirements of cGMP of the international pharmaceuticals industry.
Description
Technical field
The present invention relates to a kind of method of aseptic half-adding stopper, whole plug changes in the charging basket to plug from the cleaning of plug machine, sterilization, silication, dry back discharging, plug in the commentaries on classics charging basket is transported to above the loading hopper of bottle placer under the control of whole gnotobiosis, thereby finishes the aseptic transhipment of plug.Belong to pharmaceutical machinery technical field.
Background technology
Vacuum freeze drying (abbreviation freeze dryer) but be exactly that the hydrous matter of freeze-drying or solution are freezed in advance at low temperatures, under vacuum environment, make the material dehydration obtain dry article then.In general, the tamponade of cillin bottle freeze-drying plug is finished at the hydraulic efficiency gear of freeze dryer inner utilization freeze dryer, so, cillin bottle is before advancing freeze dryer, necessarily require the false add plug, concrete action is as follows, after the bottle placer can, cillin bottle is transported to above half stopper-adding machine by load-transfer device, half stopper-adding machine has a plug loading hopper, above the cillin bottle bottleneck, the reason of half plug is to flow out the passage that aqueous vapor is escaped to the distillation of freeze-dried products to plug above the loading hopper by false add plug device quilt false add plug successively.
The handling process of traditional freeze-drying workshop cillin bottle plug is as follows: at first, the plug of buying is loaded in the rubber plug cleaning machine, in rubber plug cleaning machine inside, plug is through technologies such as cleaning, sterilization, silication, dryings, plug is arrived in the transhipment bucket by manual discharging then, artificial mobile plug transhipment bucket manually is transported to plug transhipment bucket in-to-in plug above the loading hopper of half stopper-adding machine, thereby finishes the plug transfer process near half stopper-adding machine.
Owing to be to be got involved by artificial a large amount of, and good multioperation plug is to be in uncovered state, directly contacts with external environment condition in the whole process, aseptic is very bad, might cause the microbiological contamination of plug, have contaminated excessive risk in the process, be unfavorable for that the pharmaceutical factory produces the requirement of height asepticize.
Summary of the invention
The method that the purpose of this invention is to provide a kind of aseptic half-adding stopper.
For realizing above purpose, technical scheme of the present invention provides a kind of method of aseptic half-adding stopper, it is characterized in that, is finished by following steps:
The first step installs aseptic isolation barrier additional in the outside of rubber plug cleaning machine outlet;
Second step was encased in not processed plug in the rubber plug cleaning machine, and plug has been finished processes such as cleaning, sterilization, silication, drying successively in rubber plug cleaning machine;
The 3rd step, to be placed into through the transhipment bucket of dry heat sterilization cabinet sterilization below the discharging opening of rubber plug cleaning machine in the aseptic isolation barrier, open the lid of transhipment bucket, the discharging opening of opening rubber plug cleaning machine begins sterilized plug discharging, after discharging finishes, close the lid of transhipment bucket and the discharging opening of rubber plug cleaning machine successively;
The 4th step, will transport bucket and move to gig on one side, gig is docked and locks with the transhipment bucket, make the transhipment bucket link together with gig;
In the 5th step, gig drive transhipment bucket rises to the height above the loading hopper, and the outlet of the connection hose one end connection transhipment bucket of process sterilization, the other end connects the connector above half stopper-adding machine;
The 6th step, use INTOUCH configuration software program design, operation on computers, control program is opened the valve of transhipment bucket outlet automatically by instruction, transhipment bucket in-to-in plug when the position transduser above the loading hopper is sensed signal, is closed the valve of transhipment bucket outlet because the effect of deadweight is automatically fallen into above the loading hopper above half stopper-adding machine by connection pipe, plug stops to enter above the loading hopper, and loading hopper inside adds plug to medicine bottle.
The present invention has been installed aseptic isolation barrier additional in the outside of transhipment bucket and rubber plug cleaning machine outlet, aseptic isolation barrier internal environment can reach aseptic desired hundred grades, be placed to through the transhipment bucket of dry heat sterilization cabinet sterilization and adorn sterilized plug below the discharging opening of rubber plug cleaning machine, whole process is carried out in aseptic isolation barrier, to transport bucket when the false add plug is connected by the connection hose through sterilization with half stopper-adding machine, the automation of false add plug reaches aseptic requirement.
Advantage of the present invention is to have solved traditional freeze dryer preparation workshop plug transhipment to be in the excessive risk process always; cause the pollution of plug easily; guarantee that whole plug discharging process all is in the sterility protection state, the aseptic height meets the requirement of international pharmaceuticals industry cGMP.
Description of drawings
Fig. 1 is a kind of apparatus structure scheme drawing of aseptic transhipment plug;
Fig. 2 is transhipment bucket and gig connection diagram;
Fig. 3 is transhipment bucket and half stopper-adding machine connection diagram;
Fig. 4 is a false add plug program flow diagram.
The specific embodiment
The invention will be further described below in conjunction with drawings and Examples.
Embodiment
A kind of method of aseptic half-adding stopper, finish by following steps:
The first step installs aseptic isolation barrier 2 additional in the outside of rubber plug cleaning machine 1 outlet, as shown in Figure 1;
Second step was loaded into not processed plug in the rubber plug cleaning machine 1, and plug has been finished processes such as cleaning, sterilization, silication, drying successively in rubber plug cleaning machine 1;
The 3rd step, to be placed to through the transhipment bucket 3 of dry heat sterilization cabinet sterilization below the discharging opening of rubber plug cleaning machines 1 in the aseptic isolation barrier 2, open the lid of transhipment bucket 3, the discharging opening of opening rubber plug cleaning machine 1 begins sterilized plug discharging, after discharging finishes, close the lid of transhipment bucket 3 and the discharging opening of rubber plug cleaning machine 1 successively;
The 4th step, will transport bucket 3 and move to gig 4 on one side, gig 4 is docked and locks with transhipment bucket 3, make transhipment bucket 3 link together, as shown in Figure 2 with gig 4;
In the 5th step, gig 4 drives transhipment barrel 3 height that rise to above the loading hopper 6, and connection hose 5 one ends through sterilization are connected the outlet of transporting bucket 3, and the other end connects the connector above half stopper-adding machine 8, as shown in Figure 3;
The 6th step, use INTOUCH configuration software program design, operation on computers, as shown in Figure 4, control program is opened the valve of transhipment bucket outlet automatically by instruction, transhipment bucket in-to-in plug since the effect of deadweight automatically fall into above the loading hopper above half stopper-adding machine by connection hose, when the position transduser above the loading hopper is sensed signal, close the valve of transhipment bucket outlet, plug stops to enter above the loading hopper, and loading hopper inside adds plug to medicine bottle.
Claims (1)
1. the method for an aseptic half-adding stopper is characterized in that, is finished by following steps:
The first step installs aseptic isolation barrier (2) additional in the outside of rubber plug cleaning machine (1) outlet;
Second step was loaded into not processed plug in the rubber plug cleaning machine (1), and plug has been finished processes such as cleaning, sterilization, silication, drying successively in rubber plug cleaning machine (1);
The 3rd step, to be placed to through the transhipment bucket (3) of dry heat sterilization cabinet sterilization below the discharging opening of the interior rubber plug cleaning machine of aseptic isolation barrier (2) (1), open the lid of transhipment bucket (3), the discharging opening of opening rubber plug cleaning machine (1) begins sterilized plug discharging, after discharging finishes, close the lid of transhipment bucket (3) and the discharging opening of rubber plug cleaning machine (1) successively;
The 4th step, will transport bucket (3) and move to gig (4) on one side, gig (4) is docked and locks with transhipment bucket (3), make transhipment bucket (3) and gig (4) link together;
In the 5th step, gig (4) drives transhipment bucket (3) and rises to the top height of loading hopper (6), and the outlet that connects transhipment barrel (3) through connection hose (5) one ends of sterilization, the other end connects the connector above half stopper-adding machine (8);
The 6th step, use INTOUCH configuration software program design, operation on computers, control program is opened the valve of transhipment bucket outlet automatically by instruction, transhipment bucket in-to-in plug when the position transduser above the loading hopper is sensed signal, is closed the valve of transhipment bucket outlet because the effect of deadweight is automatically fallen into above the loading hopper above half stopper-adding machine by connection hose, plug stops to enter above the loading hopper, and loading hopper inside adds plug to medicine bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810204402.8A CN101417780B (en) | 2008-12-11 | 2008-12-11 | Aseptic half-adding stopper method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810204402.8A CN101417780B (en) | 2008-12-11 | 2008-12-11 | Aseptic half-adding stopper method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101417780A true CN101417780A (en) | 2009-04-29 |
| CN101417780B CN101417780B (en) | 2010-11-10 |
Family
ID=40628809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810204402.8A Active CN101417780B (en) | 2008-12-11 | 2008-12-11 | Aseptic half-adding stopper method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101417780B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102718036A (en) * | 2012-07-06 | 2012-10-10 | 温州亚光机械制造有限公司 | Sterile material transport device |
| WO2013127222A1 (en) * | 2012-03-02 | 2013-09-06 | 楚天科技股份有限公司 | Plug transporting system and plug cleaning and adding production line between rubber plug cleaning machine and filling plug adding machine |
| CN103318818A (en) * | 2013-06-13 | 2013-09-25 | 上海东富龙科技股份有限公司 | Cork pressing device for filling machine |
| CN103600955A (en) * | 2013-11-18 | 2014-02-26 | 杭州东翠科技有限公司 | Medicinal rubber stopper transferring system and transferring method thereof |
| CN104624550A (en) * | 2014-12-19 | 2015-05-20 | 楚天科技股份有限公司 | Rubber plug or aluminum cap cleaning machine |
| CN108746136A (en) * | 2018-05-07 | 2018-11-06 | 上海东富龙科技股份有限公司 | Aluminium-plastic cap cleaning machine installs plastic-aluminum lid arrangement additional with full-automatic |
| CN110788047A (en) * | 2018-08-03 | 2020-02-14 | 楚天科技股份有限公司 | Sterile transferring system and transferring method for rubber plug cleaning machine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912359A (en) * | 1989-01-23 | 1990-03-27 | Labconco Corporation | Stoppering tray vacuum freeze dryer |
| CN2756565Y (en) * | 2004-12-15 | 2006-02-08 | 上海远东制药机械总厂 | Bottle stopper placing structure for freeze-drying machine |
-
2008
- 2008-12-11 CN CN200810204402.8A patent/CN101417780B/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013127222A1 (en) * | 2012-03-02 | 2013-09-06 | 楚天科技股份有限公司 | Plug transporting system and plug cleaning and adding production line between rubber plug cleaning machine and filling plug adding machine |
| RU2585719C2 (en) * | 2012-03-02 | 2016-06-10 | Тракинг Текнолоджи Лимитед | Plug transportation system, as well as production line for plug and cap cleaning, located between machine for cleaning rubber plug and filling and sealing machine |
| CN102718036A (en) * | 2012-07-06 | 2012-10-10 | 温州亚光机械制造有限公司 | Sterile material transport device |
| CN102718036B (en) * | 2012-07-06 | 2014-04-16 | 温州亚光机械制造有限公司 | Sterile material transport device |
| CN103318818A (en) * | 2013-06-13 | 2013-09-25 | 上海东富龙科技股份有限公司 | Cork pressing device for filling machine |
| CN103600955A (en) * | 2013-11-18 | 2014-02-26 | 杭州东翠科技有限公司 | Medicinal rubber stopper transferring system and transferring method thereof |
| CN103600955B (en) * | 2013-11-18 | 2015-11-18 | 杭州东翠科技有限公司 | A kind of medical rubber plug movement system and transfer method thereof |
| CN104624550A (en) * | 2014-12-19 | 2015-05-20 | 楚天科技股份有限公司 | Rubber plug or aluminum cap cleaning machine |
| CN108746136A (en) * | 2018-05-07 | 2018-11-06 | 上海东富龙科技股份有限公司 | Aluminium-plastic cap cleaning machine installs plastic-aluminum lid arrangement additional with full-automatic |
| CN110788047A (en) * | 2018-08-03 | 2020-02-14 | 楚天科技股份有限公司 | Sterile transferring system and transferring method for rubber plug cleaning machine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101417780B (en) | 2010-11-10 |
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| C14 | Grant of patent or utility model | ||
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Address after: 201109 Shanghai city Minhang District Fanghe Road No. 2199 Patentee after: Dongfulong Technology Group Co.,Ltd. Address before: 201109 Shanghai city Minhang District Fanghe Road No. 2199 Patentee before: SHANGHAI TOFFLON SCIENCE AND TECHNOLOGY Co.,Ltd. |