CN101406670B - Chinese patent medicine for treating brain injury coma - Google Patents
Chinese patent medicine for treating brain injury coma Download PDFInfo
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- CN101406670B CN101406670B CN2008101602900A CN200810160290A CN101406670B CN 101406670 B CN101406670 B CN 101406670B CN 2008101602900 A CN2008101602900 A CN 2008101602900A CN 200810160290 A CN200810160290 A CN 200810160290A CN 101406670 B CN101406670 B CN 101406670B
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Abstract
The invention relates to a Chinese parent medicine for treating comatose patients with brain injury. The medicine is prepared from an extract of 20 to 30 weight percent of rhubarb, 20 to 30 weight percent of Curcuma aromatica Salisb, 10 to 18 weight percent of red paeony root, 8 to 16 weight percent of szechuan lovage rhizome, 20 to 30 weight percent of couchgrass root and muskiness added according to 0.1 gram per 20 to 25 grams of rhubarb. The method has advantages of simple preparation process, scientific and reasonable formula, determined and obvious curative effect, low cost and no toxic side effect on human body. The Chinese parent medicine for treating comatose patients with brain injuries can reduce intravenous drug use, damages to liver or kidney functions and complicating diseases, and improve prognosis quality. The liquid medicine can be taken by nasal feed in early period of diseases and is convenient to take and easy to accept by patients.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine of going into a coma behind the brain injury for the treatment of.
Background technology
The severe craniocerebral injury is one of common emergency case of neurosurgery, and the state of an illness is dangerous, and disability rate and mortality rate are all higher; The traditional doctor trained in Western medicine method treatment of many clinically at present employings, intravenous administration is numerous and diverse, often causes medicine liver, renal function injury in the therapeutic process, causes the course of disease to prolong, and complication increases, and causes patient's prognosis mala, produces serious sequela.
Summary of the invention
For overcoming above-mentioned shortcoming, the object of the present invention is to provide a kind of taking convenience, determined curative effect, obvious, and the infringement that can alleviate hepatic and renal function, reduce the generation of complication, improve the Chinese medicine preparation of the treatment brain injury coma of prognosis quality.
Technical scheme of the present invention is to realize like this.By weight, it is by the extract of 20-30% Radix Et Rhizoma Rhei, 20-30% Radix Curcumae, 10-18% Radix Paeoniae Rubra, 8-16% Rhizoma Chuanxiong, 20-30% Rhizoma Imperatae, and every 20-25 gram Radix Et Rhizoma Rhei adds the medicine that 0.1 gram Moschus is made.
Preparation method of the present invention is: by weight percentage, and according to the ratio compounding pharmaceutical of Radix Et Rhizoma Rhei 20-30%, Radix Curcumae 20-30%, Radix Paeoniae Rubra 10-18%, Rhizoma Chuanxiong 8-16%, Rhizoma Imperatae 20-30%.Wherein, behind 75% the alcohol reflux that (1) adds that 8-12 doubly measures with Radix Et Rhizoma Rhei, Radix Curcumae, Rhizoma Chuanxiong, separating filtrate, reclaim ethanol, obtain medicinal liquid.Add 2-3 gram beta-schardinger dextrin-according to per 100 milliliters of medicinal liquids then, stir more than 2 hours in 50-70 ℃ of heating in water bath, place more than 10 hours, device stores in addition, gets supernatant, both medicinal liquid A, and medicinal residues were incorporated for second step into and are handled.(2) Radix Et Rhizoma Rhei, Radix Curcumae, Rhizoma Chuanxiong medicinal residues and Radix Paeoniae Rubra behind the ethanol extraction, Rhizoma Imperatae are merged, add the water boiling and extraction that 5-7 doubly measures, filter, repetitive operation once merges the medicinal liquid that obtains for twice.Per 100 milliliters of medicinal liquids add 2% chitosan gum liquid solution 35-40 milliliter, jolting, and medical liquid B is obtained in precipitation, filtration.(3) Moschus is added in the 25-30 times of water gaging, Ultrasonic Pulverization was filtered more than 10 minutes, got medicinal liquid C.(4) the above-mentioned medicinal liquid A that obtains, medical liquid B and medicinal liquid C merged, filter, concentrate, fill promptly.With the Radix Et Rhizoma Rhei is object of reference, and every 20-30 gram Radix Et Rhizoma Rhei obtains concentrated medicament 100-120 milliliter.
Application process: behind the brain injury or after the operation, on the basis of doctor trained in Western medicine conventional therapy, promptly inserted stomach tube by nasal feeding after 24-48 hour, use this medicinal liquid to the patient, each 50 milliliters, twice, two week of every day is a course of treatment.
Production technology of the present invention is simple, cost is low; The medicine prescription is scientific and reasonable, determined curative effect, obviously, to the human body safe without toxic side effect.Secondly, because the present invention adopts the method treatment brain injury coma of Chinese medicine, nasal feeding, to reduce intravenous administration, the infringement that alleviates hepatic and renal function reduces the generation of complication, improves the prognosis quality.Moreover using this medicinal liquid can in early days can be by the nasal feeding administration in the state of an illness, taking convenience, and the patient easily accepts.
The specific embodiment
According to weight percent meter, raw material of the present invention consists of: by weight percentage, and Radix Et Rhizoma Rhei 20-30%, Radix Curcumae 20-30%, Radix Paeoniae Rubra 10-18%, Rhizoma Chuanxiong 8-16%, Rhizoma Imperatae 20-30%, and every 20-25 gram Radix Et Rhizoma Rhei adds 0.1 gram Moschus.Use the ratio of said medicine, said medicine is extracted with ethanol, water respectively, and Moschus is mixed with the said extracted thing after with water dissolution, concentratedly produces medicine of the present invention.Concrete grammar is:
(1) Radix Et Rhizoma Rhei, Radix Curcumae, Rhizoma Chuanxiong are mixed, add that 8-12 doubly measures 75% alcohol reflux 1.5-2.5 hour, separating filtrate, reclaim ethanol after, every 20-30 gram Radix Et Rhizoma Rhei obtains medicinal liquid 280-360 milliliter.Add beta-schardinger dextrin-again in medicinal liquid, per 100 milliliters of medicinal liquids add the 2-3 gram, and stir 3-4 hour in 50-70 ℃ of heating in water bath, place more than 10 hours, and device stores in addition, gets supernatant, both medicinal liquid A, and medicinal residues were incorporated for second step into and are handled.This step handles based on anthraquinone analog compound, fine solubility in ethanol such as volatile oil, ligustrazine, ferulic acid; For guaranteeing that ethanol reclaims their dissolubility in water of back, adopt the beta-cyclodextrin inclusion compound technology simultaneously, so both guaranteed the concentration of active component in medicinal liquid, strengthened the stability of medicinal liquid again.
(2) will merge with the Radix Et Rhizoma Rhei behind the ethanol extraction, Radix Curcumae, Rhizoma Chuanxiong medicinal residues and Radix Paeoniae Rubra, Rhizoma Imperatae, and add the decocting that 5-7 doubly measures and boiled 1-12 hour, filter, repetitive operation once, merging filtrate, 20-25 gram Rhizoma Imperatae obtains medicinal liquid 100-120 milliliter.Afterwards, per 100 milliliters of medicinal liquids add 2% chitosan gum liquid solution 35-40 milliliter, jolting, and medical liquid B is obtained in precipitation, filtration.Make the precipitation clarifier with chitosan, not only can remove larger particles in the decocting liquid, keep effective polymer substance, improve stability.
(3) Moschus is added in the 25-30 times of water gaging, Ultrasonic Pulverization 25-30 minute, filter, obtain medicinal liquid C.
(4) will more than the medicinal liquid A, medical liquid B and the medicinal liquid C that obtain merge, filter, concentrate, fill promptly.With the Radix Et Rhizoma Rhei is object of reference, and every 20-30 gram Radix Et Rhizoma Rhei obtains concentrated medicament 100-120 milliliter.
Model case:
Example 1: the king * *, the man, 27 years old, traffic accident injured women's head-ornaments portion stupor and was admitted to hospital in 1 hour, is diagnosed as: 1, two frontal lobe brain contusion, 2, traumatic subarachnoid hemorrhage.The patient does not have the operation indication, gives expectant treatment, and the 24 hours slotting stomach tubes of being admitted to hospital give 50 milliliters of this medicinal liquids, twice of every day by nasal feeding.The patient is clear-headed after 7 days, and complication such as stress ulcer, hyperpyrexia, tic do not take place.
Example 2: Lee * *, the man, 67 years old, traumatic injury head stupor was admitted to hospital in 2 hours, was diagnosed as: 1, acute right temporo epidural hematoma, 2, left volume temporal lobe contusion and laceration of brain.The back emergency case row bone lobe of being admitted to hospital is opened the right temporo epidural hematoma of cranium and is removed art, and 24 hours slotting stomach tubes of postoperative give 50 milliliters of this medicinal liquids, twice of every day by nasal feeding.The patient is drowsiness after 3 days, and is clear-headed after 5 days, and complication such as stress ulcer, hyperpyrexia, tic do not take place.
Example 3: Korea Spro *, the woman, 38 years old, traffic accident injured head stupor and was admitted to hospital in 1 hour, is diagnosed as: 1, diffuse axonal injury, 2, acute left volume temporo subdural hematoma, 3, left volume temporal lobe contusion and laceration of brain.The back emergency case row bone lobe of being admitted to hospital is opened the volume temporo subdural hematoma removing of a cranium left side and is added the lobe decompression of boning, and 24 hours slotting stomach tubes of postoperative give 50 milliliters of this medicinal liquids, twice of every day by nasal feeding.Patient's twinge is reacted again after 4 days, and clear-headed after 11 days, stress gastric ulcer appearred in 2 days in postoperative, cures in 3 days after the continuation medication, complication such as hyperpyrexia, tic do not occur.
Claims (1)
1. Chinese patent medicine for the treatment of brain injury coma, it is characterized in that: by weight, it is by the extract of 20-30% Radix Et Rhizoma Rhei, 20-30% Radix Curcumae, 10-18% Radix Paeoniae Rubra, 8-16% Rhizoma Chuanxiong, 20-30% Rhizoma Imperatae, and every 20-25 gram Radix Et Rhizoma Rhei adding 0.1 gram Moschus is made medicine, wherein
(1) behind 75% the alcohol reflux that Radix Et Rhizoma Rhei, Radix Curcumae, Rhizoma Chuanxiong is added 8-12 doubly measures, separating filtrate, reclaim ethanol, obtain medicinal liquid, add 2-3 gram beta-schardinger dextrin-according to per 100 milliliters of medicinal liquids then, stir more than 2 hours in 50-70 ℃ of heating in water bath, place more than 10 hours, device stores in addition, gets supernatant, i.e. medicinal liquid A;
(2) Radix Et Rhizoma Rhei, Radix Curcumae, Rhizoma Chuanxiong medicinal residues and Radix Paeoniae Rubra behind the ethanol extraction, Rhizoma Imperatae are merged, add the water boiling and extraction that 5-7 doubly measures, filter, repetitive operation once merges the medicinal liquid that obtains for twice; Per 100 milliliters of medicinal liquids add 2% chitosan gum liquid solution 35-40 milliliter, jolting, and medical liquid B is obtained in precipitation, filtration;
(3) Moschus is added in the 25-30 times of water gaging, Ultrasonic Pulverization was filtered more than 10 minutes, got medicinal liquid C;
The above-mentioned medicinal liquid A that obtains, medical liquid B and medicinal liquid C are merged, filter, concentrate, and every 20-30 gram Radix Et Rhizoma Rhei obtains concentrated medicament 100-120 milliliter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101602900A CN101406670B (en) | 2008-11-19 | 2008-11-19 | Chinese patent medicine for treating brain injury coma |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101602900A CN101406670B (en) | 2008-11-19 | 2008-11-19 | Chinese patent medicine for treating brain injury coma |
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| Publication Number | Publication Date |
|---|---|
| CN101406670A CN101406670A (en) | 2009-04-15 |
| CN101406670B true CN101406670B (en) | 2011-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008101602900A Expired - Fee Related CN101406670B (en) | 2008-11-19 | 2008-11-19 | Chinese patent medicine for treating brain injury coma |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102784A (en) * | 1994-02-28 | 1995-05-24 | 虹雨集团公司 | Chinese patent medicine for prevention and control of ischemic cardio-cerebral angiopathy |
| CN1857446A (en) * | 2006-03-27 | 2006-11-08 | 深圳市生物谷科技有限公司 | Musk containing medicine composition |
| CN1879840A (en) * | 2005-06-17 | 2006-12-20 | 张晴龙 | A nano 'Xing Nao Jing' injection and method for preparing same |
| CN1907345A (en) * | 2006-08-23 | 2007-02-07 | 张文芳 | Chinese traditional medicine composition for treating cerebral apoplexy |
-
2008
- 2008-11-19 CN CN2008101602900A patent/CN101406670B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102784A (en) * | 1994-02-28 | 1995-05-24 | 虹雨集团公司 | Chinese patent medicine for prevention and control of ischemic cardio-cerebral angiopathy |
| CN1879840A (en) * | 2005-06-17 | 2006-12-20 | 张晴龙 | A nano 'Xing Nao Jing' injection and method for preparing same |
| CN1857446A (en) * | 2006-03-27 | 2006-11-08 | 深圳市生物谷科技有限公司 | Musk containing medicine composition |
| CN1907345A (en) * | 2006-08-23 | 2007-02-07 | 张文芳 | Chinese traditional medicine composition for treating cerebral apoplexy |
Non-Patent Citations (2)
| Title |
|---|
| 章铨荣.中西医结合疗法治疗脑外伤.《中西医结合实用临床急救》.1999,第6卷(第1期), * |
| 罗学裕.脑损伤后综合征之分型论治.《湖南中医药导报》.1997,第3卷(第4期), * |
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| CN101406670A (en) | 2009-04-15 |
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