CN1857446A - Musk containing medicine composition - Google Patents
Musk containing medicine composition Download PDFInfo
- Publication number
- CN1857446A CN1857446A CNA2006100658469A CN200610065846A CN1857446A CN 1857446 A CN1857446 A CN 1857446A CN A2006100658469 A CNA2006100658469 A CN A2006100658469A CN 200610065846 A CN200610065846 A CN 200610065846A CN 1857446 A CN1857446 A CN 1857446A
- Authority
- CN
- China
- Prior art keywords
- extract
- monomer
- moschus
- radix
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 239000003814 drug Substances 0.000 title abstract description 43
- 241000402754 Erythranthe moschata Species 0.000 title abstract description 3
- 239000000284 extract Substances 0.000 claims description 79
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 77
- 239000000178 monomer Substances 0.000 claims description 38
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 claims description 36
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 claims description 34
- 239000008194 pharmaceutical composition Substances 0.000 claims description 30
- ALHUZKCOMYUFRB-UHFFFAOYSA-N muskone Natural products CC1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-UHFFFAOYSA-N 0.000 claims description 22
- ALHUZKCOMYUFRB-OAHLLOKOSA-N Muscone Chemical compound C[C@@H]1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-OAHLLOKOSA-N 0.000 claims description 21
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- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 6
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- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000002550 vasoactive agent Substances 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000008918 xingnaojing Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Abstract
Description
Group | Dosage (mg/kg) | Swelling rate (%) |
The fragrant danshensu GINKGO BILOBA EXTRACT of blank Zu aspirin peony extract She peony extract+She perfume (or spice) | - 0.2 30 5.0 2 20 30 | 145.26±38.38 63.88±31.77 ** 91.96±32.16 ** 96.81±27.22 * 125.69±36.21 119.21±32.02 69.27±26.51 **# |
Present composition A (height) present composition A (in) present composition A (low) | 40 20 10 | 65.45±24.43 **Δ#^ 68.34±26.32 **#^ 88.76±31.36 * |
Present composition B (height) present composition B (in) present composition B (low) | 30 15 10 | 64.23±23.11 **Δ#^ 67.87±26.56 **#^ 87.54±29.06 * |
Present composition C (height) present composition C (in) present composition C (low) | 50 30 15 | 64.67±28.02 **Δ#^ 65.87±26.56 **#^ 80.23±29.57 * |
Present composition D (height) present composition D (in) present composition D (low) | 40 20 10 | 63.98±27.89 **Δ#^ 69.19±28.61 **#^ 83.87±31.37 * |
Group | The OD value |
The normal control group | 0.067±0.022 |
Aspirin | 0.035±0.023 ** |
Radix Paeoniae Alba extract | 0.039±0.018 ** |
Moschus | 0.040±0.017 ** |
60% Carthamus yellow extract | 0.056±0.020 |
60% Radix Puerariae puerarin extract | 0.058±0.019 |
Radix Paeoniae+Moschus | 0.025±0.013 **Δ# |
Present composition A (low) present composition A (in) present composition A (height) | 0.036±0.019 **^ 0.028±0.020 **Δ#^ 0.023±0016 **ΔΔ##^ |
Present composition B (low) present composition B (in) present composition B (height) | 0.037±0.021 **^ 0.028±0.017 **Δ#^ 0.024±0.018 **ΔΔ##^ |
Glu | Asp | GABA | Gly | |
Sham operated rats | 3.77±0.91 | 3.67±1.01 | 10.69±3.40 | 2.61±0.58 |
Model group peoniflorin ligustrazine muscone present composition A present composition B | 5.59±0.93 ** 5.22±1.13 ** 4.57±1.09 ** 5.21±0.96 * 4.43±1.16 *ΔΔ# 4.25±0.79 *ΔΔ# | 5.79±0.96 ** 4.19±0.97 ΔΔ 4.21±0.88 ΔΔ 4.18±0.67 ΔΔ 4.01±0.71 ΔΔ^ 4.06±0.69 ΔΔ^ | 10.95±4.00 15.65±3.12 *Δ 14.67±3.02 *Δ 15.87±3.97 *Δ 19.43±3.11 *ΔΔ#^ 19.02±3.86 *ΔΔ#^ | 3.41±0.62 * 4.11±0.59 **Δ 4.19±0.61 **Δ 4.11±0.62 **Δ 4.18±0.56 **ΔΔ 4.16±0.46 **ΔΔ |
Group | Dosage | The length of one's sleep (minute) |
Physiological saline Zu muskone Zu safflower Zu kudzu root extract tanshinone+Chinese herbaceous peony Zu caffeine sodium benzoate Zu present composition A present composition B | - 10mg/kg 15mg/kg 20mg/kg 20mg/kg 2mg/kg 20mg/kg 20mg/kg | 29.9±6.3 20.1±4.8 *Δ# 26.8±5.7 28.9±6.9 26.1±5.5 11.5±4.3 **ΔΔ## 15.9±5.1 **Δ# 16.3±5.2 **Δ# |
Medicine | Dosage | FBG(m mol/L) | Ins(m IU/L) |
Normal group diabetes Zu Paeoniflorin Salvia root P.E diaformin tablet pharmaceutical composition A of the present invention pharmaceutical composition B of the present invention | - - 80mg/kg 40mg/kg 80mg/kg 80mg/kg 80mg/kg | 4.96±0.40 ** 16.5±3.1 11.4±3.0 * 16.8±3.0 8.9±3.5 ** 7.9±2.0 **ΔΔ 7.4±1.5 **ΔΔ | 23.6±3.2 ** 17.5±2.3 18.9±2.7 17.3±2.1 17.6±2.6 17.8±2.1 17.1±2.2 |
Group | Serum LPO | SOD in serum | Liver L PO | Liver SOD |
High fat of blood Zu VE Zu Paeoniflorin She perfume (or spice)+ginkgo ginkgo biloba extract present composition Zu | 8.99±2.00 6.54±1.23 ** 7.89±1.17 8.59±1.21 6.98±1.16 **ΔΔ 6.37±1.21 **ΔΔ | 400.9±56.7 440.1±28.9 451.6±40.1 * 425.9±33.3 458.9±26.1 *Δ 466.1±27.3 *Δ | 6.91±1.18 5.61±1.13 * 5.89±1.37 6.33±1.33 5.22±1.11 ** 5.11±1.05 ** | 7.59±1.19 8.87±1.27 * 8.73±1.18 * 7.70±1.29 9.24±1.03 ** 9.49±1.13 ** |
Claims (4)
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CN2009102107515A Division CN101766699B (en) | 2006-03-27 | 2006-03-27 | Medicinal combination containing musk |
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CN200910210752XA Division CN101766700B (en) | 2006-03-27 | 2006-03-27 | Medicinal combination containing musk |
CN2009101774028A Division CN101664452B (en) | 2006-03-27 | 2006-03-27 | Drug combination containing musk |
CN200910177403A Division CN101664453A (en) | 2006-03-27 | 2006-03-27 | Drug combination containing musk |
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Cited By (2)
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CN101406670B (en) * | 2008-11-19 | 2011-03-23 | 张合林 | Chinese patent medicine for treating brain injury coma |
CN101347422B (en) * | 2007-07-17 | 2012-01-04 | 中国医学科学院药物研究所 | Uses of salvianolic acid A in preventing and/or treating diabetes and complication |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101347422B (en) * | 2007-07-17 | 2012-01-04 | 中国医学科学院药物研究所 | Uses of salvianolic acid A in preventing and/or treating diabetes and complication |
CN101406670B (en) * | 2008-11-19 | 2011-03-23 | 张合林 | Chinese patent medicine for treating brain injury coma |
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