CN101406441A - Shampoo compositions with function for removing dandriff - Google Patents
Shampoo compositions with function for removing dandriff Download PDFInfo
- Publication number
- CN101406441A CN101406441A CNA2008100739094A CN200810073909A CN101406441A CN 101406441 A CN101406441 A CN 101406441A CN A2008100739094 A CNA2008100739094 A CN A2008100739094A CN 200810073909 A CN200810073909 A CN 200810073909A CN 101406441 A CN101406441 A CN 101406441A
- Authority
- CN
- China
- Prior art keywords
- sodium
- shampoo compositions
- meant
- dandruff
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 239000002453 shampoo Substances 0.000 title claims abstract description 34
- 208000001840 Dandruff Diseases 0.000 claims abstract description 45
- 239000004094 surface-active agent Substances 0.000 claims abstract description 10
- -1 siloxane ester quaternary ammonium salt Chemical class 0.000 claims description 26
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 claims description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 229960003344 climbazole Drugs 0.000 claims description 18
- 239000008365 aqueous carrier Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 229920000570 polyether Polymers 0.000 claims description 12
- 229950001046 piroctone Drugs 0.000 claims description 11
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- 235000015165 citric acid Nutrition 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- 229920002907 Guar gum Polymers 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 125000002091 cationic group Chemical group 0.000 claims description 6
- 150000001768 cations Chemical class 0.000 claims description 6
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 6
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 6
- 239000003086 colorant Substances 0.000 claims description 6
- 239000000665 guar gum Substances 0.000 claims description 6
- 229960002154 guar gum Drugs 0.000 claims description 6
- 235000010417 guar gum Nutrition 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 241001597008 Nomeidae Species 0.000 claims description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 5
- KOUMISLWPGYNFV-UHFFFAOYSA-N dimethyl(tricosyl)azanium chloride Chemical compound CCCCCCCCCCCCCCCCCCCCCCC[NH+](C)C.[Cl-] KOUMISLWPGYNFV-UHFFFAOYSA-N 0.000 claims description 5
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 229940077388 benzenesulfonate Drugs 0.000 claims description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
- 239000002781 deodorant agent Substances 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 229930195712 glutamate Natural products 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 229940045998 sodium isethionate Drugs 0.000 claims description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 4
- 235000011152 sodium sulphate Nutrition 0.000 claims description 4
- LADXKQRVAFSPTR-UHFFFAOYSA-M sodium;2-hydroxyethanesulfonate Chemical compound [Na+].OCCS([O-])(=O)=O LADXKQRVAFSPTR-UHFFFAOYSA-M 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- JLHMJWHSBYZWJJ-UHFFFAOYSA-N 1,2-thiazole 1-oxide Chemical class O=S1C=CC=N1 JLHMJWHSBYZWJJ-UHFFFAOYSA-N 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 claims description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- 102000011782 Keratins Human genes 0.000 claims description 3
- 108010076876 Keratins Proteins 0.000 claims description 3
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 235000011054 acetic acid Nutrition 0.000 claims description 3
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 3
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 claims description 3
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical compound CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 claims description 3
- DTTVNCZEOYSFFF-UHFFFAOYSA-N ethoxyurea Chemical compound CCONC(N)=O DTTVNCZEOYSFFF-UHFFFAOYSA-N 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 230000007062 hydrolysis Effects 0.000 claims description 3
- 238000006460 hydrolysis reaction Methods 0.000 claims description 3
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 108700019599 monomethylolglycine Proteins 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 229920002545 silicone oil Polymers 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims description 3
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 108010064851 Plant Proteins Proteins 0.000 claims description 2
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 150000001767 cationic compounds Chemical class 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 229910001411 inorganic cation Inorganic materials 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 235000016709 nutrition Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 235000011083 sodium citrates Nutrition 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 abstract description 10
- 238000012216 screening Methods 0.000 abstract description 8
- 238000011160 research Methods 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 26
- 239000006210 lotion Substances 0.000 description 23
- 230000000694 effects Effects 0.000 description 17
- 230000001139 anti-pruritic effect Effects 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 238000003756 stirring Methods 0.000 description 9
- 238000005406 washing Methods 0.000 description 7
- 239000003085 diluting agent Substances 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 210000003128 head Anatomy 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 239000000686 essence Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 229960004125 ketoconazole Drugs 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 3
- 229960005265 selenium sulfide Drugs 0.000 description 3
- 239000011265 semifinished product Substances 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 231100000820 toxicity test Toxicity 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 229960004703 clobetasol propionate Drugs 0.000 description 2
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 description 2
- TVZPLCNGKSPOJA-UHFFFAOYSA-N copper zinc Chemical compound [Cu].[Zn] TVZPLCNGKSPOJA-UHFFFAOYSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229940086207 head & shoulders Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 101100188555 Arabidopsis thaliana OCT6 gene Proteins 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001586 eradicative effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229940084434 fungoid Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a shampoo composition which consists of 0.1 to 5 percent of a dandruff remover, 4 to 20 percent of a softener, 15 to 45 percent of a surfactant and 30 to 80 percent of enhydrous carrier. Through the research efforts such as screening antibiotic/dandruff removing components, screening softening matters, determining the optimal composition ratio, and the like, dandruff removing active components are taken as the efficacy ingredients of the composition, the optimal efficacy ratio is determined, and the antibiotic/dandruff removing active components and the cleaning/softening matters are capable of coexisting evenly.
Description
Invention field
The present invention relates to a kind of shampoo Compositions, particularly a kind of shampoo Compositions with function for removing dandriff.
Background technology
At dandruff, head pruritus is the basic reason that is caused by harmful fungoid or hypersteatosis, at present shampoo Compositions contains and has the surfactant of washing clean effect, the nourishing of antibacterial activity composition and hair care effect becomes to be grouped into, can suppress scalp, pernicious bacteria in the hair, eliminate dandruff, head pruritus, tangible antibacterial effect, but the hair compliance was not enough after such shampoo was washed, hair is difficult to combing, life-time service has minimal irritation, hair care effect deficiency etc., deficiency at the existence of existing market product, the present invention proposes products perfection, through the prescription screening, effect evaluation contrast, stability test, toxicity test, work such as product detection, adopt antibacterial substance and clean solution that combines, use user's own control to test the effect evaluation methodology of this science, screening through antibiotic/anti-dandruff composition, the screening of submissive material, best prescription proportioning determines to wait research work, screened anti-dandruff active component as the prescription functional component, clear and definite its optimal efficacy proportioning, and make antibiotic/anti-dandruff active component and wash clean/submissive material and be able to balance coexistence.
Summary of the invention
The present invention seeks to disclose a kind of shampoo Compositions, by weight, comprising with function for removing dandriff:
A) the dandruff agent of 0.1%-5% comprises Octopirox, climbazole or both mixture.
B) softener of 4%-20% comprises polyether siloxane ester quaternary ammonium salt, cation guar gum or their mixture.
C) surfactant of 15%-45% comprises AESA (AESA), ammonium lauryl sulfate (K12 ammonium), lauric acid amide of ethanol, cocamido propyl betaine or their mixture.
D) aqueous carrier of 30%-80%.
The dandruff agent
Compositions of the present invention comprises the dandruff removing agent of safe and effective amount.Dandruff removing agent accounts for the 0.1%-5% of shampoo Compositions weight, is preferably 0.3%-5%, more preferably 0.5%-3%.Octopirox, climbazole, both salt and derivant thereof are applicable to the present invention.
Above-mentioned dandruff removing agent can use separately, also can be used in combination the ratio Octopirox that is used in combination mutually: climbazole is 1%-4%: 1%, be preferably 1.5%-3.5%: 1%.
Can add salicylic acid, selenium sulfide or pyridine sulfidion copper zinc in the above-mentioned dandruff removing agent.
Softener
Softener of the present invention can also be substituted by following material: docosyl trimethyl ammonia chloride, silicone, cationic albumen, emulsified silicone oil, quaternized glucose polyether ester, cationic cellulose, octadecyl trimethyl ammonium chloride or dodecyl amine oxide except that polyether siloxane ester quaternary ammonium salt, cation guar gum or their mixture.
Softener can use separately, also can be used in combination mutually, preferred 4%, 6% or 8% polyether siloxane ester quaternary ammonium salt, and perhaps 4%, 6%, 8% polyether siloxane ester quaternary ammonium salt mixes use with the cation guar gum of 2%-4%.
Surfactant
Surfactant of the present invention can be substituted by following material: aliphatic alcohol sulfate, sodium alkyl benzene sulfonate and α-sodium olefin sulfonate polyoxyethylenated alcohol sodium sulfate and sodium lauryl sulphate, alkylolamides (FFA), fatty alcohol-polyoxyethylene ether (AE), laureth carboxylic acid sodium (AEC), alkylphenol polyoxyethylene (APE or OP), sulphosuccinates, cocoyl sodium isethionate or N-acyl glutamate.
The preferred 12%-15% AESA of surfactant, 8%-10% ammonium lauryl sulfate K12 ammonium, 1%-4% cocamido propyl betaine and 2%-4% lauric acid amide of ethanol.
Aqueous carrier
The aqueous carrier of compositions of the present invention is according to selecting the content and the kind of carrier with required other characteristic of the compatibility of other component and product.This aqueous carrier is water basically.The preferred deionized water that uses.According to the desirable characteristics of product, also can use the water of the natural origin that contains inorganic cation.Can contain other conditioner in this aqueous carrier, antiseptic, pH regulator agent, thickening agent, coloring agent, wetting agent, freshener or deodorant tune.
Compositions of the present invention contains the aqueous carrier of about 30%-80% usually, preferably the aqueous carrier of about 50%-75%.
Can add other component in the aqueous carrier is formulated in the present composition.These components comprise: other conditioner, and as amine oxide, vitamin E, hydrolysis of keratin, protein, plant extraction liquid, and nutritional labeling; Antiseptic, for example p-Hydroxybenzoate, sodium benzoate, potassium sorbate, imidazolidinyl urea, isothiazolones, sodium hydroxy methyl glycinate; PH regulator agent, for example citric acid, sodium citrate, malic acid, tartaric acid, acetic acid, lactic acid; Thickening agent, for example sodium chloride, ammonia chloride, cithrol; Coloring agent is as FD ﹠amp; C or D ﹠amp; Any in the C dyestuff; Wetting agent, for example: ethoxy urea element, citric acid glyceride, glycerol, propylene glycol; Freshener, for example: Mentholum, Oleum menthae, menthyl lactate; Deodorant tune, for example: essence.
To those skilled in the art, by reading the disclosure of the specification, feature of the present invention, advantage will become apparent.
Required protection domain though detailed Description Of The Invention claims of the present invention particularly point out and know, should believe that following explanation will understand the present invention better.Except as otherwise noted, herein all percentage number averages in the weight of whole compositions.Except as otherwise noted, all ratios are weight ratio.Except as otherwise noted, the percent of all each compositions, ratio and content is all based on the actual content of composition herein, be not included in the commercially available prod can with these compositions solvent, filler or other material together.
Prescription characteristics of the present invention are by selecting suitable prescription to form, select best formula proportion, through the prescription screening, effect evaluation contrast, stability test, toxicity test, work such as product detection, adopt antibacterial substance and clean solution that combines, use user's own control to test the effect evaluation methodology of this science, screening through antibiotic/anti-dandruff composition, the screening of submissive material, best prescription proportioning determines to wait research work, screened anti-dandruff active component as the prescription functional component, clear and definite its optimal efficacy proportioning, and make antibiotic/anti-dandruff active component and wash clean/submissive material and be able to balance coexistence, make anti-dandruff, antipruritic effect is good, active component is safe, take into account and wash clean and submissive effect, antibiotic/anti-dandruff function and clean function are united two into one.
The following example has further described and has proved the specific embodiments in the scope of the invention.These embodiment only are illustrative, but not limit the scope of the invention, because can carry out multiple variation under the condition that does not deviate from technical field of the present invention and scope.
The composition of embodiment 1-3 shampoo Compositions
The composition of embodiment 4-6 shampoo Compositions
The composition of embodiment 7-9 shampoo Compositions
The composition of embodiment 10-14 shampoo Compositions
| Component | Embodiment 10 | Embodiment 11 | Embodiment 12 | Embodiment 13 | Embodiment 14 |
| Anti-dandruff dose | Octopirox, climbazole, the above total amount 0.5% of salicylic acid | The salt of Octopirox, climbazole, selenium sulfide, above total amount 1% | Octopirox, the derivant of climbazole, selenium sulfide, above total amount 2% | The derivant of Octopirox, climbazole pyridine sulfidion copper zinc, above total amount 3% | Octopirox, climbazole, above total amount 4% |
| Softener | Polyether siloxane ester quaternary ammonium salt, cation guar gum, above total is measured 5 % | Docosyl trimethyl ammonia chloride, cationic cellulose, above total amount 10% | Octadecyl trimethyl ammonium chloride, above total amount 15% | Silicone, cationic albumen, quaternized glucose polyether ester, above total amount 15% | Emulsified silicone oil or dodecyl amine oxide, above total amount 20% |
| Surfactant | Polyoxyethylenated alcohol sodium sulfate, above total amount 20% | Aliphatic alcohol sulfate and α-sodium olefin sulfonate, alkylolamides (FFA), sulphosuccinates, above total amount 25% | Alkylphenol polyoxyethylene (APE or OP), sodium alkyl benzene sulfonate, above total amount 30% | Cocoyl sodium isethionate, N-acyl glutamate and sodium lauryl sulphate, above total amount 35% | Fatty alcohol-polyoxyethylene ether (AE), laureth carboxylic acid sodium (AEC), above total amount 40% |
| Aqueous carrier | Hydrolysis of keratin, sodium hydroxy methyl glycinate; Citric acid, ethoxy urea element, essence, deionized water, above total amount 74.5% | Vitamin E, p-Hydroxybenzoate, malic acid, ammonia chloride, deionized water, above total amount 64% | Plant Aloe extraction solution, lactic acid, sodium chloride, coloring agent FD﹠C, citric acid glyceride, deionized water, above total amount 53% | Sodium benzoate, isothiazolone, acetic acid, coloring agent D﹠C, glycerol, Oleum menthae, essence, deionized water, above total amount 57% | Imidazolidinyl urea, tartaric acid, cithrol; Propylene glycol; Mentholum, deionized water, above total amount 36% |
Embodiment 15: the preparation method of anti-dandruff shampoo
The compositions of above said embodiment 1-14 can be by any conventional method preparation known in the art.They can make by following suitable mode:
The preparation method of embodiment 1-3:
A. with 6501, AESA, K12 ammonium join preparing tank, adds the water of cation guar gum, Oct, climbazole, recipe quantity, stirs and be heated to dissolving fully.
B. add cocamido propyl betaine, polyether siloxane ester quaternary ammonium salt, stir.
When treating that C. a jar interior temperature is reduced to 40-50 ℃, add citric acid, essence, pigment, antiseptic, stir pick test.
D. the inspection of semifinished product qualified after, filter, fill.
The preparation method of embodiment 4-6 (then not adding) if there is this composition in the prescription:
A. with 6501, α-sodium olefin sulfonate, sodium lauryl sulphate join preparing tank, adds the water of docosyl trimethyl ammonia chloride, Oct, climbazole, recipe quantity, stirs and be heated to dissolving fully.
B adds cocamido propyl betaine, quaternized glucose polyether ester, stirs.
When C treats that a jar interior temperature is reduced to 40-50 ℃, add tartaric acid, essence, pigment, antiseptic, stir pick test.
After the D inspection of semifinished product is qualified, filtration, fill.
The preparation method of embodiment 7-9 (then not adding) if there is this composition in the prescription:
A. with 6501, AESA, K12 sodium join preparing tank, adds the water of docosyl trimethyl ammonia chloride, Oct, climbazole, recipe quantity, stirs and be heated to dissolving fully.
B. add cocamido propyl betaine, polyether siloxane ester quaternary ammonium salt, stir.
When treating that C. a jar interior temperature is reduced to 40-50 ℃, add malic acid, essence, pigment, antiseptic, EDTA-2Na, stir pick test.
D. the inspection of semifinished product qualified after, filter, fill.
Embodiment 16: the bacteria quantified insect killing test
The shampoo stock solution of embodiment of the invention 1-14 preparation, 1: 2 diluent, 1: 4 diluent are respectively to escherichia coli effect 5min, to colibacillary killing rate product average out to 100%, 99.98%, 99.92%
The shampoo stock solution of embodiment of the invention 1-14 preparation, 1: 2 diluent are respectively to staphylococcus aureus effect 5min, and 1: 4 diluent effect 10min is to the killing rate average out to 99.95%, 99.92%, 99.92% of staphylococcus aureus.
The shampoo stock solution of embodiment of the invention 1-14 preparation, 1: 4 diluent, 1: 8 diluent are respectively to Candida albicans effect 5min, to the oidiomycetic killing rate average out to 100%, 99.95%, 99.93% of white.
The shampoo of the present invention's preparation to escherichia coli, staphylococcus aureus, Candida albicans antibiotic rate 10 minutes action time all 〉=90.0%
The shampoo stock solution spraying experimenter of embodiment of the invention 1-14 preparation acts on 15min, to the average eradicative rate average out to 92.07% of watch face natural bacteria.
Embodiment 17: the prescription contrast test
Contrast product 1 title: the Ketoconazol/Clobetasol Propionate hair lotion (trade name: health king's lotion) that Kuning Dianhong Pharmaceutical Co., Ltd. produces;
Contrast product 2 titles: the TPIATOP (trade name: adopt happy lotion) that Xian-Janssen Pharmaceutical Ltd. produces;
Contrast product 3 titles: the anti-dandruff products of daily use chemicals class such as Rejoice, Head﹠Shoulders.
Contrast product 4-7: according to the relevant anti-dandruff lotion of technical solution of the present invention preparation.
Contrast of main active prescription and pluses and minuses
| Name of product | The prescription main active | Pluses and minuses |
| Contrast product 1 health king lotion | Ketoconazole+clobetasol propionate | Anti-dandruff, antipruritic, wash clean, submissive effective; Main active is antibiotic and hormone, and allergy and zest are arranged, unsuitable life-time service |
| Contrast product 2 is adopted happy lotion | Ketoconazole | Anti-dandruff, antipruritic effect good, but compliance is bad, the difficult combing of hair; Main active is an antibiotic, unsuitable life-time service |
| Daily use chemicals series products such as contrast product 3 Rejoice, Head﹠Shoulders | ZPT | Wash clean, compliance is good, but anti-dandruff, antipruritic effect is not obvious |
| Contrast product 4 | OCT or its salt, derivant | Anti-dandruff, antipruritic effect is general |
| Contrast product 5 | Climbazole | Anti-dandruff, antipruritic effect is general |
| Contrast product 6 | OCT: climbazole is 1.5: 1 | Anti-dandruff, antipruritic effect is better |
| Contrast product 7 | OCT: climbazole is 2.5: 1 | Anti-dandruff, antipruritic effect is better |
| The shampoo of the embodiment of the invention 10 preparations | OCT: climbazole is 3.5: 1 | Anti-dandruff, antipruritic, wash clean, submissive effective; Be the safety active component, but life-time service |
Embodiment 18: the product controlled trial
Be clean, sterilization/the anti-dandruff and compliance function of washing of checking dandruff-controlling shampoo of the present invention, carried out 100 routine user own control tests, test grouping: matched group 1: health king's lotion; Matched group 2: adopt happy lotion; Test group: dandruff-controlling shampoo embodiment 1-14 of the present invention.
Three hair salons have carried out 100 routine user own controls tests (hair have been divided into two in the Nanning city, half compares, second half is tested, the collator is with health king lotion or adopt happy lotion, the experimenter uses dandruff-controlling shampoo of the present invention), with washing clean degree, anti-dandruff effect, antipruritic effect, compliance, the dandruff time occurring after washing, the head pruritus time occurs after washing is evaluation index, and the result is as follows:
| Product | Anti-dandruff effect | Antipruritic effect | Wash clean degree | Submissive life | Head pruritus, dandruff time appear after washing | Untoward reaction |
| Embodiment of the invention 1-14 lotion | Good | Good | Good | Better | 7～10 days | Do not have |
| Adopt happy lotion | Good | Good | Better | Relatively poor | 3～5 days | Hair is withered |
| Health king's lotion | Good | Good | Good | Better | 7～10 days | Idol has anaphylaxis |
Above result shows: wash clean degree with adopt happy lotion poorer slightly, anti-dandruff, antipruritic effect, three's basically identical, it is relatively poor that compliance is adopted happy lotion, washes back hair bunchy, combing easily, occur dandruff and head pruritus interval after washing, lotion of the present invention was adopted happy lotion 3-5 days generally at 7-10 days.
As seen product of the present invention is anti-dandruff, antipruritic, wash clean, submissive effect reaches similar optimum product level respectively, and resultant effect is better than like product.
Embodiment 19: safety and stability test
Embodiment of the invention 1-14 lotion proves per os LD50＞5000mg/kgbw female, male mice by chmice acute per os toxicity test, the nontoxic level in true border.Embodiment of the invention 1-14 lotion proves rabbit skin nonirritant by skin limb irritant test.Embodiment of the invention 1-14 lotion is by acute eye irritation test, and the result is subexcite.
Embodiment of the invention 1-14 lotion was placed in 54 ℃ of calorstats after 14 days, and it is little that the quantitative sterilization result shows that killing rate descends; Embodiment of the invention 1-14 lotion was deposited under the room temperature natural conditions 2 years, and it is little that the quantitative sterilization result shows that killing rate descends; Character and other quality control indexs do not have significant change yet, show that lotion of the present invention is at 2 years effects steady quality in the phase.
Claims (8)
1, a kind of shampoo Compositions with function for removing dandriff by weight, comprising:
A.0.1%-5% dandruff agent comprises Octopirox, climbazole or both mixture;
B.4%-20% softener comprises polyether siloxane ester quaternary ammonium salt, cation guar gum or their mixture;
C.15%-45% surfactant comprises AESA (AESA), ammonium lauryl sulfate (K12 ammonium), lauric acid amide of ethanol, cocamido propyl betaine or their mixture;
D.30%-80% aqueous carrier.
2, shampoo Compositions as claimed in claim 1 is characterized in that wherein dandruff removing agent accounts for the 0.1%-5% of shampoo Compositions weight, is preferably 0.3%-5%, more preferably 0.5%-3%; Octopirox: climbazole is 1%-4%: 1%, be preferably 1.5%-3.5%: 1%; Octopirox wherein, climbazole can be enough both salt and derivant thereof replace.
3, shampoo Compositions as claimed in claim 1 or 2 is characterized in that softener is wherein substituted by following material: docosyl trimethyl ammonia chloride, silicone, cationic albumen, emulsified silicone oil, quaternized glucose polyether ester, cationic cellulose, octadecyl trimethyl ammonium chloride or dodecyl amine oxide.
4, shampoo Compositions as claimed in claim 1 or 2 is characterized in that surfactant is wherein substituted by following material: aliphatic alcohol sulfate, sodium alkyl benzene sulfonate and α-sodium olefin sulfonate polyoxyethylenated alcohol sodium sulfate and sodium lauryl sulphate, alkylolamides (FFA), fatty alcohol-polyoxyethylene ether (AE), laureth carboxylic acid sodium (AEC), alkylphenol polyoxyethylene (APE or OP), sulphosuccinates, cocoyl sodium isethionate or N-acyl glutamate.
5, shampoo Compositions as claimed in claim 3 is characterized in that surfactant is wherein substituted by following material: aliphatic alcohol sulfate, sodium alkyl benzene sulfonate and α-sodium olefin sulfonate polyoxyethylenated alcohol sodium sulfate and sodium lauryl sulphate, alkylolamides (FFA), fatty alcohol-polyoxyethylene ether (AE), laureth carboxylic acid sodium (AEC), alkylphenol polyoxyethylene (APE or OP), sulphosuccinates, cocoyl sodium isethionate or N-acyl glutamate.
6,, it is characterized in that wherein aqueous carrier accounts for the 30%-80% of shampoo Compositions, preferred 50%-75% as claim 1,2 or 5 described shampoo Compositions; According to selecting the content and the kind of carrier with required other characteristic of the compatibility of other component of shampoo Compositions and product; This aqueous carrier is a water; The preferred deionized water that uses.
7, shampoo Compositions as claimed in claim 6 is characterized in that wherein aqueous carrier contains the water of the natural origin of inorganic cation; Contain other conditioner in this aqueous carrier, antiseptic, pH regulator agent, thickening agent, coloring agent, wetting agent, freshener or deodorant tune.
8, shampoo Compositions as claimed in claim 7 is characterized in that other conditioner wherein is meant amine oxide, vitamin E, hydrolysis of keratin, protein, plant extraction liquid or nutritional labeling; Antiseptic is meant p-Hydroxybenzoate, sodium benzoate, potassium sorbate, imidazolidinyl urea, isothiazolones or sodium hydroxy methyl glycinate; The pH regulator agent is meant citric acid, sodium citrate, malic acid, tartaric acid, acetic acid or lactic acid; Thickening agent is meant sodium chloride, ammonia chloride or cithrol; Coloring agent is meant FD﹠amp; C or D﹠amp; Any in the C dyestuff; Wetting agent is meant ethoxy urea element, citric acid glyceride, glycerol or propylene glycol; Freshener is meant Mentholum, Oleum menthae or menthyl lactate; Deodorant tune is meant essence.
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