CN101401854A - Medicament formulation for treating epilepsy and preparation thereof - Google Patents
Medicament formulation for treating epilepsy and preparation thereof Download PDFInfo
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- CN101401854A CN101401854A CNA2008101974941A CN200810197494A CN101401854A CN 101401854 A CN101401854 A CN 101401854A CN A2008101974941 A CNA2008101974941 A CN A2008101974941A CN 200810197494 A CN200810197494 A CN 200810197494A CN 101401854 A CN101401854 A CN 101401854A
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Abstract
The invention relates to a medicinal preparation for treating epileptics, which is mainly prepared from the following components in weight portion: 8 to 12 portions of spina data seed, 8 to 12 portions of seed of snakegourd, 8 to 12 portions of pinenut kernel, 8 to 12 portions of semen biotae shelled, 8 to 12 portions of linseed, 8 to 12 portions of walnut seed, 6 to 10 portions of sesame, 6 to 10 portions of soybean, 6 to 10 portions of sunflower seed and 6 to 10 portions of rape seed. The preparation method comprises the following steps: after feeding each raw material in a crusher to crush, mixing the raw materials evenly; adding water into the mixed materials, and soaking the materials for 24 hours; feeding the mixed materials in a steamer to steam for 3 to 5 hours; adding active dry yeast powder into the mixture; and after stirring evenly, putting the mixture in a fermentation cellar to ferment for 15 days, and crushing the mixture after drying. The medicinal preparation has remarkable curative effect, can control epileptic seizure well after an epileptic patient takes the preparation, has the function of reinvigoration, and can promote the rehabilitation of the organism of a patient well. At the same time, because the medicinal preparation is a pure plant preparation, the medicinal preparation has no any toxic and side effect after the epileptic patient takes for a long time.
Description
Technical field
The present invention relates to a kind of antiepileptic, especially relate to a kind of pharmaceutical preparation and preparation method thereof of treatment epileptics of pure plant type.
Background technology
Epilepsy is one group of disease and syndrome, is feature with the intermittent central nervous system function imbalance due to the unexpected repeatedly over-discharge of brain neuroblastoma.Often epilepsy is divided into constitutional and Secondary cases two big classes clinically.Because most epilepsy is to be secondary to the organic of brain or metabolic obstacle, is also referred to as secondary epilepsy or symptomatic epilepsy.At present, some Western medicine is used to control the outbreak of secondary epilepsy, as phenobarbital, carbamazepine, sodium valproate, phenytoin Sodium etc.But Western medicine is cured the symptoms, not the disease, and is unsuitable for taking for a long time.As taking Western medicine for a long time, comparatively serious toxic and side effects appears easily, and further influence patient health, and cause patient habit-forming easily.Though the quality of life that has operative treatment can improve epileptic patient now, operation adaptability crowd is few, the expense costliness, and risk is very high.
Summary of the invention
The present invention solves in the existing epileptics treatment means, and the western medicine toxic and side effects is big, unsuitable life-time service; Operative treatment has a big risk, and causes technical problems such as sequela easily; It is a kind of without any side effects that the spy provides, can take for a long time, therapeutic effect significantly, the pharmaceutical preparation of the treatment epileptics of pure plant type.
Above-mentioned technical problem of the present invention is mainly solved by following technical proposals: its prescription is mainly made by following components in weight portion:
Semen Ziziphi Spinosae 8-12 part, Fructus Trichosanthis core 8-12 part, Semen pini koraiensis 8-12 part, Semen Platycladi 8-12 part, Fructus Cannabis 8-12 part, semen juglandis 8-12 part, Semen Sesami 6-10 part, Semen Glycines 6-10 part, Semen arachidis hypogaeae 6-10 part, Semen Helianthi 6-10 part, Semen Allii Tuberosi 6-10 part.
The method for preparing the pharmaceutical preparation of above-mentioned treatment epileptics may further comprise the steps:
A. after by described proportioning each raw material being sent into the pulverizer pulverizing, mixing is mixed thoroughly, obtains former medicated powder;
B. in former medicated powder, add its weight 2-3 water doubly, soak after 24 hours the former medicine that obtains swelling;
C. the former medicine that will swell is sent in the steamer, feeds steam then, steam 3-5 hour after, taking-up is dried, and obtains the former medicine of ripening;
D. the active dry yeast powder is added in the former medicine of ripening by weight 1: 1000 ratio, put into the fermentation fermentation in pits after mixing thoroughly, after 15 days the medicine piece that ferments is taken out, send into drying machine drying, the oven dry back is pulverized and just become pharmaceutical preparation of the present invention.
In the present invention, Semen Ziziphi Spinosae has nourishing the liver, and mind calming is calmed the nerves, and the effect of arresting sweating has calmness, convulsion, manic, the syngignoscism of inhibition.Modern medicine study shows that Semen Ziziphi Spinosae and phenobarbital class medicine have approximate effect, but without any side effects.
Fructus Trichosanthis core has the effect of removing heat-phlegm, lung moistening the chest stuffiness relieving, can control phlegm-heat cough and typhoid expectorant accumulation of heat at chest, and can remove the excessive thirst symptom of calentura.
Semen Platycladi contains significant quantities of fat oil and a small amount of volatile oil, energy tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Be used for restlessness of asrhenia type and insomnia, severe palpitation, diseases such as dryness of the intestine constipation.Modern medicine study proves: Semen Platycladi has the improvement effect to passive time wall study of the destructive mice of preceding basal ganglia, and the acquired disturbance that damage is caused also has the tendency of improvement.
Semen pini koraiensis contains the necessary fatty acid of abundant vitamin A and E and human body, oleic acid linoleic acid plus linolenic acid, also has in other plant unexistent Pinolenic acid etc., therefore has the effect of face nursing and life prolonging, allaying tiredness.Modern medicine study shows, contains more P elements in the Semen pini koraiensis, thereby also of great advantage to brain and nervous system.
Fructus Cannabis can be moisturized the laxation relieving constipation, is used for blood deficiency and depleted fluid, symptoms such as dryness of the intestine constipation.
The semen juglandis benefiting qi and nourishing blood, moistening the lung and resolving the phlegm, the beneficial gate of vitality, sharp three warmers, warming the lung intestine moistening.
Semen Sesami has detoxifcation, relieving constipation, and effects such as QI invigorating are applicable to diseases such as constipation, deficient five internal organs.
Semen Glycines is a Semen sojae atricolor, contains compositions such as daidzein, genistein, soyasapogenol, trace element manganese in its hydrolyzate.Have investigation to show: among about 1/3 the child epileptic, its serum Mn is lower than normal children, so abundant manganese element has certain benefit to the treatment of child's epileptics in the Semen sojae atricolor.In addition, there is a certain amount of phosphatase material in normal brain cell, but famine this kind of enzyme in epileptic's the brain, and be rich in nitro phosphatase material behind the fermented soybean, so can mitigate the disease.
The content of unsaturated fatty acids such as the oleic acid of Semen arachidis hypogaeae and linoleic acid is higher, phospholipid, plant sterol content are also more, long-term edible, can the nutrition brain, help the synthetic of neurotransmitter, thereby remedy the epileptic, particularly the shortage of some neurotransmitteies of essential epilepsy patient reduces induced seizures.
The fat of Semen Helianthi all is unsaturated fatty acid, and energy trophocyte is impelled the regeneration of cell.Semen Allii Tuberosi can temperature can loose, and is used for promoting the circulation of blood and stagnates, broken stagnation of QI.
The traditional Chinese medical science is thought: though the epilepsy diseased region is at brain, with the not normal substantial connection that exists of human five internal organs's six internal organs function.The inventor has further explored epilepsy invasion mechanism by long-term practice; Epileptic patient is in life, when the upset that is subjected to wind, fire, expectorant, the stasis of blood, extraneous factor such as frightened, and during the influencing of self emotion, its enterogastric peristalsis will change, when the ANOMALOUS VARIATIONS of enterokinesia runs up to a certain degree, then can cause the malfunction of a plurality of internal organs of human body; And the malfunction of each internal organs, then cause knot in the sputum easily, painstaking effort are unsuccessful and disturb the chain reaction that QI-blood circulation such as key clearly has some setbacks on the stasis of blood, stagnation of phlegm blood stasis, cause brain neuroblastoma unit excited (sun) and suppress (the moon) disequilibrium, so brain neuroblastoma unit's paradoxical discharge and cause epilepsy.And during epilepsy, promptly excited when neuron when men outnumbered women than flower, show as the outbreak of part epilepsy and complete tetanus clonic epilepsy; And when the neuron excess of YIN leading to deficiency of YANG, promptly suppress than flower, show as inattentive epilepsy outbreak.
According to epilepsy invasion mechanism, the inventor is by studying for a long period of time, testing, screened above-mentionedly have warming the lung intestine moistening, mind tranquilizing and the heart calming, eliminate the phlegm have one's ideas straightened out, the drug component of effects such as clearing heart fire, blood circulation promoting and blood stasis dispelling, compensate qi and blood, broken stagnation of QI, by reasonable compatibility, synergism is nursed one's health the enterogastric peristalsis of human body with the combined effect of medication, nutrition, promote QI-blood circulation, allow each function of human body recover normal, and then allow the activity of brain neuroblastoma unit be in poised state, the outbreak of final Taking Control of Epilepsy.In addition, the present invention adopts the preparation method of medicine fermentation, can allow the effective ingredient of each component decomposes out in the medicine, better to be absorbed by human body.
Therapeutic effect of the present invention is remarkable, after the epileptic takes, can be good at the Taking Control of Epilepsy outbreak, and has the vital base and primordial QI consolidating effect, can well promote the rehabilitation of patient's body.Because the present invention is the pure plant type preparation, epileptic's life-time service is without any side effects simultaneously.
The specific embodiment
Below by specific embodiment, technical scheme of the present invention is described in further detail.
Embodiment 1: (every part is 100g with 12 parts, after down together) Semen Ziziphi Spinosae, 12 parts of Fructus Trichosanthis core, 8 Semen pini koraiensis, 8 parts of Semen Platycladi, 12 parts of Fructus Cannabis, 8 semen juglandiss, 6 portions of Semen Sesamis, 8 portions of Semen Glyciness, 8 portions of Semen arachidis hypogaeaes, 6 parts of Semen Helianthi, 6 parts of Semen Allii Tuberosi are sent into the pulverizer pulverizing, mixing is mixed thoroughly, obtains former medicated powder; Add the water of 2 times of its weight then in the former medicated powder, soak after 24 hours, the former medicine that will swell is sent in the steamer, feeds steam then, steam 5 hours after, taking-up is dried, and obtains the former medicine of ripening; The ratio of active dry yeast powder (being easy on the market buy) by weight 1: 1000 added in the former medicine of ripening, put into the fermentation fermentation in pits after mixing thoroughly, after 15 days the medicine piece that ferments is taken out, send into drying machine drying, oven dry back pulverizing just becoming pharmaceutical preparation of the present invention.
Embodiment 2: after 8 parts of Semen Ziziphi Spinosaes, 8 parts of Fructus Trichosanthis core, 10 parts of Semen pini koraiensis, 12 parts of Semen Platycladi, 10 parts of Fructus Cannabis, 12 parts of semen juglandiss, 10 portions of Semen Sesamis, 10 portions of Semen Glyciness, 10 portions of Semen arachidis hypogaeaes, 10 parts of Semen Helianthi, 10 parts of Semen Allii Tuberosi are sent into the pulverizer pulverizing, mixing is mixed thoroughly, obtains former medicated powder; Add the water of 3 times of its weight then in the former medicated powder, soak after 24 hours, the former medicine that will swell is sent in the steamer, feeds steam then, steam 4 hours after, taking-up is dried, and obtains the former medicine of ripening; The active dry yeast powder is added in the former medicine of ripening by weight 1: 1000 ratio, put into the fermentation fermentation in pits after mixing thoroughly, after 15 days the medicine piece that ferments is taken out, send into drying machine drying, the oven dry back is pulverized and just become pharmaceutical preparation of the present invention.
Embodiment 3: after 10 parts of Semen Ziziphi Spinosaes, 10 parts of Fructus Trichosanthis core, 12 parts of Semen pini koraiensis, 10 parts of Semen Platycladi, 8 parts of Fructus Cannabis, 10 parts of semen juglandiss, 8 portions of Semen Sesamis, 6 portions of Semen Glyciness, 6 portions of Semen arachidis hypogaeaes, 8 parts of Semen Helianthi, 8 parts of Semen Allii Tuberosi are sent into the pulverizer pulverizing, mixing is mixed thoroughly, obtains former medicated powder; Add the water of 2.5 times of its weight then in the former medicated powder, soak after 24 hours, the former medicine that will swell is sent in the steamer, feeds steam then, steam 3 hours after, taking-up is dried, and obtains the former medicine of ripening; The active dry yeast powder is added in the former medicine of ripening by weight 1: 1000 ratio, put into the fermentation fermentation in pits after mixing thoroughly, after 15 days the medicine piece that ferments is taken out, send into drying machine drying, the oven dry back is pulverized and just become pharmaceutical preparation of the present invention.
Embodiment 4: after 8 parts of Semen Ziziphi Spinosaes, 10 parts of Fructus Trichosanthis core, 8 parts of Semen pini koraiensis, 10 parts of Semen Platycladi, 12 parts of Fructus Cannabis, 8 parts of semen juglandiss, 8 portions of Semen Sesamis, 10 portions of Semen Glyciness, 8 portions of Semen arachidis hypogaeaes, 10 parts of Semen Helianthi, 8 parts of Semen Allii Tuberosi are sent into the pulverizer pulverizing, mixing is mixed thoroughly, obtains former medicated powder; Add the water of 2 times of its weight then in the former medicated powder, soak after 24 hours, the former medicine that will swell is sent in the steamer, feeds steam then, steam 5 hours after, taking-up is dried, and obtains the former medicine of ripening; The active dry yeast powder is added in the former medicine of ripening by weight 1: 1000 ratio, put into the fermentation fermentation in pits after mixing thoroughly, after 15 days the medicine piece that ferments is taken out, send into drying machine drying, the oven dry back is pulverized and just become pharmaceutical preparation of the present invention.
Embodiment 5: after 9 parts of Semen Ziziphi Spinosaes, 11 parts of Fructus Trichosanthis core, 10 parts of Semen pini koraiensis, 12 parts of Semen Platycladi, 8 parts of Fructus Cannabis, 12 parts of semen juglandiss, 7 portions of Semen Sesamis, 6 portions of Semen Glyciness, 7 portions of Semen arachidis hypogaeaes, 10 parts of Semen Helianthi, 7 parts of Semen Allii Tuberosi are sent into the pulverizer pulverizing, mixing is mixed thoroughly, obtains former medicated powder; Add the water of 3 times of its weight then in the former medicated powder, soak after 24 hours, the former medicine that will swell is sent in the steamer, feeds steam then, steam 3 hours after, taking-up is dried, and obtains the former medicine of ripening; The active dry yeast powder is added in the former medicine of ripening by weight 1: 1000 ratio, put into the fermentation fermentation in pits after mixing thoroughly, after 15 days the medicine piece that ferments is taken out, send into drying machine drying, the oven dry back is pulverized and just become pharmaceutical preparation of the present invention.
The inventor adopts the present invention to treat 279 routine all kinds of epileptics in nearly 3 years diagnosis and treatment process.Wherein male's 181 examples, women's 98 examples, the age is at 3-70 between year, 32.7 years old mean age.Among the above-mentioned patient, major part was once taken the epilepsy Western medicine, as phenobarbital, sodium valproate etc., but all was to take stopgap measures to effect a permanent cure, and effect is not satisfactory.
During treatment, take by the embodiment of the invention 3 compounding pharmaceutical preparations to the patient, 3 times on the one, each 50g, serve on 3-4 the course of treatment at 20 days courses of treatment.Its clinical efficacy sees Table 1.
Table 1: clinical efficacy statistical table
Above-mentioned statistical data shows: the present invention reaches 98.2% to each epileptoid total effective rate.
Be the several clinical cases in inventor's diagnosis and treatment process below:
Be the several clinical cases in inventor's diagnosis and treatment process below:
(1) just yellow, the man 16 years old now, lives innovation road, town, Lianjiang dan mountain range, Guangdong Province No. 316.Morbidity in 4 years old, numb limbs and tense tendons during morbidity, dizziness, loss of consciousness, facial hemiparalysis, spit out white foams, extremity harden.Outbreak back tired unable, be hard and dry, Subsidiary Hospital of Guangdong Medical College is diagnosed as: epilepsy, electroencephalogram is unusual, it is invalid once to seek medical advice in many ways.Disease is not sent out once in the treatment of going to a doctor to here so far with from April, 2005, and yet recovery fully of the memory of going down in the former treatment, now in the middle school.
(2) Wang Haisi, the woman 6 years old now, lives five villages, Xing Ma township, Nanjiang County, Sichuan Province, one society.Twitching because of hyperpyrexia in 1 year old half causes the epileptics outbreak, because child is little, one day sometimes big petit mal tens times, has no curative effect though seek medical advice by every means.To 2007, when treasure is asked in here, little girl 5 years old half, show as dementia, not sociable, walk have no sense of propriety, the very important person that has a meal feeds, defecation is disorderly drawn.Through pharmaceutical preparation treatment with me, doing well,improving after ten days, the little girl recovers normally substantially after January, can speak, can see walked, oneself is had a meal, own defecation, the cleverness that just becomes after February is exquisite.
(3) model outstanding person, the man 31 years old now, lives divert water via a canal from the yellow River into Qingdao No. 617, building, management board the Yellow River of Shandong Province's Accessories during Binzhou.Once the anterior tumor of the right brain of excision, after fall in a swoon soon, twitch, spit out white foams, lose consciousness fully, be diagnosed as secondary epilepsy, seek medical advice integrative therapy, have no curative effect, and Western medicine had allergies, in February, 2004, the pharmaceutical preparation treatment through me recovered normal, did not have morbidity so far.
(4) Yang Zhikun, the man 35 years old now, lives bold and unconstrained basic 132-401 under the Qingyuan City city, Guangdong Province.Had a high fever, and be diagnosed as " encephalitis " and cause epilepsy in 12 years old.During each outbreak, tic of the limbs, fall down, turn over, spit out white foams, think to know on two unclear, show effect about 5 minutes at every turn, month send out 7--8 time, fatigue and weak, urinary incontinence after the outbreak, perspiration is many.Therapeutic Method is used up, but has no curative effect.When asking precious here in February, 2004, the hallucination auditory hallucination is arranged during patient, bigoted, to like to get angry and quarrel, memory obviously goes down, and through surplus with this epilepsy medicament preparation for treating moon, its mental symptom is eliminated fully, never falls ill so far, devotes oneself to work again already.
Claims (2)
1. pharmaceutical preparation for the treatment of epileptics, it is characterized in that mainly making: Semen Ziziphi Spinosae 8-12 part, Fructus Trichosanthis core 8-12 part, Semen pini koraiensis 8-12 part by following components in part by weight in this pharmaceutical preparation, Semen Platycladi 8-12 part, Fructus Cannabis 8-12 part, semen juglandis 8-12 part, Semen Sesami 6-10 part, Semen Glycines 6-10 part, Semen arachidis hypogaeae 6-10 part, Semen Helianthi 6-10 part, Semen Allii Tuberosi 6-10 part.
2. prepare the method for the pharmaceutical preparation of the described treatment epileptics of claim 1, it is characterized in that this method may further comprise the steps:
A. after by described proportioning each raw material being sent into the pulverizer pulverizing, mixing is mixed thoroughly, obtains former medicated powder;
B. in former medicated powder, add its weight 2-3 water doubly, soak after 24 hours the former medicine that obtains swelling;
C. the former medicine that will swell is sent in the steamer, feeds steam then, steam 3-5 hour after, taking-up is dried, and obtains the former medicine of ripening;
D. the active dry yeast powder is added in the former medicine of ripening by weight 1: 1000 ratio, put into the fermentation fermentation in pits after mixing thoroughly, after 15 days the medicine piece that ferments is taken out, send into drying machine drying, the oven dry back is pulverized and just become pharmaceutical preparation of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101974941A CN101401854B (en) | 2008-10-31 | 2008-10-31 | Medicament formulation for treating epilepsy and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101974941A CN101401854B (en) | 2008-10-31 | 2008-10-31 | Medicament formulation for treating epilepsy and preparation thereof |
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| CN101401854A true CN101401854A (en) | 2009-04-08 |
| CN101401854B CN101401854B (en) | 2012-07-18 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103478549A (en) * | 2013-08-29 | 2014-01-01 | 山东卫康生物医药科技有限公司 | Whole-grain full-nutrition formula food for epileptic consumption |
| CN103860834A (en) * | 2014-04-11 | 2014-06-18 | 郑家园 | Sea cucumber ingredient containing traditional Chinese medicine preparation for treating epilepsy |
| CN103877344A (en) * | 2014-04-11 | 2014-06-25 | 郑家园 | Sea cucumber containing traditional Chinese medicinal preparation for treating epilepsy |
| CN104257772A (en) * | 2014-09-23 | 2015-01-07 | 湖南华瑞动物药业有限公司 | Preparation method of Chinese patent medicine for animals and application of Chinese patent medicine in medicines of strengthening body resistance and eliminating evil as well as clearing heat and toxic materials |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103798A (en) * | 1994-06-25 | 1995-06-21 | 车李会 | Capsule for curing epilepsy |
| CN1051237C (en) * | 1994-06-30 | 2000-04-12 | 许新升 | Meicinal prepn. "Kexianling" for curing epilepsy |
| CN1748774A (en) * | 2005-10-20 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | Brain tonifying preparation and new preparing method |
| CN101161280B (en) * | 2006-10-12 | 2011-03-23 | 吴家平 | Medicine for curing epilepsy |
| CN101129941A (en) * | 2007-08-20 | 2008-02-27 | 陈江 | Oral liquid of gold ginseng for treating epilepsy |
-
2008
- 2008-10-31 CN CN2008101974941A patent/CN101401854B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103478549A (en) * | 2013-08-29 | 2014-01-01 | 山东卫康生物医药科技有限公司 | Whole-grain full-nutrition formula food for epileptic consumption |
| CN103478549B (en) * | 2013-08-29 | 2014-09-03 | 山东卫康生物医药科技有限公司 | Whole-grain full-nutrition formula food for epileptic consumption |
| CN103860834A (en) * | 2014-04-11 | 2014-06-18 | 郑家园 | Sea cucumber ingredient containing traditional Chinese medicine preparation for treating epilepsy |
| CN103877344A (en) * | 2014-04-11 | 2014-06-25 | 郑家园 | Sea cucumber containing traditional Chinese medicinal preparation for treating epilepsy |
| CN103860834B (en) * | 2014-04-11 | 2016-05-11 | 朱长怀 | A kind of Chinese medicine preparation for the treatment of epilepsy |
| CN104257772A (en) * | 2014-09-23 | 2015-01-07 | 湖南华瑞动物药业有限公司 | Preparation method of Chinese patent medicine for animals and application of Chinese patent medicine in medicines of strengthening body resistance and eliminating evil as well as clearing heat and toxic materials |
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| CN101401854B (en) | 2012-07-18 |
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