CN101391061B - Novel antibiotic substitute - Google Patents
Novel antibiotic substitute Download PDFInfo
- Publication number
- CN101391061B CN101391061B CN2008102264314A CN200810226431A CN101391061B CN 101391061 B CN101391061 B CN 101391061B CN 2008102264314 A CN2008102264314 A CN 2008102264314A CN 200810226431 A CN200810226431 A CN 200810226431A CN 101391061 B CN101391061 B CN 101391061B
- Authority
- CN
- China
- Prior art keywords
- sodium
- antibiotic
- rice bran
- carbonate
- antibiotic substitute
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses an ingredient for an antibiotic substitute and a preparation process, and mainly relates to the agricultural biotechnology and feed additive field. The formula ingredient includes montmorillonite gel, sodium metasilicate, carbonate, reducing sugar, sodium selenite and rice bran. By adopting the solid aerobic biological fermentation technology, the preparation process of the invention has simple process and fine stability. The antibiotic substitute can improve animal healthy level and the resistance ability and anti-stress capability for pathogeny microbial beings through enhancing animal nonspecific and specific immunity ability, so as to improve animals food consumption, daily gain and food conversion ratio, ensure animals producing performance under the no antibiotic condition, and avoid the generation of antibiotic remain and drug-resistant strain in the animals production. The antibiotic substitute can play an important role in improving the stockbreeding sustainable development and enhancing human healthy level.
Description
Technical field
The present invention is a kind of antibiotic substitute, is mainly used in the immunologic function that improves animal, relates generally to agricultural biotechnologies and feed additive field.
Technical background
Raising along with aquaculture intensification degree and breeding performonce fo animals, the stress level of animal constantly increases, resistivity to various pathogenic microorganisms descends, often be in clinical or subclinical pathological state, thereby have influence on animal and produce the performance of potential and the economic benefit of aquaculture, for prevent disease and increasing economic efficiency, general way is to add antibiotic and chemical synthesis class medicine in feed.But antibiotic use causes antibody-resistant bacterium and even can resist the generation of multiple antibiotic superbug, and the quality of animal product also constantly reduces because of the medicament residue problem.Human health in the generation of antibody-resistant bacterium and the medicament residue serious threat in the animal product, and the production of green safety animal product has become the worldwide animal foodstuff theme in producing, reduces or forbids that antibiotic use is imperative.
Because most livestock and poultry species all is to cultivate under the condition that contains antibiotic feed of feeding, the antibiotic of stopping using merely can cause the efficiency of feed utilization of animal to descend, and M ﹠ M rises, and causes aquaculture cost to increase, and causes the tremendous economic loss.For all very high China and Asia of the density of population and livestock and poultry density, breeding environment is abominable, and is higher to antibiotic degree of dependence, and the loss meeting that the forbidding antibiotic causes is all bigger than any other area.
Feed safety is the basis of animal food safety, along with growth in the living standard, people more and more pay close attention to meat product safety and human body health, requirement to feed safety is more and more higher, and therefore exploitation and use " green " feed addictive will be the severe problems that China's feedstuff industry and safe animal product production are faced.The research and development antibiotic substitute becomes forbidding antibiotic prerequisite, is the key that keeps animal husbandry production sustainable development.
In recent years, the researcher finds organic acid, enzyme preparation, functional oligosaccharide, probiotics, Chinese herbal medicine and extract etc. both at home and abroad, all can play the effect of antibiotic substitute under given conditions, but owing to there are various problems, the application of above product is very limited, have shortcomings such as strong, the easy caking of hygroscopicity as acidulant and functional oligosaccharide, enzyme preparation and probiotics have poor heat stability, easily the weakness of inactivation; Chinese herb feed additive exists cost height, resource-constrained, the not shortcoming such as science, quality instability of filling a prescription.Be badly in need of the development of new antibiotic substitute.
Summary of the invention
Use the various negative effects bring and the shortcoming of existing antibiotic substitute in order to overcome antibiotic, we adopt solid aerobic bioreactor fermentation technique to invent a kind of antibiotic substitute, the present invention can be by improving the non-specific and specific immunity level of animal, improve the animal health level and to the resistivity and the anti-stress ability of various pathogenic microorganisms, thereby improve feed intake, daily gain, the feed conversion rate of animal; Guarantee the production performance of animal under forbidding antibiotic condition, avoid the generation of antibiotic residue and antibody-resistant bacterium in the animal product.The present invention is for promoting sustainable development of animal husbandry, and it is significant to improve human living standard and health status.
Contain montmorillonite gelling, sodium metasilicate, carbonate, reduced sugar, sodium selenite, rice bran in the constituent of the present invention.
Main component content is in the constituent: montmorillonite gelling 0-0.1g/kg, sodium metasilicate 3-20g/kg, carbonate 0.8-10g/kg, reduced sugar 2-8g/kg, sodium selenite 0-0.3g/kg, rice bran 962-995g/kg.
Montmorillonite gelling described in the constituent is purified by the natural montmorillonite of high-quality, contains SiO
257.5-60%, Al
2O
319.5-21.5%, MgO 3.5-4.1%, Na
2O 3.5-4.1%.
Sodium metasilicate described in the constituent is one or both in metasilicate pentahydrate sodium and the non-hydrate sodium metasilicate.
Carbonate described in the constituent is one or both in sodium carbonate and the potash.
Reduced sugar described in the constituent can be more than one in glucose, lactose, galactolipin, maltose, the sucrose.
Rice bran described in the constituent is fresh full-cream rice bran, and crude fat content is more than 16%, and moisture is below 13%.
The specific embodiment
For further understanding the present invention, describe feature of the present invention with example below, but example does not limit the right protection scope.It only is the part in the right protection scope.
Example 1
Constituent: per 1000 parts of content
0.1 part of montmorillonite gelling
12 parts of metasilicate pentahydrate sodiums
1.5 parts in sodium carbonate
2.2 parts in potash
0.2 part of sodium selenite
5 parts in brown sugar
979 parts in rice bran
Production technology: (1) will account for montmorillonite gelling, metasilicate pentahydrate sodium, sodium carbonate, potash and the whole part sodium selenite and the brown sugar of content 6.7% separately in the formula components, dissolve in successively while stirring in 310 parts of water and make uniform liquid, and the liquid of making is sneaked into 979 parts of rice brans while stirring.(2) rice bran that mixes being placed on temperature is that 25 ℃, relative humidity are that 85% environment carries out the aerobic solid fermentation, and the time is 7-15 days, by overturning temperature is controlled at 30-60 ℃ around here, simultaneously supplemental oxygen.(3) successively remaining 93.3% montmorillonite gelling, metasilicate pentahydrate sodium, sodium carbonate, potash are dissolved in 82 parts of water while stirring, and the liquid after this dissolving evenly sneaked in the rice bran that had fermented, treat its fully absorb the back dry, pulverize, pack is finished product.
Egg cock feeding experiment
630 of 1 age in days egg cocks are divided equally three groups, each three repetition.The common chick material of control group fed, antibiotic group are added the antibiotics growth accelerator on common chick material basis, test group is expecting to add example 1 product by 4 ‰ on the basis common chick, and 1 age in days begins, and finish 8 ages in week.In carrying out artificial heat stress test the 7th week.The speed of weight increment of determination test chicken, feed intake, the price of deed.The result shows that the production performance of test group is higher than control group under the normal temperature, does not have significant difference with the antibiotic group, but under the heat stress condition, test group production performance level is higher than control group and antibiotic group.Illustrate that product of the present invention can substitute antibiotic and improve production performance and the anti-heat stress ability of egg cock.Result of the test sees Table 1, table 2.
Table 1 normal temperature 0-6 egg cock production performance in age in week
| Group | Daily gain (g) | Daily ingestion amount (g) | Feed consumption/weightening finish |
| Control group | 8.54±0.39 | 20.75±0.62 | 2.43±0.08 |
| Test group | 8.89±0.13 | 21.35±0.59 | 2.40±0.03 |
| The antibiotic group | 8.99±0.23 | 21.28±0.45 | 2.37±0.05 |
Table 2 heat stress condition is descended 7-8 egg cock production performance in age in week
| Group | Daily gain (g) | Daily ingestion amount (g) | Feed consumption/weightening finish |
| Control group | 13.84±1.39 | 39.91±4.82 | 2.89±0.29 |
| Test group | 14.85±1.46 | 41.56±3.75 | 2.81±0.41 |
| The antibiotic group | 13.91±1.21 | 39.87±3.22 | 2.88±0.31 |
Immunity promotes performance test
Add the product of example 1 to egg cock daily ration by 4 ‰ and carry out feeding experiment, 270 of test chicken meters are divided equally three groups, are respectively blank group, antibiotic group and test group, every group of 90 chickens.1 age in days begins, and finish 8 ages in week.All test chickens are malicious seedling eye droppings a little less than 3 ages in days immunity ewcastle disease II system, 1 plumage part/only; In 10 age in days neck hypodermic injection H9 subtype avian influenza inactivated vaccines, 0.3ml/ only; 20 ages in days immunity Newcastle disease attenuated seedling (Lasota system), drinking-water, 2 plumage parts/only.Select 10 execution at random for every group in 28 ages in days, 35 ages in days, measure the immune organ index.Artificial heating is brought up to 30 ℃ with room temperature during the 43-47 age in days, causes artificial heat stress, before and after heat stress respectively every group select 10 blood samplings, separation of serum is measured ewcastle disease ND, AI antibody horizontal.The result shows that the thymus index of test group and index and spleen index and antibody horizontal all are higher than control group and antibiotic group.Illustrate that product of the present invention has not only improved non-specific immune function and the anti-heat stress ability of egg cock, and can improve artificial immunity blood serum special antibody horizontal.Result of the test sees Table 3, table 4.
Table 3 egg cock different days thymus index and index and spleen index
Serum antibody level before and after table 4 heat stress
Example 2
Constituent: per 1000 parts of content
13 parts of metasilicate pentahydrate sodiums
1.3 parts in sodium carbonate
2.4 parts in potash
0.3 part of sodium selenite
4 parts in brown sugar
979 parts in rice bran
Production technology: (1) is with 0.7 part of metasilicate pentahydrate sodium, 0.1 part of sodium carbonate, 0.15 part of potash, 0.2 part of sodium selenite, 4 portions of brown sugar, dissolve in successively while stirring in 310 parts of water and make uniform liquid, and the liquid of making is sneaked into 979 parts of rice brans while stirring.(2) rice bran that mixes being placed on temperature is that 25 ℃, relative humidity are that 85% environment carries out the aerobic solid fermentation, and the time is 7-15 days, around here by overturning control temperature with increase oxygen.(3) successively remaining 12.3 parts of metasilicate pentahydrate sodium, 1.2 parts of sodium carbonate, 2.25 parts of potash are dissolved in 82 parts of water while stirring, and the liquid after this dissolving evenly sneaked in the rice bran that had fermented, treat its fully absorb the back dry, pulverize, pack is finished product.
The growing and fattening pigs feeding experiment
20 of 60 age in days tri-crossbreedings, average weight 20kg divides two groups, the commercially available fattening pannage of control group fed, test group is additionally added 4 ‰ examples, 2 products, 30 days experimental periods.Term day weightening finish, material anharmonic ratio.Result's (seeing Table 5) shows that product of the present invention can improve the production performance of growing and fattening pigs, reduces diarrhea rate.
Table 5 growing and fattening pigs production performance
| Daily gain (gram) | Daily ingestion amount (gram) | The material anharmonic ratio | Diarrhoea (number * fate) | |
| Control group | 546.84±32.64 | 1768.5±50.99 | 3.24±0.16 | 16 |
| Test group | 595.67±40.67 | 1842.0±68.93 | 3.09±0.14 | 3 |
Claims (6)
1. an antibiotic substitute is characterized in that being made by montmorillonite gelling, sodium metasilicate, carbonate, reduced sugar, sodium selenite, rice bran; Each composition consumption is montmorillonite gelling 0-0.1g/kg, sodium metasilicate 3-20g/kg, carbonate 0.8-10g/kg, reduced sugar 2-8g/kg, sodium selenite 0-0.3g/kg, rice bran 962-995g/kg; Production technology is: will account for water-soluble the making of montmorillonite gelling, 6.7% sodium metasilicate, 6.7% carbonate and the Restore All sugar of total content 6.7% and sodium selenite earlier and sneak into rice bran behind the solution and carry out the fermentation of solid aerobic bioreactor; Secondly will account for the montmorillonite gelling, 93.3% sodium metasilicate of total amount 93.3% and 93.3% carbonate makes the aqueous solution and evenly sneaks into the rice bran that ferments; Carry out drying, pulverizing, pack at last.
2. one kind as right 1 described antibiotic substitute, it is characterized in that: used montmorillonite gelling is purified by the natural montmorillonite of high-quality, contains SiO
257.5-60%, Al
2O
319.5-21.5%, MgO 3.5-4.1%, Na
2O 3.5-4.1%.
3. one kind as right 1 described antibiotic substitute, and it is characterized in that: used sodium metasilicate is one or both in metasilicate pentahydrate sodium and the non-hydrate sodium metasilicate.
4. one kind as right 1 described antibiotic substitute, and it is characterized in that: used carbonate is one or both in sodium carbonate and the potash.
5. one kind as right 1 described antibiotic substitute, and it is characterized in that: used reduced sugar is more than one in glucose, lactose, galactolipin, maltose, the sucrose.
6. one kind as right 1 described antibiotic substitute, and it is characterized in that: used rice bran is fresh full-cream rice bran, and crude fat content is more than 16%, and moisture is below 13%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102264314A CN101391061B (en) | 2008-11-11 | 2008-11-11 | Novel antibiotic substitute |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102264314A CN101391061B (en) | 2008-11-11 | 2008-11-11 | Novel antibiotic substitute |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101391061A CN101391061A (en) | 2009-03-25 |
| CN101391061B true CN101391061B (en) | 2011-04-27 |
Family
ID=40491702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008102264314A Active CN101391061B (en) | 2008-11-11 | 2008-11-11 | Novel antibiotic substitute |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101391061B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103329944A (en) * | 2013-06-20 | 2013-10-02 | 张芝仁 | Agricultural antibiotic agent |
| CN107372636A (en) * | 2017-07-18 | 2017-11-24 | 池州市小池生态农业发展有限公司 | One kind synthesis agricultural antibiotic agent body |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836544A (en) * | 2006-04-21 | 2006-09-27 | 浙江大学 | Meat quality-improving agent for fowl and livestock |
| CN101040872A (en) * | 2007-04-29 | 2007-09-26 | 济南康众医药科技开发有限公司 | Smectite dry mixture and the preparing method |
-
2008
- 2008-11-11 CN CN2008102264314A patent/CN101391061B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836544A (en) * | 2006-04-21 | 2006-09-27 | 浙江大学 | Meat quality-improving agent for fowl and livestock |
| CN101040872A (en) * | 2007-04-29 | 2007-09-26 | 济南康众医药科技开发有限公司 | Smectite dry mixture and the preparing method |
Non-Patent Citations (2)
| Title |
|---|
| 李海宁等.蒙脱石的药用价值及存在问题.《湖北农业科学》.2003,(第2期),93-94. * |
| 韩秀山等.无抗生素饲料控制仔猪腹泻的几点措施.《湖南饲料》.2007,(第7期),20-21. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101391061A (en) | 2009-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103355545B (en) | Fermentation type botanical weaned piglet feed additive | |
| CN106360040B (en) | Composite Chinese herbal medicine probiotic feed additive for enhancing growth performance and immune function of broiler chickens | |
| CN103168965B (en) | Anti-stress synbiotics traditional Chinese medicine composition applicable to chicken and preparation method of anti-stress synbiotics traditional Chinese medicine composition | |
| CN106260504B (en) | Method for producing microbial fermentation wet feed by using beer yeast paste | |
| CN103330059B (en) | Health care composition for livestock as well as preparation method and application thereof | |
| CN101690743A (en) | Traditional Chinese medicine biological agent for improving immunity of livestock and preparation method thereof | |
| CN103598485A (en) | Preparation method and application of Chinese herbal immunopotentiator used for snakeheads | |
| CN103385350B (en) | Soft particle milk replacer containing high fructose corn syrup and preparation thereof | |
| CN111011643A (en) | Bacterium enzyme fermented traditional Chinese medicine for improving growth performance of broiler chicken and preparation method thereof | |
| CN103598483A (en) | Microorganism feed supplement for lowering stress of piglets and preparation method thereof | |
| CN104585507B (en) | A kind of feeding prebiotic type acidulant of green and preparation method thereof | |
| CN110946907A (en) | Traditional Chinese medicine composition for young poultry, liquid fermented traditional Chinese medicine preparation and preparation method thereof | |
| CN112136965B (en) | Immunity-enhancing and growth-promoting fermented Chinese herbal medicine feed additive and preparation method thereof | |
| CN105815550B (en) | One plant can reduce scatol in extensive broiler breeding, the lactobacillus plantarum of indoles release and its application | |
| CN102726605A (en) | Micro-ecological synbiotic Chinese herbal medicine feed addictive, preparation method and application thereof | |
| CN102925374B (en) | Saccharomyces cerevisiae new strains, and the feed addictive containing it, batch | |
| CN101715893B (en) | Pure natural piglet immunological enhancement feed additive and application thereof | |
| CN101391061B (en) | Novel antibiotic substitute | |
| CN101874812A (en) | Composite bacteria preparation and application thereof in weight increment of immature livestock and control of diarrhea | |
| CN106538825A (en) | Poultry nonreactive feedstuff | |
| CN103404709B (en) | Feed additive produced from waste liquid and dregs in pharmaceutical factory and preparation method of feed additive | |
| CN107873956A (en) | A kind of preparation method and application of leaf of Moringa feed additive | |
| CN103205377B (en) | Quality bacillus coagulans for breeding broilers and application of excellent bacillus coagulans | |
| CN110178968A (en) | A kind of functional feedstuff additive and preparation method thereof | |
| CN103190544B (en) | Duckling anti-stress synbiotics and traditional Chinese medicine composition and preparation method of composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: SONG JINCAI ZHANG SHUGUANG Effective date: 20120903 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20120903 Address after: 100081 information building, 12, Zhongguancun South Road, Haidian District, Beijing 301 Patentee after: China Grains and Oils Group Corporation Agricultural Science and Technology Co., Ltd. Address before: 100081 information building, 12, Zhongguancun South Road, Haidian District, Beijing 301 Patentee before: China Grains and Oils Group Corporation Agricultural Science and Technology Co., Ltd. Patentee before: Song Jincai Patentee before: Zhang Shuguang |
|
| C56 | Change in the name or address of the patentee |
Owner name: COFCO FEED TECHNOLOGY (BEIJING) CO., LTD. Free format text: FORMER NAME: ZHONGGU GROUP AGRICULTURE + ANIMAL HUSBANDRY TECHNOLOGY CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 100081 information building, 12, Zhongguancun South Road, Haidian District, Beijing 301 Patentee after: COFCO (Beijing) feed Technology Co., Ltd. Address before: 100081 information building, 12, Zhongguancun South Road, Haidian District, Beijing 301 Patentee before: China Grains and Oils Group Corporation Agricultural Science and Technology Co., Ltd. |