CN101390818A - Pimple removing scream - Google Patents
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- CN101390818A CN101390818A CNA2007100357841A CN200710035784A CN101390818A CN 101390818 A CN101390818 A CN 101390818A CN A2007100357841 A CNA2007100357841 A CN A2007100357841A CN 200710035784 A CN200710035784 A CN 200710035784A CN 101390818 A CN101390818 A CN 101390818A
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Abstract
The invention relates to an anti-acne facial cream which comprises Chinese traditional medicine composition and substrate formulation; the Chinese traditional medicine composition at least contains five of the following ingredients, smilax glabra, coix seed, kudzu root, astragalus, chrysanthemum, dwarf lilyturf tuber, lucid ganoderma and giant knotweed rhizome; the Chinese traditional medicine composition contains at least five of the following ingredients by weight: 5-20% of smilax glabra, 5-40% of coix seed, 3-20% of kudzu root, 5-30% of astragalus, 3-35% of chrysanthemum, 3-40% of dwarf lilyturf tuber, 3-20% of lucid ganoderma and 3-20% of giant knotweed rhizome. The anti-acne facial cream has the advantages of preventing and treating the acne, quick effect, obvious effect, no pockmark, uneasy recurrence, being used for cosmetic whitening, having the functions of skin mildness, moisture retention and sunscreen, reducing the oil secretion and promoting the cell metabolism.
Description
[technical field]
The present invention relates to a kind of Chinese medicine preparation, especially relate to the pure Chinese prescription of a kind of employing through be processed into be used for prophylactic treatment acne and skin whitening and have skin care, preserve moisture explosion-proof, reduce fat secretion, promote multi-functional Pimple removing screams such as cellular metabolism.
[background technology]
Acne claims comedo again, be by pilosebaceous a kind of skin folliculus imbalance, because the cutaneous gland of androgen sensitivity is synthetic and secretion, make these folliculus keratinization epitheliums unusual, caused the inflammation that propionibacterium acnes (Propionibacterium acnes) (also being skin ulcer kitchen propionibacterium) brings out in the bubble.
Treatment for this inflammation at present has following difficulty: the one acne is the common inflammation of a kind of lasting pilosity and recurrence, wherein allegro city life mode, irrational in addition diet, not have enough sleep, work and rest undesired all be to cause this disease to continue a chief reason multiple and recurrence.This reason has limited endo-medicine reaches treatment order ground with endocrine regulation therapeutic modality greatly just; The curative effect of its two hormones and antibiotics is affirmed, but the side effect of abuse is very big, unsuitable conventional application; The all spendable product of its three full face is also few; The product of the various exterior-applied formulations of its four pure Chinese prescription through being processed into is also few, and the effect of prevention and treatment comedo is uncertain, and it is unhappy to take effect.
For the yellow, skin whitening is to use one of purpose of cosmetics, and it is beautiful that skin is considered in vain.Aspect skin whitening, in the cosmetics made of (grass) medicine good effect is arranged.During (grass) medicine is made in research and development cosmetics, to form activity be index can suppress the mould activity of tyrosine and to suppress melanin.Allly can suppress the mould activity of tyrosine and suppress melanin to form active extract and just be considered to have whitening effect.
Having aspect the selection medical material at present: its a pair of skin has certain stimulation, as the Radix Angelicae Dahuricae, Radix Aconiti Lateralis Preparata etc.; Its two Ores class medicine is brought heavy metal easily into, is unfavorable for life-time service as Cinnabaris (main component is HgS).Have at present (grass) medicine is made in pox whitening effect pure cosmetics in the patent application that similar products like and State Intellectual Property Office are announced in the market at home seldom.
[summary of the invention]
In order to overcome the above-mentioned shortcoming of prior art, the invention provides a kind of Pimple removing scream that adopts pure Chinese medicine to make, can be used for prevention and treatment comedo, its effect is obvious, and effect is fast, more the no pockmark in back, be difficult for recurrence and can be used for skin whitening, and have skin care concurrently, it is explosion-proof to preserve moisture, and reduces fat secretion and promotes cellular metabolism.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Pimple removing scream, comprise Chinese prescription and matrix formulations, at least comprise 5 kinds in Rhizoma Smilacis Glabrae, Semen Coicis, Radix Puerariae, the Radix Astragali, Flos Chrysanthemi, Radix Ophiopogonis, Ganoderma and the Rhizoma Polygoni Cuspidati component in the described Chinese prescription, the weight percent content of each component is: Rhizoma Smilacis Glabrae 5～20%, Semen Coicis 5～40%, Radix Puerariae 3～20%, the Radix Astragali 5～30%, Flos Chrysanthemi 3～35%, Radix Ophiopogonis 3～40%, Ganoderma 3～20%, Rhizoma Polygoni Cuspidati 3～20%.
Component Semen Coicis in the described Chinese prescription, the Radix Astragali, Flos Chrysanthemi and in Radix Ophiopogonis optional three kinds when forming new Chinese prescription, the weight percent content of the above-mentioned three kinds of new Chinese prescriptions of ingredients constitute in this new Chinese prescription is at least 15%.
When forming the component Semen Coicis in the described Chinese prescription, Radix Ophiopogonis new Chinese prescription, the percentage by weight of above-mentioned two kinds of new Chinese prescriptions of ingredients constitute is 10～80%.
Component Semen Coicis in the described Chinese prescription, Flos Chrysanthemi and appointing in Radix Ophiopogonis, got two kinds when forming new Chinese prescription, and the percentage by weight of above-mentioned two kinds of new Chinese prescriptions of ingredients constitute is 13～65%.
In the described Chinese medicinal components Radix Ophiopogonis with Radix Asparagi replace, the Radix Astragali with Radix Codonopsis or Radix Ginseng replace, Flos Chrysanthemi replaces with Flos Chrysanthemi Indici.
The parts by weight of each component are in the described Chinese medicinal components: 20 parts of Rhizoma Smilacis Glabraes, 40 parts of Semen Coiciss, 10 parts of Radix Puerariaes, 15 parts of the Radixs Astragali, 20 parts of Flos Chrysanthemis, 40 parts of Radix Ophiopogonis, 10 parts of Ganodermas, 10 parts of Rhizoma Polygoni Cuspidati.
The weight percent content of each component is in the described matrix formulations: liquid Paraffin 11～15%, vaseline 4～6%, Cera Flava 1～4%, octadecanol 2～4%, stearic acid 4～8%, tween 80 are 3～4%, silk dish-80 is 1～2%, gelatin 0.1～1%, sodium lauryl sulphate 0.1～0.5%, glycerol 3～5%, nipalgin are 0.1～0.4%, all the other are purified water.
The parts by weight of each component are in the described matrix formulations: 14 parts of liquid Paraffin, 5 parts in vaseline, 3 parts in Cera Flava, 3 parts of octadecanol, 5 parts of stearic acids, tween 80 are that 3.6 part, threads dish-80 is that 1.4 parts, gelatin are that 0.5 part, 0.3 part of sodium lauryl sulphate, glycerol are 4 parts, 0.2 part of nipalgin, 60.2 parts of purified water.
Good effect of the present invention is: Chinese prescription has the effect of heat-clearing and toxic substances removing, damp eliminating heat, the dark complexion of dispelling, granulation promoting; The extracting solution of Flos Chrysanthemi, Radix Ophiopogonis has inhibitory action to various pathogens; The The pharmacological results that the extracting solution of prescription of the present invention is done is: propionibacterium acnes is had inhibitory action, and the mould suppression ratio of tyrosine is more than 70%.The present invention is used for prevention and treatment comedo and skin whitening, and its effect is obvious, and effect is fast, and more the no pockmark in back is not easy recurrence; And have skin care concurrently, preserve moisture explosion-proof, reduce fat secretion, promote the function of cellular metabolism, be a kind of cosmetics that are used for prophylactic treatment acne and skin whitening.
[description of drawings]
The invention will be further described below in conjunction with accompanying drawing and example.
Fig. 1 reads a secondary data for getting extracting solution sample of the present invention and reference substance solution at 20 minutes per minutes of (25 ℃～30 ℃) constant temperature continuous detecting, is vertical coordinate minute being the curve chart of abscissa with trap A.
[specific embodiment]
A kind of Pimple removing scream, the parts by weight of each component are in the Chinese medicinal components of choosing: 20 parts of Rhizoma Smilacis Glabraes, 40 parts of Semen Coiciss, Radix Puerariae 10,15 parts of the Radixs Astragali, 20 parts of Flos Chrysanthemis, 40 parts of Radix Ophiopogonis, 10 parts of Ganodermas, 10 parts of Rhizoma Polygoni Cuspidati, wherein can select for use Radix Ophiopogonis Radix Asparagi to replace, the Radix Astragali can select that Radix Codonopsis or Radix Ginseng replace, Flos Chrysanthemi can select for use Flos Chrysanthemi Indici to replace for use.
The parts by weight of each component of matrix formulations are: 14 parts of liquid Paraffin, 5 parts in vaseline, 3 parts in Cera Flava, 3 parts of octadecanol, 5 parts of stearic acids, 3.6 parts of tween 80s ,-801.4 parts on silk dish, 0.5 part in gelatin, 0.3 part of sodium lauryl sulphate, 4 parts of glycerol, 0.2 part of nipalgin, 60.2 parts of purified water.Preparation method of the present invention is: by above-mentioned parts by weight, Rhizoma Smilacis Glabrae, Semen Coicis, Radix Puerariae, the Radix Astragali, Flos Chrysanthemi, Radix Ophiopogonis, the Ganoderma of getting in the described Chinese prescription are pulverized, the degree that its powder of Rhizoma Polygoni Cuspidati is pulverized was No. two sieves, and the sieve aperture internal diameter of No. two sieves is (meansigma methods) 850um ± 29um.As solvent, prepare extracting solution with ethanol-water system.The water-bath ethanol evaporation, the aqueous solution of preparation extracting solution is water system, and is standby during for emulsifying.
Get 4 parts of glycerol, add 6 parts of water as glycerol diluent (standby when supplying emulsifying); Get 0.2 part of nipalgin, liquid Paraffin 14 minutes, 5 parts in vaseline, 3 parts in Cera Flava, 3 parts of octadecanol, 5 parts of stearic acids, getting tween 80 is 3.6 parts, silk dish-80 is 1.4 parts, makes oil phase, and is standby during for emulsifying.
Get above-mentioned water system, oil phase and mix at 80 ± 5 ℃ and make its emulsifying, add the glycerol diluent successively, mix and make its emulsifying, put coldly, get product after the ageing.
Using method: one day one to twice.Earlier with clear water the face wash clean after, spread upon on the face equably with the present invention and to get final product.Result of use the best before sleeping.
Clinical effectiveness: anti-acne
All effective to all types of comedos, its effective percentage 90%.
1, no pus head type comedo once takes effect.Diameter can disappear in one day less than 0.4cm's; Diameter can disappear in 2～3 days more than the 0.6cm fully.
2, for the type that the pus head is arranged, the pus head is at comedo bean point, and naked eyes look it is that the HUANGBAI(sic) color dot is embedded in the epidermis, extrude to being mixed with blood and pus not thickly through external force, diameter used one day below 0.6cm, the pus point can disappear substantially, disappears fully in 3～5 days.
3, for the pus head is arranged itself, and it is not only big but also dark, caused comedo, its further development of may command, can disappear in 3～7 days substantially in red and swollen position, discharge pus head by extruding this moment, but preventing from scar or under the situation of not pushing discharge pus head, after 15 days, the pus head can come off when washing one's face automatically.
4, do not have tangible redness for epidermis, or Qiu Qizhuan is arranged, touching has cyst, and this type of blackhead is arranged after the maturation, and the difference by weight can have obvious effects in 8～24 hours, dispeled fully in 3～10 days.
5, have blackhead for skin, but also do not caused inflamed symptom.The present invention can reduce such blackhead greatly and cause inflamed probability, is using the quantity that formed blackhead in 10 days later on obviously to reduce, later on can not long substantially or the youthful and the elderly.
6, can prevent growth by the caused all types of comedo of different reasons.
7, the time that takes effect for the situation of the skin keratinization hardening on comedo surface has different prolongations; The anti-acne effect is answered the people and is different in addition.There are indivedual user after using 5～7 days, just can see effect,, have the face of many user satisfactory for result, but take effect slower to the skin of cervical region at chin using the effect at position that difference is also arranged with the difference of a user.8, the responding time for treatment pox seal (being the bolarious impression that stays after comedo is healed) is to be generally 1～15 day according to the degree of comedo to skin lesion.
Clinical effectiveness: whiten
The speed of whitening is fast, and effect is strong, and 3 days can take effect, visible obvious effects in 5～7 days.Effective equally for the crowd that skin is innately black, most user facial skin after using a period of time of the present invention is obviously white than cervical region, but not sun-proof, effective percentage can reach 90%.
Other effects:
Explosion-proof and preserve moisture, effect is strong.With the plain beauty cream of the Radix Ginseng tire of certain factory is contrast (be that winter, place are Shaoguan season), used 2 times in one day, use a period of time (each uses once sooner or later) continuously, in this case, use the plain beauty cream of Radix Ginseng tire of this factory after, facial skin has and continues several seconds pain, increase noon and use once, promptly one day 3 times, use the plain beauty cream of Radix Ginseng tire of this factory after, skin does not just have this pain.The present invention's each use does not sooner or later once just have this pain.
Pore refining, effects such as skin care are normally following in the daily schedule, and effect is obvious.Shorten 1～2 hour the length of one's sleep, can keep the state of original skin, the situation of often staying up late can keep original skin condition substantially.
The detection of effective ingredient in the extracting solution:
Chlorogenic acid:
The extracting solution (with before shaking up) of getting this product ethanol-water system is after being heated to dissolving in the water-bath, add 95% ethanol, 80～100ml, put coldly, filter, get filtrate, in water-bath, steam, add dilute hydrochloric acid 1ml and ethyl acetate 50ml, ultrasonic 10 minutes to 5～10ml, get upper solution (being the ethyl acetate layer), evaporate to dryness in water-bath, the residual dissolve with methanol of using mixedly 1ml is as need testing solution.It is an amount of that other gets the chlorogenic acid reference substance, adds ethanol and make the solution that every 1ml contains 0.5mg, in contrast product solution.According to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2005) experiment, draw need testing solution 1～2ul; Reference substance solution 1ul puts respectively on the polyamide thin film, is developing solvent with the upper solution of toluene-ethyl acetate-formic acid-glacial acetic acid-water (1:15:1:1:2), launches, and takes out, and dries, and puts under the ultra-violet lamp (365nm) and inspects.In the test sample chromatograph, on the corresponding position of reference substance chromatograph, show the speckle of same color.
The pharmacological evaluation of extracting solution:
Detection to the propionibacterium acnes minimal inhibitory concentration: propionibacterium acnes is had inhibitory action.
Inhibiting mensuration to tryrosinase: get this product extracting solution 1ml, be settled in the 25ml volumetric flask with pH6.8 (1/15mol/L) phosphate buffer, standby after filtering as sample solution.
Detection method:
Get the phosphate buffer heating for dissolving of tyrosine 30mg, put cold back as the 0.0.3% tyrosine solution with pH6.8.
Get Mushroom Tyrosinase 5mg (10000IU) and add water 50ml, filter the aqueous solution (being 200IU) of Mushroom Tyrosinase
Use the pH6.8 phosphate buffer in zero clearing under the 475nm wavelength on ultraviolet-visible spectrophotometer earlier.
Get pH6.8 phosphate buffer 2ml, add sample solution 2ml, add 0.03% tyrosine reactant liquor 2ml again.Mix, shake up.Be blank.
Extracting sample solution 2ml adds 0.03% tyrosine reactant liquor 2ml respectively and mixes with the aqueous solution 2ml (200IU) of Mushroom Tyrosinase, shakes up.Be sample.
Get pH6.8 phosphate buffer 2ml, add 0.03% tyrosine reactant liquor 2ml respectively and mix, shake up with the aqueous solution 2ml (200IU) of Mushroom Tyrosinase.Be reference substance.
Get above-mentioned sample and reference substance solution and hatched 30 minutes, place immediately on the ultraviolet-visible spectrophotometer, measure absorption value at 475nm wavelength place at (25 ℃～30 ℃) constant temperature;
Suppression ratio=(A reference substance-(A sample-A blank))/(A reference substance) * 100%.Wherein A sample-A blank is the influence of deduction extracting solution to experiment.
The result: suppression ratio is more than 70%.
Mechanism to the inhibition of tryrosinase:
Influence to response speed:
Detection method:
Referring to Fig. 1, get extracting solution sample of the present invention and reference substance solution and read a secondary data at 20 minutes per minutes of (25 ℃～30 ℃) constant temperature continuous detecting, be vertical coordinate minute to be the curve chart of abscissa with trap A, series 1 is contrast solution among the figure; Series 2 is sample solution.Shown by Fig. 1 result: the response speed behind the application of sample obviously descends.The have inhibitory action of this extracting solution to enzyme activity is described;
Detection to the micrococcus luteus inhibition:
Detection method:
The preparation of test sample storing solution
It is fixed molten standby as the test sample storing solution to 100ml with purified water to get extracting solution 1～2ml.
The preparation of micrococcus luteus (Micrococcus Luteus) bacteria suspension:
Get the Nutrient agar slant culture of micrococcus luteus, be inoculated on the Nutrient agar inclined-plane, cultivated 20～22 hours, lawn is washed with 0.9% sterilize sodium chloride solution or medium ii I or nutrient broth at 35～37 ℃, standby.
Contain the preparation of flat pair of dish of bacterium layer:
The directly about 90mm of cut-off, the flat pair of dish of high 16～17mm injects sterilising medium (the antibiotic calibrating medium ii that heat is melted respectively; Ph6.5～6.6) 20ml makes and evenly spread out cloth at the bottom of the dish, places to make on the horizontal stand and solidifies, as the stratum.Other gets the sterilising medium that above-mentioned heat is melted, and puts to be chilled to 48～50 ℃ and to add the micrococcus luteus bacteria suspensions an amount of (get clearly, inhibition zone is to spend.) shake up, in each two dish, add 5ml respectively, make at bottom and evenly spread out cloth, as the bacterium layer.After the cooling, (it is standby that external diameter 7.8 ± 0.1mm) uses the potlery tile dome to cover for internal diameter 6.0mm ± 0.1mm, high 10.0mm ± 0.1mm for two rustless steel tubules of distance placement of an about 40mm in each two dish on the placement horizontal stand.
Checking method:
Get the phosphate buffer (pH6.0 ± 0.05) that test sample storing solution 2ml uses and be settled to 100ml.Get this solution 0.3ml and be added dropwise in the rustless steel tubule in the flat pair of dish that contains the bacterium layer, in 35～37 ℃ calorstat, cultivated 16～18 hours.
(phosphate buffer (pH6.0 ± 0.05): getting dipotassium hydrogen phosphate 2g and potassium dihydrogen phosphate 8g, add water and make into 1000ml, considered, is that 6.0 ± 0.05. is in case of necessity 115 ℃ of sterilizations 30 minutes at pH meter adjusted pH .)
Result: can get inhibition zone clearly.
(annotate and be equipped with: what inhibition zone became when phosphate buffer pH6.5 was above is fuzzy.If the inhibition zone that the reason of bacterium liquid causes is fuzzy, with the Nutrient agar inclined-plane training several generations of cultivating, can get inhibition zone clearly to micrococcus luteus more.)
Case: Xu Lei, the man, 23 years old, whole face all was a comedo, but the few of pus arranged, and some position comedos grow in flakes, and cause skin breakage, liquid body exudate, a small amount of blood streak is arranged, and through the treatment of Shaoguan institute of traditional Chinese medicine, intravenous injection cefazolin and oral several doses of Chinese medicines all lose curative effect.After January, use this product, comedo less after 3 days disappears substantially, grow in flakes, and skin breakage place, all wound healings after 5 days have not had comedo after 12 days substantially, and facial skin is obviously white than cervical region.
Claims (8)
1, a kind of Pimple removing scream, comprise Chinese prescription and matrix formulations, it is characterized in that: comprise 5 kinds in Rhizoma Smilacis Glabrae, Semen Coicis, Radix Puerariae, the Radix Astragali, Flos Chrysanthemi, Radix Ophiopogonis, Ganoderma and the Rhizoma Polygoni Cuspidati component in the described Chinese prescription at least, the weight percent content of each component is: Rhizoma Smilacis Glabrae 5～20%, Semen Coicis 5～40%, Radix Puerariae 3～20%, the Radix Astragali 5～30%, Flos Chrysanthemi 3～35%, Radix Ophiopogonis 3～40%, Ganoderma 3～20%, Rhizoma Polygoni Cuspidati 3～20%.
2, a kind of Pimple removing scream as claimed in claim 1, it is characterized in that: the component Semen Coicis in the described Chinese prescription, the Radix Astragali, Flos Chrysanthemi and in Radix Ophiopogonis optional three kinds when forming new Chinese prescription, the weight percent content of the above-mentioned three kinds of new Chinese prescriptions of ingredients constitute in this new Chinese prescription is at least 15%.
3, a kind of Pimple removing scream as claimed in claim 1 or 2 is characterized in that: when forming the component Semen Coicis in the described Chinese prescription, Radix Ophiopogonis new Chinese prescription, the percentage by weight of above-mentioned two kinds of new Chinese prescriptions of ingredients constitute is 10～80%.
4, a kind of Pimple removing scream as claimed in claim 1 or 2, it is characterized in that: the component Semen Coicis in the described Chinese prescription, Flos Chrysanthemi and appointing in Radix Ophiopogonis, got two kinds when forming new Chinese prescription, and the percentage by weight of above-mentioned two kinds of new Chinese prescriptions of ingredients constitute is 13～65%.
5, a kind of Pimple removing scream as claimed in claim 1 or 2 is characterized in that: in the described Chinese medicinal components Radix Ophiopogonis with Radix Asparagi replace, the Radix Astragali with Radix Codonopsis or Radix Ginseng replace, Flos Chrysanthemi replaces with Flos Chrysanthemi Indici.
6, a kind of Pimple removing scream as claimed in claim 1, it is characterized in that: the parts by weight of each component are in the described Chinese medicinal components: 20 parts of Rhizoma Smilacis Glabraes, 40 parts of Semen Coiciss, 10 parts of Radix Puerariaes, 15 parts of the Radixs Astragali, 20 parts of Flos Chrysanthemis, 40 parts of Radix Ophiopogonis, 10 parts of Ganodermas, 10 parts of Rhizoma Polygoni Cuspidati.
7, a kind of Pimple removing scream as claimed in claim 1, it is characterized in that: the weight percent content of each component is in the described matrix formulations: liquid Paraffin 11～15%, vaseline 4～6%, Cera Flava 1～4%, octadecanol 2～4%, stearic acid 4～8%, tween 80 are 3～4%, silk dish-80 is 1～2%, gelatin 0.1～1%, sodium lauryl sulphate 0.1～0.5%, glycerol 3～5%, nipalgin are 0.1～0.4%, all the other are purified water.
8, as claim 1 or 7 described a kind of Pimple removing screams, it is characterized in that: the parts by weight of each component are in the described matrix formulations: 14 parts of liquid Paraffin, 5 parts in vaseline, 3 parts in Cera Flava, 3 parts of octadecanol, 5 parts of stearic acids, tween 80 are that 3.6 part, threads dish-80 is that 1.4 parts, gelatin are that 0.5 part, 0.3 part of sodium lauryl sulphate, glycerol are 4 parts, 0.2 part of nipalgin, 60.2 parts of purified water.
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| CN2007100357841A CN101390818B (en) | 2007-09-21 | 2007-09-21 | Pimple removing scream |
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| CN2007100357841A CN101390818B (en) | 2007-09-21 | 2007-09-21 | Pimple removing scream |
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| CN101390818B CN101390818B (en) | 2010-12-01 |
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| CN103893070A (en) * | 2009-08-14 | 2014-07-02 | 株式会社爱茉莉太平洋 | Composition containing natural extract |
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| CN102415979A (en) * | 2011-12-23 | 2012-04-18 | 庄晓曦 | Whitening and freckle-removing cream and preparation method thereof |
| CN102415979B (en) * | 2011-12-23 | 2013-01-16 | 庄晓曦 | Whitening and freckle-removing cream |
| CN104586667A (en) * | 2013-10-31 | 2015-05-06 | 广州市纳爱生物科技有限公司 | Plant essence acne-removal cream |
| CN105496874A (en) * | 2015-12-24 | 2016-04-20 | 吴金玉 | Whitening and moisturizing cream containing plant extracts and preparation method of whitening and moisturizing mask |
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| CN105997655A (en) * | 2016-06-21 | 2016-10-12 | 安徽诚亚生物科技有限公司 | Whitening cream and preparation method thereof |
| CN106237176A (en) * | 2016-09-13 | 2016-12-21 | 佛山市顺德区宝铜金属科技有限公司 | A kind of anti-acne disappears the compositions of skin ulcer |
| CN107898688A (en) * | 2017-12-05 | 2018-04-13 | 北京军秀咨询有限公司 | A kind of multiple-effect acne-removing beauty frost containing vegetable active extract and preparation method thereof |
| CN108852941A (en) * | 2018-08-28 | 2018-11-23 | 珠海欧维斯科技有限公司 | A kind of skin care composite plant extract liquid and its preparation method and application |
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