CN101385842B - Medicine for treating chronic hepatitis b and preparation method thereof - Google Patents
Medicine for treating chronic hepatitis b and preparation method thereof Download PDFInfo
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- CN101385842B CN101385842B CN2008101577608A CN200810157760A CN101385842B CN 101385842 B CN101385842 B CN 101385842B CN 2008101577608 A CN2008101577608 A CN 2008101577608A CN 200810157760 A CN200810157760 A CN 200810157760A CN 101385842 B CN101385842 B CN 101385842B
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Abstract
The invention relates to a medicine for treating chronic hepatitis B and a preparation method thereof. The medicine is constituted by the following materials according to the percentage: 20-25.4 percent of radix codonopsitis, 11-16.4 percent of radix astragali, 9-14.2 percent of atractylodes ovata, 9-14.2 percent of salvia miltiorrhiza, 6-12 percent of radix curcumae, 6-12 percent of herba artemisiae capillaries, 6-12 percent of angelica, 6-12 percent of radix bupleuri, 1-3 percent of bear bile, 1-5 percent of liquorice. The materials are prepared into pills after the steps of cleaning, drying, pulverizing, screening and honey refining, therefore, the invention has the advantages of simple manufacturing, convenient medicine taking, obviously curative effect, low price and no toxicity and side effect and is particularly suitable for the treatment of the chronic hepatitis B.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of hepatopathy and preparation method thereof, medicine of particularly a kind of remaining jaundice for the treatment of chronic hepatitis, hepatitis interstitialis chronica and preparation method thereof.
Background technology:
Chronic hepatitis B, hepatitis hepatitis interstitialis chronica belongs to the Chinese medicine jaundice, hypochondriac pain, the tympanites category, China belongs to HBV and infects high popular district, chronic HBV infection person 1.2 hundred million, account for national population>10%, account for infectious disease dead first because of hepatitis B associated death 300,000 examples every year, at present, in treatment, still the sure medicine of inefficacy, though, glycyrrhizic acid two amine injection 150mg adopted now mostly, reduced glutathion 1.2g~1.8g adds in the liquid, intravenous drip once a day, general hepatoprotective such as vitamin adds the yellow particulate medicine of mattress Cape jasmine again, and still, therapeutic effect is relatively poor, treatment time is long, and price is higher.
Summary of the invention:
Purpose of the present invention be exactly to provide a kind of make simple, taking convenience, evident in efficacy, have no side effect, the medicine of cheap treatment chronic viral hepatitis B and preparation method thereof.
The object of the present invention is achieved like this: a kind of medicine for the treatment of chronic viral hepatitis B, it is characterized in that it by following raw material by weight forming: Radix Codonopsis 20%-25.4%, Radix Astragali 11%-16.4%, Rhizoma Atractylodis Macrocephalae 9%-14.2%, Radix Salviae Miltiorrhizae 9%-14.2%, Radix Curcumae 6%-12%, Herba Artemisiae Scopariae 6%-12%, Radix Angelicae Sinensis 6%-12%, Radix Bupleuri 6%-12%, Fel Ursi 1%-3%, Radix Glycyrrhizae 1%-5%.
Preparation method of the present invention is made up of following steps:
1), cleans: by the described prescription of claim 1 raw material is mixed, clean up with clear water;
2), oven dry is ground into powder and sieved: cleaned raw material is put into drying baker dry, grind into powder then, reuse 100 purpose sieves sieve raw material, the medicamental pulverata that granule is little filters out, for future use, grinding into powder again that granule is big sieved, and finally reaches the purpose of sieving;
3), refining Mel: Mel is put into pot with the low baking temperature refining, coagulate as the maltosemalt sugar shape, the not order of stirring is burnt, and the addition of Mel is 1 times of whole dried medicine weight;
4), make pill: refined honey is mixed with above-mentioned medicamental pulverata rubs, place half an hour by evenly, rub once more by, the honeyed pill of making 6 grams get final product.
This invention also can be made into medicamental pulverata electuary, the watered pill, capsule.
The jaundice of chronic hepatitis B, hepatitis hepatitis interstitialis chronica is based on hepatocellular jaundice, Chinese medicine is thought, jaundice be experience that epidemic disease caused by damp-heat pathogen poison, liver and gall mechanism of qi are obstructed, catharsis is not normal, bile excessive due to, clinical minute YANG jaundice and YIN jaundice, wherein YANG jaundice divide again damp and hot double table, thermogravimetric in wet, weight in wet base in heat, pattern of syndrome such as hot and suffocating, the malicious jaundice of epidemic disease of gallbladder internal organs, YIN jaundice is divided cold-damp syndrome and two kinds of pattern of syndrome of syndrome of spleen-deficiency again.The remaining jaundice of chronic hepatitis B because of its course of disease with the passing of time, belong to syndrome of spleen-deficiency more, doublely see that damp stops up resistance, qi depression to blood stasis, treatment is when stressing to set upright, the damp eliminating heresy of holding concurrently, vital energy regualting and blood circulation-promoting recover to help healthy energy.
Radix Codonopsis: invigorating the spleen and replenishing QI is a monarch drug, contain Saponin, micro-alkaloid, saccharide, vitamin B1, B2, multiple needed by human inorganic elements and aminoacid etc., can enhancing body resistance, tame rabbit erythrocyte and hemoglobin are increased, and effects such as antiulcer, promoting leucocytes are arranged;
The Radix Astragali: replenishing QI to invigorate the spleen, contain glycoside, polysaccharide, aminoacid and trace element etc., effect such as have the enhancing human body immunity function, protect the liver;
The Rhizoma Atractylodis Macrocephalae: replenishing QI to invigorate the spleen, contain atractylone, atractylodes lactone and mannose, fructose etc., can the liver protecting, prevent the effect that liver glycogen reduces due to the carbon tetrachloride;
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling is adjuvant drug altogether; Contain TANSHINONES, danshensu, vitamin E etc., can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration, and anti-fibrosis effect is arranged;
Radix Curcumae: dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the function of the gallbladder to alleviate jaundice, contain volatile oil, curcumin, starch, fatty wet goods, can promote bile secretion and drainage, and hepar damnification is had protective effect;
Herba Artemisiae Scopariae eliminating damp-heat promoting the function of the gallbladder to alleviate jaundice, its main component are nopinene, Herba Artemisiae Scopariae hydrocarbon, capillon and folic acid, and remarkable choleretic effect is arranged, and increasing bile secretion simultaneously, also increase solids in the bile, cholic acid and bilirubinic excretion;
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, contain ligustilide, angelicone, ferulic acid, succinic acid etc., the hepatic injury that mouse carbon tetrachloride is caused has protective effect, and can promote liver cell regeneration and the effect that recovers some function of liver;
Radix Bupleuri: dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the function of the gallbladder to alleviate jaundice, contain hitodesterol, oxeye alcohol and saikoside, anti-liver injury, function of gallbladder promoting, transaminase lowering effect are preferably arranged;
Fel Ursi liver heat removing function of gallbladder promoting, contain ursodesoxycholic acid, chenodeoxycholic acid, deoxycholic acid, cholic acid and cholesterol, bilirubin, inorganic salt etc., choleretic effect is arranged, can promote bile secretion, common bile duct, sphincter there are relexation, and dissolving cholelithiasis, detoxifcation, effect such as antibacterial are arranged;
Radix Glycyrrhizae: QI invigorating invigorating middle warmer, coordinating the actions of various ingredients in a prescription are messenger drug, contain glycyrrhizin, some poisonous substance are had the Detoxication of similar glucuronic acid.
More than all medicine compatibilities, the effect of replenishing QI to invigorate the spleen, damp eliminating jaundice eliminating, regulating the flow of QI to dissipate blood stasis, and make simple, taking convenience, have no side effect, cheap.
The present invention has good effect by clinical trial: compare with the yellow particulate medicine of mattress Cape jasmine and see attached list 1,2,3;
Treatment back and preceding relatively * p<0.05 of treatment, * * p<0.01
Treatment back and preceding relatively * p<0.05 of treatment, * * p<0.01
Table 3 liang group total effects relatively
Treatment group and matched group compare P<0.05, two group total effective rate and cure rate relatively has significant difference p<0.01
From above form, this invention and matched group all can improve the liver function of chronic hepatitis B patient, and the treatment group obviously is better than matched group aspect horizontal reducing TBIL, DBIL, ALT, AST and improve ALB, and therapeutic effect is obvious.
The specific embodiment:
Embodiment 1: to make 6 kilograms of pills is example, gets Radix Codonopsis 630 grams, the Radix Astragali 480 grams, the Rhizoma Atractylodis Macrocephalae 285 grams, Radix Salviae Miltiorrhizae 285 grams, Radix Curcumae 210 grams, Herba Artemisiae Scopariae 330 grams, Radix Angelicae Sinensis 330 grams, Radix Bupleuri 330 grams, Fel Ursi 30 grams, Radix Glycyrrhizae 90 grams; At first above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker and dry, grind to form graininess then, reuse 100 purpose sieves sieve ground raw material, the medicine that granule is little filters out, for future use, grinding into powder again that granule is big sieved, and finally reaches the purpose of sieving; Then 3 kilograms of Mel are put into pot with the low baking temperature refining, coagulated as the maltosemalt sugar shape, the not order of stirring is burnt; At last refined honey is mixed with above-mentioned medicamental pulverata and rubs by evenly, place half an hour, rub once more by, the honeyed pill of making 6 grams get final product.
Embodiment 2: to make 6 kilograms of pills is example, gets Radix Codonopsis 672 grams, the Radix Astragali 402 grams, the Rhizoma Atractylodis Macrocephalae 336 grams, Radix Salviae Miltiorrhizae 336 grams, Radix Curcumae 270 grams, Herba Artemisiae Scopariae 336 grams, Radix Angelicae Sinensis 270 grams, Radix Bupleuri 270 grams, 45 kilograms of Fel Ursis, 63 kilograms in Radix Glycyrrhizae; Manufacture method is with embodiment 1.
Embodiment 3: to make 6 kilograms of pills is example, gets Radix Codonopsis 735 grams, the Radix Astragali 345 grams, the Rhizoma Atractylodis Macrocephalae 420 grams, Radix Salviae Miltiorrhizae 420 grams, Radix Curcumae 330 grams, Herba Artemisiae Scopariae 210 grams, Radix Angelicae Sinensis 210 grams, Radix Bupleuri 210 grams, 75 kilograms of Fel Ursis, 45 kilograms in Radix Glycyrrhizae; Manufacture method is with embodiment 1.
Embodiment 4, be example, get Radix Codonopsis 630 grams, the Radix Astragali 480 grams, the Rhizoma Atractylodis Macrocephalae 285 grams, Radix Salviae Miltiorrhizae 285 grams, Radix Curcumae 210 grams, Herba Artemisiae Scopariae 330 grams, Radix Angelicae Sinensis 330 grams, Radix Bupleuri 330 grams, Fel Ursi 30 grams, Radix Glycyrrhizae 90 grams to make 3 kilograms of medicamental pulverata electuaries; At first above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker and dry, grind to form graininess then, reuse 100 purpose sieves sieve ground raw material, the medicine that granule is little filters out, for future use, grinding into powder again that granule is big sieved, and finally reaches the purpose of sieving; Be that the unit pack gets final product with 6 grams at last.
Embodiment 5, be example, get Radix Codonopsis 672 grams, the Radix Astragali 402 grams, the Rhizoma Atractylodis Macrocephalae 336 grams, Radix Salviae Miltiorrhizae 336 grams, Radix Curcumae 270 grams, Herba Artemisiae Scopariae 336 grams, Radix Angelicae Sinensis 270 grams, Radix Bupleuri 270 grams, 45 kilograms of Fel Ursis, 63 kilograms in Radix Glycyrrhizae to make 3 kilograms of capsules; Manufacture method incapsulates with 0.5 gram at last as different from Example 4 and gets final product.
Claims (2)
1. medicine for the treatment of chronic viral hepatitis B, it is characterized in that it by following raw material by weight forming: Radix Codonopsis 20%-25.4%, Radix Astragali 11%-16.4%, Rhizoma Atractylodis Macrocephalae 9%-14.2%, Radix Salviae Miltiorrhizae 9%-14.2%, Radix Curcumae 6%-12%, Herba Artemisiae Scopariae 6%-12%, Radix Angelicae Sinensis 6%-12%, Radix Bupleuri 6%-12%, Fel Ursi 1%-3%, Radix Glycyrrhizae 1%-5%.
2. preparation method for the treatment of the medicine of chronic viral hepatitis B is characterized in that it is made up of following steps:
1), cleans: by the described prescription of claim 1 raw material is mixed, clean up with clear water;
2), oven dry is ground into powder and sieved: cleaned raw material is put into drying baker dry, grind into powder then, reuse 100 purpose sieves sieve raw material, the medicamental pulverata that granule is little filters out, for future use, grinding into powder again that granule is big sieved, and finally reaches the purpose of sieving;
3), refining Mel: Mel is put into pot with the low baking temperature refining, coagulate as the maltosemalt sugar shape, the not order of stirring is burnt, and the addition of Mel is 1 times of whole dried medicine weight;
4), make pill: refined honey is mixed with above-mentioned medicamental pulverata rubs, place half an hour by evenly, rub once more by, the honeyed pill of making 6 grams get final product.
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CN2008101577608A CN101385842B (en) | 2008-10-14 | 2008-10-14 | Medicine for treating chronic hepatitis b and preparation method thereof |
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CN2008101577608A CN101385842B (en) | 2008-10-14 | 2008-10-14 | Medicine for treating chronic hepatitis b and preparation method thereof |
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CN101385842A CN101385842A (en) | 2009-03-18 |
CN101385842B true CN101385842B (en) | 2010-12-29 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102166329B (en) * | 2010-03-17 | 2012-08-22 | 慕少英 | Medicine for treating leukopenia caused by chronic hepatitis B or interferon and preparation method thereof |
CN105343317A (en) * | 2015-11-11 | 2016-02-24 | 界首市华盛塑料机械有限公司 | Traditional Chinese medicine preparation for treating hepatitis B |
CN107233538A (en) * | 2017-08-03 | 2017-10-10 | 陕西中医肝肾病医院 | A kind of Chinese medicine and preparation method for treating hepatitis B |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1076626A (en) * | 1993-01-19 | 1993-09-29 | 李先文 | Medicine taken after being mixed with boiling water for liver trouble |
CN1173346A (en) * | 1996-06-26 | 1998-02-18 | 麻凯 | Chinese Patent drug able to regulate human body protein for treatment of liver disease |
CN1176123A (en) * | 1996-02-15 | 1998-03-18 | 邵阳县中医院 | Medicine for chronic hepatitis B and its preparation |
CN1233487A (en) * | 1998-04-24 | 1999-11-03 | 汪东平 | Medicine for treating hepatitis B |
CN1253830A (en) * | 1999-12-06 | 2000-05-24 | 黄培乐 | Chinese medicine prescription for curing hepatitis, cholangitis, pancreatitis and cirrhosis |
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2008
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1076626A (en) * | 1993-01-19 | 1993-09-29 | 李先文 | Medicine taken after being mixed with boiling water for liver trouble |
CN1176123A (en) * | 1996-02-15 | 1998-03-18 | 邵阳县中医院 | Medicine for chronic hepatitis B and its preparation |
CN1173346A (en) * | 1996-06-26 | 1998-02-18 | 麻凯 | Chinese Patent drug able to regulate human body protein for treatment of liver disease |
CN1233487A (en) * | 1998-04-24 | 1999-11-03 | 汪东平 | Medicine for treating hepatitis B |
CN1253830A (en) * | 1999-12-06 | 2000-05-24 | 黄培乐 | Chinese medicine prescription for curing hepatitis, cholangitis, pancreatitis and cirrhosis |
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