CN101379990A - Bactericide agent composition - Google Patents
Bactericide agent composition Download PDFInfo
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- CN101379990A CN101379990A CNA2008101329858A CN200810132985A CN101379990A CN 101379990 A CN101379990 A CN 101379990A CN A2008101329858 A CNA2008101329858 A CN A2008101329858A CN 200810132985 A CN200810132985 A CN 200810132985A CN 101379990 A CN101379990 A CN 101379990A
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- Prior art keywords
- difenoconazole
- probenazole
- prochloraz
- agent
- bactericide
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Abstract
The invention relates a sterilization composite, consisting of siple dosage A which is Difenoconazole, and ingredient B that is selected from one of the bactericides such as probenazole, Imazalil and Prochloraz. The formulation screening test proves that Difenoconazole, probenazole, and Difenoconazole, Imazalil, and Difenoconazole, Prochloraz are mixed together according to the weight ratio of 1:50-50:1, so that the goals of synergy, simultaneous treatment, drug fastness resistance, deferred drug fastness and dosage reduction of the Difenoconazole; therefore, the bactericides are combined to prepare various preparation products, thereby the sterilization composite is proposed.
Description
Technical field
The present invention relates to a kind of microbicide compositions and uses thereof, especially a kind of preparation of compositions and application with Difenoconazole and some systemic fungicide.
Background technology
(difenoconazole) is suitable for Difenoconazole, and be anti--3-chloro-4-(4-methyl-2-(1H-1,2,4-triazole-1 ylmethyl)-1,3-dioxolane-2-yl) phenyl-4-chlorphenyl ether
Be a kind of efficient, wide spectrum, new type bactericide, be mainly used in cereal crop, paddy rice, wheat, barley, cotton, soybean, fruit tree, various crop such as vegetables, control is because of imperfect fungus, sac fungi, fungus-caused multiple diseases such as basidiomycetes, if tree, the scab of vegetables, leaf spot, powdery mildew, rust, rice sheath blight disease, rice kernel smut, sheath is rotten sick, false smut, the short bunt of wheat, bunt, dust-brand looses, glume blight, root rot, banded sclerotial blight, full rot, early stage rust, powdery mildew, stinking smut of barley, loose kernel smut, stripe disease, net blotch, full rot, soybean, cotton seedling blight, root rot etc. all have preventive effect preferably.Difenoconazole not only has the bactericidal activity of wide spectrum, also a lot of pathogens is had lasting protection and therapeutic activity simultaneously.Make one of national agricultural [technology center project verification recommended variety.But the difenoconazole technical material domestic production is less, and price is higher, is difficult to prevent and treat in the farmland aspect the disease large tracts of land and generally applies.And if the long-term single use of a kind of medicine all produces resistance inevitably, bactericide is all the more so.Therefore, by composite channel, employing Difenoconazole and other bactericide are that the bactericidal composition of primary activity composition will be an effective way of resisting resistance, delaying drug resistance development.
The inventor's result of study has confirmed The above results, through a large amount of research and tests, filtered out Difenoconazole and probenazole, pressed down mould azoles, Prochloraz, Fenamidone can reach synergy after composite, doublely control, resist pesticide resistance, delay pesticide resistance, can reach purposes such as reducing the Difenoconazole consumption, and the combination of these bactericide made various formulation products, thereby the present invention is proposed.
Summary of the invention
The purpose of this invention is to provide a kind of bactericidal composition that to contain Difenoconazole and at least a systemic fungicide compound be active component,, improve bactericidal activity, enlarge fungicidal spectrum by composite, and reduce Difenoconazole consumption, reduce cost; With the combination of this active ingredient, be equipped with proper assistant, thinner etc. and make operable formulation product and uses thereof.The largest benefit of said composition is a coordinate plant growth in sterilization, when making plant ripe, reaches sterilization effects and also facilitates for the farmland mechanized operation.
The objective of the invention is to realize by following measures;
A kind of bactericidal composition comprises Difenoconazole (A) and at least a (B) bactericide as active component, and its two weight ratio is 1: 50-50: 1.
The B bactericide that is specially adapted to composition of the present invention is as follows:
1. the chemical name of probenazole (thiabendazole) is α-(4-thiazolyl)-1H-benzimidazole;
2. the chemical name that presses down mould azoles (imazalil) is 1-{2-(2,4 dichloro benzene base)-2-(2-propenyloxy group) ethyl }-the 1H-imidazoles;
3. the chemical name of Prochloraz (prochloraz) is N-propyl group-N-[α-(2,4, the 6-Trichlorophenoxy)-1H-imidazoles-1-formamide;
Above-mentioned active component all is bactericide well known in the art, can buy by various commercial channel.
Amount of application and both portfolio ratios and synergy degree separately when the consumption of the active component of using depends on independent use in the bactericidal composition of the present invention, simultaneously also relevant with the target bacterial classification.The weight ratio of Difenoconazole and systemic fungicide is 1:50-50:1 generally speaking, but is 1:20-20:1 than the ratio of greater inequality example.
Also can comprise carrier or thinner in the bactericidal composition of the present invention can be any addible component, and active component and carrier or thinner are mixed with each application target final products, as aqueous emulsion, suspending agent, wetting powder, water-dispersible grain agent formulation.
The present invention also comprises the method for preparing above-mentioned microbicide compositions, and it comprises active component is mixed mutually with at least a carrier or thinner.Carrier and thinner refer to filler, solvent, surfactant etc.Also can add other functional aids such as antifreeze, thickener, stabilizing agent, defoamer, disintegrant in case of necessity.
Described carrier, filler are white carbon, precipitated calcium carbonate, potter's clay, kaolin, diatomite, swollen ravine soil talcum powder, can use separately, also can two kinds or above mixing use.
Described stabilizing agent has BHT, triphenyl phosphite, epoxychloropropane, tributyl phosphate, triethanolamine, can use separately, also can mix use.
Described solvent, cosolvent are toluene, trimethylbenzene, chlorobenzene, solvent naphtha, alpha-methyl-naphthalene, turpentine oil, carrene, butanols, isoamyl alcohol, N.N-dimethyl formamide, dimethyl sulfoxide (DMSO), methyl cellosolve, ethyl cellosolve etc., and the use of the mixing between the different solvents is regular.
Described antifreeze is ethylene glycol, glycerine, propane diols, urea, glycerine etc.
Surfactant can be emulsifier, dispersant, wetting agent or bleeding agent.Surfactant can be nonionic with ionic, also can be two or more compound uses.Described emulsifier is alkylphenol-polyethenoxy (polyoxypropylene) ether, benzylphenol APEO, phenethyl phenol polyethenoxy ether, alkyl benzene sulphonate (sodium salt or calcium salt) or directly uses commercially available emulsifier monomer and composite product.The newborn 500# series of the example of collective such as farming, 600# series, 400# series and composite kind 2201,0203B, etc., these all are emulsifier productions well known in the art, market is on sale.
Described dispersant, wetting agent, bleeding agent are lignin-sulphonate's (sodium salt or calcium salt), Negel, bleeding agent OT, fatty acid amide-N methyl taurine sodium salt, sodium sulfate of polyethenoxy ether of fatty alcohol, draw back branch, JFC; can use separately, also can compoundly use.Above-mentioned surfactant all is materials well known in the art, can obtain by various commercial channel.
Described thickener has gum Arabic, CMC, xanthans, bentonite, silicic acid, can use separately, also can two or more mixing use.
Described defoamer has bubble enemy, silicone, C
8-10Fatty alcohol, C
10-20Saturated fat acids (as capric acid, stearic acid etc.) and amide-type.
Described binding agent is starch, dextrin, gypsum, polyvinyl alcohol, rosin, paraffin wax, CMC, sodium silicate.Can use separately, also can two or morely use with.
According to the preparation type difference, the weight percentage of active constituent is distinguished to some extent: in aqueous emulsion, the suspending agent, active constituent accounts for 5～50%, and preferable content is 5～40%; Active constituent accounts for 5～90% in wetting powder, the water dispersible granules, is preferably 10～80%.
The present composition can be used by commonsense method, as adds water spray and make cauline leaf and handle, but also root is executed, and can also dress seed and seed pelleting uses.Amount of application of the present invention changes with weather condition and crop state, can prevent and treat purpose by using suitable formulation to reach.
Embodiment
The present invention is elaborated with following specific embodiment, but the present invention only limits to these examples absolutely not.Percentage all is weight percentage in all prescriptions.The processing technology of the various preparations of the present composition and equipment are known.
The processing of suspending agent: press formula rate, with the pesticide activity component of capacity, surfactant, after thickener, film forming agent, carrier or filler and part water mix, through high speed shear, the sand milling of excuting a law, semi-finished product, add water after the analysis and mix to filter and get product.The suspended emulsion production technology according to the kind difference, can directly adopt this method, also the former medicine of solid can be made suspending agent, and the former medicine of liquid is made the technology of mixing behind the aqueous emulsion.Capital equipment is batching still, colloid mill or even matter mixer, sand mill.
Wetting powder processing: pesticide activity component, auxiliary agent, filler are mixed the mixed again wetting powder that gets after airslide disintegrating mill is pulverized in proportion.
The processing of water dispersible granules: pesticide activity component, auxiliary agent and filler are mixed in proportion,, add the water of 15-20% then, go on foot successfully through kneading, granulation, dry through comminution by gas stream.
Go out sieve behind the machine the water dispersible granules product.Capital equipment: mixer, airslide disintegrating mill, kneader, Squeezinggranulator.Drying equipment (can be drying room, fluid-bed drying), or fluidized granulating machine, screening machine.
Formulation Example 1 30% Difenoconazole probenazole water dispersible granules
Difenoconazole 3%
Probenazole 27%
Polyvinyl alcohol 5%
Sodium Laurylsulfate 4%
Wooden calcium sulfonate 4%
Kaolin 30%
Water 27%
Formulation Example 2 20% Difenoconazoles press down mould azole suspending agent
Difenoconazole 5%
Press down mould azoles 15%
Polyoxyethylene alcohol (75% saponification rate) 5%
Organic silicone 0.4%
Lignosulfonates 12%
Propane diols 10%
Water 62.6%
Formulation Example 3 30% Difenoconazole Prochloraz wetting powders
Difenoconazole 6%
Carbendazim 24%
Alkyl polyoxy ethyl ether sulfonate 10%
Sodium lignin sulfonate 8%
NONIN HS 240 4%
Kaolin 48%
Application example (is example with the rice sheath blight disease)
Difenoconazole in probenazole, press down mould azoles, Prochloraz composition as follows to the toxicity test method and the effect of Rhizoctonia solani Kuhn:
Rhizoctonia solani Kuhn is a separation and Culture 72 hours on the paddy rice diseased plant of gathering from the field, gets a certain amount of medicament, prepares the mother liquor of each medicament with acetone by the active ingredient of medicament, is diluted to the respective concentration soup with sterile water then and prepares medium.Then Rhizoctonia solani Kuhn is inoculated on the medium that contains soup, other is provided with a contrast, is placed in the constant temperature ware to cultivate 72 hours.
Mycelial growth inhibition rate (%)=(contrast colony diameter-processing colony diameter)/(contrast colony diameter-bacterium cake diameter) * 100
Each is handled mycelia growth inhibiting rate according to medicament, calculate each medicament EC50, calculate the toxicity index of medicament and the co-toxicity coefficient of using with (CTC) according to the abundant method of Sun Yun again, the CTC value is synergistic effect greater than 100, near 100 being addition, be antagonism less than 100.
Table 1, composition are to rice sheath blight disease co-toxicity coefficient measurement result
| Medicament | Inhibiting rate % (0.05mg/ml) | EC 50(mg/L) | Co-toxicity coefficient CTC |
| Difenoconazole | 82.9 | 0.0045 | / |
| Probenazole | 90.5 | 0.0039 | / |
| Prochloraz | 91.5 | 0.0041 | / |
| Press down mould azoles | 91.7 | 0.0052 | / |
| The Difenoconazole probenazole | 94.2 | 0.0029 | 267.24 |
| The Difenoconazole Prochloraz | 92.4 | 0.0030 | 232.74 |
| Difenoconazole presses down mould azoles | 91.8 | 0.0038 | 220.65 |
Difenoconazole and probenazole, Prochloraz, the composition that presses down mould azoles all show certain inhibition effect and synergistic effect preferably to Rhizoctonia solani Kuhn.
Embodiment 1
The preparation of Formulation Example 1 and Difenoconazole and probenazole done prevent and treat the rice sheath blight disease efficiency test.
Trial crops: paddy rice China excellent 86
Use the phase: paddy rice booting stage
The test block is divided into four sub-districts, respectively at paddy rice spray water after booting stage, 10% Difenoconazole WDG, 40% probenazole SC and 30% Difenoconazole probenazole WDG, two parallel lines great-jump-forward sampling methods are adopted in the laggard line sampling investigation of two weeks, and each sub-district is all spot-check 200 clumps.Check weighing is carried out to each cell production in the harvesting back, and spike of rice is carried out the medicament residue analysis.
| Medicament | Morbidity strain tree | Incidence of disease % | Volume increase (kilogram) |
| Blank | 192 | 96 | 0 |
| Difenoconazole EC | 106 | 53 | 31 |
| Probenazole SC | 126 | 63 | 20 |
| Difenoconazole probenazole WDG | 47 | 23.5 | 60 |
The result shows that Difenoconazole+probenazole has higher preventive effect to rice sheath blight disease, clicks height than it, and to rice safety, noresidue, to the increasing production of rice effect also clearly.
Embodiment 2
With the preparation of Formulation Example 2 and Difenoconazole, press down the agent of mould azoles list and do the control test that prevents and treats citrus scab.
Trial crops: oranges and tangerines
Use the phase: oranges and tangerines vegetative period
The test region is divided into four sub-districts, respectively at water spray behind the oranges and tangerines fallen flowers, 10% Difenoconazole WDG, 22.2% presses down mould azoles EC and 20% Difenoconazole presses down mould azoles SC, the disease rate was respectively handled in investigation before oranges and tangerines expanded, and adopted two parallel lines great-jump-forward sampling methods, each sub-district is all spot-check 200 clumps, calculates preventive effect.After oranges and tangerines are gathered every cell production being carried out check weighing, is reference with the blank district.And mandarin tree carried out the medicament residue analysis, the result shows that Difenoconazole presses down mould azoles to oranges and tangerines safety, noresidue.
Test data such as following table:
| Medicament | Morbidity strain tree | Incidence of disease % | Volume increase (kilogram) |
| Blank | 189 | 94.5 | 0 |
| Difenoconazole WDG | 158 | 79 | 30 |
| Press down mould azoles EC | 140 | 70 | 23 |
| Difenoconazole+but mould azoles SC | 178 | 89 | 57 |
Embodiment 3
The control test that prevents and treats pear scab is done in preparation and Difenoconazole, the agent of Prochloraz list of Formulation Example 3.
Control crop: pears (kind is sense kind pear)
Crop target: scab (Venturia nashicola)
Environmental condition: test site is positioned at Xinji City, Hebei province, the test orchard age of tree 13 years.Generation throughout the year of pears black heart and morbidity are heavier, and physical features is smooth, and soil property is a sandy loam, and water and fertilizer condition is better, 3 meters of spacing in the rows, 6 meters of line-spacings.The cultivation condition uniformity, the Pass Test requirement.In pear scab premorbid first time medicine for the first time.Adopting high pressure power driven sprayer spray medicine, is blank with the clear water.Dosage is 12.5L/ strain tree, even spraying.
Disease index value and field efficacy such as following table:
Show that through field control effectiveness test triazole bactericidal agent and Prochloraz are composite to have imitation preferably to pear scab.
Claims (4)
1. bactericidal composition, it is characterized in that, comprise Difenoconazole (A) and at least a following (B) bactericide that is selected from: probenazole, press down mould azoles, Prochloraz bactericidal composition according to claim 1, it is characterized in that A and B weight ratio are 1: 50～50: 1.
2. bactericidal composition according to claim 1 is characterized in that, A and B weight ratio are 1: 20～20: 1.
3. according to claim 1 or 2 or 3 described bactericidal compositions, it is characterized in that, contain carrier or thinner.
4. according to claim 1 or 2 or 3 described bactericidal compositions, it is characterized in that, can be multiple formulation, be aqueous emulsion, suspending agent, wetting powder, water dispersible granules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101329858A CN101379990A (en) | 2008-07-04 | 2008-07-04 | Bactericide agent composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101329858A CN101379990A (en) | 2008-07-04 | 2008-07-04 | Bactericide agent composition |
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| CN101379990A true CN101379990A (en) | 2009-03-11 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700033A (en) * | 2009-11-02 | 2010-05-05 | 陕西汤普森生物科技有限公司 | Bactericidal composition containing prochloraz manganese and difenoconazole |
| CN101836654A (en) * | 2010-02-23 | 2010-09-22 | 唐满仓 | Aqueous suspension bactericide containing difenoconazole and prochloraz manganese and preparation method |
| CN102113522A (en) * | 2010-12-31 | 2011-07-06 | 张胜勇 | Botanical pesticide special for killing plant pathogenic fungi |
| CN102113491A (en) * | 2010-12-31 | 2011-07-06 | 张胜勇 | Botanical pesticide special for killing plant pathogenic fungi |
| CN102578129A (en) * | 2012-02-06 | 2012-07-18 | 山东禾宜生物科技有限公司 | Bactericide for controlling sigatoka |
| CN101720780B (en) * | 2010-01-05 | 2012-09-26 | 陕西美邦农资贸易有限公司 | Bactericidal composition containing flusilazole and probenazole |
| CN103348987A (en) * | 2013-07-31 | 2013-10-16 | 河北博嘉农业有限公司 | Film-spreading oil agent capable of preventing and curing rice banded sclerotial blight |
| CN103947667A (en) * | 2014-04-18 | 2014-07-30 | 北京明德立达农业科技有限公司 | Disease-resistant composition and application thereof |
| CN104082340A (en) * | 2014-06-27 | 2014-10-08 | 浙江天一农化有限公司 | Composite germicide for crops |
| CN105766979A (en) * | 2014-12-26 | 2016-07-20 | 陈淑琴 | Fungicide for preventing and treating powdery mildew of astragali and preparing method of fungicide |
| CN114271289A (en) * | 2021-12-23 | 2022-04-05 | 山东贵合生物科技有限公司 | Long-acting bactericidal composition and preparation method thereof |
-
2008
- 2008-07-04 CN CNA2008101329858A patent/CN101379990A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700033A (en) * | 2009-11-02 | 2010-05-05 | 陕西汤普森生物科技有限公司 | Bactericidal composition containing prochloraz manganese and difenoconazole |
| CN101720780B (en) * | 2010-01-05 | 2012-09-26 | 陕西美邦农资贸易有限公司 | Bactericidal composition containing flusilazole and probenazole |
| CN101836654A (en) * | 2010-02-23 | 2010-09-22 | 唐满仓 | Aqueous suspension bactericide containing difenoconazole and prochloraz manganese and preparation method |
| CN102113522A (en) * | 2010-12-31 | 2011-07-06 | 张胜勇 | Botanical pesticide special for killing plant pathogenic fungi |
| CN102113491A (en) * | 2010-12-31 | 2011-07-06 | 张胜勇 | Botanical pesticide special for killing plant pathogenic fungi |
| CN102578129A (en) * | 2012-02-06 | 2012-07-18 | 山东禾宜生物科技有限公司 | Bactericide for controlling sigatoka |
| CN103348987A (en) * | 2013-07-31 | 2013-10-16 | 河北博嘉农业有限公司 | Film-spreading oil agent capable of preventing and curing rice banded sclerotial blight |
| CN103947667A (en) * | 2014-04-18 | 2014-07-30 | 北京明德立达农业科技有限公司 | Disease-resistant composition and application thereof |
| CN103947667B (en) * | 2014-04-18 | 2016-02-10 | 北京明德立达农业科技有限公司 | Disease resistance composition and use thereof |
| CN104082340A (en) * | 2014-06-27 | 2014-10-08 | 浙江天一农化有限公司 | Composite germicide for crops |
| CN105766979A (en) * | 2014-12-26 | 2016-07-20 | 陈淑琴 | Fungicide for preventing and treating powdery mildew of astragali and preparing method of fungicide |
| CN114271289A (en) * | 2021-12-23 | 2022-04-05 | 山东贵合生物科技有限公司 | Long-acting bactericidal composition and preparation method thereof |
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Open date: 20090311 |