CN101374537B - 干细胞的mntf分化和生长 - Google Patents

干细胞的mntf分化和生长 Download PDF

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Publication number
CN101374537B
CN101374537B CN200680041827.0A CN200680041827A CN101374537B CN 101374537 B CN101374537 B CN 101374537B CN 200680041827 A CN200680041827 A CN 200680041827A CN 101374537 B CN101374537 B CN 101374537B
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China
Prior art keywords
mntf
cell
cells
differentiation
stem cell
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Expired - Fee Related
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CN200680041827.0A
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English (en)
Chinese (zh)
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CN101374537A (zh
Inventor
D·M·德施潘德
D·A·科尔
P-Y·D·寇
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Genervon Biopharmaceuticals LLC
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Genervon Biopharmaceuticals LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200680041827.0A 2005-11-10 2006-11-10 干细胞的mntf分化和生长 Expired - Fee Related CN101374537B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US73570205P 2005-11-10 2005-11-10
US60/735,702 2005-11-10
US84176606P 2006-09-01 2006-09-01
US60/841,766 2006-09-01
US85802206P 2006-11-10 2006-11-10
PCT/US2006/043874 WO2007058982A2 (en) 2005-11-10 2006-11-10 Mntf differentiation and growth of stem cells
US60/858,022 2006-11-10

Publications (2)

Publication Number Publication Date
CN101374537A CN101374537A (zh) 2009-02-25
CN101374537B true CN101374537B (zh) 2016-04-20

Family

ID=38049179

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200680041827.0A Expired - Fee Related CN101374537B (zh) 2005-11-10 2006-11-10 干细胞的mntf分化和生长

Country Status (7)

Country Link
US (1) US8986676B2 (enExample)
EP (1) EP1965826B1 (enExample)
JP (2) JP5270362B2 (enExample)
CN (1) CN101374537B (enExample)
AU (1) AU2006315668B2 (enExample)
CA (1) CA2626728A1 (enExample)
WO (1) WO2007058982A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2028268A1 (en) * 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
CN101951942B (zh) * 2008-02-21 2014-09-03 健能万生物制药公司 Mntf肽组合物及使用方法
JPWO2010137722A1 (ja) * 2009-05-26 2012-11-15 武田薬品工業株式会社 再生医薬のスクリーニング方法
US9770471B2 (en) 2011-08-17 2017-09-26 President And Fellows Of Harvard College Conversion of somatic cells into functional spinal motor neurons, and methods and uses thereof
CN110684734A (zh) * 2011-11-04 2020-01-14 纪念斯隆-凯特琳癌症中心 用于植入的中脑多巴胺（da）神经元
CN104073468B (zh) * 2014-07-16 2016-04-27 栾佐 获得人源OPCs的方法和OPCs培养基
CN106459912B (zh) 2014-11-14 2021-05-25 再生医科学股份有限公司 软骨细胞的无血清培养方法、及无血清培养基
WO2016210123A1 (en) 2015-06-26 2016-12-29 Genervon Biopharmaceuticals, LLC Methods of using gm604 in modulating als disease biomarkers leading to prognosis and therapeutic treatment for als disease
CN110381981A (zh) * 2016-12-23 2019-10-25 健能万生物制药公司 在诊断和治疗阿尔茨海默病中使用gm6的方法
US12364985B2 (en) * 2018-05-11 2025-07-22 Georgia Tech Research Corporation Systems and methods for electronic surface antigen expression analysis using magnetophoresis
CN118853569B (zh) * 2024-09-29 2025-03-04 星奕昂(上海)生物科技有限公司 一种拟胚体消化液及其在分离造血干细胞中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044175A2 (en) * 2001-11-20 2003-05-30 Genervon Biopharmaceuticals Llc Methods and use of motoneuronotropic factors
WO2004065410A2 (en) * 2003-01-21 2004-08-05 Genervon Biopharmaceuticals Llc Mntf peptides and compositions and methods of use
WO2005047487A2 (en) * 2003-11-07 2005-05-26 Genervon Biopharmaceuticals Llc Motoneuronotrophic factor gene sequences

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6309877B1 (en) * 1996-09-27 2001-10-30 Km Biotech, Inc. Polynucleotides encoding motoneuronotrophic factors
US6300117B1 (en) 1997-09-15 2001-10-09 Genencor International, Inc. Proteases from gram-positive organisms
AU2001263199B2 (en) 2000-05-17 2004-09-16 Asterias Biotherapeutics, Inc. Neural progenitor cell populations
US7390659B2 (en) * 2002-07-16 2008-06-24 The Trustees Of Columbia University In The City Of New York Methods for inducing differentiation of embryonic stem cells and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044175A2 (en) * 2001-11-20 2003-05-30 Genervon Biopharmaceuticals Llc Methods and use of motoneuronotropic factors
WO2004065410A2 (en) * 2003-01-21 2004-08-05 Genervon Biopharmaceuticals Llc Mntf peptides and compositions and methods of use
WO2005047487A2 (en) * 2003-11-07 2005-05-26 Genervon Biopharmaceuticals Llc Motoneuronotrophic factor gene sequences

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bain et al..Embryonic stem cells express neuronal properies in vitro.《Developmental Biology》.1995,第168卷(第2期), *

Also Published As

Publication number Publication date
AU2006315668B2 (en) 2013-06-20
JP2013177388A (ja) 2013-09-09
EP1965826B1 (en) 2014-12-31
EP1965826A2 (en) 2008-09-10
CN101374537A (zh) 2009-02-25
HK1125824A1 (zh) 2009-08-21
US8986676B2 (en) 2015-03-24
WO2007058982A3 (en) 2008-09-25
CA2626728A1 (en) 2007-05-24
WO2007058982A2 (en) 2007-05-24
JP2009515891A (ja) 2009-04-16
AU2006315668A1 (en) 2007-05-24
US20090117085A1 (en) 2009-05-07
EP1965826A4 (en) 2010-08-25
JP5270362B2 (ja) 2013-08-21

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