CN101347608A - Chinese medicine soft capsules with cholagogic efficacy and preparation method thereof - Google Patents
Chinese medicine soft capsules with cholagogic efficacy and preparation method thereof Download PDFInfo
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- CN101347608A CN101347608A CNA2008101247468A CN200810124746A CN101347608A CN 101347608 A CN101347608 A CN 101347608A CN A2008101247468 A CNA2008101247468 A CN A2008101247468A CN 200810124746 A CN200810124746 A CN 200810124746A CN 101347608 A CN101347608 A CN 101347608A
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- soft capsule
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- rhizoma zingiberis
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Abstract
The invention relates to a Chinese medicine extract soft capsule which can normalize gallbladder and a preparation method thereof, and the soft capsule is a medicine soft capsule agent that is prepared by supercritical extract of carbon dioxide with the raw material of ginger. The soft capsule consists of liquid medicine and a capsule shell, and the liquid medicine is clear or suspensoid liquid that consists of the supercritical extract of carbon dioxide of ginger and adjuvant. The Chinese medicine extract soft capsule of the invention has high active ingredients and rapid dissolution of the ingredients, spiciness of the medicine is covered, and the medicine is more convenient for carrying and taking.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine extraction composition soft capsule and preparation method thereof with cholagogic efficacy.
Background technology
Digestive tract disease has become one of main killer who threatens human health at present, and wherein cholecystitis increases year by year as common and frequently-occurring disease, and the function of gallbladder promoting medicine is one of choice drug of cholecystitis and gallstone treatment.Bile promotes the wriggling of fat, electrolytical absorption and small intestinal, and the function of gallbladder promoting medicine increases bile secretion, helps the eliminating of calculus.Chinese medicine Rhizoma Zingiberis Recens (dry rhizome of zingiberaceous plant Zingiberofficinale Rosc.) acrid in the mouth is hot in nature, has warming middle-JIAO and pursues effects such as cold, that recuperating depleted YANG is promoted blood circulation, and long-term and extensive use basis are arranged clinically.Pharmacological research shows that its carbon dioxide supercritical fluid extraction thing has significant function of gallbladder promoting and analgesic activity.The present invention is based on traditional Chinese medicine, in conjunction with adopting the modern science extractive technique, the development Rhizoma Zingiberis Recens extract soft capsule preparation that pharmacologically active is strong, medicine stability good, drug quality is controlled.This preparation has been covered medicine acid, makes the effective ingredient stripping fast, is convenient for carrying and administration.
Summary of the invention
The object of the present invention is to provide function of gallbladder promoting soft capsule of a kind of Rhizoma Zingiberis Recens extract and preparation method thereof.It not only has significant choleretic effect, and has good analgesia and antiinflammatory action; Steady quality, the effective ingredient stripping is fast, carries and convenient drug administration.
The supercritical carbon dioxide extraction owner of Rhizoma Zingiberis Recens of the present invention will be contained zingiberol (Zingiberol), zingiberene (Zingiberence) gingerol (Gingerol), shogaol (Shogaol), zingiberone (Zingerone), zingiberone compositions such as (Zingiberone).Its preparation method is that exsiccant Rhizoma Zingiberis Recens is crushed to below the granularity 1mm, puts in the supercritical carbon dioxide extraction device, at 25～30MPa, extracts 3-4h under 35～50 ℃, obtains Rhizoma Zingiberis Recens extract.
Rhizoma Zingiberis Recens extract of the present invention through high-efficient liquid phase technique measure gingerol content 〉=20%, determined by ultraviolet spectrophotometry gets effective site (total phenols) content 〉=50%.Principal character peak total in the infrared spectrogram (seeing accompanying drawing) has: (1) 3445 ± 8cm
-1(broad peak, s); (2) 2928 ± 1cm
-1(three peaks or four peaks, vs); (3) 1710 ± 2cm
-1(bimodal or three peaks, w); (4) 1604 ± 1cm
-1(three peaks, w); (5) 1516 ± 1cm
-1(vs or s); (6) 1455 ± 2cm
-1(three peaks, vs or bimodal, m); (7) 1376 ± 1cm
-1(s or m); (8) 1271 ± 1cm
-1(s or m); (9) 1153cm
-1(s or m); (10) 1123 ± 1cm
-1(s or m); (11) 1035 ± 1cm
-1(s or m); (12) 816 ± 1cm
-1(bimodal, s or m); (13) 729 ± 4cm
-1(s, m or w) (14) 558 ± 4cm
-1(m or w).
Soft capsule of the present invention is made up of medicinal liquid and softgel shell.It is characterized in that medicinal liquid contains the supercritical carbon dioxide extraction thing of Rhizoma Zingiberis Recens, and be equipped with clarification or suspendible liquid that pharmaceutic adjuvant is formed, adjuvant has diluent, antioxidant and suspending agent; Softgel shell is made up of gelatin and glycerol (adding an amount of antioxidant, antiseptic).
Diluent of the present invention can be one or more in Polyethylene Glycol, propylene glycol, vegetable oil or the mineral oil; Antioxidant can be one or more in ascorbic acid, sodium ascorbate, ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, glycine, sodium sulfite, sodium pyrosulfite, inositol, citric acid, succinic acid, malic acid, hydroquinone, the lecithin; Suspending agent can be one or more in methylcellulose, ethylhydroxyethylcellulose, hydroxypropyl emthylcellulose, chitin, chitose, xanthan gum, the agar; Antiseptic can be one or more in benzoic acid, sodium benzoate, benzyl alcohol, sorbic acid, sorbic acid methyl ester, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, P-hydroxybenzoic acid Bian ester, the Sodium Methyl Hydroxybenzoate.
The preparation method of medicine of the present invention may further comprise the steps:
1, the Rhizoma Zingiberis after will purifying was pulverized 20 mesh sieves, put in the supercritical carbon dioxide extraction device, at 25～30MPa, extracted 3-4h under 35 ℃～50 ℃, obtained Rhizoma Zingiberis Recens extract;
2, through high-efficient liquid phase technique measure content 〉=20% of gingerol (in 6-Gingerol) in the extract, determined by ultraviolet spectrophotometry gets content 〉=50% of effective site total phenols (in 6-Gingerol);
3, the Rhizoma Zingiberis extract that will extract gained adds and to contain in the vegetable oil or Polyethylene Glycol of suspending agent, antiseptic, mixes, and adds antioxidant, makes suspension, is soft capsule content;
4, gelatin places the glue jar, adds the pure water of solubilized gelatin amount, dissolves the back and adds glycerol, antiseptic, the back vacuumize degassing that stirs, insulation set aside for use;
5, the medicinal liquid for preparing is poured in the pellet processing machine into the compacting soft capsule.
The soft capsule of cholagogic efficacy of the present invention can be used for treating cholecystitis and cholelithiasis.Discover that its choleretic effect intensity and action time all obviously surpass ursodesoxycholic acid, and analgesia, antiphlogistic effects are remarkable.
Test 1 pair of excretory influence of rat bile: Rhizoma Zingiberis Recens extract 0.15g/kg, collected bile respectively before administration and after the administration every 30 minutes, Rhizoma Zingiberis Recens extract administration rat bile secretion in 30 minutes to 180 minutes significantly increases, persistent period reaches 3 hours, all is better than action intensity and action time ursodesoxycholic acid (0.1g/kg).
The influence of 3 pairs of mice ear of experiment: on the mice auricle swelling model of dimethylbenzene as proinflammatory agent, the Rhizoma Zingiberis in 0.1～1.2g/kg dosage range all has tangible antiinflammatory action.
Description of drawings
Rhizoma Zingiberis supercritical extract infared spectrum
The specific embodiment
Following examples are represented practicality of the present invention, and the present invention is not limited.
Embodiment 1
(1) Rhizoma Zingiberis after will purifying was pulverized 20 mesh sieves, put in the supercritical carbon dioxide extraction device, at 25～30MPa, extracted 3～4h under 35 ℃～50 ℃, obtained Rhizoma Zingiberis Recens extract;
(2) Rhizoma Zingiberis extract joins by every capsules 0.05～0.8g among the vegetable oil 100～500mg that contains an amount of antiseptic, adds an amount of antioxidant, and mixing is made soft capsule content;
(3) with gelatin and glycerol 1.0: 0.3～0.4 dissolving by weight, add an amount of antiseptic, vacuumize degassing behind the stirring and evenly mixing, insulation set aside for use;
(4) be prepared into soft capsule through encapsulating machine, dry, clean, dry, promptly.
Get Rhizoma Zingiberis extract, join in the vegetable oil that contains an amount of antiseptic and suspending agent by every capsules 0.05～0.8g, add an amount of antioxidant, mixing is made soft capsule content; With embodiment 1 preparation soft capsule.
Get Rhizoma Zingiberis extract, join in the Polyethylene Glycol that contains an amount of antiseptic by every capsules 0.05～0.8g, mix, add an amount of antioxidant, mixing is made soft capsule content; With embodiment 1 preparation soft capsule.
Get Rhizoma Zingiberis Recens extract, join in the Polyethylene Glycol that contains an amount of antiseptic and suspending agent by every capsules 0.05～0.8g, mix, add an amount of antioxidant, mixing is made soft capsule content; With embodiment 1 preparation soft capsule.
Claims (8)
1, the present invention is a kind of Chinese medicinal soft capsule with cholagogic efficacy and preparation method thereof, and it is made up of medicinal liquid and softgel shell.It is characterized in that medicinal liquid contains the supercritical carbon dioxide extraction thing of Rhizoma Zingiberis Recens, and be equipped with clarification or suspendible liquid that pharmaceutic adjuvant is formed; Adjuvant comprises diluent, antioxidant and suspending agent.Softgel shell is made up of gelatin and glycerol.
2, soft capsule according to claim 1 is characterized in that: diluent is one or more in Polyethylene Glycol, propylene glycol, vegetable oil or the mineral oil.
3, soft capsule according to claim 1 is characterized in that: antioxidant is one or more in ascorbic acid, sodium ascorbate, ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, glycine, sodium sulfite, sodium pyrosulfite, inositol, citric acid, succinic acid, malic acid, hydroquinone, the lecithin.
4, soft capsule according to claim 1 is characterized in that: suspending agent is one or more in methylcellulose, ethylhydroxyethylcellulose, hydroxypropyl emthylcellulose, chitin, chitose, xanthan gum, the agar.
5, soft capsule according to claim 1 is characterized in that: antiseptic is one or more in benzoic acid, sodium benzoate, benzyl alcohol, sorbic acid, sorbic acid methyl ester, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, P-hydroxybenzoic acid Bian ester, the Sodium Methyl Hydroxybenzoate.
6, soft capsule according to claim 1 is characterized in that the content of each constituent in the medicinal liquid:
Component amount (gram/grain)
Extract 0.05～0.8
Diluent 0.05～2
Antioxidant 0.0004～0.002
Suspending agent 0.03～0.5
7, preparation method according to claim 1 is characterized in that: the weight ratio with gelatin, G ﹠ W in the soft capsule shell of cholagogic efficacy is 1.0: 0.3～0.5: 1.0
8, extract soft capsule preparation method according to claim 1 may further comprise the steps:
(1) Rhizoma Zingiberis after will purifying was pulverized 20 mesh sieves, put in the supercritical carbon dioxide extraction device, at 25～30MPa, extracted 3-4h under 35 ℃～50 ℃, obtained Rhizoma Zingiberis Recens extract;
(2) through high-efficient liquid phase technique measure content 〉=20% of gingerol in the extract, determined by ultraviolet spectrophotometry gets content 〉=50% of extract total phenols;
(3) extract is joined in the vegetable oil or Polyethylene Glycol that contains suspending agent, antiseptic, mix, add antioxidant, make suspension, be soft capsule content;
(4) gelatin places the glue jar, adds the pure water of solubilized gelatin amount, dissolves the back and adds glycerol, antiseptic, the back vacuumize degassing that stirs, insulation set aside for use;
(5) medicinal liquid for preparing is poured in the pellet processing machine into the compacting soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101247468A CN101347608A (en) | 2008-09-01 | 2008-09-01 | Chinese medicine soft capsules with cholagogic efficacy and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101247468A CN101347608A (en) | 2008-09-01 | 2008-09-01 | Chinese medicine soft capsules with cholagogic efficacy and preparation method thereof |
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| CN101347608A true CN101347608A (en) | 2009-01-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008101247468A Pending CN101347608A (en) | 2008-09-01 | 2008-09-01 | Chinese medicine soft capsules with cholagogic efficacy and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657841A (en) * | 2012-06-08 | 2012-09-12 | 桂林三金药业股份有限公司 | Ginger phenols extract preparation and preparation method thereof |
| WO2013110812A1 (en) * | 2012-01-27 | 2013-08-01 | Denali Pharma | Composition in the form of a gel capsule comprising ginger powder and a coating agent |
| CN104147557A (en) * | 2012-06-08 | 2014-11-19 | 桂林三金药业股份有限公司 | Shogaol extract soft capsule and preparation method thereof |
-
2008
- 2008-09-01 CN CNA2008101247468A patent/CN101347608A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013110812A1 (en) * | 2012-01-27 | 2013-08-01 | Denali Pharma | Composition in the form of a gel capsule comprising ginger powder and a coating agent |
| FR2986136A1 (en) * | 2012-01-27 | 2013-08-02 | Denali Pharma | COMPOSITION IN THE FORM OF A GELULE COMPRISING GINGER POWDER AND A COATING AGENT |
| CN102657841A (en) * | 2012-06-08 | 2012-09-12 | 桂林三金药业股份有限公司 | Ginger phenols extract preparation and preparation method thereof |
| CN104147557A (en) * | 2012-06-08 | 2014-11-19 | 桂林三金药业股份有限公司 | Shogaol extract soft capsule and preparation method thereof |
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Open date: 20090121 |