CN101342363B - Preparation of sedative and brain-invigorating oral liquid - Google Patents
Preparation of sedative and brain-invigorating oral liquid Download PDFInfo
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Abstract
The present invention relates to a preparation technique of a tranquilizer, in particular to the improvement of the preparation technique of the tranquilizer, which relates to the technical field of Chinese medicine preparation. The improved preparation technique includes the following steps: in the process of the preparation of tranquilizer extract, extract solution is filtered by an ultramicro filter membrane with a pore diameter between 20mm and 200mm, and after being collected, clear solution is concentrated, so that the tranquilizer extract is finally obtained; in the process of the preparation of the tranquilizer, the mixed liquor is filtered by a tubular ultrafiltration membrane device, the molecular weight cutoff of the membrane pore diameter is between 5000 and 200000, the filtering pressure is between 0.1MPa and 0.4 MPa, the filtering temperature is between 0 DEG C and 40 DEG C, and the membrane flux is between 50L/m<2>h and 300L/m<2>h. The adoption of the ultramicro filter membrane reduces the usage of ethanol and even can realize non-ethanol production, the production period is shortened, and the production cost and the energy consumption are reduced. At the same time,since the filtering technique of the tubular ultrafiltration membrane is adopted to terminally filter the prepared liquor, the clarity of the liquor is improved, the product quality is increased, andthe stability of the product quality is ensured.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, specifically is that the preparation technology of ANSHEN BUNAO YE improves.
Background technology
ANSHEN BUNAO YE is by Cornu Cervi Pantotrichum, Radix Polygoni Multiflori Preparata, Herba Epimedii, Rhizoma Zingiberis, Fructus Jujubae, Radix Glycyrrhizae, the refining liquid preparation of Chinese medicine that forms of vitamin B1 seven flavor medicine, having promotes the production of body fluid mends marrow, strengthen mental effect, be used for diseases such as neurasthenia, insomnia, forgetful, headache, extensively be subjected to the welcome of consumer.But because traditional processing technology limits, the same with other oral preparation of Chinese traditional medicinal, in producing and storing, easily produce and precipitate, to put more obviously for a long time, constant product quality is poor.
" preparation technology who discloses ANSHEN BUNAO YE of Chinese pharmacopoeia comprises step 1 preparation Cornu Cervi Pantotrichum extracting solution at 2005 editions; Step 2 is extracted Rhizoma Zingiberis volatile oil; Step 3 preparation ANSHEN BUNAO YE extractum: get Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, decoct with water three times, merge extractive liquid, filters, concentrate, add ethanol and remove precipitation, filter, filtrate concentrates, and gets ANSHEN BUNAO YE extractum, and is standby; Step 4 preparation ANSHEN BUNAO YE: it is evenly mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution, adds vitamin B1, sodium benzoate and benzoic acid, and the Rhizoma Zingiberis Recens volatile oil mixing leaves standstill clarification, filters, and adds purified water to 10000ml, promptly.
Adopt traditional aqueous extraction-alcohol precipitation technology in this technology, be used to remove impurity such as starch, polysaccharide, phlegmatic temperament, resin, tannin.But in actual production, the Chinese crude drug volume is big, and the ethanol consumption is many, and loss is big, the cost height, and at the bottom of the boiling point, be unfavorable for safety in production, poor stability, cycle are grown, labor intensity is big, production environment is poor.
The traditional Pulvis Talci of general employing helped filter plate frame filtering and impurity removing refining when ANSHEN BUNAO YE preparing process herb liquid filtered, because this filter type relies the molding situation in the Pulvis Talci filter cake, improper when amount of talc, operate when improper, the Pulvis Talci filter cake will be not tight, have a strong impact on the effect of medical filtration, make medicinal liquid clarity not reach requirement, thereby need prepare the Pulvis Talci filter cake again repeats to filter to medicinal liquid, cause the operating time to prolong, complex operation step still can not guarantee product quality.
Chinese patent CN100998846A discloses a kind of film production process of ANSHEN BUNAO YE, pro-extracts and has adopted the ceramic membrane filter technology generations for coarse filtration, membrane aperture 0.22um, adopt doughnut film device filtering technique in medicinal liquid preparation terminal, because membrane aperture 0.22um, membrane aperture is relatively large, still can not reach the effect that replaces alcohol precipitation process fully, so medicinal liquid still needs through relevant treatment, otherwise just can not guarantee the clarity of product.
The doughnut membrane filter system has following shortcoming to overcome:
(1) the doughnut membrane material is polypropylene (PP), and big to the macromolecular substances absorbability in the material, performance degradation is fast slowly.
(2) hollow-fibre membrane polypropylene (PP) material easy fracture, working pressure has only 0.1mpa, and the fracture back is difficult for finding, influences separating effect
(3) the micropore runner of hollow-fibre membrane is the finger-like pore structure, interior exodermis, and pollutant easily deposit, and it is difficult to clean.
(4) the hollow-fibre membrane runner is less, is about below 1 millimeter, and the Flow of Goods and Materials resistance is big, and the flux of unit square is little.
(5) hollow-fibre membrane external pressure dead-end filtration form, no stationary flowpath, trapped substance do not discharge (or discharging little), and be dirty stifled fast, and the dead angle is many, cleans not thoroughly, influences the quality of subsequent product.
Therefore, we think necessary existing preparation technology are improved.
Summary of the invention
The objective of the invention is to improve the existing preparation technology of ANSHEN BUNAO YE, reduce the ethanol consumption, do not have alcoholization production, shorten the production cycle, cut down the consumption of energy, reduce production costs, promote product quality, guarantee product quality until reaching.
The preparation technology of ANSHEN BUNAO YE of the present invention: preparation 10000ml finished product medicinal liquid feeds intake by following medical material amount:
Cornu Cervi Pantotrichum 30g Radix Polygoni Multiflori Preparata 625g Herba Epimedii 500g
Rhizoma Zingiberis 125g Radix Glycyrrhizae 62.5g Fructus Jujubae 125g
Vitamin B1 5g
Prepare by following steps:
Step 1 preparation Cornu Cervi Pantotrichum extracting solution: " the Chinese pharmacopoeia decoction and alcohol sedimentation technique prepares Cornu Cervi Pantotrichum extracting solution by 2005 editions;
Step 2 is extracted Rhizoma Zingiberis volatile oil: extract volatile oil by vapor distillation, medicinal residues are standby;
Step 3 preparation ANSHEN BUNAO YE extractum: get the Rhizoma Zingiberis medicinal residues that extract behind the Rhizoma Zingiberis volatile oil and Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of recipe quantity, decoct with water three times, merge extractive liquid,, with extracting solution is the supermicro filtration membrane filtration of 20nm～200nm by the aperture, filter pressure is controlled at 0.1～0.4MPa, and temperature is controlled at 15 ℃～85 ℃, collects clear liquid, clear liquid is concentrated, obtain ANSHEN BUNAO YE extractum;
Step 4 preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution, and vitamin B1, sodium benzoate and benzoic acid behind the adding water dissolution stir; Add Rhizoma Zingiberis volatile oil and an amount of mixing of purified water, the medicinal liquid that mixes is filtered by tubular ultra-filtration membrane equipment, membrane aperture is the molecular weight 5000～200000 that dams, filter pressure: 0.1～0.4MPa, and filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H, filtrate adds purified water to 10000ml, stirs, promptly.
For further guaranteeing product quality, step 3 " preparation ANSHEN BUNAO YE extractum " also can adopt following method: Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of getting above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, decoct with water three times, merge extractive liquid,, with extracting solution is the supermicro filtration membrane filtration of 20nm～200nm by the aperture, clear liquid is concentrated into relative density under 80 ℃, is determined as 1.05～1.40 concentrated solution, add the ethanol accent and contain the alcohol amount to 65%, stir evenly, leave standstill, get supernatant, filter, concentrate, get ANSHEN BUNAO YE extractum.
Perhaps step 3 " preparation ANSHEN BUNAO YE extractum " also can adopt following method: Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of getting above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, decoct with water three times, merge extractive liquid,, with extracting solution is the supermicro filtration membrane filtration of 20nm～200nm by the aperture, clear liquid is filtered through tubular ultra-filtration membrane, membrane aperture is the molecular weight 5000～200000 that dams, filter pressure: 0.1～0.4MPa again, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.
The involved supermicro filtration membrane of preparation ANSHEN BUNAO YE extractum part can adopt inorganic ceramic film, stainless steel membrane, organic membrane etc. multiple, preferred inorganic ceramic film of the present invention or rustless steel tubular type film.
In the improvement technology of ANSHEN BUNAO YE preparation, in our the pro-extraction process, medical material water extract adopts inorganic ceramic film or rustless steel tubular type membrane filtration technique.Inorganic ceramic film refers to the anisotropic membrane that is prepared from material through special technology such as ceramic material such as aluminium oxide, zirconium oxide, titanium oxides, membrane aperture 20nm～200nm; Rustless steel tubular type film is to adopt high-tech with firm 316L powder of stainless steel lining body and TiO
2Inert coatings combines, and forms a kind of separation aperture and is respectively 20nm and the nonpolar inorganic material film of 100nm, and peculiar asymmetry membrane structure is by TiO
2Stratum disjunctum, small-bore supporting layer, large aperture supporting layer constitute.Two kinds of supermicro filtration membranes are single tube shape and multichannel tubulose structure.The tube wall micropore that gathers, under the effect of operation pressure reduction, feed liquid is cross-flow passes in the film pipe, and entering per-meate side less than the part of membrane aperture by fenestra becomes filtrate, and hold back and become concentrated solution, thereby reach separation, remove impurity and the purified purpose of material greater than the material tunicle in aperture.
Simultaneously, adopted tubular ultra-filtration membrane equipment, overcome the shortcoming of hollow-fibre membrane, tubular ultra-filtration membrane involved in the present invention is multichannel tubulose structure, the wall pipe micropore that gathers.Its tubular membrane has excellent intensity, antipollution, antioxidation, acid and alkali-resistance (pH1-13) performance, and pure water flux is up to 750L/m
2H, operating pressure can reach 10bar, and operating temperature can reach 80 ℃.Under the stressed outside effect, feed liquid flows in film pipe inboard (or outside), and liquid sees through film, and the impurity tunicle is held back, thereby reaches separation, remove impurity and purified purpose.
The advantage of tubular membrane equipment is as follows: (1) tubular membrane material is little to the macromolecular substances absorbability in the material, and performance degradation is slow.(2) tubular membrane polyester prop carrier has good ductility and the resistance to pressure pressure of the highest 0.8mpa of bearing, and tubular membrane can be born higher pressure separating effect and is better than hollow-fibre membrane.(3) tubular membrane the micropore runner be cavernous structure, the film outside does not have cortex, is easy to the infiltration of feed liquid, the little cleaning of resistance is easy.(4) division of tubular membrane molecular weight is meticulous, can adapt to different separation requirement.(5) the tubular membrane minimum is 5 millimeters passages, can not have clogging when separating.(6) tubular membrane is intrinsic pressure cross-flow circulating filtration, and runner is fixed, no dead angle.Cleaning and sterilizing is thorough.
Adopt high-tech ultrafilter membrane isolation technics to handle Chinese traditional medicine water extract, compare macromole, tannin and other non-active ingredients of removing effectively in the medicinal liquid, make the quality of product obtain significant raising, shortened the production cycle with alcohol deposition method commonly used.This technology can reduce consumption of ethanol in the production greatly, even can not need to adopt the alcohol precipitation process remove impurity, and realize not having alcoholization and produce, make production operation safer, thereby the operating pressure that alleviates the back operation reduces production costs, and has played the effect of " double gain ".
Good effect of the present invention is: by adopting supermicro filtration membrane the medicinal liquid of preceding extraction is effectively filtered, reduce the ethanol consumption, even can realize not having alcoholization and produce, shorten the production cycle, cut down the consumption of energy, reduce production costs, simultaneously, the medicinal liquid after preparing is carried out end-filtration, improve medicinal liquid clarity by the tubular ultra-filtration membrane filtering technique, promote product quality, guarantee product quality stability.
Set forth technical scheme of the present invention and beneficial effect below by specific embodiment.
The specific embodiment
Embodiment 1 former technology
One, preparation Cornu Cervi Pantotrichum extracting solution: get Cornu Cervi Pantotrichum 30g, add water logging and cross powder, soaked 1 hour, decoct five times, gradation is filtered, and merging filtrate concentrates.Get Cera Flava, add in the Cornu Cervi Pantotrichum concentrated solution after the fusion, stir, be cooled to the wax layer and solidify fully, remove the dewax layer, filter, add ethanol and regulate it and contain the alcohol amount, stir, leave standstill, get supernatant, filter, reclaim ethanol, be concentrated in right amount, add 95% ethanol again, leave standstill, get supernatant, filter, reclaim ethanol, add water and ethanol and regulate its concentration to 10% (containing the alcohol amount is 20～30%), get Cornu Cervi Pantotrichum extracting solution.
Two, preparation Rhizoma Zingiberis volatile oil: the Rhizoma Zingiberis 125g with recipe quantity, add water, extract volatile oil by vapor distillation, medicinal residues are standby.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 625g, the Herba Epimedii 500g, Fructus Jujubae 125g and the Radix Glycyrrhizae 62.5g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water was respectively 6 times of primary doses, 5 times, merge extractive liquid,, merge extractive liquid,, be concentrated into relative density 1.10 (80 ℃), add ethanol 3000ml, stir evenly, standing over night, get supernatant, filter, concentrate, get ANSHEN BUNAO YE extractum 1200ml, standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum, Rhizoma Zingiberis volatile oil and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
15g adds purified water to 10000ml, mix homogeneously.
Embodiment 2
One, preparation Cornu Cervi Pantotrichum extracting solution: get Cornu Cervi Pantotrichum 300g, prepare Cornu Cervi Pantotrichum extracting solution with embodiment 1 method.
Two, preparation Rhizoma Zingiberis volatile oil: the Rhizoma Zingiberis 1250g with recipe quantity, add water, extract volatile oil by vapor distillation, medicinal residues are standby.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 6250g, the Herba Epimedii 5000g, Fructus Jujubae 1250g and the Radix Glycyrrhizae 625g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water is respectively 6 times of primary doses, 5 times, and merge extractive liquid, filters extracting solution with ceramic membrane, membrane aperture 200nm, filter pressure is controlled at 0.1～0.4MPa, and temperature is controlled at 15 ℃～85 ℃, collects clear liquid.Clear liquid is concentrated into relative density 1.25 (80 ℃), adds ethanol 7000ml, stir evenly, standing over night is got supernatant, filters, and concentrates, and gets ANSHEN BUNAO YE extractum 12000ml, and is standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered filter pressure with tubular ultra-filtration membrane: 0.1～0.4MPa, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 3
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 6250g, the Herba Epimedii 5000g, Fructus Jujubae 1250g and the Radix Glycyrrhizae 625g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water is respectively 6 times of primary doses, 5 times, and merge extractive liquid, filters extracting solution with ceramic membrane, membrane aperture 100nm, filter pressure is controlled at 0.1～0.4MPa, and temperature is controlled at 15 ℃～85 ℃, obtains clear liquid.
Above-mentioned clear liquid is concentrated into relative density 1.25 (80 ℃), adds ethanol 7000ml, stir evenly, standing over night is got supernatant, filters, and concentrates, and gets ANSHEN BUNAO YE extractum 12000ml, and is standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered filter pressure with tubular ultra-filtration membrane: 0.1～0.4MPa, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 4
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 6250g, the Herba Epimedii 5000g, Fructus Jujubae 1250g and the Radix Glycyrrhizae 625g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water is respectively 6 times of primary doses, 5 times, and merge extractive liquid, filters said extracted liquid with ceramic membrane, membrane aperture 20nm, filter pressure is controlled at 0.1～0.4MPa, and temperature is controlled at 15 ℃～85 ℃, obtains clear liquid.
Above-mentioned clear liquid is concentrated into relative density 1.25 (80 ℃), adds ethanol 7000ml, stir evenly, standing over night is got supernatant, filters, and concentrates, and gets ANSHEN BUNAO YE extractum 12000ml, and is standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered filter pressure with tubular ultra-filtration membrane: 0.1～0.4MPa, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 5
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 6250g, the Herba Epimedii 5000g, Fructus Jujubae 1250g and the Radix Glycyrrhizae 625g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water is respectively 6 times of primary doses, 5 times, merge extractive liquid,, with said extracted liquid with rustless steel tubular type membrane filtration mistake, membrane aperture 100nm, filter pressure is controlled at 0.1～0.4MPa, and temperature is controlled at 15 ℃～85 ℃, obtains clear liquid.
Above-mentioned clear liquid is concentrated into relative density 1.20 (80 ℃), adds ethanol 7000ml, stir evenly, standing over night is got supernatant, filters, and concentrates, and gets ANSHEN BUNAO YE extractum 12000ml, and is standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered filter pressure with tubular ultra-filtration membrane: 0.1～0.4MPa, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 6
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 6250g, the Herba Epimedii 5000g, Fructus Jujubae 1250g and the Radix Glycyrrhizae 625g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water is respectively 6 times of primary doses, 5 times, merge extractive liquid,, with said extracted liquid with rustless steel tubular type membrane filtration mistake, membrane aperture 20nm, filter pressure is controlled at 0.1～0.4Mpa, and temperature is controlled at 15 ℃～85 ℃, obtains clear liquid.
Above-mentioned clear liquid is concentrated into relative density 1.25 (80 ℃), adds ethanol 7000ml, stir evenly, standing over night is got supernatant, filters, and concentrates, and gets ANSHEN BUNAO YE extractum 12000ml, and is standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered filter pressure with tubular ultra-filtration membrane: 0.1～0.4MPa, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 7
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 6250g, the Herba Epimedii 5000g, Fructus Jujubae 1250g and the Radix Glycyrrhizae 625g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water is respectively 6 times of primary doses, 5 times, and merge extractive liquid, filters said extracted liquid with ceramic membrane, membrane aperture 20nm, filter pressure is controlled at 0.1～0.4Mpa, and temperature is controlled at 15 ℃～85 ℃, obtains clear liquid.Above-mentioned clear liquid is concentrated, get ANSHEN BUNAO YE extractum 12000ml, standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered with tubular ultra-filtration membrane, and membrane aperture is a molecular cut off 5000, filter pressure: 0.1～0.4MPa, and filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 8
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: with embodiment 7.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered with tubular ultra-filtration membrane, and membrane aperture is a molecular cut off 50000, filter pressure: 0.1～0.4MPa, and filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 9
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: with embodiment 7.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered with tubular ultra-filtration membrane, and membrane aperture is a molecular cut off 200000, filter pressure: 0.1～0.4MPa, and filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 10
One, preparation Cornu Cervi Pantotrichum extracting solution: with embodiment 2.
Two, preparation Rhizoma Zingiberis volatile oil: with embodiment 2.
Three, preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata 6250g, the Herba Epimedii 5000g, Fructus Jujubae 1250g and the Radix Glycyrrhizae 625g that get above-mentioned Rhizoma Zingiberis medicinal residues and recipe quantity, the water that adds 8 times of primary doses, soaked 1 hour, decocted 2 hours, filtrate is put into basin, medicinal residues decoct 2 times again, each 1 hour, amount of water is respectively 6 times of primary doses, 5 times, and merge extractive liquid, filters said extracted liquid with ceramic membrane, membrane aperture 200nm, filter pressure is controlled at 0.1～0.4MPa, and temperature is controlled at 15 ℃～85 ℃, obtains clear liquid.
Above-mentioned clear liquid is filtered with tubular ultra-filtration membrane equipment, and membrane aperture is a molecular cut off 50000, filter pressure: 0.1～0.4MPa, and filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Concentrate, get ANSHEN BUNAO YE extractum 12000ml, standby.
Four, preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution; Add and used dissolved sodium benzoate of an amount of purified water and benzoic acid; Add the vitamin B after dissolving then
150g adds purified water, stirs; Adding Rhizoma Zingiberis volatile oil mixes.
The medicinal liquid that mixes is filtered with tubular ultra-filtration membrane, and membrane aperture is a molecular cut off 50000, filter pressure: 0.1～0.4MPa, and filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.Filtrate adds purified water to 100000ml, stirs.
Embodiment 11
Get according to 3 batch samples of embodiment 8 methods preparation with according to 3 batch samples of embodiment 1 former prepared and carry out the quality contrast:
Embodiment 12
Get according to 3 batch samples of embodiment 8 methods preparation with according to prerequisite water intaking extract ceramic membrane filter, terminal medicinal liquid and carry out the quality contrast with the sample of doughnut membrane filtration process preparation:
Claims (4)
1. the preparation technology of an ANSHEN BUNAO YE, preparation 10000ml finished product medicinal liquid feeds intake by following medical material amount:
Cornu Cervi Pantotrichum 30g Radix Polygoni Multiflori Preparata 625g Herba Epimedii 500g
Rhizoma Zingiberis 125g Radix Glycyrrhizae 62.5g Fructus Jujubae 125g
VITAMIN B15 g
Prepare by following steps:
Step 1 preparation Cornu Cervi Pantotrichum extracting solution: get Cornu Cervi Pantotrichum, add water logging and cross powder, soaked 1 hour, decoct five times, gradation is filtered, merging filtrate, concentrate, get Cera Flava, add after the fusion in the Cornu Cervi Pantotrichum concentrated solution, stir, be cooled to the wax layer and solidify fully, remove the dewax layer, filter, add ethanol and regulate it and contain the alcohol amount, stir, leave standstill, get supernatant, filter, reclaim ethanol, be concentrated in right amount, add 95% ethanol again, leave standstill, get supernatant, filter, reclaim ethanol, add water and ethanol is regulated its concentration to 10%, containing the alcohol amount is 20～30%, Cornu Cervi Pantotrichum extracting solution;
Step 2 is extracted Rhizoma Zingiberis volatile oil: adopt vapor distillation to extract volatile oil;
Step 3 preparation ANSHEN BUNAO YE extractum: get the Rhizoma Zingiberis medicinal residues and Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of recipe quantity that extract behind the Rhizoma Zingiberis volatile oil, decoct with water three times, merge extractive liquid, filters, and filtrate concentrates, and gets ANSHEN BUNAO YE extractum, and is standby;
Step 4 preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution, and vitamin B1, sodium benzoate and benzoic acid behind the adding water dissolution add purified water and stir; Add the Rhizoma Zingiberis volatile oil mixing, medical filtration adds purified water to 10000ml, stirs evenly, promptly;
It is characterized in that:
Step 3 preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of getting Rhizoma Zingiberis medicinal residues and recipe quantity, decoct with water three times, merge extractive liquid,, with extracting solution is the supermicro filtration membrane filtration of 20nm～200nm by the aperture, filter pressure is controlled at 0.1～0.4MPa, temperature is controlled at 15 ℃～85 ℃, and clear liquid is concentrated, and obtains ANSHEN BUNAO YE extractum;
Step 4 preparation ANSHEN BUNAO YE: it is mixed to get high fructose syrup, ANSHEN BUNAO YE extractum and Cornu Cervi Pantotrichum extracting solution, add vitamin B1, sodium benzoate and benzoic acid, stir, add Rhizoma Zingiberis volatile oil and an amount of mixing of purified water, with the medicinal liquid that mixes is the tubular ultra-filtration membrane equipment filtration of molecular cut off 5000～200000 by membrane aperture, filter pressure: 0.1～0.4MPa, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H, filtrate adds purified water to 10000ml, stirs, promptly.
2. the preparation technology of ANSHEN BUNAO YE according to claim 1 is characterized in that: said supermicro filtration membrane is inorganic ceramic film or rustless steel tubular type film in the step 3 preparation ANSHEN BUNAO YE extractum.
3. the preparation technology of ANSHEN BUNAO YE according to claim 1, it is characterized in that: step 3 preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of getting Rhizoma Zingiberis medicinal residues and recipe quantity, decoct with water three times, merge extractive liquid,, with extracting solution by the aperture be the supermicro filtration membrane of 20nm～200nm filter clear liquid, clear liquid is concentrated into relative density under 80 ℃, is determined as 1.05～1.40 concentrated solution, add the ethanol accent and contain the alcohol amount to 65%, stir evenly, leave standstill, get supernatant, filter, concentrate, get ANSHEN BUNAO YE extractum.
4. the preparation technology of ANSHEN BUNAO YE according to claim 1, it is characterized in that: step 3 preparation ANSHEN BUNAO YE extractum: Radix Polygoni Multiflori Preparata, Herba Epimedii, Fructus Jujubae and the Radix Glycyrrhizae of getting Rhizoma Zingiberis medicinal residues and recipe quantity, decoct with water three times, merge extractive liquid,, with extracting solution is the supermicro filtration membrane filtration of 20nm～200nm by the aperture, collect clear liquid, clear liquid is filtered through tubular ultra-filtration membrane, membrane aperture is the molecular weight 5000～200000 that dams, filter pressure: 0.1～0.4MPa, filtration temperature: 0 ℃～40 ℃, membrane flux: 50～300L/m
2H.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1853715A (en) * | 2005-04-21 | 2006-11-01 | 王达桂 | Anshen Bunao soft capasule and preparation thereof |
| CN1853713A (en) * | 2005-04-21 | 2006-11-01 | 石药集团中奇制药技术（石家庄）有限公司 | Anshen Bunao drip ball and preparation thereof |
| CN100998846A (en) * | 2006-10-18 | 2007-07-18 | 吉林敖东延边药业股份有限公司 | Membrane production technology of spirit quieting brain supplementing liquid and its product |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1853715A (en) * | 2005-04-21 | 2006-11-01 | 王达桂 | Anshen Bunao soft capasule and preparation thereof |
| CN1853713A (en) * | 2005-04-21 | 2006-11-01 | 石药集团中奇制药技术（石家庄）有限公司 | Anshen Bunao drip ball and preparation thereof |
| CN100998846A (en) * | 2006-10-18 | 2007-07-18 | 吉林敖东延边药业股份有限公司 | Membrane production technology of spirit quieting brain supplementing liquid and its product |
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