CN215196343U

CN215196343U - Amino acid separation and purification device

Info

Publication number: CN215196343U
Application number: CN202120800223.1U
Authority: CN
Inventors: 蔡卫国; 薛锦文; 吴波涛; 戴超
Original assignee: Yichang Sanxia Punuoding Bio Pharmaceutical Co ltd
Current assignee: Yichang Sanxia Punuoding Bio Pharmaceutical Co ltd
Priority date: 2021-04-19
Filing date: 2021-04-19
Publication date: 2021-12-17
Anticipated expiration: 2031-04-19

Abstract

The utility model discloses an amino acid separation and purification device, which comprises a liquid inlet pipeline connected with a liquid inlet of a circulating storage tank, wherein the liquid outlet of the circulating storage tank is connected with a liquid inlet of a nanofiltration membrane filter through a liquid outlet pipeline, a stock solution outlet of the nanofiltration membrane filter is connected with the liquid inlet pipeline through a liquid return pipeline, a filtrate outlet of the nanofiltration membrane filter is connected with a liquid inlet of a reverse osmosis membrane filter through a liquid conveying pipeline, a concentrated solution outlet of the reverse osmosis membrane filter is connected with a liquid discharge pipeline, and a water outlet of the reverse osmosis membrane filter is connected with a water inlet of a water tank through a water discharge pipeline; the utility model discloses can effectively get rid of the pyrogen of sneaking into in the amino acid.

Description

Amino acid separation and purification device

Technical Field

The utility model relates to a separation and purification technical field specifically indicates an amino acid separation and purification device.

Background

When a large amount of intravenous infusion is clinically carried out, if the liquid medicine contains pyrogen, patients can have symptoms of cold tremor, high fever, sweating, fainting, vomiting and the like, and even can be shocked by severe patients, and the phenomenon is called pyrogen reaction. The main cause of the pyrogen reaction is caused by contaminated pyrogens in the injection solution or infusion set.

Amino acids are often used as pharmaceutical intermediates or as components of injections, and thus pyrogen control is an important step in amino acid production. The removal of pyrogens (bacterial endotoxins, etc.) by the existing processes is not thorough enough, and the pyrogens in the final product cannot be stably controlled within a low limit, or a large amount of product loss is caused while the pyrogens are removed.

Disclosure of Invention

An object of the utility model is to overcome the aforesaid not enough, provide an amino acid separation and purification device, can effectively get rid of the pyrogen of sneaking into in the amino acid.

The utility model discloses a solve above-mentioned technical problem, the technical scheme who adopts is: the utility model provides an amino acid separation and purification device, includes the inlet line who is connected with circulation storage tank inlet, circulation storage tank liquid outlet is connected with receiving filter membrane filter inlet through going out the liquid pipeline, receives filter membrane filter stoste export through returning liquid pipeline and inlet line connection, receives filter membrane filter filtrate export and is connected with reverse osmosis membrane filter inlet through sending liquid pipeline, reverse osmosis membrane filter concentrate export and flowing back pipeline connection, reverse osmosis membrane filter delivery port pass through water drainage pipeline and be connected with the water pitcher water inlet.

Preferably, the water outlet of the water tank is connected with the water inlet of the circulating storage tank through a water outlet pipeline.

Preferably, a stirring device is further arranged in the circulating storage tank.

Preferably, agitating unit is including spacing rotatory sleeve in circulation storage tank top, rotatory sleeve upper portion cover is established and is fixed with ring gear, ring gear and straight-teeth gear meshing, straight-teeth gear bottom center and servo motor output shaft, be equipped with in the rotatory sleeve rather than vertical sliding fit's (mixing) shaft, the (mixing) shaft bottom is equipped with stirring vane and scrapes the brush, and the (mixing) shaft top is connected with lifter plate one end through first bearing, the lifter plate other end is connected with the telescoping device.

Preferably, the bottom of the servo motor and the bottom of the telescopic device are both fixed to the top of the circulating storage tank through mounting brackets.

Preferably, guide rails are arranged on two sides of the stirring shaft, sliding grooves are formed in two sides in the rotating sleeve, and the guide rails are in sliding fit with the sliding grooves.

Preferably, the rotating sleeve is retained to the top of the circulation tank by a second bearing.

Preferably, the scraping brush comprises a scraping rod vertically connected with the bottom of the stirring shaft, and bristles are arranged at the end part of the scraping rod.

The utility model has the advantages that: the separation and purification device of the utility model completely removes pyrogen and greatly reduces the loss of products caused by interception; the method has the advantages of effectively saving energy consumption, recycling water, reducing the volume of filtrate, saving the use of steam in the subsequent concentration process, achieving the light transmittance of more than 50% through the filtration of the nanofiltration membrane and the reverse osmosis membrane, and reducing the use of active carbon in the subsequent decolorization process.

Drawings

FIG. 1 is a schematic structural diagram of an amino acid separation and purification apparatus;

FIG. 2 is a schematic sectional view of the circulation tank of FIG. 1;

fig. 3 is a schematic view of the structure of the stirring shaft and the rotating sleeve in fig. 2.

Detailed Description

The invention is described in further detail below with reference to the figures and the embodiments.

As shown in fig. 1 to 3, an amino acid separation and purification device, include the inlet line 2 of being connected with 1 inlet of circulation storage tank, 1 liquid outlet of circulation storage tank is connected with receiving filter membrane filter 4 inlet through going out liquid pipeline 3, receives filter membrane filter 4 stoste export and is connected with inlet line 2 through returning liquid pipeline 5, receives filter membrane filter 4 filtrating export and is connected with 7 inlets of reverse osmosis membrane filter through sending liquid pipeline 6, 7 concentrate exports of reverse osmosis membrane filter are connected with drainage pipeline 8, and 7 delivery ports of reverse osmosis membrane filter pass through drainage pipeline 9 and are connected with 10 water inlets of water pitcher.

In the present embodiment, the nanofiltration membrane of the nanofiltration membrane filter 4 has a pore size of 1nm or more, typically 1-2nm, and is a functional semipermeable membrane that allows solvent molecules or some low molecular weight solutes or low valence ions to permeate. Theoretically, amino acid molecules can pass through a nanofiltration membrane, while pyrogens cannot pass through, so that the pyrogens can be separated. However, in practical use, due to the influence of the feed concentration, the flow rate and the like, a certain amount (30%) of amino acid is trapped and flows out with the remaining material, resulting in yield loss. The reverse osmosis membrane of the reverse osmosis membrane filter 7 is generally used for water purification, because other molecules cannot permeate through the semipermeable membrane and separate these substances from water under the action of higher osmotic pressure than the solution. In the scheme, the reverse osmosis membrane is used for removing water and concentrating the filtrate. When the material reverse osmosis membrane is used, the material enters the reverse osmosis membrane from the shell, water molecules can permeate the membrane core and flow out from the outlet of the membrane core, and concentrated material flows out from the shell.

Preferably, the water outlet of the water tank 10 is connected with the water inlet of the circulating storage tank 1 through a water outlet pipeline 11.

Preferably, a stirring device 12 is also arranged in the circulating storage tank 1. The stirring device 12 can prevent the materials in the circulating storage tank 1 from precipitating, and can quickly mix the water and the stock solution entering the circulating storage tank 1.

Preferably, agitating unit 12 includes the rotatory sleeve 12.1 of spacing in circulation storage tank 1 top, rotatory sleeve 12.1 upper portion cover is established and is fixed with ring gear 12.2, ring gear 12.2 and straight-teeth gear 12.3 meshing, straight-teeth gear 12.3 bottom center and servo motor 12.4 output shaft, be equipped with in the rotatory sleeve 12.1 rather than vertical sliding fit's (mixing) shaft 12.5, (mixing) shaft 12.5 bottom is equipped with stirring vane 12.6 and scraping brush 12.7, and (mixing) shaft 12.5 top is connected with lifter plate 12.9 one end through first bearing 12.8, the lifter plate 12.9 other end is connected with telescoping device 12.10. Servo motor 12.4 during operation can drive spur gear 12.3 rotatory, and then drives ring gear 12.2 and rotates to make rotatory sleeve 12.1 rotate, finally can make (mixing) shaft 12.5 rotate, can drive stirring vane 12.6 and scrape brush 12.7 and rotate together, stirring vane 12.6's rotation can effectively mixed material, and the rotation of scraping brush 12.7 can avoid impurity adhesion at circulation storage tank 1 inside wall.

Preferably, the bottom of the servo motor 12.4 and the bottom of the telescopic device 12.10 are fixed on the top of the circulating storage tank 1 through a mounting bracket 12.11.

Preferably, guide rails 12.12 are arranged on two sides of the stirring shaft 12.5, sliding grooves 12.13 are arranged on two inner sides of the rotating sleeve 12.1, and the guide rails 12.12 are in sliding fit with the sliding grooves 12.13. After the design, when the telescopic device 12.10 drives the lifting plate 12.9 to periodically ascend and descend, the stirring shaft 12.5 can be driven to periodically ascend and descend, the stirring shaft 12.5 can axially slide due to the matching between the guide rail 12.12 and the sliding chute 12.13, the stirring shaft 12.5 can also be driven to rotate by the rotation of the rotating sleeve 12.1, and meanwhile, the rotation process of the stirring shaft 12.5 cannot be influenced in the lifting process of the lifting plate 12.9 due to the arrangement of the first bearing 12.8; in the process of rotating and lifting the stirring shaft 12.5, the stirring blade 12.6 and the scraping brush 12.7 can also rotate and lift, so that the stirring and uniformly mixing range of the stirring blade 12.6 and the cleaning area of the scraping brush 12.7 are increased. In this embodiment, the telescopic device 12.10 may be an electric push rod or a pneumatic telescopic rod.

Preferably, the rotating sleeve 12.1 is retained at the top of the circulation tank 1 by a second bearing 12.14.

Preferably, the scraping brush 12.7 comprises a scraping rod 12.15 vertically connected with the bottom of the stirring shaft 12.5, and the end of the scraping rod 12.15 is provided with bristles 12.16.

The working principle of the embodiment is as follows:

the amino acid fermentation liquor is firstly filtered to remove solid impurities, the pH value is adjusted by acidification, the analytic solution (or eluent after chromatographic extraction) after continuous ion exchange is introduced into a circulating storage tank 1 through a liquid inlet pipeline 2, then enters a nanofiltration membrane filter 4 through a liquid outlet pipeline 3, is further purified through a nanofiltration membrane, and the purified filtrate flows out of a membrane core and is sent into a reverse osmosis membrane filter 7 through a liquid sending pipeline 6 to be further concentrated in a reverse osmosis membrane; the stock solution from the shell of the nanofiltration membrane filter 4 returns to the liquid inlet pipeline 2 through the liquid return pipeline 5 and then enters the circulating storage tank 1 for circulation; the filtrate fed into the reverse osmosis membrane filter 7 is further concentrated by the reverse osmosis membrane and then enters the next process through the drainage line 8, and the water filtered and flowed out of the membrane core of the reverse osmosis membrane filter 7 can enter the water tank 10 through the drainage line 9 and then enters the circulating storage tank 1 through the water outlet line 11, and is mixed with the stock solution again and then is recycled for treatment.

In this process, the servo motor 12.4 during operation of agitating unit 12 can drive spur gear 12.3 rotatory, and then drive ring gear 12.2 and rotate to make revolving sleeve 12.1 rotate, finally can make (mixing) shaft 12.5 rotate, can drive stirring vane 12.6 and scrape brush 12.7 rotatory together, stirring vane 12.6's rotation can effectively mix the material, and the rotation of scraping brush 12.7 can avoid impurity adhesion at circulation storage tank 1 inside wall. When the telescopic device 12.10 drives the lifting plate 12.9 to periodically ascend and descend, the stirring shaft 12.5 can be driven to periodically ascend and descend, the stirring shaft 12.5 can axially slide due to the matching between the guide rail 12.12 and the sliding groove 12.13, the stirring shaft 12.5 can also be driven to rotate by the rotation of the rotating sleeve 12.1, and meanwhile, the rotation process of the stirring shaft 12.5 cannot be influenced in the lifting process of the lifting plate 12.9 due to the arrangement of the first bearing 12.8; in the process of rotating and lifting the stirring shaft 12.5, the stirring blade 12.6 and the scraping brush 12.7 can also rotate and lift, so that the stirring and uniformly mixing range of the stirring blade 12.6 and the cleaning area of the scraping brush 12.7 are increased.

The above embodiments are merely preferred technical solutions of the present invention, and should not be considered as limitations of the present invention, and the features in the embodiments and the examples in the present application may be arbitrarily combined with each other without conflict. The protection scope of the present invention shall be defined by the claims and the technical solutions described in the claims, including the technical features of the equivalent alternatives as the protection scope. Namely, equivalent alterations and modifications within the scope of the invention are also within the scope of the invention.

Claims

1. An amino acid separation and purification device, which is characterized in that: including inlet line (2) of being connected with circulation storage tank (1) inlet, circulation storage tank (1) liquid outlet is connected with receive filter membrane filter (4) inlet through going out liquid pipeline (3), receives filter membrane filter (4) stoste export and is connected with inlet line (2) through returning liquid pipeline (5), receives filter membrane filter (4) filtrating export and is connected with reverse osmosis membrane filter (7) inlet through sending liquid pipeline (6), reverse osmosis membrane filter (7) concentrate export is connected with drain line (8), and reverse osmosis membrane filter (7) delivery port passes through drain line (9) and is connected with water pitcher (10) water inlet.

2. The apparatus for separating and purifying amino acid according to claim 1, wherein: the water outlet of the water tank (10) is connected with the water inlet of the circulating storage tank (1) through a water outlet pipeline (11).

3. The apparatus for separating and purifying amino acid according to claim 1 or 2, wherein: and a stirring device (12) is also arranged in the circulating storage tank (1).

4. The apparatus for separating and purifying amino acid according to claim 3, wherein: agitating unit (12) are including spacing rotatory sleeve (12.1) at circulation storage tank (1) top, rotatory sleeve (12.1) upper portion cover is established and is fixed with ring gear (12.2), ring gear (12.2) and straight-teeth gear (12.3) meshing, straight-teeth gear (12.3) bottom center and servo motor (12.4) output shaft, be equipped with in rotatory sleeve (12.1) rather than vertical sliding fit's (mixing) shaft (12.5), (mixing) shaft (12.5) bottom is equipped with stirring vane (12.6) and scrapes brush (12.7), and (mixing) shaft (12.5) top is connected with lifter plate (12.9) one end through first bearing (12.8), lifter plate (12.9) other end is connected with telescoping device (12.10).

5. The apparatus for separating and purifying amino acid according to claim 4, wherein: the bottom of the servo motor (12.4) and the bottom of the telescopic device (12.10) are fixed at the top of the circulating storage tank (1) through mounting brackets (12.11).

6. The apparatus for separating and purifying amino acid according to claim 4, wherein: guide rails (12.12) are arranged on two sides of the stirring shaft (12.5), sliding grooves (12.13) are formed in two sides of the inner portion of the rotating sleeve (12.1), and the guide rails (12.12) are in sliding fit with the sliding grooves (12.13).

7. The apparatus for separating and purifying amino acid according to claim 4, wherein: the rotating sleeve (12.1) is limited at the top of the circulating storage tank (1) through a second bearing (12.14).

8. The apparatus for separating and purifying amino acid according to claim 4, wherein: the scraping brush (12.7) comprises a scraping rod (12.15) vertically connected with the bottom of the stirring shaft (12.5), and bristles (12.16) are arranged at the end part of the scraping rod (12.15).