CN101342355B - Compound cornel mix medicament for treating menorrhalgia - Google Patents

Abstract

The present invention relates to the field of medicine formulation, in particular to a compound evodia rutaecarpa mixture used to treat dysmenorrhea. The compound evodia rutaecarpa mixture adopts medcinal evodia fruit, turmeric root-tuber, safflower, nutgrass galingale rhizome, Chinese angelica, red paeony root, angelica dahurica, szechuan lovage rhizome, rhizoma corydalis, cassia barkcassia bark, frankincense and myrrh as materials, which are baked and then pulverized to prepare the compound evodia rutaecarpa mixture. The weight percentages of the materials are as follows: 15 percent to 18 percent of medcinal evodia fruit, 5 percent to 7 percent of turmeric root-tuber, 10 percent to 12 percent of safflower, 4 percent to 6 percent of nutgrass galingale rhizome, 10 percent to 13 percent of Chinese angelica, 10 percent to 12 percent of red paeony root, 3 percent to 5 percent of angelica dahurica, 10 percent to 12 percent of szechuan lovage rhizome, 5 percent to 7 percent of rhizoma corydalis, 3 percent to 5 percent of cassia barkcassia bark, 5 percent to 7 percent of frankincense and 3 percent to 5 percent of myrrh. The cost of the materials of the compound evodia rutaecarpa mixture for curing dysmenorrhea is low, the curative effect of the compound evodia rutaecarpa mixture is high in curing primary dysmenorrhea, and the compound evodia rutaecarpa mixture has no toxic side effects.

Description

A kind of compound recipe Fructus Evodiae confection that is used for the treatment of dysmenorrhea

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of compound recipe Fructus Evodiae confection that is used for the treatment of dysmenorrhea.

Background technology

As everyone knows, dysmenorrhea is one of modal symptom of gynecological, be meant pass through before and after or menstrual phase hypogastralgia appears, weigh down to expand, companion's soreness of waist or other discomforts, person's severe pain faintness person very, degree has a strong impact on the live and work quality.Dysmenorrhea can be divided into constitutional and Secondary cases two big classes, and the former is meant that the genitals does not have the dysmenorrhea of organic disease, and the latter is meant the caused dysmenorrhea of pelvic cavity organic disease.This prescription mainly is the treatment primary dysmenorrhea.Primary dysmenorrhea is more common in young women, and its etiology and pathogenesis says by theory of Chinese medical science and mainly contain four, and one is a qi depression to blood stasis, and feelings will is not relaxed, stagnation of QI due to depression of the liver, blood is capable to be obstructed, and, or produces and stays in the surplus blood in born of the same parents and give birth to stomachache through stasis, hold and form the stasis of blood, stagnation of QI and blood may bring about pain causes dysmenorrhea; It two is a damp-heat accumulation, and menstrual period, puerperal invade in the damp and hot heresy, or in accumulate and damp and hotly tie mutually with blood, damp-heat accumulation and block uterus, thus cause dysmenorrhea; It three is a cold and stagnate, occupies wetland for a long time, or drenches with rain menstrual period, or experience damp puerperal, causes the cold-damp visitor in uterus, and blood is cold coagulation, cold coagulation humidity hysteresis, stagnation of QI-blood when passing through, stagnation of QI and blood may bring about pain; It four is a caused by liver and kidney deficiency, body void, or voluminous exhaustion due to sexual indulgence usually, or after the serious disease, undermine Liver and kidney, deficiency of qi and blood, vessels of the uterus lose supports, the Rong Ze pain.In a word, primary dysmenorrhea is mainly qi depression to blood stasis, cold and stagnate, damp-heat accumulation, caused by liver and kidney deficiency card.Clinical treatment mainly is application calmness to the ill, eases pain, separates the spasm Drug therapy.Use the prostate synthetase inhibitors, by suppressing the prostate synzyme, prevented strong or spastic uterine contraction, as ibuprofen, ketoprofen, fenamic acids etc., but cure the symptoms, not the disease, and do not control dysmenorrhea, the women's pain that causes many dysmenorrheas is anaesthetic such as intramuscular injection pethidine unbearably the time, has had a strong impact on healthy.

Summary of the invention

Purpose of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, provide a kind of cost low, treatment primary dysmenorrhea curative effect height has no side effect, and can strengthen patient's Abwehrkraft des Koepers, be applicable to the compound recipe Fructus Evodiae confection of the dysmenorrhea that the treatment a variety of causes causes.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of compound recipe Fructus Evodiae confection that is used for the treatment of dysmenorrhea, adopt Fructus Evodiae, Radix Curcumae, Flos Carthami, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Paeoniae Rubra, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Rhizoma Corydalis, Cortex Cinnamomi, Olibanum, Myrrha is that raw material stoving is ground into powder and is prepared from, and it is characterized in that raw material is formed to be by weight percentage: Fructus Evodiae 15～18%, Radix Curcumae 5～7%, Flos Carthami 10～12%, Rhizoma Cyperi 4～6%, Radix Angelicae Sinensis 10～13%, Radix Paeoniae Rubra 10～12%, the Radix Angelicae Dahuricae 3～5%, Rhizoma Chuanxiong 10～12%, Rhizoma Corydalis 5～7%, Cortex Cinnamomi 3～5%, Olibanum 5～7%, Myrrha 3～5%.

The compound recipe Fructus Evodiae confection cost of material that the present invention treats dysmenorrhea is low, and treatment primary dysmenorrhea curative effect height has no side effect.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

Embodiment 1:

At first get clean Fructus Evodiae 17, Radix Curcumae 6, Flos Carthami 11, Rhizoma Cyperi 5, Radix Angelicae Sinensis 12, Radix Paeoniae Rubra 11, the Radix Angelicae Dahuricae 5, Rhizoma Chuanxiong 11, Rhizoma Corydalis 7, Cortex Cinnamomi 4, Olibanum 6, Myrrha 5 by following component (weight %), above-mentioned 12 kinds of raw material gross weights are 227 grams, oven dry together, grind and grind into fine powder, cross 100 mesh sieves, preserve in the nontoxic freshness protection package of packing into.With Fructus Evodiae, Radix Curcumae, Flos Carthami, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Paeoniae Rubra, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Rhizoma Corydalis, Cortex Cinnamomi, Olibanum, Myrrha mixed powder, press the about 10cm*10cm of umbilicus size, with nylon stocking is the pouch that cloth is seamed into, medicated powder is packed in the pouch, use moxa stick moxibustion umbilical part SHENJUE acupoint position about 10 minutes every night, again medicated powder in the deck is placed on the umbilical part SHENJUE acupoint, use immobilization with adhesive tape, changed dressings once in 24 hours, and used during menstrual onset, dysmenorrhea stopped after disappearing 3.

In order to be used compound recipe Fructus Evodiae confection treatment primary dysmenorrhea of the present invention, to reach optimum efficiency, can begin through preceding 3 days, with after the warm water foot bath,, get Fructus Evodiae medicated powder separately and add an amount of mashed garlic furnishing ointment before sleeping every night by rubbing the bilateral Yongquan acupoint, spread on the bilateral Yongquan acupoint, it is fixing that the reuse SHANGSHI ZHITONG GAO spreads on the outside, and every night once, logotype to menstrual onset stops.

Fructus Evodiae nature and flavor suffering, hardship, heat are returned liver, spleen, stomach, kidney channel in of the present invention group.Have dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal function, be used for headache due to JUE YIN disorder, colic of cold type stomachache, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation etc., its chemical constituent contains limonin, alkaloid, quinolones, indole quinazoline class etc.Fructus Evodiae is mainly analgesic activity to the central nervous system, and test confirms and can significantly postpone the pain sensation response time.Radix Curcumae is the tuber of zingiberaceous plant Radix Curcumae, Rhizoma Curcumae Longae, Rhizoma Curcumae, its nature and flavor suffering, hardship, cold, and GUIXIN, lung, Liver Channel have the function of promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs, promoting the function of the gallbladder to alleviate jaundice, the relieving restlessness that clears away heart-fire, and can treat all pains of breast abdomen side of body rib, women's example warp, jaundice etc.The Radix Curcumae chemical constituent contains volatile oil, Camphora, sesquiterpene, curcumin etc.Experimental results show that the humoral immunization that the contained volatile oil of Radix Curcumae can be regulated the toxic hepatitis mice, effect with immunosuppressant.Flos Carthami is the flower of Compositae Flos Carthami platymiscium Flos Carthami, and its nature and flavor suffering, temperature are gone into the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, and the function of eliminating stasis to stop pain can treat that amenorrhea, lump in the abdomen, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, traumatic injury etc.Flos Carthami contains Flos Carthami quinone glycoside, Carthamus yellow etc.Zoopery shows that the Flos Carthami decoct mainly is excitation to the intestinal tube smooth muscle, and intestine in vitro spasm due to the acetylcholine is had spasmolysis.Zoopery confirms: Flos Carthami is irritated stomach or intraperitoneal administration all has tangible antiinflammatory action, and can enhancing human body immunity mechanism.Rhizoma Cyperi is the dry rhizome of sedge dried tuber, nature and flavor suffering, little hardship, little sweet, flat, return liver, spleen, tri-jiao channel, have bleed resolving depression, menstruction regulating and pain relieving, analgesic, regulate the flow of vital energy, diuresis, repercussive function, can treat incoordination between the liver and stomach, stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea, bleeding not during menses etc.When the dry root that is classified as umbelliferae angelica, nature and flavor are sweet, hot, warm, return liver, the heart, spleen channel, and having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the function of loosening bowel to relieve constipation is used for that blood deficiency and yellow complexion, menoxenia, amenorrhea stimulate the menstrual flow, asthenia cold abdominalgia, rheumatism splenalgia, traumatic injury etc.Test confirms: water decoction of Angelica sinensis all has significant inhibitory effect to the active chronic inflammation that multiple proinflammatory agent causes, the immunologic function of human body is had obvious facilitation.Radix Paeoniae Rubra is the dry root of ranunculaceae plant Radix Paeoniae, the nature and flavor hardship, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain is used for conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, WEIJIA stomachache etc., paeoniflorin has sedation, smooth muscle spasm to anti-acetylcholine causes has inhibitory action to the rat smooth muscle, and can resist the uterine contraction that pituitrin causes.Radix Angelicae Dahuricae nature and flavor suffering, temperature are returned stomach, large intestine, lung meridian.Have functions such as diffusing wind dehumidifying, understand things pain-stopping, detumescence and apocenosis, can treat leucorrhea with red and white discharge, cold-damp stomachache, carbuncle pyogenic infections from tumour or sore etc.Rhizoma Chuanxiong nature and flavor suffering, perfume (or spice) are returned liver, gallbladder, pericardium channel, have the function of blood-activating and qi-promoting, wind-expelling pain-stopping, are used for the treatment of menoxenia, amenorrhea dysmenorrhea, difficult labour, produce stasis of blood stop block pain, placenta retention etc.Rhizoma Corydalis nature and flavor suffering, hardship, temperature are returned liver, spleen channel, have the blood of controlling, promoting the circulation of QI, analgesic function, are used for the breast side of body, epigastric pain, amenorrhea dysmenorrhea, silt resistance in puerperal, treating swelling and pain by traumatic injury etc.Cortex Cinnamomi nature and flavor suffering, sweet, big heat, fragrance, go into the liver,kidney,spleen warp, have warming middle-JIAO recuperating depleted YANG, dispersing cold for relieving pain, warming and recuperating the gate of life kidney fire, promoting flow of qi by warming channel, antidotal function, being used for the treatment of that stomachache is had loose bowels, colic of cold type is run quickly intestinal, chills and pain of the waist and kness, amenorrhea lump in the abdomen, positive cellulitis, multiple abscess and empty sun is floating more, heat in the upper and cold in the lower, stomach abdomen cold type of pain, cold spleen lumbago etc.Olibanum nature and flavor suffering, hardship, temperature, GUIXIN, liver, spleen channel have regulating qi and activating blood, analgesic therapy, chase after malicious function, are used for the treatment of coagulation of QI-blood, trusted subordinate's pain, rheumatalgia, dysmenorrhea, postnatal blood stasis twinge etc.Myrrha nature and flavor suffering, hardship, flat are gone into Liver Channel, have diffusing blood blood stasis removing, and the function of subduing swelling and relieving pain is used for the treatment of all pains of trusted subordinate, lump in the abdomen, cellulitis and swells and ache etc.Modern pharmacological research, Myrrha can improve immune function of human body, promotes lymphocytic conversion, strengthens the function of reticuloendothelial system.Myrrha can be invigorated blood circulation and pain relieving, dissipating blood stasis and invigorate blood circulation, detumescence and analgesic therapy.12 flavor herbal prescriptions, the specially good effect of playing primary dysmenorrhea altogether.

Embodiment 2:

Get clean Fructus Evodiae 15, Radix Curcumae 7, Flos Carthami 12, Rhizoma Cyperi 4, Radix Angelicae Sinensis 13, Radix Paeoniae Rubra 12, the Radix Angelicae Dahuricae 5, Rhizoma Chuanxiong 12, Rhizoma Corydalis 5, Cortex Cinnamomi 5, Olibanum 7, Myrrha 3 by following component (weight %), getting above-mentioned 12 kinds of raw material gross weights is 227 grams, the oven dry of putting together, grind and grind into fine powder, cross 100 mesh sieves, preserve in the nontoxic freshness protection package of packing into.

But each raw material of the present invention also blended embodiment of the listed ratio of according to the form below (percentage by weight) is realized.Its processing technique is identical with embodiment 1.

Below in conjunction with my institute, promptly the clinical preliminary test that carries out of Shandong Province Wendeng Central Hospital, Weihai City is done further, is described in detail the present invention:

1, case is selected: this organizes 60 examples, and age 19-43 year, all cases all are the different primary dysmenorrhea diseases of degree.

2, Therapeutic Method: beginning through preceding 3 days, it is preceding with after the warm water foot bath, by rubbing the bilateral Yongquan acupoint to sleep every night, get Fructus Evodiae medicated powder separately and add an amount of mashed garlic furnishing ointment, spread on the bilateral Yongquan acupoint, it is fixing that the reuse SHANGSHI ZHITONG GAO spreads on the outside, every night once, logotype to menstrual onset stops.Press the about 10cm*10cm of umbilicus size, with nylon stocking is the pouch that cloth is seamed into, compound recipe Fructus Evodiae confection of the present invention is packed in the pouch, use moxa stick moxibustion umbilical part SHENJUE acupoint position about 10 minutes every night, again medicated powder in the deck is placed on the umbilical part SHENJUE acupoint, use immobilization with adhesive tape, changed dressings once in 24 hours, use during menstrual onset, dysmenorrhea stopped after disappearing 3.Before each menstruation disappears is a course of treatment, totally two courses of treatment.

3, therapeutic effect: use compound recipe Fructus Evodiae confection of the present invention to treat 60 examples altogether, effective 58 examples of result, invalid 2 examples, effective percentage is 97%, inefficiency is 3%.

Claims (1)

1. compound recipe Fructus Evodiae confection that is used for the treatment of dysmenorrhea, adopting Fructus Evodiae, Radix Curcumae, Flos Carthami, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Paeoniae Rubra, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Rhizoma Corydalis, Cortex Cinnamomi, Olibanum, Myrrha is that raw material stoving is ground into powder and is prepared from, and it is characterized in that raw material is formed to be by weight percentage: Fructus Evodiae 15～18%, Radix Curcumae 5～7%, Flos Carthami 10～12%, Rhizoma Cyperi 4～6%, Radix Angelicae Sinensis 10～13%, Radix Paeoniae Rubra 10～12%, the Radix Angelicae Dahuricae 3～5%, Rhizoma Chuanxiong 10～12%, Rhizoma Corydalis 5～7%, Cortex Cinnamomi 3～5%, Olibanum 5～7%, Myrrha 3～5%.