CN101584849B

CN101584849B - Compound angelica-Szechuan lovage rhizome soup used for treating premenstrual catatonic syndrome

Info

Publication number: CN101584849B
Application number: CN2009100160565A
Authority: CN
Inventors: 王海荣; 吕迎丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-06-16
Filing date: 2009-06-16
Publication date: 2011-06-22
Anticipated expiration: 2029-06-16
Also published as: CN101584849A

Abstract

The invention relates to the field of medicament formulations, in particular to compound angelica-Szechuan lovage rhizome soup used for treating premenstrual catatonic syndrome. Angelica, Szechuan lovage rhizome, rhizoma cyperi, fructus evodiae, raw scallion white, dried ginger, wild pepper, red paeony root, radix bupleuri, liquorice, faeces togopteri, leonurus, cassia bark, dried rehmannia, achyranthes root and red sage root taken as raw materials are decocted, and then the dregs are removed to obtain filtered juice. The raw materials comprise the following components by weight percentage: 10to 14 percent of the angelica, 8 to 12 percent of the Szechuan lovage rhizome, 6 to 10 percent of the rhizoma cyperi, 2 to 6 percent of the raw scallion white, 5 to 7 percent of the fructus evodiae, 2 to 6 percent of the dried ginger, 2 to 6 percent of the wild pepper, 5 to 7 percent of the red paeony root, 6 to 10 percent of the radix bupleuri, 5 to 7 percent of the liquorice, 2 to 6 percent of the faeces togopteri, 6 to 10 percent of the leonurus, 2 to 5 percent of the cassia bark, 2 to 6 percent of the dried rehmannia, 2 to 6 percent of the achyranthes root and 6 to 10 percent of the red sage root. The compound angelica-Szechuan lovage rhizome soup has low cost and high treatment effect on treating the premenstrual catatonic syndrome, has no toxic and side effect, has the efficacies ofrelieving pain and regulating menses, promoting qi circulation and removing obstruction in the collateral, dissipating cold and dispelling stasis, and regulating vital energy and soothing liver, and can effectively regulate endocrine systems of women, reduce abnormal release of beta endorphin and reduce the sensibility.

Description

A kind of compound Chinese angelica-root lovage rhizome soup that is used for the treatment of premenstrualtension syndrome

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of compound Chinese angelica-root lovage rhizome soup that is used for the treatment of premenstrualtension syndrome.

Background technology

As everyone knows, investigation shows: there is premenstrualtension syndrome in 87% above 20-45 year women.Premenstrualtension syndrome is meant the women of child-bearing age before menstruation 7-14 days, occurs the symptom of aspects such as a series of spirit, behavior and body constitution repeatedly.Symptom immediately disappears behind the menstrual onset.Because primary disease spirit, dysthymic disorder are more outstanding, it is in extensive range to think that in recent years this disease symptoms involves.Except that the psychoneurosis shape, also relate to several tracts that do not link mutually.Comprise diversified device matter and functional symptom.The unusual release of β endorphins or be that a series of neuroendocrines that cause the various performances of premenstrualtension syndrome the change when basic reason of premenstrualtension syndrome is exactly luteal phase to the sensitivity of β endorphins.The β endorphins suppresses maincenter amine system, norepinephrine or dopamine is discharged reduce, and prolactin antagonist and vassopressin increase and suppress prostaglandin and cause fluid retention, distending pain of the breast, constipation and abdominal distention etc. in the effect of enteral.

The relevant premenstrualtension syndrome symptom of clinical treatment premenstrualtension syndrome is kind surplus in the of 150 nearly, but every patient also not all possesses all symptoms.Each one has oneself outstanding symptom.The order of severity varies with each individual, and is not to immobilize.But the appearance of symptom with disappear with the relation of menstruation then basic fixed be the primary disease characteristics.It is different in size that stadium continues, and it is longer that severe patient need be treated stadium.Have 40% patient's stadium to continue 1-5 approximately, 10% patient is sustainable more than 10 years.Classical symptom was everlasting through the last week, increased the weight of gradually.To the menstruation last 2-3 days the most serious.Through after suddenly disappear.Have nothing to do with age, parity.About 80% patient need heal with medicine.The clinical treatment premenstrualtension syndrome is based on symptomatic treatment.Traditional remedies comprises: take analgesic, tranquilizer and methods such as spasmolytic, hormone therapy, but these can not be treated all at the cause of disease.The sensitivity that is to say the unusual release of basic reason β endorphins during luteal phase of premenstrualtension syndrome or β endorphins increases and causes that the various performances that a series of neuroendocrines of premenstrualtension syndrome change are solved at all.

Summary of the invention

Purpose of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, and a kind of compound Chinese angelica-root lovage rhizome soup that is used for the treatment of premenstrualtension syndrome is provided, and with low cost, treatment premenstrualtension syndrome curative effect height has no side effect.Has the pain relieving regulating menstruation, promoting QI circulation for relieving depression, cold expelling blood stasis dispelling, the soothing the liver effect of regulating the flow of vital energy.Can regulate women's hormonal system effectively, reduce the unusual release of β endorphins, reduce its sensitivity.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of compound Chinese angelica-root lovage rhizome soup that is used for the treatment of premenstrualtension syndrome, adopt Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Cyperi, Fructus Evodiae, rareripe is white, Rhizoma Zingiberis, Pericarpium Zanthoxyli, Radix Paeoniae Rubra, Radix Bupleuri, Radix Glycyrrhizae, Oletum Trogopterori, Herba Leonuri, Cortex Cinnamomi, Radix Rehmanniae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae is a raw material, described 16 flavor Chinese herbal medicine are soaked, remove slag after decocting filtered juice, it is characterized in that the raw material composition is by weight percentage: Radix Angelicae Sinensis 10～14%, Rhizoma Chuanxiong 8～12%, Rhizoma Cyperi 6～10%, rareripe white 2～6%, Fructus Evodiae 5～7%, Rhizoma Zingiberis 2～6%, Pericarpium Zanthoxyli 2～6%, Radix Paeoniae Rubra 5～7%, Radix Bupleuri 6～10%, Radix Glycyrrhizae 5～7%, Oletum Trogopterori 2～6%, Herba Leonuri 6～10%, Cortex Cinnamomi 2～5%, Radix Rehmanniae 2～6%, Radix Achyranthis Bidentatae 2～6%, Radix Salviae Miltiorrhizae 6～10%.

The present invention is used for the treatment of the compound Chinese angelica-root lovage rhizome soup of premenstrualtension syndrome, and with low cost, treatment premenstrualtension syndrome curative effect height has no side effect.Has the pain relieving regulating menstruation, promoting QI circulation for relieving depression, cold expelling blood stasis dispelling, the soothing the liver effect of regulating the flow of vital energy.Can regulate women's hormonal system effectively, reduce the unusual release of β endorphins, reduce its sensitivity.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

Embodiment 1:

At first get clean, the Rhizoma Zingiberis 4 white 4 of whenever taking medicine, Pericarpium Zanthoxyli 4, Radix Paeoniae Rubra 6.1, Radix Bupleuri 8.1, Radix Glycyrrhizae 6.1, Oletum Trogopterori 4, Herba Leonuri 8.1, Cortex Cinnamomi 3.3, Radix Rehmanniae 4, Radix Achyranthis Bidentatae 4, Radix Salviae Miltiorrhizae 8.1 into, Radix Angelicae Sinensis 12, Rhizoma Chuanxiong 10, Rhizoma Cyperi 8.1, Fructus Evodiae 6.1, rareripe by following component (weight %).Get above-mentioned 16 kinds of raw material gross weights, 248 grams.At room temperature 16 flavor Chinese herbal medicine are added water to 700～900ml, soaked 6～8 hours, tortured about 90～120 minutes with slow fire then, remove slag about filtrate 200ml, medicinal residues add water 300～400ml again, torture 40～60 minutes, remove slag filtrate 60～100ml, altogether 260～300ml left and right sides medicine soup, promptly make the compound Chinese angelica-root lovage rhizome soup.Pack in the aseptic vial, seal bottle cap is standby.Every day, potion was oral at twice, each preceding 15 days morning and evenings of menstruation (medicine) being taken before meal 130～150ml, and menstruation promptly stops after arriving, and takes continuously 3 months, until clinical symptom disappearance.

Principal agent Radix Angelicae Sinensis nature and flavor of the present invention are sweet, hot, warm, have tonifying blood and regulating menstruation, moisturize the function of laxation.Chemical constituent: root contains volatile oil 0.2～0.4%, and main component is positive butylidenephthalide for the n-butene lactone in the oil, in addition, and still fatty oil, vitamin B ₁₂, vitamin E, Yan acid etc.Cure mainly chronic pelvic inflammatory disease, dysmenorrhea, headache due to deficiency of blood, blood deficiency and constipation etc.Rhizoma Chuanxiong nature and flavor suffering, temperature have blood circulation promoting and blood stasis dispelling, dispel the wind, the function of promoting the circulation of QI to relieve pain.Pharmacological action: contain volatile oil (including a kind of lactone derivatives), volatility oily alkaloid and ferulic acid.The effect that has vitamin antagonist E to lack can bring high blood pressure down by blood vessel dilating, and escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, vibrio cholera etc. are all had inhibitory action.Cure mainly: dizziness headache, amenorrhea stomachache, menoxenia, hypochondriac pain due to stagnation of liverQI, skin ulcer Ulcers swell and ache.The hot little sweet tepor of Rhizoma Cyperi nature and flavor has promoting QI circulation for relieving depression, the function of pain relieving regulating menstruation.Pharmacological action: the effect that has direct inhibition uterine smooth muscle to shrink, and can obviously improve the threshold of pain, analgesic effect is arranged.Cure mainly: depression of QI, distending pain in the chest and hypochondrium, menoxenia, dysmenorrhea.The Fructus Evodiae property and flavor of peppery and warm has warming middle-JIAO to dispel cold, preventing or arresting vomiting, analgesic function.Contain volatile oil, main component is Fructus Evodiae hydrocarbon and limonin, indoles alkaloid, Fructus Evodiae alkali, demethyl Fructus Evodiae alkali.Pharmacological action: the effect of shrinking the uterus is arranged.Cure mainly: abdominal part cold type of pain, vomiting, diarrhoea, headache due to JUE YIN disorder.Rareripe is white: property and flavor of peppery and warm, the cold expelling that induces sweat activates yang.Containing volatile oil, is allicin in the oil.Cure mainly: exterior cold disease, stagnation of QI abdominal distention.The Rhizoma Zingiberis property and flavor of peppery and warm, warming spleen and stomach for dispelling cold, warming the lung to relieve cough.Rhizoma Zingiberis is longer than warming middle-JIAO, cures mainly Deficiency and coldness of spleen and stomach, lung cold cough.Can strengthen blood circulation, stimulate gastric secretion, excited intestinal tube, facilitating digestion.The Pericarpium Zanthoxyli property and flavor of peppery and warm has warming spleen and stomach for dispelling cold, the parasiticidal function of pain relieving.Cure mainly: abdominal part cold type of pain, ascarid card etc.Radix Paeoniae Rubra nature and flavor picric acid is slightly cold, and has the effect of invigorate blood circulation, nourish blood yin fluid astringing, easing the affected liver to relieve pain.Cure mainly: depression of liver-QI, pain in chest and hypochondrium, extremity contraction urgency, the high Sheng of liver-yang, headache are dizzy.Radix Bupleuri nature and flavor hardship is slightly cold, and has the effect of giving birth to sun heat radiation, resolving depression soothing liver-QI.Cure mainly: half exterior and half interior disease, hypochondriac pain due to stagnation of liverQI, menoxenia etc.The Radix Glycyrrhizae nature and flavor are sweet flat, and invigorating the spleen and replenishing QI promotes the production of body fluid and middle emergency, heat-clearing and toxic substances removing, moistening the lung and resolving phlegm, are in harmonious proportion the property of medicine.Pharmacological action: Radix Glycyrrhizae can be detoxified, and the poisoning of medicine (chloral hydrate, cocaine, pilocarpine, barbital), food, interior metabolism product is all had must Detoxication.Enoxolone has the effect of adrenocortical hormone sample again, and Radix Glycyrrhizae also has antiacid and spasmolysis, antiinflammatory, antianaphylaxis reagentia, and is effective to menopathy and toxenia of late pregnancy.Oletum Trogopterori is sweet in flavor and warm in property, has the effect of eliminating stasis to stop pain.Pharmacological action: the effect of the smooth muscle spasm of alleviation is arranged, give birth to invigorating blood circulation.Cure mainly: dysmenorrhea, amenorrhea due to stagnation of blood, all stasis of bloods stagnate and suffer from abdominal pain.Herba Leonuri nature and flavor toil is flat.Has promoting blood flow to regulate menstruation, the anthydropic effect of dissipating blood stasis.Pharmacological action: containing alkaloid has excited uterus, makes uterotonic effect, also has the anxious significantly diuresis of blood pressure lowering, contains the retinoid material, and the effect of liver heat removing and eyesight improving, promoting blood flow to regulate menstruation is arranged.Cortex Cinnamomi property acrid-sweet flavor temperature, warming and recuperating the gate of life kidney fire, dispersing cold for relieving pain.Pharmacological action: the blood vessel dilating effect is arranged.Cure mainly: YANG-depletion, insufficiency of kidney-YANG, cold type of pain in the abdomen.Radix Rehmanniae nature and flavor sweetness and bitterness is cold, has the effect of heat clearing away, removing heat from blood, YIN nourishing.Pharmacological action: contain rehmanin, mannitol, glucose, irony agent vitamin A etc.Can make vasoconstriction, have boost, the effect of diuresis, blood sugar lowering.Be longer than clearing away heat and nourishing YIN.Cure mainly: consumption of YIN caused by febrile disease, fever due to yin deficiency, macule is told nosebleed and is had blood in stool flaming up of heart-fire, aphtha of the mouth and tongue, laryngopharynx swelling and pain.Radix Achyranthis Bidentatae nature and flavor picric acid is flat to have promoting blood circulation to restore menstrual flow, easing joint movement, the effect of conducting blood to flow downwards.Pharmacological action: contain Radix Achyranthis Bidentatae Saponin, phlegmatic temperament agent potassium salt.Slight diuresis is arranged, can strengthen uterine contraction, relatively promoting blood circulation to restore menstrual flow.Cure mainly: menstruation is smooth, amenorrhea, the headache of liver-fire upper punch, bones and muscles pain, waist knee joint flaccidity syndrome and arthralgia syndrome.Radix Salviae Miltiorrhizae nature and flavor hardship is slightly cold.The energy promoting blood flow to regulate menstruation, clearing away heat and cooling blood.Pharmacological action: contain several crystallization shape and color elements, comprise TANSHINONES, salviol and vitamin E, sedation is arranged.Cure mainly: menoxenia, stasis metrorrhagia, prolonged lochia, amenorrhea; Lumbago and skelalgia due to the stasis of blood stagnates; The heat branch of joining the army, dysphoria and insomnia; Sore, carbuncle and painful swelling etc.The ingenious combination of 16 flavor Chinese herbal medicine, medicine is coordinated mutually, and combined effect reduces the unusual release of β endorphins in hormonal system, reduces its sensitivity.Deal with problems from the source.

Embodiment 2:

At first get clean, the Rhizoma Zingiberis 5.9 white 3.5 of whenever taking medicine, Pericarpium Zanthoxyli 3.8, Radix Paeoniae Rubra 6.2, Radix Bupleuri 7.9, Radix Glycyrrhizae 5.3, Oletum Trogopterori 3.8, Herba Leonuri 7.3, Cortex Cinnamomi 3.8, Radix Rehmanniae 3.1, Radix Achyranthis Bidentatae 4.2, Radix Salviae Miltiorrhizae 8.3 into, Radix Angelicae Sinensis 13, Rhizoma Chuanxiong 9, Rhizoma Cyperi 8.6, Fructus Evodiae 6.3, rareripe by following component (weight %).Get above-mentioned 16 kinds of raw material gross weights, 248 grams.At room temperature 16 flavor Chinese herbal medicine are added water to 700～900ml, soaked 6～8 hours, tortured about 90～120 minutes with slow fire then, remove slag about filtrate 200ml, medicinal residues add water 300～400ml again, torture 40～60 minutes, remove slag filtrate 60～100ml, altogether 260～300ml left and right sides medicine soup, promptly make the compound Chinese angelica-root lovage rhizome soup.Pack in the aseptic vial, seal bottle cap is standby.Every day, potion was oral at twice, each preceding 15 days morning and evenings of menstruation (medicine) being taken before meal 130～150ml, and menstruation promptly stops after arriving, and takes continuously 3 months, until clinical symptom disappearance.

But each raw material of the present invention also blended embodiment of the listed ratio of according to the form below (percentage by weight) is realized.Its processing technique is identical with embodiment 1.

Embodiment	Radix Angelicae Sinensis	Rhizoma Chuanxiong	Rhizoma Cyperi	Rareripe is white	Fructus Evodiae	Rhizoma Zingiberis	Pericarpium Zanthoxyli	Radix Paeoniae Rubra	Radix Bupleuri	Radix Glycyrrhizae	Oletum Trogopterori	Herba Leonuri	Cortex Cinnamomi	Radix Rehmanniae	Radix Achyranthis Bidentatae	Radix Salviae Miltiorrhizae
																	3	10	12	6	6	5	2	6	7	6	7	6	6	2	3	6	10
4	14	8	10	2	7	6	2	5	10	5	2	10	5	6	2	6
																	5	12	10	7	5	6	5	4	6	9	6	3	8	3	2	4	10
6	13	9	9	6	5	4	4	6	6	7	4	9	3	6	3	6

Below in conjunction with my institute is that the clinical trial that Wendeng Central Hospital, Weihai City carries out is done to describe in further detail to the present invention:

1, case is selected: this group has been set up menstrual cycle women 80 examples, age 23-45 year, wherein married woman's 47 examples, unmarried women 33 examples.All case all is the different premenstrualtension syndrome of degree.

2, Therapeutic Method: every day, potion was oral at twice, each preceding 15 days morning and evenings of menstruation (medicine) being taken before meal 130～150ml, and menstruation promptly stops after arriving, and takes continuously 3 months.

3, therapeutic effect: use compound Chinese angelica-root lovage rhizome soup medicament of the present invention to treat 80 examples altogether, effective 68 examples of result, produce effects 10 examples, invalid 2 examples, effective percentage is 97.5%, inefficiency is 2.5%.

Claims

1. compound Chinese angelica-root lovage rhizome soup that is used for the treatment of premenstrualtension syndrome, adopt Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Cyperi, Fructus Evodiae, rareripe is white, Rhizoma Zingiberis, Pericarpium Zanthoxyli, Radix Paeoniae Rubra, Radix Bupleuri, Radix Glycyrrhizae, Oletum Trogopterori, Herba Leonuri, Cortex Cinnamomi, Radix Rehmanniae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae is a raw material, described 16 flavor Chinese herbal medicine are soaked, remove slag after decocting filtered juice, it is characterized in that the raw material composition is by weight percentage: Radix Angelicae Sinensis 10～14%, Rhizoma Chuanxiong 8～12%, Rhizoma Cyperi 6～10%, rareripe white 2～6%, Fructus Evodiae 5～7%, Rhizoma Zingiberis 2～6%, Pericarpium Zanthoxyli 2～6%, Radix Paeoniae Rubra 5～7%, Radix Bupleuri 6～10%, Radix Glycyrrhizae 5～7%, Oletum Trogopterori 2～6%, Herba Leonuri 6～10%, Cortex Cinnamomi 2～5%, Radix Rehmanniae 2～6%, Radix Achyranthis Bidentatae 2～6%, Radix Salviae Miltiorrhizae 6～10%.