CN101342200A - Patrinai villosa tablet and preparation method - Google Patents
Patrinai villosa tablet and preparation method Download PDFInfo
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- CN101342200A CN101342200A CNA2008100585630A CN200810058563A CN101342200A CN 101342200 A CN101342200 A CN 101342200A CN A2008100585630 A CNA2008100585630 A CN A2008100585630A CN 200810058563 A CN200810058563 A CN 200810058563A CN 101342200 A CN101342200 A CN 101342200A
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Abstract
The invention relates to a dahurican patrinia tablet and a manufacturing method thereof, which is the rootstalk of Patrinia scabiosaefolia Fisch.ex Trev. that is a valerianaceae plant and an extract tablet of a root. An extract and auxiliary materials are pressed into the tablet and coated with a film. The manufacturing method is as follows: raw medicine materials are grinded; then the raw medicine materials are moistened, soaked and percolated by ethanol until color gets light; percolation solution is concentrated to obtain the extract; the extract is dried and grinded into extract powder; starch is proportionally added and mixed with the extract powder evenly; the starch and the extract powder undergo the processes of damp granulation, drying and finishing; magnesium stearate is added and mixed together; and the extract powder, the starch and the magnesium stearate are made into the tablet by die pressing and coated with the film by a coating machine. The dahurican patrinia tablet has the beneficial effects of improving the structure of a pill flan, substituting the film for sugarcoat and solving problems that a patient suffering diabetic can not take the tablet and the sugar-coat is affected with damp, gets mildew and goes bad easily. Compared with the prior medicine, the quality guarantee period of the medicine is prolonged by over 50 percent. The release time of the tablet is shortened to 10 minutes from 30 to 60 minutes. Therefore, the tablet is absorbed by people more easily and drug action is quicker.
Description
Technical field
The invention belongs to a kind of Chinese patent medicine, Baijiang Tablets and production method.
Background technology
Baijiang Tablets is the Chinese patent medicine of Cure for insomnia, is applicant unit initiative, once records in " health ministry drug standard Chinese traditional patent formulation preparation ", becomes the known Cheng Fang of common people, is used widely, for the medical and health cause of country contributes.Along with the crowd's of use expansion, its some problems also come out thereupon.Mainly be that sugar-coat packing moisture-sensitive is rotten, the diabetes patient can not take, and diabetic population is insomnia's a multiple colony, and medication is comparatively extensive.In addition, the disintegration time of existing tablet is longer, the hardness deficiency, and the tablet quality is not good enough.
Summary of the invention
The objective of the invention is to propose a kind of follow-on Baijiang Tablets, make it not contain sugar, fast, the easily absorption of disintegrate, to overcome the existing above-mentioned shortcoming of Baijiang Tablets.
This Baijiang Tablets that the present invention proposes is the extractum sheet of Valerianaceae plant Patrinia scabiosaefolia Fisch Patriniascabiosaefolia Fisch rhizome and root, it is characterized in that the extractum sheet adds the adjuvant compacting in flakes and wrap film-coat and form by extractum.
Described adjuvant is starch and magnesium stearate.
Weight portion ratio relation with the Herba Patriniae crude drug powder of dry weight basis and starch, magnesium stearate is:
1000 parts of Herba Patriniaes
2.78 parts of starch
1.4 parts of magnesium stearate.
The production method of Baijiang Tablets of the present invention is characterized in that:
(1) the Herba Patriniae crude drug that will make is only pulverized;
(2) make solvent with ethanol, fine powder of last step carry out moistening, the dipping, with ethanol percolation to color light till;
(3) concentrate percolate and get extractum, extract dry also is ground into extract powder;
(4) extract powder adds the starch mixing in proportion, adds purified water again, ethanol carries out wet granulation, drying, granulate;
(5) will go up the product of step behind the granulate and add magnesium stearate and carry out always mixing, be molded into plain sheet;
(6) pack warehouse-in with coating machine to behind the plain sheet peplos.
The smashing fineness in (1) step is 24 orders or thinner.(2) step, used ethanol was 60% ethanol, and dip time is 24 hours.
The simmer down to tilting type vacuum concentration tank in (3) step concentrates, temperature≤70 ℃, and relative density is controlled at 1.35-1.40; The extractum smashing fineness is 100 orders or thinner.
Used ethanol of (4) step is 90% ethanol.
Useful point of the present invention is: improved the structure of the big son of tablet, replaced sugar-coat with thin film, having overcome the diabetes patient can not take, and make moist the easily problem of moldy metamorphism of sugar coating.The shelf-life of medicine, more former medicine can prolong more than 50%.The disintegration time of tablet also shortened in 10 minutes from original 30-60 minute, easier being absorbed by the body, and drug effect takes effect faster.
Description of drawings
Fig. 1 is the process chart that Herba Patriniae is made the extract powder part.
Fig. 2 is that the Herba Patriniae extract powder adds the process chart that adjuvant is made the Baijiang Tablets part.
The specific embodiment
As mentioned above, the rhizome of Herba Patriniae and the root crude drug 1000g that get after the clean system are ground into 24 order coarse powder, add 60% ethanol, flood 24 hours.With the same ethanol percolation liquid of must filtering.Repeatedly percolation to color light till.The liquid of filtering that merges each time percolation concentrates with the tilting type vacuum concentration tank.Steam pressure is controlled at below the 0.35MPa, kettle temperature≤70 ℃, and drying takes the dish out of the pot when being concentrated to relative density 1.35-1.40.Spissated extractum is contained in the dish, uses the heated-air circulation oven drying.80 ℃ of baking temperatures, sabot thickness 1.50-1.20cm.Dried extractum is block, and it is stand-by to be crushed to 100 orders with pulverizer, and during pulverizing, built-in temperature is no more than 60 ℃.
Next carry out wet granulation.Step is: get whole extract powders and mix thoroughly by adding starch 2.78g, add the composite wetting agent of ethanol and purified water simultaneously and make sabot granulating behind the soft material.Sabot thickness≤2cm, the wet mixing time is no less than 5min, and used ethanol is 90% ethanol.
The granule that last step obtains was with drying machine under 60 ℃ of temperature dry 6 hours.Turn over grain therebetween, when initial every 30min/ time, after 4 times every 1h/ time.
Dried granule enters the granulate operation, and the special container of packing into after the mixing of adding fluidizer magnesium stearate is airtight.Carry out tabletting with tablet machine, mould is that Φ 7mm is recessed deeply, and the weight differential of tabletting is controlled at 0.1g ± 7.4%
After this with coating machine tablet is carried out film coating.This routine coating machine efficient coated machine of JGB-150D type that to be applicant unit dispatch from the factory available from the strong board Pharmaceutical machine-building company limited in Wenzhou in July, 2007.
Above-mentioned material makes 10000 tablets.Through check, all qualified.
The Baijiang Tablets of producing with the method carries out clinical trial in Yunnan Duo Jia provincial hospital, and proving for Cure for insomnia (being insomnia) has clinical efficacy preferably, and untoward reaction is slight, without any side effects.And can improve its concomitant symptom, even indivedual case can reach the degree of clinical cure.Owing to adopted film coating to replace traditional sugar-coat, eliminated numerous diabetes patients can not with obstacle, avoided the problem of the moldy metamorphism that makes moist easily simultaneously, medicine guaranteed the quality time lengthening more than 50%, the disintegration time of tablet also shortened in 10 minutes from original 30-60 minute, easier being absorbed by the body, drug effect takes effect faster, and the trier is reflected well.
Claims (7)
1, a kind of Baijiang Tablets is the extractum sheet of Valerianaceae plant Patrinia scabiosaefolia Fisch rhizome and root, it is characterized in that the extractum sheet adds adjuvant compacting in flakes and wrap film-coat and form by extractum.
2, Baijiang Tablets according to claim 1 is characterized in that described adjuvant is starch and magnesium stearate.
3, Baijiang Tablets according to claim 1 and 2 is characterized in that with the weight portion ratio relation of the Herba Patriniae crude drug powder of dry weight basis and starch, magnesium stearate being:
1000 parts of Herba Patriniaes
2.78 parts of starch
1.4 parts of magnesium stearate.
4, the production method of Baijiang Tablets is characterized in that:
(1) the Herba Patriniae crude drug that will make is only pulverized;
(2) make solvent with ethanol, fine powder of last step carry out moistening, the dipping, with ethanol percolation to color light till;
(3) concentrate percolate and get extractum, extract dry also is ground into extract powder;
(4) extract powder adds the starch mixing in proportion, adds purified water again, ethanol carries out wet granulation, drying, granulate;
(5) will go up the product of step behind the granulate and add magnesium stearate and carry out always mixing, be molded into plain sheet;
(6) pack warehouse-in with coating machine to behind the plain sheet peplos.
5, Baijiang Tablets production method according to claim 4 is characterized in that the smashing fineness in (1) step is 24 orders or thinner, and (2) step, used ethanol was 60% ethanol, and dip time is 24 hours.
6, Baijiang Tablets production method according to claim 4 is characterized in that the simmer down to tilting type vacuum concentration tank in (3) step concentrates, temperature≤70 ℃, and relative density is controlled at 1.35-1.40; The extractum smashing fineness is 100 orders or thinner.
7, Baijiang Tablets production method according to claim 4 is characterized in that used ethanol of (4) step is 90% ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100585630A CN101342200A (en) | 2008-06-14 | 2008-06-14 | Patrinai villosa tablet and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100585630A CN101342200A (en) | 2008-06-14 | 2008-06-14 | Patrinai villosa tablet and preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN101342200A true CN101342200A (en) | 2009-01-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CNA2008100585630A Pending CN101342200A (en) | 2008-06-14 | 2008-06-14 | Patrinai villosa tablet and preparation method |
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| CN (1) | CN101342200A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058637A (en) * | 2011-01-21 | 2011-05-18 | 云南云河药业有限公司 | Preparation method of patrimia scabiosaefolia extract |
| CN113057994A (en) * | 2021-04-09 | 2021-07-02 | 一力制药(南宁)有限公司 | Patrinia scabiosaefolia active component, preparation method and application thereof |
-
2008
- 2008-06-14 CN CNA2008100585630A patent/CN101342200A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058637A (en) * | 2011-01-21 | 2011-05-18 | 云南云河药业有限公司 | Preparation method of patrimia scabiosaefolia extract |
| CN102058637B (en) * | 2011-01-21 | 2012-07-18 | 云南云河药业有限公司 | Preparation method of patrimia scabiosaefolia extract |
| CN113057994A (en) * | 2021-04-09 | 2021-07-02 | 一力制药(南宁)有限公司 | Patrinia scabiosaefolia active component, preparation method and application thereof |
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Open date: 20090114 |