CN101116737A - Method for preparing traditional Chinese medicine for treating coronary disease - Google Patents

Abstract

The invention discloses a preparation method of the traditional Chinese medicine of treating coronary heart disease, the principal character is that: the invention adopts seven traditional Chinese medicinal materials such as sandalwood, lignum acronychiae, Kaempferia galanga L, nutmeg, radices salviae miltiorrhizae, fructus and sea backthern as the raw materials. First, lignum acronychiae, Kaempferia galanga L, nutmeg, are ground into thin powder and sterilize. Second, radices salviae miltiorrhizae, fructus and sea backthern are extracted for three times to combine the filtrate, recover ethanol, reduce pressure, contract, discharge ingredients and recover paste. Third, the thick paste is arranged inside the vacuum dryer to dry the paste into dry paste and ground into thin powder. The powder is evenly mixed with the thin powder of sandalwood, lignum acronychiae, Kaempferia galanga L, nutmeg to be dried in low temperature, pressed into tablets and coated with a film. The traditional Chinese medicine made by the unique technology and ingredients has fine curative effects to coronary heart disease and the functions of promoting blood circulation by removing blood stasis and reinforce heart and relieve pain, in particular the prominent lenitive effects to the symptoms of palpitations and angina.

Description

A kind of treatment coronary heart disease preparation method of Chinese medicine

Technical field

The present invention relates to a kind of preparation method of Chinese medicine, refer in particular to a kind of treatment coronary heart disease preparation method of Chinese medicine.

Background technology

Coronary heart disease is a kind of frequently-occurring disease common in person in middle and old age, and its cardinal symptom is vexed cardiopalmus, angina pectoris.It has caused very big harm for patient's life, health.At present, the Chinese medicine of existing multiple treatment coronary heart disease is using on market and the hospital clinical, and its treatment function and effect have nothing in common with each other.Its preparation technology is directly not identical with composition yet.

Summary of the invention

The technical problem to be solved in the present invention provides a kind of treatment coronary heart disease preparation method of Chinese medicine, and the technology of this preparation method and prescription are very unique, and the Chinese medicine of making has excellent curative to coronary heart disease.

Technical problem of the present invention is solved by following technical scheme: a kind of treatment coronary heart disease preparation method of Chinese medicine, it is characterized in that: the raw material of this Chinese medicine is a Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, Semen Myristicae, Radix Salviae Miltiorrhizae, Fructus Choerospondiatis, Fructus Hippophae is totally 7 flavor Chinese crude drugs, the percentage ratio that each flavor accounts for the raw material gross weight is Lignum Santali Albi 4%～5%, Lignum Dalbergiae Odoriferae 8%～10%, Rhizoma Kaempferiae 6%～8%, Semen Myristicae 13%～15%, Radix Salviae Miltiorrhizae 35%～42%, Fructus Choerospondiatis 13%～15%, Fructus Hippophae 13%～15%, with Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, behind the Semen Myristicae four flavor decontaminations, be ground into 80 orders～100 purpose fine powders successively, mix pack according to the above ratio, carry out the Co60 sterilization, with Radix Salviae Miltiorrhizae, Fructus Choerospondiatis, Fructus Hippophae three flavor medical materials mix according to the above ratio to put in the extraction pot and extract three times, add for the first time 7～9 times of weight of above-mentioned three flavor medical materials, concentration is 95% ethanol, extracted 1.5 hours～2.5 hours, filter filtrate I; Add for the second time 7～9 times of weight of above-mentioned three flavor medical materials, concentration and be 70% ethanol, extracted 1.5 hours～2.5 hours, filter filtrate II, merging filtrate I and II put in the receiver, merging filtrate is sucked in the haplo-effect concentrator, reclaim the ethanol concentrating under reduced pressure, its vacuum is that 0.02～0.08Mpa, temperature are 55 ℃～85 ℃, being concentrated into relative density is 1.18～1.20, gets concentrated solution I; The water that medicinal residues after the secondary alcohol extraction is added 7～9 times of weight of above-mentioned three flavor medical materials, boiled 1.5 hours～2.5 hours, filter filtrate II I, discard medicinal residues, filtrate II I is put in the receiver, again filtrate II I is sucked in the above-mentioned haplo-effect concentrator, proceed concentrating under reduced pressure with concentrated solution I merging, its vacuum is 0.02～0.08MPa, temperature is 65 ℃～95 ℃, being concentrated into relative density is 1.32～1.34, stop to concentrate, cream is received in discharging, again thick paste is placed vacuum desiccator, became dried cream in 7 hours～9 hours with 60 ℃ of oven dry of temperature, dried cream powder is broken into 80 orders～100 order fine powders, with above-mentioned Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, Semen Myristicae four flavor mixing fine powders mix mixes granulation, drying again thoroughly, compacting in flakes, the bag film-coat, packing promptly.

Advantage of the present invention is: technology of this preparation method and prescription are very unique, and the Chinese medicine of making has excellent curative to coronary heart disease.The effect that blood circulation promoting and blood stasis dispelling, heart tonifying pain relieving are arranged particularly has the very strong effect that alleviates at the vexed cardiopalmus of coronary heart disease, angina pectoris symptom.

Description of drawings

Fig. 1 is the process chart of this preparation method

The specific embodiment

Get raw material Lignum Santali Albi 25.6g, Lignum Dalbergiae Odoriferae 51.2g, Rhizoma Kaempferiae 38.4g, Semen Myristicae 76.8g, Radix Salviae Miltiorrhizae 230.4g, Fructus Choerospondiatis 76.8g, the Fructus Hippophae 76.8g of this Chinese medicine.Raw material is pressed following processing:

Lignum Santali Albi: choose decontamination, be broken into fringe.Drinking water is cleaned, oven dry, and coarse crushing, sterilization, loading amount is 5～6kg/ bag, 121 ℃ of temperature, 10 minutes time, dry 18 minutes, coarse crushing, in small, broken bits, get clean medicated powder warehouse-in.

Lignum Dalbergiae Odoriferae: choose decontamination, be broken into fringe.

Rhizoma Kaempferiae: choose decontamination.

Semen Myristicae: choose decontamination.

Radix Salviae Miltiorrhizae: choose decontamination, drinking water is cleaned, moistening, and section 2-4mm, 70 ℃ of dryings,

Get clean medical material warehouse-in.

Fructus Choerospondiatis: choose decontamination, coarse crushing becomes fragment.

Fructus Hippophae: choose decontamination.

Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, Semen Myristicae four Chinese medicine material joined successively carry out coarse crushing in the boulder crusher, sieve number 40 orders, flour extraction are 93.76%.Then the coarse crushing powder is joined and be ground into fine powder in the Universalpulverizer, sieve number 80 orders, flour extraction are 93.76%.Fine powder is always mixed the back pack, carry out the Co60 sterilization, sterilization finishes the back sampling and does the bacterium inspection.

Radix Salviae Miltiorrhizae, Fructus Choerospondiatis, Fructus Hippophae three flavor medical materials are put in the multifunctional alcohol extraction pot and extracted three times.Add for the first time 3072g concentration and be 95% ethanol, extracted 2 hours, filter filtrate I.For the second time adding 3072g concentration is 70% ethanol, extracts 2 hours, filter filtrate II, merging filtrate I and II put in the filling of storage liquid, it is 1.19 (60 ℃ of surveys) that filtrate is sucked haplo-effect concentrator recovery ethanol concentrating under reduced pressure (its vacuum: 0.06Mpa, temperature: 75 ℃) to relative density, gets concentrated solution I; Medicinal residues after the secondary alcohol extraction add 3072g water, boil 2 hours, filter filtrate II I, discard medicinal residues.Filtrate II I is put in the receiver, in the above-mentioned haplo-effect concentrator of resorb, proceed concentrating under reduced pressure (its vacuum: 0.06MPa with concentrated solution I merging, temperature: 85 ℃) stops to concentrate to relative density 1.33 (60 ℃ of surveys), cream is received in discharging, and paste-forming rate is 45.6%, changes purifying area over to.

Thick paste is packed in the drip pan; 1.5kg/ dish places vacuum desiccator, 60 ℃ of temperature; dried 8 hours; shovel out dried cream, dried cream is pulverized (80 mesh sieve) with Universalpulverizer, becomes fine powder; the extract powder yield is 33.46%; pulverize 99.5%, add Lignum Santali Albi; Lignum Dalbergiae Odoriferae; Rhizoma Kaempferiae; Semen Myristicae four Chinese medicine material fine powder (yield is 93.76%); hydroxypropyl cellulose mixed at high speed 1 minute, wet-mixed granulation machine running discharging in 10 seconds; granulate with oscillating granulator 16 mesh sieves; granule is loaded onto drip pan, and sabot thickness 1.5cm pushes baking oven; 45 ℃ of bake out temperatures; dried 2.5 hours, and dried after 1 hour, pull out and turn over; going out baking oven to the time post-tensioning dries in the air to room temperature; gradation adds magnesium stearate with oscillating granulator 16 mesh sieve granulate, the granule behind the granulate, and is mixed after 15 minutes in the multidirectional movement mixer of packing into.Discharging with diameter 9mm dark recessed punch die tabletting, is adjusted pressure 18KN, and the heavy 0.3g/ sheet of sheet adds tabletting in the material bin after the useless sheet of the tablet weight variation overshoot limit that tab is heavily produced grinds with mortar again, gets the film coating powder; Be made into 5% alcoholic solution; Plain sheet is poured in the coating pan, is made 1000, heavy this usage of Chinese materia medica of 0.31g of every of specification and consumption: oral, one time 3～4,3 times on the one.

Claims (1)

1. treat the coronary heart disease preparation method of Chinese medicine for one kind, it is characterized in that: the raw material of this Chinese medicine is a Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, Semen Myristicae, Radix Salviae Miltiorrhizae, Fructus Choerospondiatis, Fructus Hippophae is totally 7 flavor Chinese crude drugs, the percentage ratio that each flavor accounts for the raw material gross weight is Lignum Santali Albi 4%～5%, Lignum Dalbergiae Odoriferae 8%～10%, Rhizoma Kaempferiae 6%～8%, Semen Myristicae 13%～15%, Radix Salviae Miltiorrhizae 35%～42%, Fructus Choerospondiatis 13%～15%, Fructus Hippophae 13%～15%, with Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, behind the Semen Myristicae four flavor decontaminations, be ground into 80 orders～100 purpose fine powders successively, mix pack according to the above ratio, carry out the Co60 sterilization, with Radix Salviae Miltiorrhizae, Fructus Choerospondiatis, Fructus Hippophae three flavor medical materials mix according to the above ratio to put in the extraction pot and extract three times, add for the first time 7～9 times of weight of above-mentioned three flavor medical materials, concentration is 95% ethanol, extracted 1.5 hours～2.5 hours, filter filtrate I; Add for the second time 7～9 times of weight of above-mentioned three flavor medical materials, concentration and be 70% ethanol, extracted 1.5 hours～2.5 hours, filter filtrate II, merging filtrate I and II put in the receiver, merging filtrate is sucked in the haplo-effect concentrator, reclaim the ethanol concentrating under reduced pressure, its vacuum is that 0.02～0.08Mpa, temperature are 55 ℃～85 ℃, being concentrated into relative density is 1.18～1.20, gets concentrated solution I; The water that medicinal residues after the secondary alcohol extraction is added 7～9 times of weight of above-mentioned three flavor medical materials, boiled 1.5 hours～2.5 hours, filter filtrate II I, discard medicinal residues, filtrate II I is put in the receiver, again filtrate II I is sucked in the above-mentioned haplo-effect concentrator, proceed concentrating under reduced pressure with concentrated solution I merging, its vacuum is 0.02～0.08MPa, temperature is 65 ℃～95 ℃, being concentrated into relative density is 1.32～1.34, stop to concentrate, cream is received in discharging, again thick paste is placed vacuum desiccator, became dried cream in 7 hours～9 hours with 60 ℃ of oven dry of temperature, dried cream powder is broken into 80 orders～100 order fine powders, with above-mentioned Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, Semen Myristicae four flavor mixing fine powders mix mixes granulation, drying again thoroughly, compacting in flakes, the bag film-coat, packing promptly.

Images