CN101337057A - 脂清颗粒及其制备方法 - Google Patents
脂清颗粒及其制备方法 Download PDFInfo
- Publication number
- CN101337057A CN101337057A CNA2008100633884A CN200810063388A CN101337057A CN 101337057 A CN101337057 A CN 101337057A CN A2008100633884 A CNA2008100633884 A CN A2008100633884A CN 200810063388 A CN200810063388 A CN 200810063388A CN 101337057 A CN101337057 A CN 101337057A
- Authority
- CN
- China
- Prior art keywords
- granule
- zhiqing
- preparation
- gram
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000706 filtrate Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 201000005577 familial hyperlipidemia Diseases 0.000 claims abstract description 15
- 210000000582 semen Anatomy 0.000 claims abstract description 15
- 239000004375 Dextrin Substances 0.000 claims abstract description 8
- 229920001353 Dextrin Polymers 0.000 claims abstract description 8
- 235000019425 dextrin Nutrition 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 7
- 230000000694 effects Effects 0.000 claims description 20
- 210000004369 blood Anatomy 0.000 claims description 17
- 239000008280 blood Substances 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 15
- 230000001603 reducing effect Effects 0.000 claims description 12
- 238000001694 spray drying Methods 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- 241000721047 Danaus plexippus Species 0.000 claims 1
- 230000006837 decompression Effects 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 238000003809 water extraction Methods 0.000 claims 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract description 4
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract description 4
- 238000002791 soaking Methods 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract 2
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract 1
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract 1
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 1
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract 1
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 1
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 240000001398 Typha domingensis Species 0.000 abstract 1
- 241000221013 Viscum album Species 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 16
- 210000002966 serum Anatomy 0.000 description 14
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 14
- 230000037396 body weight Effects 0.000 description 13
- 208000031226 Hyperlipidaemia Diseases 0.000 description 9
- 150000002632 lipids Chemical class 0.000 description 9
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical group C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 8
- 108010028554 LDL Cholesterol Proteins 0.000 description 7
- 108010023302 HDL Cholesterol Proteins 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 238000010241 blood sampling Methods 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 239000000470 constituent Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 5
- 229960002297 fenofibrate Drugs 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 238000012856 packing Methods 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- VWDXGKUTGQJJHJ-UHFFFAOYSA-N Catenarin Natural products C1=C(O)C=C2C(=O)C3=C(O)C(C)=CC(O)=C3C(=O)C2=C1O VWDXGKUTGQJJHJ-UHFFFAOYSA-N 0.000 description 4
- 239000010282 Emodin Substances 0.000 description 4
- RBLJKYCRSCQLRP-UHFFFAOYSA-N Emodin-dianthron Natural products O=C1C2=CC(C)=CC(O)=C2C(=O)C2=C1CC(=O)C=C2O RBLJKYCRSCQLRP-UHFFFAOYSA-N 0.000 description 4
- YOOXNSPYGCZLAX-UHFFFAOYSA-N Helminthosporin Natural products C1=CC(O)=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O YOOXNSPYGCZLAX-UHFFFAOYSA-N 0.000 description 4
- NTGIIKCGBNGQAR-UHFFFAOYSA-N Rheoemodin Natural products C1=C(O)C=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1O NTGIIKCGBNGQAR-UHFFFAOYSA-N 0.000 description 4
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 4
- 150000004056 anthraquinones Chemical class 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 4
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 4
- VASFLQKDXBAWEL-UHFFFAOYSA-N emodin Natural products OC1=C(OC2=C(C=CC(=C2C1=O)O)O)C1=CC=C(C=C1)O VASFLQKDXBAWEL-UHFFFAOYSA-N 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 229930182470 glycoside Natural products 0.000 description 4
- 150000002338 glycosides Chemical class 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 description 4
- 241000407170 Curcuma Species 0.000 description 3
- 235000014375 Curcuma Nutrition 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 241000233948 Typha Species 0.000 description 3
- 210000004913 chyme Anatomy 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 210000001105 femoral artery Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- 208000004930 Fatty Liver Diseases 0.000 description 2
- 206010019708 Hepatic steatosis Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- NZPQWZZXRKZCDU-UHFFFAOYSA-N chrysophanol Natural products Cc1cc(O)c2C(=O)c3c(O)cccc3Oc2c1 NZPQWZZXRKZCDU-UHFFFAOYSA-N 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 229940109262 curcumin Drugs 0.000 description 2
- 235000012754 curcumin Nutrition 0.000 description 2
- 239000004148 curcumin Substances 0.000 description 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 2
- 229930004069 diterpene Natural products 0.000 description 2
- -1 diterpene compound Chemical class 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 208000010706 fatty liver disease Diseases 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- FFWOKTFYGVYKIR-UHFFFAOYSA-N physcion Chemical compound C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1O FFWOKTFYGVYKIR-UHFFFAOYSA-N 0.000 description 2
- OISYIJRGMYJBRH-UHFFFAOYSA-N physcione Natural products COc1cc(O)c2C(=O)c3ccc(O)cc3C(=O)c2c1 OISYIJRGMYJBRH-UHFFFAOYSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229930004725 sesquiterpene Natural products 0.000 description 2
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 150000003505 terpenes Chemical class 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 238000013218 HFD mouse model Methods 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008202 granule composition Substances 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012821 model calculation Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108700022737 rat Fat1 Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA2008100633884A CN101337057A (zh) | 2008-08-12 | 2008-08-12 | 脂清颗粒及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA2008100633884A CN101337057A (zh) | 2008-08-12 | 2008-08-12 | 脂清颗粒及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101337057A true CN101337057A (zh) | 2009-01-07 |
Family
ID=40211322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2008100633884A Pending CN101337057A (zh) | 2008-08-12 | 2008-08-12 | 脂清颗粒及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101337057A (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101732513B (zh) * | 2009-09-16 | 2011-04-06 | 马兆臣 | 用于治疗高脂血症的首明山胶囊及其制备方法 |
CN105287975A (zh) * | 2015-12-11 | 2016-02-03 | 林天东 | 一种治疗高血脂症的中药组合物及其制剂 |
CN106360731A (zh) * | 2016-09-28 | 2017-02-01 | 天津拓华生物科技有限责任公司 | 一种昆虫油保健品及其制备方法 |
-
2008
- 2008-08-12 CN CNA2008100633884A patent/CN101337057A/zh active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101732513B (zh) * | 2009-09-16 | 2011-04-06 | 马兆臣 | 用于治疗高脂血症的首明山胶囊及其制备方法 |
CN105287975A (zh) * | 2015-12-11 | 2016-02-03 | 林天东 | 一种治疗高血脂症的中药组合物及其制剂 |
CN105287975B (zh) * | 2015-12-11 | 2018-03-27 | 林天东 | 一种治疗高血脂症的中药组合物及其制剂 |
CN106360731A (zh) * | 2016-09-28 | 2017-02-01 | 天津拓华生物科技有限责任公司 | 一种昆虫油保健品及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100402081C (zh) | 治疗妇科疾病的中成药及其制备方法 | |
WO2006060951A1 (fr) | Composition pharmaceutique pour le traitement et/ou la prevention de l’hyperlipidemie, procedes de production et utilisation de cette composition | |
WO2007006203A1 (fr) | Préparation de capsule pour le traitement de l’hypertension et de maladies coronariennes et procédé de préparation de celle-ci | |
CN104083727A (zh) | 一种养肝护肝中药组合物 | |
CN103386022B (zh) | 一种治疗结核性胸膜炎的中药组合物 | |
CN101485870A (zh) | 一种健胃驱虫药 | |
CN103749818A (zh) | 一种黄精降糖降脂保健茶及其制备方法 | |
CN105918946A (zh) | 一种枣杞养肝组合物、颗粒剂及其制备方法 | |
CN102846879B (zh) | 一种降血脂的组合物 | |
CN101337057A (zh) | 脂清颗粒及其制备方法 | |
CN106109521A (zh) | 一种三七口服液 | |
CN103705578B (zh) | 具有降血脂与抑制血糖升高作用的中药制剂及其制备方法 | |
CN102228591B (zh) | 调经止痛的药物口服制剂的制备方法 | |
CN101167904B (zh) | 一种治疗高脂血症的药物组合物及其制备方法 | |
CN104606628A (zh) | 一种养颜美容、祛黄褐斑的中药组合物 | |
CN111643581B (zh) | 一种具有减肥功效的中药组合物、包含其的香囊及其制备方法 | |
CN111671792B (zh) | 一种防治肝脏损伤的中药组合物及其制备方法 | |
CN103933216B (zh) | 一种治疗代谢性高血压病的复方降压胶囊及其制备与应用 | |
CN101375978B (zh) | 一种降血脂的药物组合物 | |
CN103656226A (zh) | 一种治疗干燥综合征复方药 | |
CN102940762B (zh) | 一种治疗痛风性关节炎的中药 | |
CN101983699A (zh) | 一种治疗肾病的中药组合物及其制备方法 | |
CN101549140B (zh) | 治疗艾滋病的中药组合物及其制备方法 | |
CN104800600A (zh) | 一种治疗高血压的药物 | |
CN104587056B (zh) | 一种治疗精索静脉曲张的中药制剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE MEDICIN Free format text: FORMER OWNER: ZHEJIANG ACADEMY OF MEDICAL SCIENCE Effective date: 20100122 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20100122 Address after: Zip code 548, binwen Road, Binjiang District, Hangzhou, Zhejiang, China: 310053 Applicant after: zhejiang chinese medical university Co-applicant after: Zhejiang Academy of Medical Sciences Address before: 182, Tianmu Road, Xihu District, Zhejiang, Hangzhou, China: 310013 Applicant before: Zhejiang Academy of Medical Sciences |
|
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090107 |