CN101337050B - Traditional Chinese medicine composition for treating the cerebrovascular accident and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating the cerebrovascular accident and preparation method thereof Download PDF

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CN101337050B
CN101337050B CN2008100458368A CN200810045836A CN101337050B CN 101337050 B CN101337050 B CN 101337050B CN 2008100458368 A CN2008100458368 A CN 2008100458368A CN 200810045836 A CN200810045836 A CN 200810045836A CN 101337050 B CN101337050 B CN 101337050B
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廖玉春
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Abstract

The invention discloses a traditional Chinese medicine composition for curing the cerebrovascular accident, and the preparation method thereof. The preparation method is characterized in that the composition is prepared from the following components by the weight part: 25 to 35 parts of cornu cervi pantotrichum, 25 to 30 parts of carapax testudinis, 20 to 30 parts of cuscuta seed, 700 to 900 parts of prepared rehmannia rhizome, 350 to 450 parts of dioscorea alata, 350 to 450 parts of common macrocarpium fruit, 100 to 200 parts of cortex moutan, 100 to 200 parts of alisma rhizome, 100 to 200 parts of hoelen, 50 to 150 parts of cassia bark with the width thereof being more than 0.05 cm and 1 to 3 parts of villous amomum fruit. The effective rate of the patients with the amount of bleeding being less than 50 ml reaches 100%, and the cure rate reaches 81% to 98%.

Description

A kind of Chinese medicine composition and production method thereof for the treatment of cerebrovascular accident
Technical field
The present invention relates to a kind of treatment cerebrovascular accident medicine, especially a kind of Chinese medicine composition and production method thereof for the treatment of cerebrovascular accident.
Background technology
Progress along with society, people's material life and culture life constantly improve, rhythm of life is accelerated the appearance with some new life style, causes the sickness rate of cerebrovascular accident constantly to increase, especially the old people, through between twenty and fifty labour expenditure, the yang-energy of body is more and more not enough, and asthenic fire leaps cerebral tissue, and it is subjected to the influence of thermal expansion, oppress cerebral artery vessel and cerebral thrombosis or cerebral embolism take place, be i.e. a series of symptoms of apoplexy.In addition, carbohydrate food is in liberal supply now, and some people often eats sugar, because of sugar energy strengthening the spleen, spleen pertaining to the earth, kidney belongs to water, and earth restricting water can cause suffering from a deficiency of the kidney so eat sugar more, the appearance of new in addition life style, as the cold and cool chilled beverage of surfeit, cold and cool food, cold and cool medicine all can damage the yang-energy of human body, and many fertilities also can damage the yang-energy of human body, in typhoid fever, the infringement of YIN pathogen such as affection of dampness and inducing down, the moon is more contained, sun more declines, in excess of YIN, when the sum total that water wins causes kidney yang can't bring into normal play function, fire will be recklessly acted mutually, outwards leap, promptly kidney fire is soared, and how to follow capable position along kidney meridian and leaps.If correctly treated, occupy the part for a long time, just become the pathogenic fire at this position, under the destruction of pathogenic fire, cerebral artery vessel is broken and form cerebral hemorrhage, pathogenic fire is invaded cerebral tissue, oppress cerebral arteries and cause cerebral thrombosis or cerebral embolism, dusk servant suddenly occurs, syncope, facial hemiparalysis, symptoms such as hemiplegia, deep coma patient, it is cerebral hemorrhage, make CT examination, hemorrhage several milliliters to tens milliliters of visible brain, only facial hemiparalysis or hemiplegia mostly is cerebral thrombosis or cerebral embolism.From the whole world, many data show that the cerebrovascular accident sickness rate is in rising trend, and still do not have the specific medicament of curing cerebrovascular accident, therefore, all can see wheelchair or the apoplexy sequela patient who leans on crutch in town and country, have in addition long-term bed do not rise, can't take care of oneself, very painful, this type of number of patients is very big, brings economy and physical and mental burden often for household and colleague, and patient quality of life is also very poor.
Modern medicine thinks that the cause of disease of cerebrovascular accident is hypertension and cerebral arteriosclerosis, divide four disease types, be subarachnoid hemorrhage, cerebral thrombosis and cerebral embolism and cerebral hemorrhage, cerebral hemorrhage comprises that endocranium is hemorrhage, pontine hemorrhage, cerebellar hemorrhage, ventricular hemorrhage, and cerebral thrombosis comprises internal carotid artery thrombosis, anterior cerebral artery thrombosis, posterior inferior cerebellar artery thrombosis and vertebra one ABT.Cerebral hemorrhage and subarachnoid hemorrhage belong to the hemorrhagic cerebrovaseular accident, and cerebral thrombosis and cerebral embolism belong to the ischemic cerebral vascular accident.
Doctor trained in Western medicine is mainly being taked following measure aspect the treatment hemorrhagic cerebrovaseular accident: 1, suitable controlling blood pressure, with the plain intravenous drip of Radix Stephaniae Tetrandrae; 2, reduce intracranial pressure, can select for use 50% glucose, 20% mannitol, vein with quiet of 10% glycerol 500ml; 3, hemorrhage is as the Radix Rehmanniae, Radix Et Rhizoma Rhei, Cortex Moutan, Radix Notoginseng etc.; 4, the protection brain cell is selected adenosine triphosphate, coenzyme A, inosine etc. for use.
Doctor trained in Western medicine mainly contains the unexpected processing method of ischemic cerebral vascular: 1, microcirculation improvement, and with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Chuanxiong pin 2, use vasodilator, as nicotinic acid, hydrochloric acid small-mouthed jar alkali
Figure G2008100458368D0002154306QIETU
Drip the Radix Puerariae pin
Figure 2008100458368100002G2008100458368D0002154244QIETU
3, anticoagulant therapy is with heparin, acenocoumarol etc.
Hemorrhage more than 50ml, often adopt operative treatment, open the cranium sucking-off or take out blood stasis.Up to the present, through the said method treatment, seldom recovery from illness leaves sequela more.
Motherland's medical science is to the understanding and the treatment of cerebrovascular accident:
Chinese medicine thinks that cerebrovascular accident is to lose void with healthy energy, and diet, feelings will, overstrain internal injury etc. cause contrary wind, fire, expectorant, the stasis of blood of disorderly producing of QI and blood, and causing resistance of brain BI-syndrome involved the blood vessels or blood oozing from the body openings or subcuta neous tissue brain feeling pulse is outward basic pathogenesis.With unexpected confused servant, hemiplegia, crooked mouth and tongue, the not smoothgoing plug of speech or in silence, general numbness is a primary symptom.For " wind ", duty in the hepatic and renal YIN deficiency, liver-wind stirring up internally, excessive rising of liver-YANG and falling ill, treatment is with Saigae Tataricae Ramulus Uncariae Cum Uncis soup; Think that " fire " is that heart-fire is contained cruelly, as excited, cross happiness, the angry utmost point etc., treatment is with pressing down liver-wind soup; Think that " heat " is to talk humidogene heat, the people of obesity, surfeit is greasy, accumulatively wet raise phlegm, phlegm stagnancy heat is disturbed on the expectorant heat and is fallen ill, and treats and uses Guntan Pill; Also thinking has meridian stasis to hinder, and treats with BUYANG HUANWU TANG.Traditional Chinese medical science worker uses above-mentioned decoction for the treatment, and is always undesirable, so the apoplexy sequela patient all can be seen in town and country.The treatment sequela is often used DAHUOLUO WAN, HUATUO ZAIZAO WAN, dispelling, collateral-activating does not know that cerebral artery vessel breaks hemorrhage or thrombosis and arriving, among these sequela patient, the long-term seat that has crouches and can not walk, can't take care of oneself, state of an illness the lighter slightly also needs wheelchair or leans on crutch, the trick dyskinesia, become lifelong sequela, suffer untold misery.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of specific drug for the treatment of cerebrovascular accident is provided, effectively the sequela of control cerebrovascular takes place, and purpose of the present invention realizes by following technical proposals: the present invention is formulated by following material component and weight ratio:
Cornu Cervi Pantotrichum 25-35 Carapax et Plastrum Testudinis 25-30 Semen Cuscutae 20-30
Radix Rehmanniae Preparata 700-900 Rhizomadioscoreae 350-450 mountain cornel 350-450
Cortex Moutan 100-200 Rhizoma Alismatis 100-200 Poria 100-200
Thickness is the above Cortex Cinnamomi 50-150 of 0.05cm Fructus Amomi powder 1-3.
The present invention also can be formed by the preparation of raw material of following component and important ratio:
Cornu Cervi Pantotrichum 30 Carapax et Plastrum Testudiniss 30 Semen Cuscutae 25
Radix Rehmanniae Preparata 800 Rhizomadioscoreae 400 mountain cornels 400
Cortex Moutan 150 Rhizoma Alismatis 150 Poria 150
Thickness is above Cortex Cinnamomi 100 Fructus Amomi powder 3 of 0.05cm.
Manufacture method of the present invention is as follows:
1, Radix Rehmanniae Preparata nine is steamed nine and shine, mixes with Fructus Amomi powder for the first time and spray a small amount of Chinese liquor (spilling wet get final product) back steaming, steamed behind the gas 20 minutes in the steaming again, taking-up was shone 1-4 hour in the sun, repeatedly after 8 times, 40-80 ℃ of dry for standby;
2, Carapax et Plastrum Testudinis is standby after with edible short system, oily temperature control 180 ℃ with interior be good, treat to cool off when its yellowing is frangible standby;
3, roguing: Cornu Cervi Pantotrichum peeling hair, Cortex Moutan is removed wooden part, the Poria peeling, the mountain cornel goes most seed standby;
4, above-mentioned each component is ground into the end, fineness is the 60-100 order, and packing gets final product, or above-mentioned each component is ground into powder altogether, and pharmaceutical methods is made capsule routinely, tablet or pill, water preparation.
Usage: oral, every day three times, each consumption is no less than 10 gram crude drug dosage.
The present invention is based on invention clinical practice decades, constantly explores and the achievement that obtains, and through practice decades, the inventor thinks that this sick pathogenesis is a kidney yang deficiency, asthenic fire outward more due to.
The inventor recognizes in clinical practice, and nearly all cerebrovascular accident patient all has over a long time awake back xerostomia at premorbid, bitter taste, night urine is many, at least twice every night, 7-8 time at most, it is irregular to defecate, one day twice at least, 6-7 time at most, or several genius Xie Yici, winter, lower limb were sent out cold, evening difficulty sleep warm, have with hyperhidrosis, or the insomnia, or heart beating, the heart are tired, and what have is many with early marriage or give birth to too much history.Wherein large and small just undesired, because of kidney controlling urination and defecation, so sick position is at kidney; Many because of urinating, following cold extremities, this is an insufficiency of kidney-YANG; The back xerostomia, bitter taste of waking up be kidney yang deficiency to the utmost point, cause asthenic fire to be got over outward, cloudy because of belonging to night, at the night of more contain at the moon, sun more declining, asthenic fire leaps oral cavity then xerostomia, bitter taste, is not the hepatic and renal YIN deficiency, the deficiency of YIN must oliguria, so inventor's the understanding and the understanding of traditional medicine run in the opposite direction.Neither heart-fire contain cruelly, containing because of heart-fire is sudden and violent is excess-fire, and the medicine of controlling heart-fire exists, and but controls badly, illustrates not to be heart-fire; Neither phlegm-fire, because of phlegm-fire has so big heat cerebral artery vessel is broken.So be asthenic fire, asthenic fire can not be used heat clearing and fire purging medicine, can only conducting fire back to its origin.The high medical college in the whole nation the 184th page of Ming Dynasty physician Zhao Xianke of teaching material " theories of schools of Chinese medicine " on probation said when argumentation is fiery mutually: " healer is not known this fire of replenishing vital QI with drugs of warm nature; and, here hope its life with cold and cool this fire that directly goes out? ... Yu Jin directs at it and returns the road of unit and express it." illustrate that inventor's the method for treatment and the theory of physician's Zhao Xianke match.
Brain is to command all, and asthenic fire is invaded cerebral tissue, and heat then expands, can oppress local nervus centralis, asthenic fire is invaded to cerebral arteries, causes that arteries breaks and hemorrhage, the blood that goes out is also oppressed local nervus centralis, can both cause the pathological changes of their branch guard systems, sudden faint occurs, syncope, facial hemiparalysis, hemiplegia; urine is many, a series of symptoms such as big constipation are because of being due to the asthenic fire; the asthenic fire introducing kidney gate of vitality, and all disease knowing are removed.Radix Rehmanniae Preparata among the present invention, Gan Wen, marrow is filled out in enriching yin and nourishing kidney, and Rhizoma Dioscoreae is sweet flat, tonifying the spleen and stomach, the lung benefiting kidney, urosolic acid, puckery, tepor, liver and kidney tonifying, the arresting seminal emission hidroschesis, three medicines share, and to reach the three cloudy also merits of benefit, this is the one side of mending; Poria is sweet flat, and the light spleen that oozes wets, to help the strengthening the spleen of Rhizoma Dioscoreae, Rhizoma Alismatis is sweet cold, and promoting diuresis to eliminate damp pathogen is held concurrently and let out the kidney fire clearly, and the taste of anti-Radix Rehmanniae Preparata is greasy, Cortex Moutan is arduous, be slightly cold, let out liver-fire clearly, and the temperature of FRUCTUS CORNI PREPARATA, be adjuvant altogether, this is the one side of rushing down, and each medicine share, the energy enriching yin and nourishing kidney, add the Cortex Cinnamomi of thickness more than 0.5cm, can conducting fire back to its origin, make asthenic fire leave hemorrhage or cerebral thrombosis or and the thromboembolism position, get back to the kidney gate of vitality, thereby make asthenic fire damage to such an extent that recover to what brain caused, rebuild the normal function of brain, do not eliminated, make the function full recovery of nine orifices and limbs normal and apoplexy and apoplexy sequela do not take place for the second time.Deer is the mountain beast, belongs to sun, and Cornu Cervi Pantotrichum is the angle of head, all YANG-meridians meeting into the head, and angle ratio head is also high, so kind energy YANG invigorating is said in " herbal classic is met former " book: " Cornu Cervi is that governor vessel is sent out, and superintending and directing is the outer wall of kidney, and outer wall is both solid, fills in the kidney qi, and the gate of vitality is fire mutually, unlikely rash action.So " use Cornu Cervi Pantotrichum; in order to avoid asthenic fire continues to go up more; Testudinis is the aquatic animal of living in the rock cave of sombre humidity, belong to cloudy, the direct kiss the earth of Carapax et Plastrum Testudinis; the sombre gas that absorbs the earth is the heaviest; salty in the mouth can kidney tonifying the moon, the matter Beijing South Maxpower Technology Co. Ltd floating sun of diving, head of Testudinis Chang Zangxiang abdomen; can lead to conception vessel is so Carapax et Plastrum Testudinis is apt to the energy nourishing YIN for suppressing the hyperactive YANG.Cornu Cervi Pantotrichum gets Carapax et Plastrum Testudinis, is tonifying both YIN and YANG, is again the excellent method of YANG invigorating, and their equivalent loading just can not produce the yin or yang excess phenomenon that declines partially, and the efficacy exertion of Cornu Cervi Pantotrichum is got better, and Yin Yangde the moon helps and biochemical infinite.Semen Cuscutae suffering, sweet, flat, go into liver, kidney channel, the energy invigorating the liver and kidney, beneficial marrow is controlled frequent micturition and is drenched drop, and disease such as order is dark, dizzy, " medicine justice " carries: the patient of " it is main in falling to get son, " cerebrovascular accident urinates many exactly, night, more due to illness change occurred in brain, so the symptom of Light-headedness is often arranged, the character of fire is " on the inflammation ", existing asthenic fire has been to suffer from brain, should fall and should not rise, so Semen Cuscutae has the effect that brings out the best in each other.All medicine compatibilities become conducting fire back to its origin altogether, and warming and recuperating the kidney-YANG, fire move back the easypro agent of brain, and because of brain is commanded all, brain does not have the interference of asthenic fire, and all disease the knowing of cerebrovascular accident are removed.
The Clinical Practice result of use is very good, and patient's effective percentage of the hemorrhage 50ml of being less than is reached 100%, and cure rate reaches 81-98%.For details see attached table 1.
Figure G2008100458368D00071
Case is introduced:
Yingshan County high yield Long Ba village, the township six villager Long Ziping of society, man, 69 years old, get up to separate urine back tumbling down suddenly midnight, syncope in November, 2004 one evening, do not know how long slept on the ground, just found, send the next morning county people's hospital to make CT by its wife, show the about 30ml of cerebral hemorrhage amount, after infusing in hospital 5 days, the state of an illness increases the weight of, obnubilation, aphasia, hemiplegia, facial hemiparalysis, after the consultation of doctors, mobilization is gone home to prepare funeral affairs and is left hospital, going home two days later, it is dead not have, and asks inventor's treatment of paying a home visit, and above-mentioned symptom still exists, be unable to leave the bed, can not take food, xerostomia very; urine is many, after the four diagnostic methods, measured blood pressure again; blood pressure 180/120mmHg, is blown in the nose with the apoplexy rescue powder earlier, beaten several sneezes; some sputums that spue, and gone out a small amount of sweat, and the back repeatedly feeds for the foregoing invention Chinese medicine composition on a small quantity; can eat gruel in second day, and the treatment moon is surplus, and all diseases are known team; consolidate January; go county hospital to make CT once more, brain no abnormality seen, blood pressure 150/86mmHg.Can be competent at light, heavy physical labour, existing alive, work as ordinary person, there is not sequela.
The 16th page in the high medical college in whole nation teaching material " theories of schools of Chinese medicine " on probation, big physician Wang Bing of the Tang Dynasty says during the system side cardinal principles of righteousness of " mild disease should be treated by routine treatment; severe disease with pseudo-symptoms should be treated with drugs similar to pseudo-symptoms in mature " in elucidating " the most pure virginity will be discussed greatly ": " the small person of husband's disease; still people's fire is also; meet grass and powder steams Ruo, wooden and burn, volt can wet; can go out by water, so attack it against its property gas with discharging the retained water.Sick big very person, still imperial fire also must wet and flame, meets water and burns, and does not know its property, and with the wet discharging the retained water of water, the suitable flare that is enough to is called on day, and end the poor side of thing, knows its property person, the reason of abnormality, by it, then burning burns disappears certainly with fire, and fireworks put out." theory of this " guiding fire to origin ", have very high theory and be worth and realistic meaning, inventor's Chinese medicine composition just and this theory match, so can cure the cerebrovascular accident disease.
The specific embodiment
Embodiment 1, gets the raw materials ready by following component and weight ratio:
Cornu Cervi Pantotrichum 25g Carapax et Plastrum Testudinis 300g Semen Cuscutae 300g
Radix Rehmanniae Preparata 7000g Rhizomadioscoreae 4500g mountain cornel 3500g
Cortex Moutan 2000g Rhizoma Alismatis 1000g Poria 2000g
Thickness is the above Cortex Cinnamomi 1500g of 0.05cm Fructus Amomi powder 10g.
Manufacture method of the present invention is as follows:
1, Radix Rehmanniae Preparata nine is steamed nine and shine, mixes with Fructus Amomi powder for the first time and spray a small amount of Chinese liquor (spilling wet get final product) back steaming, steamed behind the gas 20 minutes in the steaming again, taking-up was shone 1-4 hour in the sun, repeatedly after 8 times, 40-80 ℃ of dry for standby;
2, Carapax et Plastrum Testudinis is standby after with edible short system, oily temperature control 180 ℃ with interior be good, treat to cool off when its yellowing is frangible standby;
3, roguing: Cornu Cervi Pantotrichum peeling hair, Cortex Moutan is removed wooden part, the Poria peeling, the mountain cornel goes most seed standby;
4, above-mentioned each component is ground into the end, fineness is the 60-100 order, and packing gets final product, or above-mentioned each component is ground into powder altogether, and pharmaceutical methods is made capsule routinely, tablet or pill, water preparation.
Embodiment 2, get the raw materials ready by following component and weight ratio:
Cornu Cervi Pantotrichum 350g Carapax et Plastrum Testudinis 250g Semen Cuscutae 200g
Radix Rehmanniae Preparata 9000g Rhizomadioscoreae 3500g mountain cornel 4500g
Cortex Moutan 1000g Rhizoma Alismatis 2000g Poria 1000g
Thickness is the above Cortex Cinnamomi 500g of 0.05cm Fructus Amomi powder 30g.
Manufacture method is with embodiment 1.
Embodiment 3, get the raw materials ready by following component and weight ratio:
Cornu Cervi Pantotrichum 300g Carapax et Plastrum Testudinis 280g Semen Cuscutae 250g
Radix Rehmanniae Preparata 8000g Rhizomadioscoreae 4000g mountain cornel 4000g
Cortex Moutan 1500g Rhizoma Alismatis 1500g Poria 1500g
Thickness is the above Cortex Cinnamomi 1000g of 0.05cm Fructus Amomi powder 20g.
Manufacture method is with embodiment 1.
Embodiment 4, get the raw materials ready by following component and weight ratio:
Cornu Cervi Pantotrichum 30 Carapax et Plastrum Testudiniss 30 Semen Cuscutae 25
Radix Rehmanniae Preparata 800 Rhizomadioscoreae 400 mountain cornels 400
Cortex Moutan 150 Rhizoma Alismatis 150 Poria 150
Thickness is above Cortex Cinnamomi 100 Fructus Amomi powder 3 of 0.05cm.
Manufacture method is with embodiment 1.

Claims (3)

1. a Chinese medicine composition for the treatment of cerebrovascular accident is characterized in that: formulated by following component and weight ratio
Cornu Cervi Pantotrichum 25-35 Carapax et Plastrum Testudinis 25-30 Semen Cuscutae 20-30
Radix Rehmanniae Preparata 700-900 Rhizomadioscoreae 350-450 mountain cornel 350-450
Cortex Moutan 100-200 Rhizoma Alismatis 100-200 Poria 100-200
Thickness is the above Cortex Cinnamomi 50-150 of 0.05cm Fructus Amomi powder 1-3.
2. a kind of Chinese medicine composition for the treatment of cerebrovascular accident according to claim 1 is characterized in that: formulated by following component and weight ratio
Cornu Cervi Pantotrichum 30 Carapax et Plastrum Testudiniss 30 Semen Cuscutae 25
Radix Rehmanniae Preparata 800 Rhizomadioscoreae 400 mountain cornels 400
Cortex Moutan 150 Rhizoma Alismatis 150 Poria 150
Thickness is above Cortex Cinnamomi 100 Fructus Amomi powder 3 of 0.05cm.
3. the described a kind of Chinese medicine composition production method for the treatment of cerebrovascular accident of claim 1 is characterized in that: follow these steps to carry out
(1) Radix Rehmanniae Preparata nine is steamed nine and shine, mixes with Fructus Amomi powder for the first time and spray a small amount of Chinese liquor (spilling wet get final product) back steaming, steamed behind the gas 20 minutes in the steaming again, taking-up was shone 1-4 hour in the sun, repeatedly after 8 times, 40-80 ℃ of dry for standby;
(2) Carapax et Plastrum Testudinis is standby after with edible short system, oily temperature control 180 ℃ with interior be good, treat to cool off when its yellowing is frangible standby;
(3) roguing: Cornu Cervi Pantotrichum peeling hair, Cortex Moutan is removed wooden part, the Poria peeling, the mountain cornel goes most seed standby;
(4) above-mentioned each component is ground into the end, fineness is the 60-100 order, and packing gets final product, or above-mentioned each component is ground into powder altogether, and pharmaceutical methods is made capsule routinely, tablet or pill, water preparation.
CN2008100458368A 2008-08-14 2008-08-14 Traditional Chinese medicine composition for treating the cerebrovascular accident and preparation method thereof Expired - Fee Related CN101337050B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101181463A (en) * 2007-12-05 2008-05-21 廖玉春 Chinese medicine composition for treating diabetes and method for preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101181463A (en) * 2007-12-05 2008-05-21 廖玉春 Chinese medicine composition for treating diabetes and method for preparing the same

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严浩成.六味地黄丸合补阳还五汤治疗缺血性中风的理论依据.《长春中医学院学报》.2005,第21卷(第2期),56-58、62. *
赵惠.六味地黄丸类方在心脑血管疾病中的应用.《国医论坛》.2003,第18卷(第1期),11、12. *
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