CN101326428B - 用于内窥镜的角度分辨低相干干涉测量的系统和方法 - Google Patents

用于内窥镜的角度分辨低相干干涉测量的系统和方法 Download PDF

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CN101326428B
CN101326428B CN2006800464014A CN200680046401A CN101326428B CN 101326428 B CN101326428 B CN 101326428B CN 2006800464014 A CN2006800464014 A CN 2006800464014A CN 200680046401 A CN200680046401 A CN 200680046401A CN 101326428 B CN101326428 B CN 101326428B
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sample
resolved
angle
scattered
optical
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CN101326428A (zh
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A·瓦克斯
J·W·皮蒂拉
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Duke University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4412—Scattering spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02041—Interferometers characterised by particular imaging or detection techniques
    • G01B9/02044—Imaging in the frequency domain, e.g. by using a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02083—Interferometers characterised by particular signal processing and presentation
    • G01B9/02084—Processing in the Fourier or frequency domain when not imaged in the frequency domain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02083—Interferometers characterised by particular signal processing and presentation
    • G01B9/02087—Combining two or more images of the same region
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/45—Interferometric spectrometry
    • G01J3/453—Interferometric spectrometry by correlation of the amplitudes
    • G01J3/4531—Devices without moving parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4735—Solid samples, e.g. paper, glass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Signal Processing (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Mathematical Physics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN2006800464014A 2005-10-11 2006-10-11 用于内窥镜的角度分辨低相干干涉测量的系统和方法 Expired - Fee Related CN101326428B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72560305P 2005-10-11 2005-10-11
US60/725,603 2005-10-11
PCT/US2006/039771 WO2007044821A1 (en) 2005-10-11 2006-10-11 Systems and method for endoscopic angle-resolved low coherence interferometry

Publications (2)

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CN101326428A CN101326428A (zh) 2008-12-17
CN101326428B true CN101326428B (zh) 2011-05-18

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US (3) US7595889B2 (https=)
EP (3) EP2444783B1 (https=)
JP (2) JP2009511909A (https=)
CN (1) CN101326428B (https=)
AU (1) AU2006302086B2 (https=)
CA (3) CA2967964A1 (https=)
ES (2) ES2402796T3 (https=)
PT (2) PT1934567E (https=)
WO (1) WO2007044821A1 (https=)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE454845T1 (de) 2000-10-30 2010-01-15 Gen Hospital Corp Optische systeme zur gewebeanalyse
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
WO2002088705A2 (en) 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
CA2519937C (en) 2003-03-31 2012-11-20 Guillermo J. Tearney Speckle reduction in optical coherence tomography by path length encoded angular compounding
US7102758B2 (en) 2003-05-06 2006-09-05 Duke University Fourier domain low-coherence interferometry for light scattering spectroscopy apparatus and method
ES2310744T3 (es) 2003-06-06 2009-01-16 The General Hospital Corporation Fuente de luz sintonizable en longitudes de onda.
WO2005031431A1 (de) * 2003-09-25 2005-04-07 Leica Microsystems Cms Gmbh Mikroskopobjektiv zur totalinternen-reflexions-mikroskopie und mikroskop
EP2278287B1 (en) 2003-10-27 2016-09-07 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
US8018598B2 (en) 2004-05-29 2011-09-13 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging
AU2005270037B2 (en) 2004-07-02 2012-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
JP5053845B2 (ja) 2004-08-06 2012-10-24 ザ ジェネラル ホスピタル コーポレイション 光学コヒーレンス断層撮影法を使用して試料中の少なくとも１つの位置を決定するための方法、システムおよびソフトウェア装置
JP5324095B2 (ja) 2004-08-24 2013-10-23 ザ ジェネラル ホスピタル コーポレイション 血管セグメントを画像化する方法および装置
EP1989997A1 (en) 2004-08-24 2008-11-12 The General Hospital Corporation Process, System and Software Arrangement for Measuring a Mechanical Strain and Elastic Properties of a Sample
US7365859B2 (en) 2004-09-10 2008-04-29 The General Hospital Corporation System and method for optical coherence imaging
EP1804638B1 (en) 2004-09-29 2012-12-19 The General Hospital Corporation System and method for optical coherence imaging
EP2278266A3 (en) 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
WO2006058346A1 (en) 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
WO2006095343A1 (en) * 2005-03-10 2006-09-14 Anatoly Babchenko An optical sensor and a method of its use
EP2325803A1 (en) 2005-04-28 2011-05-25 The General Hospital Corporation Evaluating optical coherence tomography information for an anatomical structure
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
DE602006017558D1 (de) 2005-08-09 2010-11-25 Gen Hospital Corp Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie
EP1940286A1 (en) 2005-09-29 2008-07-09 General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
JP4642681B2 (ja) * 2005-09-30 2011-03-02 富士フイルム株式会社 光断層画像化装置
CA2967964A1 (en) * 2005-10-11 2007-04-19 Duke University Systems and method for endoscopic angle-resolved low coherence interferometry
US8537366B2 (en) * 2005-10-11 2013-09-17 Duke University Systems and methods for endoscopic angle-resolved low coherence interferometry
JP5203951B2 (ja) 2005-10-14 2013-06-05 ザ ジェネラル ホスピタル コーポレイション スペクトル及び周波数符号化蛍光画像形成
US7796270B2 (en) 2006-01-10 2010-09-14 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
CN101384212A (zh) 2006-01-19 2009-03-11 通用医疗公司 通过上皮内腔器官束扫描对上皮内腔器官进行光学成像的方法和系统
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
US10426548B2 (en) 2006-02-01 2019-10-01 The General Hosppital Corporation Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
US9186066B2 (en) 2006-02-01 2015-11-17 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
EP3143926B1 (en) 2006-02-08 2020-07-01 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
JP2009527770A (ja) * 2006-02-24 2009-07-30 ザ ジェネラル ホスピタル コーポレイション 角度分解型のフーリエドメイン光干渉断層撮影法を遂行する方法及びシステム
EP3150110B1 (en) 2006-05-10 2020-09-02 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
US20080021276A1 (en) * 2006-07-21 2008-01-24 Oncoscope, Inc. Protective probe tip, particularly for use on a fiber-optic probe used in an endoscopic application
EP2054712B1 (en) 2006-08-25 2015-10-07 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
WO2008089342A1 (en) 2007-01-19 2008-07-24 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
US7502119B2 (en) * 2007-01-29 2009-03-10 Filmetrics, Inc. Thin-film metrology using spectral reflectance with an intermediate in-line reference
EP2602651A3 (en) 2007-03-23 2014-08-27 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
WO2008157790A2 (en) * 2007-06-20 2008-12-24 The Trustees Of Dartmouth College Pulsed lasers in frequency domain diffuse optical tomography and spectroscopy
WO2009018456A2 (en) 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
EP2191254B1 (en) 2007-08-31 2017-07-19 The General Hospital Corporation System and method for self-interference fluorescence microscopy, and computer-accessible medium associated therewith
JP2009063407A (ja) * 2007-09-06 2009-03-26 Yokogawa Electric Corp 照射集光装置
WO2009036418A1 (en) * 2007-09-13 2009-03-19 Duke University Apparatuses, systems, and methods for low-coherence interferometry (lci)
WO2009059034A1 (en) 2007-10-30 2009-05-07 The General Hospital Corporation System and method for cladding mode detection
AU2009204187B2 (en) * 2008-01-08 2015-02-05 Oncoscope, Inc. Systems and methods for tissue examination, diagnostic, treatment, and/or monitoring
US9952148B2 (en) * 2008-02-19 2018-04-24 Trustees Of Tufts College Non-invasive optical characterization of biomaterial mineralization
DE102008016973B4 (de) * 2008-04-03 2009-12-31 Precitec Optronik Gmbh Interferometer und Verfahren zum Betreiben eines Interferometers
US7898656B2 (en) * 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
US8593619B2 (en) 2008-05-07 2013-11-26 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
EP2300800A2 (en) * 2008-06-12 2011-03-30 East Carolina University Flow cytometer apparatus for three dimensional diffraction imaging and related methods
JP5795531B2 (ja) 2008-06-20 2015-10-14 ザ ジェネラル ホスピタル コーポレイション フューズドファイバオプティックカプラ構造、及びその使用方法
WO2010009136A2 (en) 2008-07-14 2010-01-21 The General Hospital Corporation Apparatus and methods for color endoscopy
KR101109968B1 (ko) * 2008-07-23 2012-02-17 올림푸스 메디칼 시스템즈 가부시키가이샤 피검체 관측 장치 및 피검체 관측 방법
WO2010039921A2 (en) 2008-10-01 2010-04-08 East Carolina University Methods and systems for optically characterizing a turbid material using a structured incident beam
US8120781B2 (en) * 2008-11-26 2012-02-21 Zygo Corporation Interferometric systems and methods featuring spectral analysis of unevenly sampled data
EP2359121A4 (en) 2008-12-10 2013-08-14 Gen Hospital Corp SYSTEMS, DEVICE AND METHOD FOR EXPANDING THE IMAGING DEPTH RANGE IN OPTICAL COHERENCE TOMOPOMAGRAPH BY OPTICAL SUB-TESTING
US8537367B2 (en) * 2009-01-17 2013-09-17 Luna Innovations Incorporated Optical imaging for optical device inspection
WO2010090837A2 (en) 2009-01-20 2010-08-12 The General Hospital Corporation Endoscopic biopsy apparatus, system and method
JP2012515930A (ja) 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
JP5325679B2 (ja) * 2009-07-03 2013-10-23 富士フイルム株式会社 低コヒーレンス光源を用いた動的光散乱測定装置及び光散乱強度測定方法
BR112012001042A2 (pt) 2009-07-14 2016-11-22 Gen Hospital Corp equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica.
TWI425188B (zh) * 2009-08-31 2014-02-01 Zygo Corp 顯微鏡系統和成像干涉儀系統
JP5560628B2 (ja) * 2009-09-04 2014-07-30 ソニー株式会社 検査装置および検査方法
JP2011095181A (ja) * 2009-10-30 2011-05-12 Sysmex Corp 粒子分析装置
US9823127B2 (en) 2010-01-22 2017-11-21 Duke University Systems and methods for deep spectroscopic imaging of biological samples with use of an interferometer and spectrometer
CA2787696A1 (en) * 2010-01-22 2011-07-28 Adam Wax Multiple window processing schemes for spectroscopic optical coherence tomography (oct) and fourier domain low coherence interferometry
EP2542145B1 (en) 2010-03-05 2020-08-12 The General Hospital Corporation Systems which provide microscopic images of at least one anatomical structure at a particular resolution
WO2011115627A1 (en) * 2010-03-19 2011-09-22 Duke University Single-mode optical fiber-based angle-resolved low coherence interferometric (lci) (a/lci) and non-interferometric systems and methods
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2575597B1 (en) 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
US9795301B2 (en) 2010-05-25 2017-10-24 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
US8462349B1 (en) * 2010-07-20 2013-06-11 Science Applications International Corporation System and method for a self-referencing interferometer
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WO2013013049A1 (en) 2011-07-19 2013-01-24 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
EP2748587B1 (en) 2011-08-25 2021-01-13 The General Hospital Corporation Methods and arrangements for providing micro-optical coherence tomography procedures
EP2565625A1 (en) * 2011-09-05 2013-03-06 Ludwig-Maximilians-Universität München Optical measurement system and method for operating an optical measurement system
US9341783B2 (en) 2011-10-18 2016-05-17 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
EP2852315A4 (en) 2012-05-21 2016-06-08 Gen Hospital Corp DEVICE, APPARATUS AND METHOD FOR CAPSULE MICROSCOPY
US9968261B2 (en) 2013-01-28 2018-05-15 The General Hospital Corporation Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
US10893806B2 (en) 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
WO2014124537A1 (en) * 2013-02-14 2014-08-21 Verisante Technology, Inc. Method and apparatus for optical measurements under ambient light conditions
WO2014144709A2 (en) 2013-03-15 2014-09-18 The General Hospital Corporation Methods and systems for characterizing an object
WO2014144307A2 (en) 2013-03-15 2014-09-18 Gebhart Steven C Probe assembly and disposable cover particularly for use in endoscope applications of low coherence interferometry
EP2997354A4 (en) 2013-05-13 2017-01-18 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
WO2015013651A2 (en) 2013-07-26 2015-01-29 The General Hospital Corporation System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
US10228556B2 (en) 2014-04-04 2019-03-12 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
US10190911B2 (en) * 2014-04-25 2019-01-29 X-Rite, Inc. Targeting system for color measurement device
JP2017525435A (ja) 2014-07-25 2017-09-07 ザ ジェネラル ホスピタル コーポレイション インビボ・イメージングおよび診断のための機器、デバイスならびに方法
US20170219485A1 (en) * 2014-10-01 2017-08-03 Purdue Research Foundation Organism Identification
WO2016145393A1 (en) * 2015-03-12 2016-09-15 Purdue Research Foundation Biodynamic microscopes and methods of use thereof
DE102016218290A1 (de) * 2016-07-15 2018-01-18 Carl Zeiss Meditec Ag Verfahren zur hochsensitiven Messung von Abständen und Winkeln im menschlichen Auge
US10434970B2 (en) * 2016-12-08 2019-10-08 Toyota Jidosha Kabushiki Kaisha Vehicle side section structure
GB201803523D0 (en) * 2018-03-05 2018-04-18 Malvern Panalytical Ltd Improved particle sizing by optical diffraction
CN109620134B (zh) * 2019-01-21 2020-05-22 浙江大学 基于光纤阵列多通道并行探测的微血管造影方法和系统
JP7149532B2 (ja) * 2019-04-26 2022-10-07 株式会社日立製作所 粒子線実験データ解析装置
US11333487B2 (en) 2019-10-28 2022-05-17 Kla Corporation Common path mode fiber tip diffraction interferometer for wavefront measurement
CN113091896B (zh) * 2021-03-18 2023-03-14 西北工业大学 基于偏振光栅的动态测量任意光场完整信息的方法及光路
CN113670854B (zh) * 2021-08-12 2024-06-11 之江实验室 一种微分干涉对比显微内窥成像系统及内窥成像方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243005A2 (en) * 1986-03-25 1987-10-28 Dolan-Jenner Industries, Inc. Fiber optic imaging system for on-line monitoring
US5601087A (en) * 1992-11-18 1997-02-11 Spectrascience, Inc. System for diagnosing tissue with guidewire
CN1341209A (zh) * 1999-01-25 2002-03-20 牛顿实验室公司 使用偏振光对组织成像

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61110033A (ja) * 1984-11-02 1986-05-28 Toray Ind Inc 凝集反応の測定装置
US4646722A (en) 1984-12-10 1987-03-03 Opielab, Inc. Protective endoscope sheath and method of installing same
US4699513A (en) * 1985-02-08 1987-10-13 Stanford University Distributed sensor and method using coherence multiplexing of fiber-optic interferometric sensors
US6564087B1 (en) 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
US6501551B1 (en) 1991-04-29 2002-12-31 Massachusetts Institute Of Technology Fiber optic imaging endoscope interferometer with at least one faraday rotator
US6134003A (en) * 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
US5956355A (en) * 1991-04-29 1999-09-21 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser
US5386817A (en) 1991-06-10 1995-02-07 Endomedical Technologies, Inc. Endoscope sheath and valve system
US5208466A (en) * 1991-10-08 1993-05-04 Beckman Instruments, Inc. Apparatus and method for aligning capillary column and detection optics
JPH0695036A (ja) * 1992-07-27 1994-04-08 Nikon Corp 光学素子
EP0658090B1 (en) 1992-09-01 1998-11-04 Edwin L. Adair Sterilizable endoscope with separable disposable tube assembly
US5643175A (en) 1992-09-01 1997-07-01 Adair; Edwin L. Sterilizable endoscope with separable disposable tube assembly
DE4411017C2 (de) * 1994-03-30 1995-06-08 Alexander Dr Knuettel Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen
US5771327A (en) 1996-11-18 1998-06-23 Optical Biopsy Optical fiber probe protector
US6002480A (en) 1997-06-02 1999-12-14 Izatt; Joseph A. Depth-resolved spectroscopic optical coherence tomography
US6091984A (en) 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
US5930440A (en) 1998-02-18 1999-07-27 Optical Biopsy Technologies, Llc Fiber optic probe protector
US20040116682A1 (en) 1998-03-06 2004-06-17 Nordine Cheikh Nucleic acid molecules and other molecules associated with the carbon assimilation pathway
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US6404497B1 (en) 1999-01-25 2002-06-11 Massachusetts Institute Of Technology Polarized light scattering spectroscopy of tissue
JP4932993B2 (ja) * 1999-03-29 2012-05-16 ボストン サイエンティフィック サイムド，インコーポレイテッド 単一モード光ファイバーカップリングシステム
US6233373B1 (en) * 1999-06-21 2001-05-15 The United States Of America As Represented By The Secretary Of The Navy Optical spectrometer with improved geometry and data processing for monitoring fiber optic bragg gratings
US20040215296A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. System and method for treating abnormal epithelium in an esophagus
CN1279345C (zh) * 2000-04-28 2006-10-11 麻省理工学院 使用场基光散射光谱学的方法和系统
WO2002021074A2 (en) 2000-09-04 2002-03-14 Forskningscenter Risø Optical amplification in coherence reflectometry
US6697652B2 (en) 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
US6775007B2 (en) * 2001-01-29 2004-08-10 Joseph A. Izatt Frequency-encoded parallel OCT and associated systems and methods
US6879851B2 (en) * 2001-06-07 2005-04-12 Lightlab Imaging, Llc Fiber optic endoscopic gastrointestinal probe
WO2003012405A2 (en) * 2001-08-03 2003-02-13 Rollins Andrew M Aspects of basic oct engine technologies for high speed optical coherence tomography and light source and other improvements in oct
US20030042438A1 (en) * 2001-08-31 2003-03-06 Lawandy Nabil M. Methods and apparatus for sensing degree of soiling of currency, and the presence of foreign material
US6863651B2 (en) 2001-10-19 2005-03-08 Visionscope, Llc Miniature endoscope with imaging fiber system
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US6879741B2 (en) 2002-11-04 2005-04-12 C Technologies, Inc Sampling end for fiber optic probe
US20090075391A1 (en) * 2003-01-17 2009-03-19 Newton Laboratories, Inc. Spectroscopic diagnostic method and system based on scattering of polarized light
US7761139B2 (en) 2003-01-24 2010-07-20 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
WO2004073501A2 (en) * 2003-02-20 2004-09-02 Gutin Mikhail Optical coherence tomography with 3d coherence scanning
EP1611411A2 (en) * 2003-03-26 2006-01-04 Southwest Sciences Incorporated Method and apparatus for imaging internal structures of transparent and translucent materials
US7102758B2 (en) 2003-05-06 2006-09-05 Duke University Fourier domain low-coherence interferometry for light scattering spectroscopy apparatus and method
US20050053974A1 (en) * 2003-05-20 2005-03-10 University Of Maryland Apparatus and methods for surface plasmon-coupled directional emission
US7428050B2 (en) * 2003-06-25 2008-09-23 The University Of Akron Multispectral, multifusion, laser-polarimetric optical imaging system
GB2407155A (en) * 2003-10-14 2005-04-20 Univ Kent Canterbury Spectral interferometry method and apparatus
AU2005270037B2 (en) * 2004-07-02 2012-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
US7417740B2 (en) * 2004-11-12 2008-08-26 Medeikon Corporation Single trace multi-channel low coherence interferometric sensor
JP4429886B2 (ja) * 2004-12-09 2010-03-10 富士フイルム株式会社 光断層映像装置
US7428057B2 (en) * 2005-01-20 2008-09-23 Zygo Corporation Interferometer for determining characteristics of an object surface, including processing and calibration
EP1839012B1 (en) * 2005-01-20 2014-05-07 Duke University Methods, systems and computer program products for characterizing structures based on interferometric phase data
EP1887946A2 (en) * 2005-06-06 2008-02-20 The Board Of Regents, The University Of Texas System Oct using spectrally resolved bandwidth
US7391520B2 (en) * 2005-07-01 2008-06-24 Carl Zeiss Meditec, Inc. Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver
JP2007029603A (ja) 2005-07-29 2007-02-08 Fujinon Corp 光診断治療装置
CA2967964A1 (en) 2005-10-11 2007-04-19 Duke University Systems and method for endoscopic angle-resolved low coherence interferometry
US7636168B2 (en) * 2005-10-11 2009-12-22 Zygo Corporation Interferometry method and system including spectral decomposition
JP2009527770A (ja) * 2006-02-24 2009-07-30 ザ ジェネラル ホスピタル コーポレイション 角度分解型のフーリエドメイン光干渉断層撮影法を遂行する方法及びシステム
US7366372B2 (en) 2006-02-27 2008-04-29 Honeywell International, Inc. Waveguide device having improved spatial filter configurations
AU2007249858B2 (en) 2006-05-12 2013-01-31 Northshore University Healthsystem Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy
US8131348B2 (en) * 2006-05-12 2012-03-06 Northshore University Healthsystem Systems, methods and apparatuses of elastic light scattering spectroscopy and low coherence enhanced backscattering spectroscopy
US20080058629A1 (en) * 2006-08-21 2008-03-06 University Of Washington Optical fiber scope with both non-resonant illumination and resonant collection/imaging for multiple modes of operation
US20080255461A1 (en) 2007-03-26 2008-10-16 Robert Weersink Real-time optical monitoring system and method for thermal therapy treatment
US7583872B2 (en) * 2007-04-05 2009-09-01 University Of Washington Compact scanning fiber device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243005A2 (en) * 1986-03-25 1987-10-28 Dolan-Jenner Industries, Inc. Fiber optic imaging system for on-line monitoring
US5601087A (en) * 1992-11-18 1997-02-11 Spectrascience, Inc. System for diagnosing tissue with guidewire
CN1341209A (zh) * 1999-01-25 2002-03-20 牛顿实验室公司 使用偏振光对组织成像

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
John W. Pyhtila et al.Rapid,depth-resolved light scattering measurements usingFourier domain,angle-resolved low coherence interferometry.Optics Express12 25.2004,12(25),6178-6183.
John W. Pyhtila et al.Rapid,depth-resolved light scattering measurements usingFourier domain,angle-resolved low coherence interferometry.Optics Express12 25.2004,12(25),6178-6183. *
John W.Pyhtila et al.Determining nuclear morphology using an improved angle-resolved low coherence interferometry system.Optics Express11 25.2003,11(25),3473-3484.
John W.Pyhtila et al.Determining nuclear morphology using an improved angle-resolved low coherence interferometry system.Optics Express11 25.2003,11(25),3473-3484. *

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