CN101316769B - Plug device for a container and container provided with one such device - Google Patents

Plug device for a container and container provided with one such device Download PDF

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Publication number
CN101316769B
CN101316769B CN2006800447220A CN200680044722A CN101316769B CN 101316769 B CN101316769 B CN 101316769B CN 2006800447220 A CN2006800447220 A CN 2006800447220A CN 200680044722 A CN200680044722 A CN 200680044722A CN 101316769 B CN101316769 B CN 101316769B
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CN
China
Prior art keywords
ring
drive member
edge
sealing arrangement
cap
Prior art date
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Active
Application number
CN2006800447220A
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Chinese (zh)
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CN101316769A (en
Inventor
安托万·阿内亚斯
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Biocorp Recherche et Developpement
Original Assignee
Biocorp Recherche et Developpement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0603508A external-priority patent/FR2900131B1/en
Application filed by Biocorp Recherche et Developpement filed Critical Biocorp Recherche et Developpement
Priority claimed from PCT/FR2006/002616 external-priority patent/WO2007063218A1/en
Publication of CN101316769A publication Critical patent/CN101316769A/en
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Publication of CN101316769B publication Critical patent/CN101316769B/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/241—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D45/00—Clamping or other pressure-applying devices for securing or retaining closure members
    • B65D45/02—Clamping or other pressure-applying devices for securing or retaining closure members for applying axial pressure to engage closure with sealing surface
    • B65D45/30—Annular members, e.g. with snap-over action or screw-threaded
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Closures For Containers (AREA)

Abstract

The invention relates to a plug device (500) comprising a elastomer plug (501) and a cover (502) for covering the neck (12) of a container and the plug (501) inserted in the neck (12). The cover (502) consists of a plastic material and comprises a ring (503) and a manoeuvring element (504). Said ring (503) can surround the plug (501) and the neck (12) when mounted, and is provided with means (503G) for being locked onto the neck (12). The manoeuvring element (504) can be mounted on the ring (503), with any angular orientation about a central axis (X503) of the ring. Said manoeuvring element is provided with an annular edge (505D) that can be engaged between an external skirt (503A) of the ring (503) and at least one lip (503G) which forms a locking means and radially extends towards the central axis (X503) of the ring, away from the skirt (503A).

Description

The container that is used for the sealing arrangement of container and has this type of device
The present invention relates to have the sealing arrangement of the container of neck, and relate to the method that this type of device is installed, and the container that is equipped with this type of device.
In the containers for medical use field, the active component that uses vial (vial) to preserve freeze dried powder, powder or solution form is known.This type of bottle need seal with sealing means so that its content remains on gratifying store status, when using it till.A kind of like this sealing arrangement of known use comes closed vial hermetically; The sealing device comprises the elastic body bottle stopper (stopper) that has gas, liquid and the complete airtight function of bacterium; The valve protection cap of processing by metal (being generally aluminium) that sealing function is provided (capsule); And the tongue that can take off, this tongue is carried out the function of tamper-evident mark and before can getting into bottle stopper, is removed.
When volume was pressed the metal valve protection cap at the top of vial, glass chip might be separated with bottle, and this chip can drop on the top of bottle stopper and constitute the risk of polluting content.In addition, no matter whether the content of bottle has lived through the lyophilisation stage, volume pressure metal valve protection cap immediately after bottle stopper is installed.To be different from the room that the content to bottle carries out disinfection also be common owing to be used to roll up the residing room of machine of pressing valve protection cap, and said different room is not aseptic usually, therefore bottle stopper is installed and the time gap installed between the valve protection cap maybe be very long.In the interbody spacer, no matter be unexpected or intentional therefore at this moment, the content of bottle all might be polluted.When using bottle, suppose hospital personnel after removing tamper-evident tongue, to carrying out disinfection by the approaching bottle stopper upper surface of opening on valve protection cap.This operation passes out of mind sometimes, possibly produce the risk of pollution thus.
US-A-05 314 084 discloses and has used enclosing cover inner cap to be locked on the neck of container with the protection bottle stopper.This locking mode depends on the elasticity of enclosing cover, and actv. always not.
More specifically, the present invention through a kind of novelty is provided special easy-on and make the sealing arrangement that the elastic body bottle stopper is protected at perfusion operation and/or the end in lyophilisation cycle immediately, to attempt to improve these defectives.
For this reason; The present invention relates to a kind of sealing arrangement that is used to have the container of neck; Said device comprises the lid that elastic body bottle stopper, plastic material are processed; Said lid covers said neck and said bottle stopper when being suitable for the appropriate location in being in said neck; Said lid comprises ring and drive member, and said ring is suitable in assembled configuration surrounding said bottle stopper and said neck, and said ring has and is used at the enterprising line-locked blocking device of said neck; Said drive member is suitable for being installed on the said ring and is suitable for becoming arbitrarily angled orientation about the central axis of said ring, and said drive member has the actuation gear that is used to actuate the blocking device that is used to lock said ring.Said sealing arrangement is characterised in that; The actuation gear of said drive member comprises the ring edge of said drive member, and said edge is suitable in the outside shirt rim of said ring and forms blocking device and engage between at least one block that said radial axis is extended from said shirt rim.
Because lid is processed by plastic material, thereby do not exist and contact with the surface of container and produce the risk of glass contamination particle.Because its structure comprises ring and drive member, thereby said ring can be installed on the container with very easy mode, when said ring arrived the final position on the container neck, the actuation gear of drive member can be actuated the blocking device of ring.Because drive member can be installed on the ring with any angular orientation, so lid is than easier to mount.In addition, especially easy and quick by the locking that the annular flange flange of drive member obtains, and do not rely on the elasticity of ring.It is easier on container, installing and lock said device automatically.
According to favourable but non-essential aspect of the present invention, said device can comprise the one or more characteristics in the claim 2 to 18.
Especially; Said drive member can be made up of the ring-type element and the cap that carry first and second devices; Block on the edge of the central opening through being hooked in ring-type element prevents that said cap from moving on said ring-type element; Only through said element is carried out elastic deformation, can cap be installed on the ring-type element, said deformation is the result who only is installed in the power that can apply before on the said ring in drive member.In the case; Each block advantageously has the hook on the edge that is used to be hooked in opening; Said hook and lean against the distance between the surface of the cap on the ring-type element; When not being installed on the said element, be parallel to the distance between the part that is used to hold the above-mentioned surface that leans against the cap on the ring-type element of edge that the central axis of ring-type element measures and ring-type element when cap.
The present invention also provides the method that aforesaid device is installed, and said method comprises:
A) on the edge of the central opening of ring-type element, apply the power of the central axis that is roughly parallel to said opening; Said power is applied to and is equipped with on the side of the relative ring-type element in the side of said cap, and so that the mode that said edge flexibly is out of shape applies said power; And
B) along the direction opposite with said power, depress said cap towards said ring-type element, so that the edge mate of the elastic deformation of its block that hooks and above-mentioned opening.
The present invention also provides a kind of container that above-mentioned sealing arrangement is installed.This type of container seals more easily than existing container and uses.
Through with the mode of instance with reference to accompanying drawing provide to description according to three embodiments of the container of principle of the present invention and device, can understand the present invention better and other advantage of the present invention will become more apparent, wherein:
Fig. 1-Fig. 5 is schematic axial, cross-sectional view and the block diagram that each step of packaging product in bottle is shown according to the present invention;
Fig. 6 and Fig. 7 are the diagrammatic perspective view that two steps using bottle are shown;
Fig. 8 is the partial enlarged drawing that the details VIII of Fig. 4 is shown;
Fig. 9 is the three-dimensional axial, cross-sectional view of amplification of lid of sealing arrangement of the bottle of Fig. 1 to Fig. 8;
Figure 10 A and 10B are the block diagrams from two different angles of the ring of the lid of Fig. 9;
Figure 11 A and 11B are the block diagrams from two different angles of the locking component part of the lid of Fig. 9;
Figure 12 A and 12B be the member that is used to lock the lid of Fig. 9, from the block diagram of two different angles of cap, wherein Figure 12 A is a part sectional view;
Figure 13 is the partial enlarged drawing of the details XIII of Fig. 4, has wherein ignored pressing plate;
Figure 14 is the partial enlarged drawing of the details XIV of Fig. 5;
Figure 15 is the exploded perspective view of the lid of Fig. 9;
Figure 16 is similarly scheming with Figure 15 according to the device of second embodiment of the present invention;
Device and Fig. 8 that Figure 17 is based on the 3rd embodiment of the present invention similarly scheme;
Figure 18 is the three-dimensional axial, cross-sectional view of amplification of lid of the device of Figure 17;
Figure 19 A and 19B belong to the ring of lid of Figure 18 from the block diagram of two different angles;
Figure 20 A and 20B belong to the blocking device part of lid of Figure 18 from the block diagram of two different angles;
Figure 21 A and 21B be the locking component that belongs to Figure 18 lid, from the block diagram of two different angles of cap, wherein Figure 21 is a part sectional view;
Figure 22 is that device and Figure 13 of Figure 17-Figure 21 similarly schemes;
Figure 23 is that device and Figure 14 of Figure 17-Figure 22 similarly schemes;
Figure 24 is the exploded perspective view of the lid of Figure 17;
Figure 25 is the view of drive element in assembling process; And
Figure 26 is the partial enlarged drawing that the details XXVI of Figure 25 is shown.
At Fig. 1, fill with product P in the vial 1, for example medicine.Pipet 2 inserts in the vial 1 via its opening 11, and opening 11 is limited the neck 12 at the edge that presents directed outwards 13.X 1Represent the diad of bottle 1.
After the medicine P that has injected scheduled volume in the bottle 1, pipet is removed, and sealing arrangement 500 is placed on the neck 12.Device 500 comprises elastic body bottle stopper 501, and its shape is suitable for part to be inserted in the opening 11, and bottle stopper 501 leans against on bottom surface 14 facing surfaces 13A edge 13 and bottle 1 simultaneously.The appropriate location that in a single day bottle stopper 501 is placed in the neck 12 just is hedged off from the outer world the content of bottle 1.Device 500 also comprises lid 502, and lid 502 is designed to isolated bottle stopper and neck 12 when said sealing arrangement is in airtight configuration.
More specifically, visible from Fig. 9, lid 502 comprises the ring 503 that plastic material is processed, and the internal diameter of ring 503 is enough to make it to surround edge 13.
Lid 502 also comprises drive member 504, drive member 504 by the part of processing with plastic material that is hereinafter referred to as " key " 505 be similarly the cap 506 that is fixed on the key 505 that plastic material processes with reversing and form.Cap 506 carries and contacts with the outside face of the annular section 505A of key 505 and through being ultrasonically welded to 6 projection 506A on the key 505.In a variant, the spot weld between the part 505 and 506 obtains through patterned heat.Patterned heat heating head capable of using carries out, and utilizes heating head to heat to have the advantage faster than ultrasonic heating.Be easy to cap 506 removed from key 505 via the spot weld of projection 506A is feasible through tearing projection 506A.
Cap 506 also has lip 506B, and lip 506B is bonded on the central opening 505B place of key 505, and this moment, these two elements were fixed to one another, thereby forms member 504.
Projection 506A is distributed in the central axis X of cap 506 regularly 506, and form wave structure 506C on every side, to be contained in part 505A in lip-deep, the adjacent depression 505P of bottle stopper 506 with opening 505B.The configuration of structure 506C and depression 505P makes it possible to cooperatively interact through shape and makes bottle stopper 506 placed in the middle on key 505, thereby before welding projection 506A, makes axis X 506Aim at the central axis X of key 505 505
Key 505 has two groups every group 2 elasticity tongue 505C, and elasticity tongue 505C forms through on the shirt rim 505J that is formed by key 505, opening 4 opening 505Q, and with axis X 505Be the center.Reference numeral 505D represents the ring edge away from part 505A of shirt rim 505J.
Each tongue 505C has from the shirt rim radially the outwards outer fin 505E of protrusion.Thus, each tongue 505C forms elastic hook.
Tongue 505C is organized as two tongue 505C 1With two tongue 505C 2, wherein, two tongue 505C 1Fin 505E extend to apart from edge 505D first apart from d 1The place, two tongue 505C 2Fin 505E extend to apart from edge 505D second distance d 2The place, and apart from d 2Greater than apart from d 1
Tongue 505C 1Extend to edge 505D from the edge of the corresponding opening 505Q far away apart from edge 505D.Tongue 505C 2Extend to direction from the edge of the corresponding opening 505Q nearer away from said edge 505D apart from edge 505D.
Ring 503 comprises the peripheral annular shirt rim 503A with first edge 503B.Within the 503A of shirt rim and with edge 503B opposite position, formed and be approximately perpendicular to ring 503 and the central axis X of shirt rim 503A 503Annular section 505C.Centering on axis X 503In 5 annular regions that distribute, part 503C is extended by 5 503D of bridge portion, and 5 503D of bridge portion are connected to the inside face of shirt rim 503A on the edge of near the 503C.The inside face of the 503D of bridge portion 503A from the shirt rim extends a segment distance to limit 5 independently housing 503E of elongation, wherein via ring 503 carrying part 503C and in Figure 10 A appreciiable one side can insert the shirt rim 505J of key 505.
In part 503C can't help annular region that the 503D of bridge portion extends, be formed with 5 opening 503F, when shirt rim 505J is inserted among the housing 503E, can insert shirt rim 505J equally in each among the opening 503F.The inside of shirt rim 503A and on the edge of 503B near alternately arrange the end of the 503D of bridge portion and the end of block 503G.
Towards each opening 503F, the inner surface radial direction ground that is provided with the 503A from the shirt rim is to axis X 503The locking stop 503G that extends.Reference numeral 503J represents the free edge of each block 503G.
Each 503D of bridge portion has the slope 503K that is used to wedge the bottle stopper 501 that disposes according to Fig. 2.Slope 503K is designed to penetrate from the teeth outwards in the bottle stopper, moves with respect to shirt rim 503 to prevent bottle stopper.
Each 503D of bridge portion surface within it is provided with crooked about 90 ° fin 503N, so as through the outside face that radially penetrates bottle stopper coupling link 503 and the bottle stopper 501 that rotates.
Device 500 is assembling in the following manner: welding helmet 506 on key 505, the axis X that then will overlap 506And X 503Alignment axis X 505, and shirt rim 505J engage got among the annular space 503V that between shirt rim 503A, the 503D of bridge portion and locking stop 503G, limits.Because the annular essence of edge 505D and space 503V, parts 504 can be installed in and encircle on 503 and need not to consider especially in advance that it is about axis X 503The angulation direction.In other words, when in the 503V of space, inserting edge 505D via the inlet of housing 503E and opening 503F, member 504 and the axis X that overlaps at present 505And X 506Can become any angle.This makes than said lid easier to mount, because need not check its direction.
The inside face of shirt rim 503A has peripheral grooves 503L, and peripheral grooves 503L forms the edge 503M near shirt rim 503A, and edge 503M is neighbouring part 503C away from edge 503B.Groove 503L is configured and is used for being installed in the fin 505E that ring held tongue 505C 503 last times when member 504.More specifically, member 504 is installed to the ring 503 last times, shirt rim 505J penetrates among the 503V of space via the entering opening of opening 503F and housing 503E.Edge 503B is then shifted to until tongue 505C in shirt rim 505 1 Fin 505E in groove 503L, engage, make member 504 and part 503C keep certain distance thus, thereby be positioned at position shown in Figure 9.
Then can bottle stopper 501 be inserted in the lid 502 and through slope 503K it is wedged.As shown in Figure 2, stack-mounted device 500 can be placed on the neck 12 of bottle 1 in this way.In this configuration, bottle stopper 501 is not exclusively closed opening 11, because bottle stopper has lateral incision 501A, thereby stays the gap 200 near the part of surperficial 13A.
Be equipped with the bottle 1 of device 500 can then be placed in the freeze drier 300, wherein the hydrone of 1 li existence of bottle such as Fig. 3 and Fig. 8 are according to arrow F 1Shown direction is discharged to the outside, and through the gap between lid 502 and the fin 13.
In like Fig. 3 and configuration shown in Figure 8, bottle stopper 501 has the projection of stopping at its outside face radially.
Afterwards, as shown in Figure 4, when device 500 is also in freeze drier 300, can apply longitudinal axis X above that with bottle 1 and opening 11 1Parallel power F 2, this axis is followed and axis X 503, X 505And X 506Overlap.Axial force F 2Be to be applied by the plate 301 that can in freeze drier, move, plate 301 also is suitable in being arranged in freeze drier, applying roughly the same power F on a collection of bottle 1 on the par line simultaneously 2
On bottle stopper 506, apply power F at member 504 2The time, tongue 505C 1Fin 505E via the mutual action between fin 505E and groove 503L with this power be delivered to the ring 503 on.Tongue 505C 1Thus as pusher, thereby make ring 503 at power F 2Effect under move or promote to the bottom surface 14 of bottle 1, make it possible to the configuration that reaches shown in Figure 5 thus.Because this moves, locking stop 503G is folding to the inside face of shirt rim 503A, and need not to cause the radially deformation of shirt rim 503A.The power F that need apply thus, for the configuration that reaches Fig. 4 and Figure 13 2Be relatively low.
In case locking stop 503G surpasses fin 13 and arrives Fig. 4 and the position of Figure 13, ring 503 just can not move to bottom surface 14 again, because part 503C leans against on the bottle stopper 101 that is engaged in the neck 12.Then, maintenance energy F 2Has following effect: from groove 503L, discharge tongue 505C 1Fin 505E, and make member 504 with respect to ring 503 bottoms of moving with the space 503V between the inside face that edge 505D is moved on to locking stop 503G and shirt rim 503A.Edge 505B engages the effect that has between locking stop 503G and shirt rim 503A be to make these blocks radially be out of shape with direction entad, and its each free edge 503J is to axis X 1Move.These edges then lean against fin 13 on the annular surface 13B of bottom surface 14, and valve protection cap 500 is locked on the neck 12 securely thus, like Fig. 5 and shown in Figure 14.
In the configuration shown in Fig. 5 and 14, tongue 505C 2Fin 505E get into groove 503L, play the function that prevents that member 504 from moving with respect to ring 503 thus.In other words, apart from d 1And d 2Difference corresponding with the stroke of member 504 between the position of Fig. 4 and Fig. 5, make thus to be locked in when being used for that lid 502 remained on the position on the neck 12 as locking stop 503G, will keep tongue 505C 2Automatically engage with groove 503L.
Because should move, fin 503N penetrates bottle stopper 501 simplely, thus bottle stopper 501 is kept securely and can not be with respect to ring 503 rotations.
Thus, the final location of lid 502 was accomplished by 2 stages.At F/s, settle bottle stopper 501, then 503A folds to exceed fin 13 towards the shirt rim with block 503G.In subordinate phase, block 503G is locked in the appropriate location by edge 505D.These two stages are by thrust F 2Carry out thrust F 2Size adapted to each in stage, kept obviously little value of the ratio value required in single stage location simultaneously, to such an extent as to the friction force that need overcome in time separates through the present invention with the deformation power that need provide, and between two stages, distributed.In addition, because shirt rim 503A does not have radial expansion when block 503G exceeds fin 13, thereby power F 2Can be less relatively, make thus lid 500 to be placed on the appropriate location than being easier to.
In a word, at F/s, configuration from the configuration transitions of Fig. 3 to configuration shown in Figure 4.In subordinate phase, configuration from the configuration transitions of Fig. 4 to configuration shown in Figure 5.
In this configuration, bottle 1 is closed by bottle stopper 501 hermetically, and by lid 502 protections, and because the locking that block 503G provides, thereby can prevent to take off said lid.
In this configuration, shown in figure 14, the lip 506B of cap 106 leans against on the outside face 501B of bottle stopper 501 via opening 505B and via the central opening 503A of part 503C, and when expectation during near the content of bottle 1, outside face 501B is exposed out.Under the effect of lip 506B, surperficial 501B is out of shape partly, and is shown in figure 14, because the material of bottle stopper 501 is more soft than the material of cap 506.
More specifically, the dish type middle body 501C of lip 506 complete insulation surfaces 501B, it is clean and sterile that this part can be considered to, because this part is hedged off from the outer world when it still is in the freeze drier 300.
When needs use the content of bottle 1, like the arrow F of Fig. 6 3Shown in, remove cap 506 through tearing projection 506A, get into above-mentioned part 501C thus, and part 501C need not to carry out disinfection.Then can in bottle 1, inject liquid to reformulate its content through syringe 400, as shown in Figure 7, use identical syringe then, utilize the known mode of medical personnel that its syringe needle is inserted the product that extraction is reformulated in the bottle stopper 501.
In second embodiment shown in Figure 16, has identical Reference numeral with above-mentioned embodiment similar elements.The lid 502 of this embodiment comprises ring 503 and the drive member 504 that is made up of key 505 and cap 506 similarly.This embodiment and the difference of a last embodiment be 4 tongue 505C of key 505 be same type and from the shirt rim ring edge 505D of 505J extends identical apart from d 1These 4 tongue 505C have the tongue 505C with a last embodiment 1Identical functions, and simultaneously be formed on the ring identical 503 in-to-in groove 503L and cooperate with a last embodiment.
The annular section 505A of key 505 has six hooks, in Figure 16, only can see two hooks wherein being represented by label 505F, and these two hooks are positioned at the opening 505B next door near the part 505A of the 505D towards the edge.These six hooks are designed to cooperate with the edge 503P of the central opening 503Q that is limited the annular section 503C that encircles 503.This cooperation occurs in member 504 when moving to the cooresponding position of Fig. 5 with the cooresponding position of Fig. 4, when the edge 505D that promptly occurs in key 505 will encircle 503 block 503G and move to the lock arrangement of neck 12.Thus, the second tongue 505C in the function of hook 505F and the last embodiment 2Function class seemingly.
In the 3rd embodiment shown in Figure 26, has identical Reference numeral at Figure 17 with the first embodiment similar elements.Following description relates to the difference with first and second embodiments basically.
The cap 506 of lid 502 carries 4 block 506A, and 4 block 506A are hooked in the edge 505B of the central opening 505B of key 505 1On.For this reason, each block 506A has and the cap 506 integrally moulded hook 506A that form 1, hook 506A 1From described block 506A radially with respect to the central axis X of cap 506 506Extend internally.When forming member 504 in that key 505 and cap 506 are fitted together, hook 506A 1Be bonded on edge 505B 1The below.More specifically, cap 506 has the surperficial 506C that is roughly the plane, and cap 506 leans against the end face 505A of the annular section 505A of key 505 thus 1On, wherein key 505 is entreated therein and is limited with opening 505B.In the configuration of stack-mounted of member 504, hook 506A 1With edge 505B 1At it away from surperficial 505A 1A side engagement.
The quantity of block 506A is not limited to 4, as long as can hook power be distributed between key 505 and cap 506.
Key 505 has one group 3 elasticity tongue 505C, and elasticity tongue 505C forms through in the 505J of shirt rim, making 3 opening 505A, and wherein, shirt rim 505J is formed by key 505, and with the axis X of the central axis of composition key 505 505Be the center.Shirt rim 505J is designated as 505D away from the ring edge of part 505A.
Each tongue 505C has from the shirt rim radially outstanding outside fin or the hook 505E of 505J.Thus, each tongue 505C forms elastic hook.
Between fin 505E and the edge 505D with axis X 505Parallel distance is designated as d 1
In addition, key 505 has the peripheral flange 505R radially outstanding and that between two opening 505Q, extend continuously from shirt rim 505J.The free edge 505R of flange 505 1And between the edge 505D and axis X 505Parallel distance is designated as d 2d 2Value greater than d 1Value.
Said flange is about axis X 505Be roughly conical butt, and 505D outwards stretches from the edge.
The ring 503 with first embodiment in identical.
When mounting cap 506 on key 505, need be with hook 506A 1Through opening 505B and edge 505B 1Cooperate.For this reason, shown in figure 25, key 505 is placed on the instrument 600, and wherein instrument 600 is defined for the annular surface 601 that receives the part 505A that leans on key 505 above that.Then, bottle stopper 506 appears at key 505 tops, simultaneously axis X 505And X 506Rough alignment, axis X 506With the central axis X of instrument 600 600 Aim at.Cap 506 then by with axis X 505, X 506And X 600Parallel power F 0Push instrument 600 to, engagement lip 506B in opening 505B makes hook 506A then thus 1Lean against the edge 505B of opening 505B 1On.As confining force F on cap 506 0The time, surperficial 506C leans against the upper surface 505A of part 505A 1On, and with power F ' 0Be passed to key 505, make shirt rim 505J thus along the arrow F among Figure 25 505Direction is slided.Because the part 505A of key 505 has leaned against on the surface 601, therefore by surface 601 in the bottom surface of part 505A 505A 2On apply directed force F 600, bottom surface 505A wherein 2Be at part 505A the next door, limit away from cap 506.Power F 600With power F 0On the contrary.
Its effect is to make edge 505B 2Near surperficial 506C, make the hook 506A of block 506A thus 1Exceed said edge and cooperation thereunder, shown in figure 26.
Hook 506A 1505B on the edge of 1Under cooperation only be through edge 505B 1Elastic deformation forms, and wherein this deformation is by means of directed force F 600Obtain.
In the configuration of Figure 16, X parallels to the axis 505Record, edge 505B 1And part 505A goes up the distance of admitting between the zone of leaning on cap 506 above that and is designated as d 3In addition, the axis X that is parallel to block 506A 506Its corresponding hook 506A of 506C that record, surperficial 1Between distance be designated as d 4
At one's leisure, that is, and when on part 505 and 506, not applying any power, apart from d 3Has the d of ratio 4Big value.Only on part 505A, apply and power F owing to instrument 600 0Directed force F in the opposite direction 600, thereby make apart from d 3Temporarily get less than apart from d 4Value, make hook 505A thus 1Be hooked in edge 505B 1Under, shown in figure 26.
Should observe, encircle for 503 last times when member 504 is installed in, in order to apply power F 600And can not reach the bottom surface 505A of the part 505A of key 505 2
Device 500 is to adopt the mode stack-mounted identical with first embodiment, and as stated, mounting cap 506 on key 505, the axis X that then will overlap 505And X 506With axis X 503Aim at, and shirt rim 505J is bonded among the annular space 503V that is limited shirt rim 503A, the 503D of bridge portion and locking stop 503G.When the opening 503F of 503V inserted edge 505D when the inlet through housing 503E with towards the space, member 504 can have the axis X with respect to present coincidence 505And X 506Any direction.
The inside face of shirt rim 503A has peripheral grooves 503L, and peripheral grooves 503L forms the edge 503M near shirt rim 503A, and edge 503M is neighbouring part 503C away from edge 503B.Groove 503L is configured and is used for being installed in the fin 505E that ring held tongue 505C 503 last times when member 504.More specifically, member 504 is installed to the ring 503 last times, shirt rim 505J penetrates among the 503V of space via the entering opening of opening 503F and housing 503E.Edge 503B is then shifted to until tongue 505C in shirt rim 505 1 Fin 505E in groove 503L, engage, make member 504 and part 503C keep certain distance thus, thereby be positioned at position shown in Figure 180.
Then can bottle stopper 501 be inserted in the lid 502 and through slope 503K it is wedged.Stack-mounted device 500 can be placed on the neck 12 of bottle 1 in this way, as is used for the shown in Figure 2 of first embodiment.
As first embodiment, be equipped with the bottle 1 of device 500 then to insert in the freeze drier 300.
In configuration shown in Figure 17, bottle stopper 501 has retention tab at its radially-outer surface.
After this, in freeze drier, as be used for the shown in Figure 4 of first embodiment, can apply direction and bottle 1 and longitudinal axis X neck 12 on 500 at device 1Parallel power F 2, this axis is followed and axis X 503, X 505And X 506Overlap.
On bottle stopper 506, apply power F at member 504 2The time, the fin 505E of tongue 505C is delivered to ring 503 with this power through the mutual action between said fin 505E and the groove 503L.Tongue 505C then is used as propelling unit, thereby at power F 2Effect will encircle down 503 and move or promote to the bottom 14 of bottle 1.Because should move, locking stop 503G is folding to the inside face of shirt rim 503A, and need not to make radially deformation of shirt rim 503A.The power F that therefore, need apply in order to reach configuration shown in Figure 22 2Less relatively.
In case locking stop 503G exceeds fin 13 and arrives position shown in Figure 22, ring 503 just no longer can move to bottom 14, because part 503C leans against on the bottle stopper 101 that cooperates with neck 12.Maintenance energy F 2Has following effect: from groove 503L, discharge fin 505E, and make member 504 move bottom with the space 503V between the inside face that edge 505D is moved on to locking stop 503G and crowd limit 503A with respect to ring 503.Edge 505B engages the effect that has between locking stop 503G and shirt rim 503A be to make these blocks radially be out of shape with direction entad, and its each free edge 503J is then to axis X 1Move.These edges then lean against fin 13 on the annular surface 13B of bottom surface 14, and valve protection cap 500 is locked on the neck 12 securely thus, and is shown in figure 23.
In configuration shown in Figure 23, flange 505R engages in groove 503L, plays the function that prevents that member 504 from moving with respect to ring 503 thus.In other words, apart from d 1And d 2Difference corresponding with the stroke of member 504 between the position of Figure 17 and Figure 22, can work as locking stop 503G thus and be locked in when being used for that lid 502 remained on the position on the neck 12, flange 505R is automatically engaged with groove 503L.
Because should move, spline 503N penetrates bottle stopper 501 simplely, thus bottle stopper 501 is kept securely and can not be with respect to ring 503 rotations.
Thus, the final location of lid 502 was accomplished by 2 stages.At F/s, settle bottle stopper 501, then 503A folds to exceed fin 13 towards the shirt rim with block 503G.In subordinate phase, block 503G is locked in the appropriate location by edge 505D.These two stages are by thrust F 2Carry out thrust F 2Size and each stage adaptation keep fully little value of the ratio value required in single stage location simultaneously, to such an extent as to the friction force that need overcome and the deformation power that need provide counteracting in time through the present invention, because they were distributed between two stages.In addition, because shirt rim 503A need not radial expansion when block 503G exceeds fin 13, thereby power F 2Can be less relatively, make thus lid 502 to be placed on the appropriate location than being easier to.
In a word, at F/s, configuration from the configuration transitions of Figure 17 to configuration shown in Figure 22.In subordinate phase, configuration from the configuration transitions of Figure 22 to configuration shown in Figure 23.
In this configuration, bottle 1 is closed by bottle stopper 501 hermetically, and by lid 502 protections, and because the locking that block 503G provides, thereby can prevent to take off said lid.
In this configuration; As first embodiment and shown in figure 23; The lip 506B of cap 506 leans against on the outside face 501B of bottle stopper 501 via opening 505B and via the central opening 503Q of part 503C, and when expectation during near the content of bottle 1, outside face 501B is exposed out.
When needs used the content of bottle 1, the entad elastic deformation through block 506A removed cap 506, and step subsequently is with identical with reference to first embodiment of Fig. 6 and Fig. 7 description.
In case removed cap 506, just can not it be replaced, because key 504 turns back to wherein apart from d 3Greater than apart from d 4 Configuration in.Cap 506 thus serves as the indicating device of first opening of device 500.Because part 505A leans against on the part 503C and bottle stopper 501 of ring 503 at present, thereby can not on part 505A, apply and power F 600Similar power, thus after removing for the first time, can't cap 506 be replaced.
Because all seal operation is in the medium that is hedged off from the outer world, to carry out, so bottle stopper 51 maintenances are aseptic, and especially its part 501C keeps aseptic, and this is applicable to above-mentioned whole 3 embodiments of lid 502.
Being used to make the part 503,505 that connects together and 506 material still can keep its mechanical specialities to select according to the scope of being placed in after under-80 ℃ to+130 ℃ the temperature.The material that is suitable for for example can be a polyformaldehyde.
More than the present invention is described as using with the bottle of the content of freeze-drying.The present invention is equally applicable to when the content of the bottle situation of freeze-drying not.In the case, after the operation that follows perfusion bottle 1 closely, can bottle stopper 501 be placed on the bottle 1; And then; In the disinfection room (not shown),, can load onto lid 502, can reach equally thus and Fig. 5, the similar seal arrangement of the configuration shown in 14 and 23 through applying axial force.
The technical characterictic of having described of the present invention can make up each other.Especially, the mode that fits together of cap 506 and lid 502 can be exchanged between the first and the 3rd embodiment.

Claims (19)

1. be used to have neck sealing arrangement of container of (12); Said device comprises the lid (502) that elastic body bottle stopper (501) and plastic material are processed; Said lid covers said neck and said bottle stopper when being suitable for the appropriate location in being in said neck; Said lid comprises ring (503) and drive member (504); Said ring (503) is suitable in assembled configuration surrounding said bottle stopper and said neck, and said ring has and be used at the enterprising line-locked blocking device of said neck (503G), and said drive member (504) is suitable for being installed on the said ring and is suitable for the central axis (X about said ring 503) become arbitrarily angled orientation; Said drive member has the actuation gear (505D) that is used to actuate said blocking device; Said sealing arrangement is characterised in that; Said actuation gear comprises the ring edge (505D) of said drive member (504), said edge be suitable for the outside shirt rim of said ring (503) (503A) and form blocking device (503G) and from said shirt rim (503A) to said axis (X 503) engage between at least one block of radially extending.
2. sealing arrangement according to claim 1; It is characterized in that; Said ring (503) comprises annular section (503C); Wherein said annular section has first opening (503Q) of centre qualification therein; So that near the surface that is exposed (501B) of said bottle stopper, said annular section is connected to said shirt rim via near a plurality of bridge portions (503D) that extend to the said block (503G), and said bridge portion and said block are defined for the annular space (503V) of the said ring edge (505D) that holds said drive member (504) together.
3. according to above-mentioned any described sealing arrangement of claim, it is characterized in that said sealing arrangement comprises the position holding device (505C that is used on said ring said drive member is remained on holding fix 1505C), at said holding fix, said actuation gear (505D) outage, and at said holding fix, with the diad (X of said neck 1) thrust (F of almost parallel 2) can be passed to said ring (503) from said drive member (504) through said holding device.
4. sealing arrangement according to claim 3 is characterized in that, said position holding device (505C 1505C) be configured for thrust (F 2) being passed to the device of said ring (503), wherein said power is roughly parallel to the diad (X of said neck 1).
5. sealing arrangement according to claim 4 is characterized in that, is installed in the configuration on the container neck at said sealing arrangement (500), is configured for thrust (F 2) be passed to the said position holding device (505C of the said device of said ring (503) 1505C) extend in said ring (503) inner radial.
6. according to claim 4 or 5 described sealing arrangements, it is characterized in that, be configured for thrust (F 2) the said position holding device that is passed to the said device of said ring (503) comprises at least one elasticity tongue (505C 1505C), said elasticity tongue has the relief part (505E) that extends radially outwardly from said drive member (504) and is suitable for cooperating in the annular groove (503L) the inside face that is formed at said ring (503).
7. sealing arrangement according to claim 1 and 2 is characterized in that, said sealing arrangement comprises and is used for going up the holding device (503L that said drive member (504) is remained on latched position at said ring (503); 505C 2503P; 505F; 505R), in said latched position, said ring edge (505D) is actuated said block (503G).
8. sealing arrangement according to claim 7 is characterized in that, the said holding device that is used for said drive member is remained on latched position comprises at least one tongue (505C 2), said tongue has the exterior section (505E) of fluctuating, and the exterior section of said fluctuating (505E) is suitable for cooperating in the annular groove (503L) in the inside face that is formed at said ring (503).
9. sealing arrangement according to claim 7; It is characterized in that; Said at least a portion that is used for the device that said drive member remains on latched position is comprised the outer, radial flange (505R) of said drive member (505), said at least a portion of said outer, radial flange (505R) are suitable for cooperating in the annular groove (503L) in being formed at the inside face of said ring.
10. sealing arrangement according to claim 9 is characterized in that, said flange (505R) tilts away from said actuation gear (505D), thereby away from the central axis (X of said drive member (504) 505).
11. sealing arrangement according to claim 3 is characterized in that, said sealing arrangement comprises and is used for going up the holding device (503L that said drive member (504) is remained on latched position at said ring (503); 505C 2503P; 505F; 505R), in said latched position, said ring edge (505D) is actuated said block (503G), said drive member is remained on the said position holding device (505C of holding fix 1505C) comprise at least one first relief part (505E) that is formed on the said drive member (504) and second relief part (503L) that is formed at least one complementation on the said ring (503); Said second relief part of the said first fluctuating partial sum cooperatively interacts when said drive member is in said holding fix, is used for said drive member (504) is remained on the said holding device (503L of said latched position; 505C 2503P; 505F; 505R) comprise at least one the 3rd relief part (505R) that is formed on the said drive member (504), and when said drive member was in said latched position, said the 3rd relief part and said second relief part cooperatively interacted.
12. sealing arrangement according to claim 11 is characterized in that, said drive member (504) is carried said the 3rd relief part (505C of the said first fluctuating partial sum 1, 505C 2, 505E; 505C; 505E; 505R); Said first relief part is suitable for when said drive member is in said holding fix cooperating with second relief part (503L) of the complementation of said ring (503), and said the 3rd relief part is suitable for when said drive member is in said latched position cooperating with second relief part (503L) of the complementation of said ring (503).
13. sealing arrangement according to claim 12 is characterized in that, said drive member (504) is carried at least two elasticity tongue (505C 1, 505C 2), said elasticity tongue have extend to apart from said ring edge (505D) apart from d 1The place said first relief part (505E) with extend to the distance said ring edge (505D) apart from d 2Said the 3rd relief part (505R) at place, said apart from d 1With apart from d 2Differ from one another, wherein said ring (503) has said second relief part (503L) that is used to hold the said first fluctuating partial sum the 3rd relief part.
14. sealing arrangement according to claim 12; It is characterized in that; Said drive member (504) is carried at least one elasticity tongue (505C); Said elasticity tongue has first relief part (505E); Said first relief part is suitable for when said drive member is in holding fix cooperating with second relief part (503L) of the complementation of said ring; And said at least one elasticity tongue (505C) is arranged in window (505Q); Said window-shaped is formed in the peripheral partitioned portion (505J) of said drive member (504), and the said holding device (505R) that is used for said drive member (504) is remained on said latched position between two windows, radially outstanding by said peripheral partitioned portion, the said holding device (505R) that is used for said drive member (504) is remained on said latched position remains said drive member (504) in the device (503G) that makes said actuation gear (505D) actuate to be used to lock said ring (505).
15. sealing arrangement according to claim 1 and 2 is characterized in that, said drive member comprises two parts, that is:
-being generally the part (505) of annular, it has said ring edge (505D), and the said part that is generally annular is suitable for partly covering said bottle stopper (501), thereby stays second opening (505B) of the exposure (501B) that is used to get into said bottle stopper; And
-cap (506); It is fixed to the said part that is generally annular releasedly and covers simultaneously said second opening at least; Said cap has central relief part (506C) on its surface towards the said part that is generally annular; Said central relief part is suitable for cooperating with the lip-deep complementary relief part (505P) that is formed at the said annular section that holds said cap, so that the central axis (X of said cap 506) aim at the central axis (X of said second opening basically 505).
16. sealing arrangement according to claim 1 and 2; It is characterized in that; Said drive member (504) is made up of the part (505) and the cap (506) that are generally annular that carry tongue (505C) and ring edge (505D), and wherein said cap is through being hooked in the said edge (505B that is generally second opening (505B) of annular part 1) on block (506A) be fixed on the said part that is generally annular, and can be only through the said part that is generally annular flexibly being out of shape and said cap being installed (F 2) on the said part that is generally annular, said distortion is only to be installed in the power (F that said ring (503) can apply before going up in said drive member 600) the result.
17. sealing arrangement according to claim 16 is characterized in that, each is hooked in the edge (505B of said second opening (505B) 1) on block (506A) have the said edge (505B that is used to be hooked in said second opening (505B) 1) on hook (506A 1), wherein said hook and lean against the distance (d between the surface (506C) of said cap (506) on the said part that is generally annular 4), be parallel to the said central axis (X of part (505) that is generally annular when not being installed on the said part that is generally annular when said cap 505) the said edge (505B of said second opening measured 1) and the said part that is generally annular be used to hold the distance (d between the part (505A) on said surface that leans against the said cap on the said part that is generally annular 3).
18. be used to the method according to claim 16 or 17 described sealing arrangements is installed, it is characterized in that, said method comprising the steps of:
A) at the edge (505B of second opening (505B) of the part (505) that is generally annular 1) on apply the central axis (X that is roughly parallel to said second opening 505) power (F 600), the said power that is roughly parallel to the central axis of said second opening is applied to and is equipped with the side (505A of said cap (506) 1) the relative side (505A that is generally the part of annular 2) on, and so that the mode that the said edge of said second opening flexibly is out of shape applies the said power of the central axis that is roughly parallel to said second opening; And
B) along the direction opposite with the said power of the central axis that is roughly parallel to said second opening, towards said be generally the annular part depress (F 0) said cap, so that the block (506A) of said cap (506) and edge (505B said second opening, said elastic deformation 1) cooperate.
19. one kind is equipped with the container (1) according to any described sealing arrangement (500) in the claim 1 to 17.
CN2006800447220A 2005-11-30 2006-11-29 Plug device for a container and container provided with one such device Active CN101316769B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0512172 2005-11-30
FR0512172A FR2893922B1 (en) 2005-11-30 2005-11-30 CLOSURE DEVICE FOR A CONTAINER AND CONTAINER EQUIPPED WITH SUCH A DEVICE
FR0603508 2006-04-20
FR0603508A FR2900131B1 (en) 2006-04-20 2006-04-20 CLOSURE DEVICE FOR A CONTAINER AND CONTAINER EQUIPPED WITH SUCH A DEVICE
PCT/FR2006/002616 WO2007063218A1 (en) 2005-11-30 2006-11-29 Plug device for a container and container provided with one such device

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CN101316769A CN101316769A (en) 2008-12-03
CN101316769B true CN101316769B (en) 2012-08-08

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FR2893922A1 (en) 2007-06-01
CN101316769A (en) 2008-12-03

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