CN101316769A - Plug device for a container and container provided with one such device - Google Patents

Plug device for a container and container provided with one such device Download PDF

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Publication number
CN101316769A
CN101316769A CNA2006800447220A CN200680044722A CN101316769A CN 101316769 A CN101316769 A CN 101316769A CN A2006800447220 A CNA2006800447220 A CN A2006800447220A CN 200680044722 A CN200680044722 A CN 200680044722A CN 101316769 A CN101316769 A CN 101316769A
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CN
China
Prior art keywords
ring
drive member
edge
cap
type element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA2006800447220A
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Chinese (zh)
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CN101316769B (en
Inventor
安托万·阿内亚斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocorp Recherche et Developpement
Original Assignee
Biocorp Recherche et Developpement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0603508A external-priority patent/FR2900131B1/en
Application filed by Biocorp Recherche et Developpement filed Critical Biocorp Recherche et Developpement
Priority claimed from PCT/FR2006/002616 external-priority patent/WO2007063218A1/en
Publication of CN101316769A publication Critical patent/CN101316769A/en
Application granted granted Critical
Publication of CN101316769B publication Critical patent/CN101316769B/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/241—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D45/00—Clamping or other pressure-applying devices for securing or retaining closure members
    • B65D45/02—Clamping or other pressure-applying devices for securing or retaining closure members for applying axial pressure to engage closure with sealing surface
    • B65D45/30—Annular members, e.g. with snap-over action or screw-threaded
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end

Abstract

The invention relates to a plug device (500) comprising a elastomer plug (501) and a cover (502) for covering the neck (12) of a container and the plug (501) inserted in the neck (12). The cover (502) consists of a plastic material and comprises a ring (503) and a manoeuvring element (504). Said ring (503) can surround the plug (501) and the neck (12) when mounted, and is provided with means (503G) for being locked onto the neck (12). The manoeuvring element (504) can be mounted on the ring (503), with any angular orientation about a central axis (X503) of the ring. Said manoeuvring element is provided with an annular edge (505D) that can be engaged between an external skirt (503A) of the ring (503) and at least one lip (503G) which forms a locking means and radially extends towards the central axis (X503) of the ring, away from the skirt (503A).

Description

The container that is used for the sealing arrangement of container and has this type of device
The present invention relates to have the sealing arrangement of the container of neck, and relate to the method that this type of device is installed, and the container that is equipped with this type of device.
In the containers for medical use field, the active component that uses vial (vial) to preserve freeze dried powder, powder or solution form is known.This type of bottle need seal with sealing means so that its content remains on gratifying store status, when using it till.A kind of like this sealing arrangement of known use comes closed vial hermetically, the sealing device comprises the elastic body bottle stopper (stopper) that has gas, liquid and the complete airtight function of bacterium, the valve protection cap of making by metal (being generally aluminium) that sealing function is provided (capsule), and the tongue that can take off, this tongue is carried out the function of tamper-evident mark and was removed before can entering bottle stopper.
When the top of vial volume was pressed the metal valve protection cap, glass chip might be separated with bottle, and this chip can drop on the top of bottle stopper and constitute the risk of polluting content.In addition, no matter whether the content of bottle has lived through the lyophilisation stage, volume pressure metal valve protection cap immediately after bottle stopper is installed.To be different from the room that the content to bottle carries out disinfection also be common owing to be used to roll up the residing room of machine of pressing valve protection cap, and described different room is not aseptic usually, therefore bottle stopper is installed and the time gap installed between the valve protection cap may be very long.In the interbody spacer, no matter be unexpected or intentional therefore at this moment, the content of bottle all might be polluted.When using bottle, suppose hospital personnel after removing tamper-evident tongue, to carrying out disinfection by the approaching bottle stopper upper surface of opening on valve protection cap.This operation passes out of mind sometimes, may produce the risk of pollution thus.
US-A-05 314 084 discloses and has used enclosing cover inner cap to be locked on the neck of container with the protection bottle stopper.This locking mode depends on the elasticity of enclosing cover, and actv. always not.
More specifically, the present invention by a kind of novelty is provided special easy-on and make the sealing arrangement that the elastic body bottle stopper is protected immediately at perfusion operation and/or the end in lyophilisation cycle, to attempt to improve these defectives.
For this reason, the present invention relates to a kind of sealing arrangement that is used to have the container of neck, described device comprises the elastic body bottle stopper, the lid that plastic material is made, described lid covers described neck and described bottle stopper when being suitable for appropriate location in being in described neck, described lid comprises ring and drive member, described ring is suitable for surrounding described bottle stopper and described neck in assembled configuration, and described ring has and is used at the enterprising line-locked blocking device of described neck, described drive member is suitable for being installed on the described ring and is suitable for becoming arbitrarily angled orientation about the central axis of described ring, and described drive member has the actuation gear that is used to actuate the blocking device that is used to lock described ring.Described sealing arrangement is characterised in that, the actuation gear of described drive member comprises the ring edge of described drive member, and described edge is suitable in the outside shirt rim of described ring and forms blocking device and engage between at least one block that described radial axis is extended from described shirt rim.
Because lid is made by plastic material, thereby do not exist and contact with the surface of container and produce the risk of glass contamination particle.Because its structure comprises ring and drive member, thereby described ring can be installed on the container in very easy mode, when described ring arrived final position on the container neck, the actuation gear of drive member can be actuated the blocking device of ring.Because drive member can be installed on the ring with any angular orientation, so the lid ratio is easier to install.In addition, especially easy and quick by the locking that the annular lip of drive member obtains, and do not rely on the elasticity of ring.Automatically it is easier installing and lock described device on container.
According to favourable but non-essential aspect of the present invention, described device can comprise the one or more features in the claim 2 to 18.
Especially, described drive member can be made up of the ring-type element and the cap of carrying first and second devices, block on the edge of the central opening by being hooked in ring-type element prevents that described cap from moving on described ring-type element, only by described element is carried out elastic deformation, cap can be installed on the ring-type element, described deformation is the result of the power that only can apply before drive member is installed on the described ring.In the case, each block advantageously has the hook on the edge that is used to be hooked in opening, described hook and lean against distance between the surface of the cap on the ring-type element, when not being installed on the described element, be parallel to the distance between the part that is used to hold the above-mentioned surface that leans against the cap on the ring-type element of edge that the central axis of ring-type element measures and ring-type element when cap.
The present invention also provides the method that aforesaid device is installed, and described method comprises:
A) on the edge of the central opening of ring-type element, apply the power of the central axis that is roughly parallel to described opening, described power is applied on the side of the ring-type element relative with the side that described cap is installed, and so that the mode that described edge flexibly is out of shape applies described power; And
B) along the direction opposite with described power, depress described cap towards described ring-type element, so that the edge mate of the elastic deformation of its block that hooks and above-mentioned opening.
The present invention also provides a kind of container that above-mentioned sealing arrangement is installed.This type of container is than easier sealing of existing container and use.
By the mode with example provide with reference to the accompanying drawings to description according to three embodiments of the container of principle of the present invention and device, can understand the present invention better and other advantage of the present invention will become more apparent, wherein:
Fig. 1-Fig. 5 is schematic axial, cross-sectional view and the block diagram that each step of packaging product in bottle is shown according to the present invention;
Fig. 6 and Fig. 7 are the diagrammatic perspective view that two steps using bottle are shown;
Fig. 8 is the partial enlarged drawing that the details VIII of Fig. 4 is shown;
Fig. 9 is the three-dimensional axial, cross-sectional view of amplification of lid of sealing arrangement of the bottle of Fig. 1 to Fig. 8;
Figure 10 A and 10B are the block diagrams from two different angles of the ring of the lid of Fig. 9;
Figure 11 A and 11B are the block diagrams from two different angles of the locking component part of the lid of Fig. 9;
Figure 12 A and 12B be the member that is used to lock the lid of Fig. 9, from the block diagram of two different angles of cap, wherein Figure 12 A is a part sectional view;
Figure 13 is the partial enlarged drawing of the details XIII of Fig. 4, has wherein ignored pressing plate;
Figure 14 is the partial enlarged drawing of the details XIV of Fig. 5;
Figure 15 is the exploded perspective view of the lid of Fig. 9;
Figure 17 similarly schemes according to the device of the 3rd embodiment of the present invention and Fig. 8;
Figure 18 is the three-dimensional axial, cross-sectional view of amplification of lid of the device of Figure 17;
Figure 19 A and 19B belong to the ring of lid of Figure 18 from the block diagram of two different angles;
Figure 20 A and 20B belong to the blocking device part of lid of Figure 18 from the block diagram of two different angles;
Figure 21 A and 21B be the locking component that belongs to Figure 18 lid, from the block diagram of two different angles of cap, wherein Figure 21 is a part sectional view;
Figure 22 is that device and Figure 13 of Figure 17-Figure 21 similarly schemes;
Figure 23 is that device and Figure 14 of Figure 17-Figure 22 similarly schemes;
Figure 24 is the exploded perspective view of the lid of Figure 17;
Figure 25 is the view of drive element in assembling process; And
Figure 26 is the partial enlarged drawing that the details XXVI of Figure 25 is shown.
At Fig. 1, fill with product P in the vial 1, for example medicine.Pipet 2 inserts in the vial 1 via its opening 11, and opening 11 is limited by the neck 12 at the edge 13 that presents directed outwards.X 1Represent the diad of bottle 1.
After the medicine P that has injected scheduled volume in the bottle 1, pipet is removed, and sealing arrangement 500 is placed on the neck 12.Device 500 comprises elastic body bottle stopper 501, and its shape is suitable for part to be inserted in the opening 11, and bottle stopper 501 leans against on bottom surface 14 facing surfaces 13A edge 13 and bottle 1 simultaneously.The appropriate location that in a single day bottle stopper 501 is placed in the neck 12 just is hedged off from the outer world the content of bottle 1.Device 500 also comprises lid 502, and lid 502 is designed to isolated bottle stopper and neck 12 when described sealing arrangement is in airtight configuration.
More specifically, as can be seen from Fig. 9, lid 502 comprises the ring 503 that plastic material is made, and the internal diameter of ring 503 is enough to make it to surround edge 13.
Lid 502 also comprises drive member 504, and drive member 504 is by the part that is hereinafter referred to as " key " made with plastic material 505 and be similarly the cap 506 that is fixed on the key 505 that plastic material makes with reversing and form.Cap 506 carrying contacts with the outside face of the annular section 505A of key 505 and by being ultrasonically welded to 6 projection 506A on the key 505.In a variant, the spot weld between the part 505 and 506 obtains by patterned heat.Patterned heat can utilize heating head to carry out, and utilizes heating head to heat to have than the fast advantage of super sonic heating.Be easy to cap 506 be removed from key 505 via the spot weld of projection 506A is feasible by tearing projection 506A.
Cap 506 also has annular lip 506B, and annular lip 506B is bonded on the central opening 505B place of key 505, and this moment, these two elements were fixed to one another, thereby forms member 504.
Projection 506A is distributed in the central axis X of cap 506 regularly 506, and form wave structure 506C on every side, to be contained in part 505A in lip-deep, the adjacent depression 505P of bottle stopper 506 with opening 505B.The configuration of structure 506C and depression 505P makes it possible to cooperatively interact by shape and makes bottle stopper 506 placed in the middle on key 505, thereby before welding projection 506A, makes axis X 506Aim at the central axis X of key 505 505
Key 505 has two groups every group 2 elasticity tongue 505C, and elasticity tongue 505C forms by open 4 opening 505Q on the shirt rim 505J that is formed by key 505, and with axis X 505Be the center.Reference numeral 505D represents the ring edge away from part 505A of shirt rim 505J.
Each tongue 505C has from the shirt rim the outer fin 505E that radially outwards protrudes.Thus, each tongue 505C forms elastic hook.
Tongue 505C is organized as two tongue 505C 1With two tongue 505C 2, wherein, two tongue 505C 1Fin 505E extend to apart from edge 505D first apart from d 1The place, two tongue 505C 2Fin 505E extend to apart from edge 505D second distance d 2The place, and apart from d 2Greater than distance d 1
Tongue 505C 1Extend to edge 505D from the edge of distance edge 505D corresponding opening 505Q far away.Tongue 505C 2Extend to direction from the edge of the nearer corresponding opening 505Q of distance edge 505D away from described edge 505D.
Ring 503 comprises the peripheral annular shirt rim 503A with first edge 503B.Within the 503A of shirt rim and with edge 503B opposite position, formed and be approximately perpendicular to ring 503 and the central axis X of shirt rim 503A 503Annular section 505C.Centering on axis X 503In 5 annular regions that distribute, part 503C is extended by 5 503D of bridge portion, and 5 503D of bridge portion are connected to the inside face of shirt rim 503A near edge 503C.The 503D of bridge portion extends a segment distance to limit 5 independently housing 503E of elongation from the inside face of shirt rim 503A, wherein via the carrying of ring 503 part 503C and in Figure 10 A appreciiable one side can insert the shirt rim 505J of key 505.
In part 503C can't help annular region that the 503D of bridge portion extends, be formed with 5 opening 503F, when shirt rim 505J is inserted among the housing 503E, can insert shirt rim 505J equally in each among the opening 503F.In the inside of shirt rim 503A and near edge 503B, alternately arrange the end of the 503D of bridge portion and the end of block 503G.
Towards each opening 503F, be provided with inner surface radial direction ground from shirt rim 503A to axis X 503The locking stop 503G that extends.Reference numeral 503J represents the free edge of each block 503G.
Each 503D of bridge portion has the slope 503K that is used to wedge according to the bottle stopper 501 of Fig. 2 configuration.Slope 503K is designed to penetrate from the teeth outwards in the bottle stopper, moves with respect to shirt rim 503 to prevent bottle stopper.
Each 503D of bridge portion surface within it is provided with crooked about 90 ° fin 503N, so as by the outside face that radially penetrates bottle stopper coupling link 503 and the bottle stopper 501 that rotates.
Device 500 is assembling in the following manner: welding helmet 506 on key 505, then the axis X that will overlap 506And X 503Alignment axis X 505, and shirt rim 505J engaged enter among the annular space 503V that between shirt rim 503A, the 503D of bridge portion and locking stop 503G, limits.Because can being installed on the ring 503, the annular essence of edge 505D and space 503V, parts 504 need not to consider especially in advance that it is about axis X 503The angulation direction.In other words, when in the 503V of space, inserting edge 505D via the inlet of housing 503E and opening 503F, member 504 and the axis X that overlaps at present 505And X 506Can become any angle.This makes than being easier to install described lid, because do not need to check its direction.
The inside face of shirt rim 503A has peripheral grooves 503L, and peripheral grooves 503L forms the edge 503M near shirt rim 503A, and edge 503M is neighbouring part 503C away from edge 503B.Groove 503L is configured to hold the fin 505E of tongue 505C when member 504 is installed on the ring 503.More specifically, in the time of on member 504 being installed to ring 503, shirt rim 505J penetrates among the 503V of space via opening 503F and the entering opening of housing 503E.Edge 503B is then shifted to until tongue 505C in shirt rim 505 1 Fin 505E in groove 503L, engage, make member 504 and part 503C keep certain distance thus, thereby be positioned at position shown in Figure 9.
Then bottle stopper 501 can be inserted in the lid 502 and by slope 503K it is wedged.As shown in Figure 2, stack-mounted device 500 can be placed on the neck 12 of bottle 1 in this way.In this configuration, bottle stopper 501 is not exclusively closed opening 11, because bottle stopper has lateral incision 501A, thereby stays gap 200 near the part of surperficial 13A.
Be equipped with the bottle 1 of device 500 can then be placed in the freeze drier 300, wherein the hydrone of 1 li existence of bottle such as Fig. 3 and Fig. 8 are according to arrow F 1Shown direction is discharged to the outside, and by the gap between lid 502 and the fin 13.
In as Fig. 3 and configuration shown in Figure 8, bottle stopper 501 has the projection of stopping at its outside face radially.
Afterwards, as shown in Figure 4, when device 500 is also in freeze drier 300, can apply longitudinal axis X thereon with bottle 1 and opening 11 1Parallel power F 2, this axis is followed and axis X 503, X 505And X 506Overlap.Axial force F 2Be to be applied by the plate 301 that can move in freeze drier, plate 301 also is suitable for applying roughly the same power F on a collection of bottle 1 on the par line simultaneously in being arranged in freeze drier 2
On bottle stopper 506, apply power F at member 504 2The time, tongue 505C 1Fin 505E via the mutual action between fin 505E and groove 503L with this power be delivered to the ring 503 on.Tongue 505C 1Thus as pusher, thereby make ring 503 at power F 2Effect under move or promote to the bottom surface 14 of bottle 1, make it possible to the configuration that reaches shown in Figure 5 thus.Because this moves, locking stop 503G is folding to the inside face of shirt rim 503A, and need not to cause the radially deformation of shirt rim 503A.Thus, the power F that need apply for the configuration that reaches Fig. 4 and Figure 13 2Be relatively low.
In case locking stop 503G surpasses fin 13 and arrives Fig. 4 and the position of Figure 13, ring 503 just can not move to bottom surface 14 again, because part 503C leans against on the bottle stopper 101 that is engaged in the neck 12.Then, maintenance energy F 2Has following effect: from groove 503L, discharge tongue 505C 1Fin 505E, and member 504 is moved with the bottoms of space 503V between the inside face that edge 505D is moved on to locking stop 503G and ring 503A with respect to ring 503.Edge 505B engages the effect that has between locking stop 503G and shirt rim 503A be to make these blocks radially be out of shape with direction entad, and its each free edge 503J is to axis X 1Move.These edges then lean against fin 13 on the annular surface 13B of bottom surface 14, and valve protection cap 500 is locked on the neck 12 securely thus, as Fig. 5 and shown in Figure 14.
In the configuration shown in Fig. 5 and 14, tongue 505C 2Fin 505E enter groove 503L, play thus preventing member 504 with respect to the ring 503 functions that move.In other words, apart from d 1And d 2Difference corresponding with the stroke of member 504 between the position of Fig. 4 and Fig. 5, make thus to be locked in when being used for that lid 502 remained on position on the neck 12 as locking stop 503G, will keep tongue 505C 2Automatically engage with groove 503L.
Because should move, fin 503N penetrates bottle stopper 501 simplely, thus bottle stopper 501 is kept securely and can not be with respect to ring 503 rotations.
Thus, the final location of lid 502 was finished by 2 stages.At F/s, settle bottle stopper 501, then that block 503G is folding to exceed fin 13 towards shirt rim 503A.In subordinate phase, block 503G is locked in the appropriate location by edge 505D.These two stages are by thrust F 2Carry out thrust F 2Size adapted to each in stage, kept obviously little value of the ratio value required in single stage location simultaneously, to such an extent as to the friction force that need overcome in time separates by the present invention with the deformation power that need provide, and distributed between two stages.In addition, because shirt rim 503A does not have radial expansion when block 503G exceeds fin 13, thereby power F 2Can be less relatively, make thus lid 500 to be placed on the appropriate location than being easier to.
In a word, at F/s, configuration from the configuration transitions of Fig. 3 to configuration shown in Figure 4.In subordinate phase, configuration from the configuration transitions of Fig. 4 to configuration shown in Figure 5.
In this configuration, bottle 1 is closed hermetically by bottle stopper 501, and by lid 502 protections, and because the locking that block 503G provides, thereby can prevent to take off described lid.
In this configuration, as shown in figure 14, the lip 506B of cap 106 leans against on the outside face 501B of bottle stopper 501 via opening 505B and via the central opening 503A of part 503C, and when expectation during near the content of bottle 1, outside face 501B is exposed out.Under the effect of lip 506B, surperficial 501B is out of shape partly, as shown in figure 14, because the material of bottle stopper 501 is more soft than the material of cap 506.
More specifically, the dish type middle body 501C of lip 506 complete insulation surfaces 501B, it is clean and sterile that this part can be considered to, because this part is hedged off from the outer world when it still is in the freeze drier 300.
When needs use the content of bottle 1, as the arrow F of Fig. 6 3Shown in, remove cap 506 by tearing projection 506A, enter above-mentioned part 501C thus, and part 501C need not to carry out disinfection.Then can in bottle 1, inject liquid to reformulate its content, as shown in Figure 7, use identical syringe then, utilize the known mode of medical personnel that its syringe needle is inserted the product that extraction is reformulated in the bottle stopper 501 by syringe 400.
In second embodiment shown in Figure 16, has identical Reference numeral with above-mentioned embodiment similar elements.The lid 502 of the present embodiment comprises ring 503 and the drive member 504 that is made of key 505 and cap 506 similarly.The present embodiment and the difference of a last embodiment be 4 tongue 505C of key 505 be same type and extend identical apart from d from the ring edge 505D of shirt rim 505J 1These 4 tongue 505C have the tongue 505C with a last embodiment 1Identical functions, and simultaneously be formed on the ring identical 503 in-to-in groove 503L and cooperate with a last embodiment.
The annular section 505A of key 505 has six hooks, only can see two hooks wherein being represented by label 505F in Figure 16, and these two hooks are positioned near the opening 505B next door towards the part 505A of edge 505D.These six hooks are designed to cooperate with the edge 503P of the central opening 503Q that is limited by the annular section 503C that encircles 503.This cooperation occurs in member 504 when moving to the cooresponding position of Fig. 5 with the cooresponding position of Fig. 4, when the edge 505D that promptly occurs in key 505 will encircle 503 block 503G and move to the lock arrangement of neck 12.Thus, the second tongue 505C in the function of hook 505F and the last embodiment 2Function class seemingly.
In the 3rd embodiment shown in Figure 26, has identical Reference numeral at Figure 17 with the first embodiment similar elements.Following description relates to the difference with first and second embodiments substantially.
4 block 506A of cap 506 carryings of lid 502,4 block 506A are hooked in the edge 505B of the central opening 505B of key 505 1On.For this reason, each block 506A has and the cap 506 integrally moulded hook 506A that form 1, hook 506A 1From described block 506A radially with respect to the central axis X of cap 506 506Extend internally.When key 505 and cap 506 being fitted together and form member 504, hook 506A 1Be bonded on edge 505B 1The below.More specifically, cap 506 has the surperficial 506C that is roughly the plane, and cap 506 leans against the end face 505A of the annular section 505A of key 505 thus 1On, wherein key 505 is limited with opening 505B in the central.In the configuration of stack-mounted of member, hook 506A 1With edge 505B 1At it away from surperficial 505A 1A side engagement.
The quantity of block 506A is not limited to 4, as long as hook power can be distributed between key 505 and cap 506.
Key 505 has one group 3 elasticity tongue 505C, and elasticity tongue 505C forms by make 3 opening 505A in the 505J of shirt rim, and wherein, shirt rim 505J is formed by key 505, and with the axis X of the central axis of composition key 505 505Be the center.Shirt rim 505J is designated as 505D away from the ring edge of part 505A.
Each tongue 505C has radially outstanding outside fin or hook 505E from shirt rim 505J.Thus, each tongue 505C forms elastic hook.
Between fin 505E and the edge 505D with axis X 505Parallel distance is designated as d 1
In addition, key 505 has the peripheral flange 505R radially outstanding and that extend continuously from shirt rim 505J between two opening 505Q.The free edge 505R of flange 505 1And between the edge 505D and axis X 505Parallel distance is designated as d 2d 2Value greater than d 1Value.
Described flange is about axis X 505Be roughly conical butt, and outwards stretch from edge 505D.
The ring 503 with first embodiment in identical.
When mounting cap 506 on key 505, need be with hook 506A 1By opening 505B and edge 505B 1Cooperate.For this reason, as shown in figure 25, key 505 is placed on the instrument 600, and wherein instrument 600 is defined for the annular surface 601 that receives the part 505A that leans on key 505 thereon.Then, bottle stopper 506 appears at key 505 tops, simultaneously axis X 505And X 506Rough alignment, axis X 506With the central axis X of instrument 600 600 Aim at.Cap 506 then by with axis X 505, X 506And X 600Parallel power F 0Push instrument 600 to, engagement lip 506B in opening 505B makes hook 506A then thus 1Lean against the edge 505B of opening 505B 1On.As confining force F on cap 506 0The time, surperficial 506C leans against the upper surface 505A of part 505A 1On, and with power F ' 0Be passed to key 505, make shirt rim 505J thus along the arrow F among Figure 16 505Direction is slided.Because the part 505A of key 505 has leaned against on the surface 601, therefore by surface 601 at the bottom surface of part 505A 505A 2On apply directed force F 600, bottom surface 505A wherein 2Be at part 505A the next door, limit away from cap 506.Power F 600With power F 0On the contrary.
Its effect is to make edge 505B 2Near surperficial 506C, make the hook 506A of block 506A thus 1Exceed described edge and cooperation thereunder, as shown in figure 26.
Hook 506A 1At edge 505B 1Under cooperation only be by edge 505B 1Elastic deformation forms, and wherein this deformation is by means of directed force F 600Obtain.
In the configuration of Figure 16, X parallels to the axis 505Record, edge 505B 1And part 505A goes up the distance of admitting between the zone of leaning on cap 506 thereon and is designated as d 3In addition, the axis X that is parallel to block 506A 506Its corresponding hook 506A of 506C that record, surperficial 1Between distance be designated as d 4
At one's leisure, that is, and when on part 505 and 506, not applying any power, apart from d 3Has the d of ratio 4Big value.Only on part 505A, apply and power F owing to instrument 600 0Direction opposite effect power F 600, thereby make apart from d 3Temporarily get less than distance d 4Value, make hook 505A thus 1Be hooked in edge 505B 1Under, as shown in figure 26.
Should observe, when member 504 is installed on the ring 503, in order to apply power F 600And can not reach the bottom surface 505A of the part 505A of key 505 2
Device 500 is to adopt the mode stack-mounted identical with first embodiment, and as mentioned above, mounting cap 506 on key 505, then the axis X that will overlap 505And X 506With axis X 503Aim at, and shirt rim 505J is bonded among the annular space 503V that is limited by shirt rim 503A, the 503D of bridge portion and locking stop 503G.When by the inlet of housing 503E with towards the opening 503F of space 503V insertion edge 505D, member 504 can have the axis X with respect to present coincidence 505And X 506Any direction.
The inside face of shirt rim 503A has peripheral grooves 503L, and peripheral grooves 503L forms the edge 503M near shirt rim 503A, and edge 503M is neighbouring part 503C away from edge 503B.Groove 503L is configured to hold the fin 505E of tongue 505C when member 504 is installed on the ring 503.More specifically, in the time of on member 504 being installed to ring 503, shirt rim 505J penetrates among the 503V of space via opening 503F and the entering opening of housing 503E.Edge 503B is then shifted to until tongue 505C in shirt rim 505 1 Fin 505E in groove 503L, engage, make member 504 and part 503C keep certain distance thus, thereby be positioned at position shown in Figure 9.
Then bottle stopper 501 can be inserted in the lid 502 and by slope 503K it is wedged.Stack-mounted device 500 can be placed on the neck 12 of bottle 1 in this way, as is used for the shown in Figure 2 of first embodiment.
As first embodiment, be equipped with the bottle 1 of device 500 then to insert in the freeze drier 300.
In configuration shown in Figure 17, bottle stopper 501 has retention tab at its radially-outer surface.
After this, in freeze drier, as be used for the shown in Figure 4 of first embodiment, can apply direction and bottle 1 and longitudinal axis X neck 11 on 500 at device 1Parallel power F 2, this axis is followed and axis X 503, X 505And X 506Overlap.
On bottle stopper 506, apply power F at member 504 2The time, the fin 505E of tongue 505C is delivered to ring 503 with this power by the mutual action between described fin 505E and the groove 503L.Tongue 505C then is used as propelling unit, thereby at power F 2Effect will encircle down 503 and move or promote to the bottom 14 of bottle 1.Because should move, locking stop 503G is folding to the inside face of shirt rim 503A, and need not to make radially deformation of shirt rim 503A.Therefore, the power F that need apply in order to reach configuration shown in Figure 22 2Less relatively.
In case locking stop 503G exceeds fin 13 and arrives position shown in Figure 22, ring 503 just no longer can move to bottom 14, because part 503C leans against on the bottle stopper 101 that cooperates with neck 12.Maintenance energy F 2Has following effect: from groove 503L, discharge fin 505E, and make member 504 with respect to encircling 503 bottoms of moving with the space 503V between the inside face that edge 505D is moved on to locking stop 503G and ring 503A.Edge 505B engages the effect that has between locking stop 503G and shirt rim 503A be to make these blocks radially be out of shape with direction entad, and its each free edge 503J is then to axis X 1Move.These edges then lean against fin 13 on the annular surface 13B of bottom surface 14, and valve protection cap 500 is locked on the neck 12, as shown in figure 23 securely thus.
In configuration shown in Figure 23, flange 505R engages in groove 503L, plays thus to prevent that member 504 is with respect to ring 503 functions that move.In other words, apart from d 1And d 2Difference corresponding with the stroke of member 504 between the position of Figure 17 and Figure 22, can work as locking stop 503G thus and be locked in when being used for that lid 502 remained on position on the neck 12, flange 505R is automatically engaged with groove 503L.
Because should move, spline 503N penetrates bottle stopper 501 simplely, thus bottle stopper 501 is kept securely and can not be with respect to ring 503 rotations.
Thus, the final location of lid 502 was finished by 2 stages.At F/s, settle bottle stopper 501, then that block 503G is folding to exceed fin 13 towards shirt rim 503A.In subordinate phase, block 503G is locked in the appropriate location by edge 505D.These two stages are by thrust F 2Carry out thrust F 2Size adapted to each in stage, kept fully little value of the ratio value required in single stage location simultaneously, to such an extent as to the friction force that need overcome and deformation power counteracting in time that need provide by the present invention, because they were distributed between two stages.In addition, because shirt rim 503A need not radial expansion when block 503G exceeds fin 13, thereby power F 2Can be less relatively, make thus lid 500 to be placed on the appropriate location than being easier to.
In a word, at F/s, configuration from the configuration transitions of Figure 17 to configuration shown in Figure 22.In subordinate phase, configuration from the configuration transitions of Figure 22 to configuration shown in Figure 23.
In this configuration, bottle 1 is closed hermetically by bottle stopper 501, and by lid 502 protections, and because the locking that block 503G provides, thereby can prevent to take off described lid.
In this configuration, as first embodiment and as shown in figure 23, the lip 506B of cap 106 leans against on the outside face 501B of bottle stopper 501 via opening 505B and via the central opening 503Q of part 503C, and when expectation during near the content of bottle 1, outside face 501B is exposed out.
When needs used the content of bottle 1, the entad elastic deformation by block 506A removed cap 506, and step subsequently is with identical with reference to first embodiment of Fig. 6 and Fig. 7 description.
In case removed cap 506, just it can not be replaced, because key 504 turns back to its middle distance d 3Greater than distance d 4 Configuration in.Cap 506 thus serves as the indicating device of first opening of device 500.Because part 505A leans against on the part 503C and bottle stopper 501 of ring 503 at present, thereby can not apply on part 505A and power F 600Similar power, thus after removing for the first time, cap 506 can't be replaced.
Because all seal operation is to carry out in the medium that is hedged off from the outer world, so bottle stopper 51 maintenances are aseptic, and especially its part 501C keeps aseptic, and this is applicable to above-mentioned whole 3 embodiments of lid 502.
Being used to make the part 503,505 that connects together and 506 material still can keep its mechanical specialities to select according to the scope of being placed in after under-80 ℃ to+130 ℃ the temperature.The material that is suitable for for example can be a polyformaldehyde.
More than the present invention is described as using with the bottle of the content of freeze-drying.The present invention is equally applicable to when the content of the bottle situation of freeze-drying not.In the case, after the operation that follows perfusion bottle 1 closely, bottle stopper 501 can be placed on the bottle 1, and then, in the disinfection room (not shown),, can load onto lid 502, can reach equally thus and the similar seal arrangement of configuration shown in Fig. 5,14 and 23 by applying axial force.
The technical characterictic of having described of the present invention can make up mutually.Especially, the mode that fits together of cap 506 and lid 502 can be exchanged between the first and the 3rd embodiment.

Claims (20)

1. be used to have neck sealing arrangement of container of (12), described device comprises the lid (502) that elastic body bottle stopper (501) and plastic material are made, described lid covers described neck and described bottle stopper when being suitable for appropriate location in being in described neck, described lid comprises ring (503) and drive member (504), described ring (503) is suitable for surrounding described bottle stopper and described neck in assembled configuration, and described ring has and is used at the enterprising line-locked blocking device of described neck (503G), and described drive member (504) is suitable for being installed on the described ring and is suitable for central axis (X about described ring 503) become arbitrarily angled orientation, described drive member has the actuation gear (505D) that is used to actuate described blocking device, described sealing arrangement is characterised in that, described actuation gear comprises the ring edge (505D) of described drive member (504), described edge be suitable for the outside shirt rim of described ring (503) (503A) and form blocking device (503G) and from described shirt rim (503A) to described axis (X 503) engage between at least one block of radially extending.
2. device according to claim 1, it is characterized in that, described ring (503) comprises annular section (503C), wherein said annular section has the opening (503Q) that limits in the central, so that the surface that is exposed (501B) near described bottle stopper, described annular section is connected to described shirt rim via near a plurality of bridge portions (503D) that extend to the described locking stop (503G), and described bridge portion and described block are defined for the annular space (503V) of the described ring edge (505D) that holds described drive member (504) together.
3. according to above-mentioned any described device of claim, it is characterized in that described device comprises the position holding device (505C that is used on described ring described member being remained on holding fix 1505C), at described holding fix, described actuation gear (505D) outage, and at described holding fix, with the diad (X of described neck 1) thrust (F of almost parallel 2) can be passed to described ring (503) from described drive member (504) by described holding device.
4. device according to claim 3 is characterized in that, described position holding device (505C 1505C) be configured for thrust (F 2) being passed to the device of described ring (503), wherein said power is roughly parallel to the diad (X of described neck 1).
5. device according to claim 4 is characterized in that, in described sealing arrangement (500) is installed in configuration on the container neck, and described position holding device and force transfering device (505C 1505C) extend in described ring (503) inner radial.
6. according to claim 4 or 5 described devices, it is characterized in that described force transfering device comprises at least one elasticity tongue (505C 1505C), described elasticity tongue has the relief part (505E) that extends radially outwardly from described drive member (504) and is suitable for cooperating in the annular groove (503L) the inside face that is formed at described ring (503).
7. according to above-mentioned any described device of claim, it is characterized in that described device comprises and is used for going up the holding device (503L that described member (504) is remained on latched position at described ring (503); 505C2; 503P; 505F; 505R), in described latched position, described ring edge (505D) is actuated described locking stop (503G).
8. device according to claim 7 is characterized in that, the described holding device that is used for described member is remained on latched position comprises at least one tongue (505C 2), described tongue has the exterior section (505E) of fluctuating, and the exterior section of described fluctuating (505E) is suitable for middle cooperation of annular groove (503L) in the inside face that is formed at described ring (503).
9. device according to claim 7, it is characterized in that, described at least a portion that is used for the device that described member remains on latched position is comprised the outer, radial flange (505R) of described drive member (505), described at least a portion of described outer, radial flange (505R) are suitable for cooperating in the annular groove (503L) in being formed at the inside face of described ring.
10. device according to claim 9 is characterized in that, described flange (505R) tilts away from described actuation gear (505D), thereby away from the central axis (X of described drive member (504) 505).
11., it is characterized in that described holding device comprises at least one the relief part (505E that is formed on the described drive member (504) according to any described device in the claim 3 to 10; 505R) and be formed at least one complementary relief part (503L) on the described ring (503), described relief part cooperates when described member is in described holding fix and/or described latched position.
12. device according to claim 11 is characterized in that, described drive member (504) carrying two class relief part (505C 1, 505C 2, 505E; 505C, 505E, 505R), described two class relief part are suitable for cooperating with the complementary shared relief part (503L) of described (503) respectively when described member is in one of described holding fix and latched position.
13. the described device according to claim 12 is characterized in that, at least two elasticity tongue (505C of described drive member (504) carrying 1, 505C 2), described elasticity tongue has and extends to apart from described ring edge (505D) different distance (d 1, d 2) relief part (505E), wherein said ring (503) has the annular groove (503L) that is used to hold described relief part.
14. described device according to claim 12, it is characterized in that, described drive member (504) is carried at least one elasticity tongue (505C), described elasticity tongue has relief part (505E), described relief part is suitable for cooperating with the complementary relief part (503L) of described ring when described member is in holding fix, and described or each tongue (505C) is arranged in window (505Q), described window-shaped is formed in the peripheral partitioned portion (505J) of described drive member (504), and be used for described drive member (504) is remained on a kind of like this device (505R) of configuration between two windows, above the outside face of described peripheral partitioned portion, extend, in described configuration, described second device (505D) is actuated the device (503G) that is used to lock described ring (505).
15., it is characterized in that described drive member (504) has be suitable at least one hook (505F) of cooperating with described annular section (503C) when described member is positioned at latched position according to claim 2 and 11 described devices.
16., it is characterized in that described drive member comprises two parts, that is: according to above-mentioned any described device of claim
-being generally the part (505) of annular, it has the described ring edge (505D) of actuating, and the described part that is generally annular is suitable for partly covering described bottle stopper (501), thereby stays the opening (505B) of the exposure (501B) that is used to enter described bottle stopper; And
-cap (506), it is fixed to the described part that is generally annular releasedly and covers simultaneously described opening at least, described cap has central relief part (506C) on its surface towards the described part that is generally annular, described central relief part is suitable for cooperating with the lip-deep complementary relief part (505P) that is formed at the described annular section that holds described cap, so that the central axis (X of described cap 506) aim at the central axis (X of described opening substantially 505).
17. according to above-mentioned any described device of claim, it is characterized in that, described drive member (504) is by the carrying first and second device (505C, ring-type element 505D) (505) and cap (506) are formed, the edge (505B of the central opening (505B) of wherein said cap by being hooked in described ring-type element 1) on block (506A) be fixed on the described ring-type element, and can be only described cap be installed (F by described ring-type element flexibly is out of shape 2) on described ring-type element, described distortion is only to be installed in described ring (503) in described drive member to go up the power (F that can apply before 600) the result.
18. device according to claim 17 is characterized in that, each block (506A) has the described edge (505B that is used to be hooked in described opening (505B) 1) on hook (506A 1), wherein said hook and lean against distance (d between the surface (506C) of the described cap (506) on the described ring-type element 4), be parallel to the central axis (X of described ring-type element (505) when not being installed on the described ring-type element when described cap 505) the described edge (505B that measures 1) and the part that is used to hold the described surface that leans against the described cap on the described ring-type element (505A) of described ring-type element between distance (d 4).
19. be used to install method according to the device of claim 17 or 18, it is characterized in that, said method comprising the steps of:
A) at the edge (505B of the central opening (505B) of ring-type element (505) 1) on apply the central axis (X that is roughly parallel to described opening 505) power (F 600), described power is applied to and is equipped with the side (505A of described cap (506) 1) side (505A of relative ring-type element 2) on, and so that the mode that described edge flexibly is out of shape applies described power; And
B) along the direction opposite, depress (F towards described ring-type element with described power 0) described cap, so that the edge (505B of its block that hooks (560A) and described elastic deformation 1) cooperate.
20. one kind is equipped with the container (1) according to any described sealing arrangement (500) in the claim 1 to 18.
CN2006800447220A 2005-11-30 2006-11-29 Plug device for a container and container provided with one such device Active CN101316769B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0512172A FR2893922B1 (en) 2005-11-30 2005-11-30 CLOSURE DEVICE FOR A CONTAINER AND CONTAINER EQUIPPED WITH SUCH A DEVICE
FR0512172 2005-11-30
FR0603508 2006-04-20
FR0603508A FR2900131B1 (en) 2006-04-20 2006-04-20 CLOSURE DEVICE FOR A CONTAINER AND CONTAINER EQUIPPED WITH SUCH A DEVICE
PCT/FR2006/002616 WO2007063218A1 (en) 2005-11-30 2006-11-29 Plug device for a container and container provided with one such device

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CN101316769A true CN101316769A (en) 2008-12-03
CN101316769B CN101316769B (en) 2012-08-08

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FR (1) FR2893922B1 (en)

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CN105793912A (en) * 2013-12-02 2016-07-20 蛇牌股份公司 Security seal for medical sterile container
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FR2893922B1 (en) 2010-05-14
CN101316769B (en) 2012-08-08

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