CN101316605A - 泛素c末端水解酶l1的新用途 - Google Patents

泛素c末端水解酶l1的新用途 Download PDF

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Publication number
CN101316605A
CN101316605A CNA2006800437290A CN200680043729A CN101316605A CN 101316605 A CN101316605 A CN 101316605A CN A2006800437290 A CNA2006800437290 A CN A2006800437290A CN 200680043729 A CN200680043729 A CN 200680043729A CN 101316605 A CN101316605 A CN 101316605A
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China
Prior art keywords
uch
cancer metastasis
inhibitor
cells
protein
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Pending
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CNA2006800437290A
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English (en)
Chinese (zh)
Inventor
李公珠
金贤晶
赵政宇
孟哲永
南俞琼
林相美
金荣美
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Ewha Womans University
SK Inc
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Ewha Womans University
SK Holdings Co Ltd
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Publication of CN101316605A publication Critical patent/CN101316605A/zh
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
CNA2006800437290A 2005-11-24 2006-11-24 泛素c末端水解酶l1的新用途 Pending CN101316605A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020050113101A KR100732298B1 (ko) 2005-11-24 2005-11-24 유비키틴 ｃ-말단 가수분해제-ｌ1을 이용한 암전이 진단용조성물
KR1020050113101 2005-11-24

Publications (1)

Publication Number Publication Date
CN101316605A true CN101316605A (zh) 2008-12-03

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ID=38067427

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CNA2006800437290A Pending CN101316605A (zh) 2005-11-24 2006-11-24 泛素c末端水解酶l1的新用途

Country Status (6)

Country Link
US (1) US20090208508A1 (https=)
EP (1) EP1993581A4 (https=)
JP (1) JP2009517381A (https=)
KR (1) KR100732298B1 (https=)
CN (1) CN101316605A (https=)
WO (1) WO2007061256A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110684740A (zh) * 2019-08-09 2020-01-14 无锡傲锐东源生物科技有限公司 一种抗人泛素羧基末端水解酶-1(uch-l1)的单克隆抗体及其应用
CN112891542A (zh) * 2021-02-01 2021-06-04 暨南大学 一种包含UCHs抑制剂的药物组合物及其应用
CN113970643A (zh) * 2021-11-23 2022-01-25 北京大学人民医院 检测抗uch-l1表位的自身抗体的试剂在制备sle血清诊断相关产品中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009027349A2 (en) * 2007-08-24 2009-03-05 Oryzon Genomics Sa Treatment and prevention of neurodegenerative diseases
WO2010123365A1 (en) * 2009-04-24 2010-10-28 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Increasing the immunogenicity of epithelial cells infected with human papilloma virus (hpv)
KR101384642B1 (ko) * 2012-06-22 2014-04-22 이화여자대학교 산학협력단 Ｎ―말단이 제거된 유비퀴틴 ｃ―말단 가수분해효소―ｌ１（ｎｔ―ｕｃｈ―ｌ１）를 유효성분으로 포함하는 파킨슨병 예방 및 치료용 약학적 조성물
WO2014185561A1 (ko) * 2013-05-13 2014-11-20 이화여자대학교 산학협력단 신규한 화합물 또는 이의 약학적으로 허용 가능한 염 및 이를 유효성분으로 함유하는 ｕｃｈ－ｌ１ 관련 질환의 예방 또는 치료용 약학적 조성물
EP3887831A1 (en) 2018-11-26 2021-10-06 Baseline Global, Inc. Methods, systems, and a kit for diagnosis, detection, monitoring and treatment of traumatic brain injury

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837529T2 (de) * 1997-02-12 2007-07-26 Electrophoretics Ltd., Cobham Proteinmarker für lungenkrebs und deren verwendung
KR100545076B1 (ko) 2003-01-27 2006-01-24 김현기 인간 원암유전자 ｈｐｐ1 및 이에 의해 코드되는 단백질
US7319010B2 (en) * 2003-05-12 2008-01-15 The Regents Of The University Of Michigan Detection and treatment of cancers of the colon
KR100520800B1 (ko) 2003-05-19 2005-10-12 김진우 인간 원암유전자 ｐｉｇ２ 및 이에 의해 코드되는 단백질
JP2005272350A (ja) * 2004-03-24 2005-10-06 Vitamin C60 Bioresearch Kk 癌転移阻害剤

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110684740A (zh) * 2019-08-09 2020-01-14 无锡傲锐东源生物科技有限公司 一种抗人泛素羧基末端水解酶-1(uch-l1)的单克隆抗体及其应用
CN110684740B (zh) * 2019-08-09 2020-12-08 无锡傲锐东源生物科技有限公司 一种抗人泛素羧基末端水解酶-1(uch-l1)的单克隆抗体及其应用
CN112891542A (zh) * 2021-02-01 2021-06-04 暨南大学 一种包含UCHs抑制剂的药物组合物及其应用
CN113970643A (zh) * 2021-11-23 2022-01-25 北京大学人民医院 检测抗uch-l1表位的自身抗体的试剂在制备sle血清诊断相关产品中的应用

Also Published As

Publication number Publication date
WO2007061256A1 (en) 2007-05-31
EP1993581A4 (en) 2009-08-05
EP1993581A1 (en) 2008-11-26
KR20070054952A (ko) 2007-05-30
US20090208508A1 (en) 2009-08-20
KR100732298B1 (ko) 2007-06-25
JP2009517381A (ja) 2009-04-30

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