CN101306009A - Function food for protecting nourishing the liver - Google Patents
Function food for protecting nourishing the liver Download PDFInfo
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- CN101306009A CN101306009A CNA2008100286164A CN200810028616A CN101306009A CN 101306009 A CN101306009 A CN 101306009A CN A2008100286164 A CNA2008100286164 A CN A2008100286164A CN 200810028616 A CN200810028616 A CN 200810028616A CN 101306009 A CN101306009 A CN 101306009A
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- taurine
- functional food
- alginate
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Abstract
The invention discloses a functional food for protecting and nourishing a liver, which comprises the active ingredients by the weight percentages as follows: 5 to 75 percent of alginate, 10 to 80 percent of taurine and 15 to 85 percent of L-arginine. In the active ingredients of the functional food, the alginate has the function of regulating the liver immune system, the taurine has the detoxification function, and the L-arginine has the functions of relaxing the blood vessels and increasing the blood flow volume. The functional food combines the functions of the alginate, the taurine and the L-arginine according to a certain rule, and manufactures the functional food according to a certain component proportion, thereby leading the alginate, the taurine and the L-arginine to be put into full-play during the process of protecting and nourishing the liver, and achieving the purpose of effectively protecting and nourishing the liver.
Description
Technical field
The present invention relates to a kind of functional food that is used for protecting and nourishing liver, relating in particular to a kind of is the functional food that is used for protecting and nourishing liver of feedstock production with Sargassum extract and aminoacid.
Background technology
Liver is human body maximum, most important detoxifcation internal organs, and it is to having powerful defence function of detoxification from toxin external and that body self metabolism produces.In the daily life, the chemical harmful substance can enter liver and transform by gastrointestinal tract, blood circulation, and therefore, liver is subjected to the infringement of these toxicants easily, causes chemical liver injury.Whenever hepatocyte is impaired, as hepatocellular degeneration, when downright bad, the glutamate pyruvate transaminase in the hepatocyte just is discharged in the blood, and serum glutamic pyruvic transminase is raise, and a principal character of liver function injury is that glutamate pyruvate transaminase (ALT) raises.Along with the variation of living environment, economic pressures that people bear and stress surpassed the people body and mind can degree of support the time, hepatocyte just sustains damage; Workload is overweight and the working time is long and cause have a rest and take food unordered, all can directly hurt hepatocyte; The variation of social environment on the other hand brings the new synthetic medicament and the increase of chemical drugs, even brings the pollution and the public hazards thereof of environment, and it is the same with alcoholism, is the straight reason that produces hepatic injury.People are in the process of creating social civilization, also to oneself bringing many injuries.Hepatopathy has seriously reduced patient's quality of life, has shortened patient's life-span.Although people are to existing significant raising of the importance of protecting and nourishing liver, and relative prevention and health care measure is arranged, in the annual health check-up or indirect review, the hepatocyte damaged causes the recall rate of Glutamate pyruvate transaminase rises still rising.
At present, most of hepatocyte injury persons mainly are by Drug therapy.Though the effect of medicine glutamate pyruvate transaminase lowering is obvious, but, it is a lot of to damage hepatocellular factor, and have tangible repeatability, if separately by Drug therapy, in case the medicine toxic side effect, the liver that so this toxic and side effects can only rely on patient is removed, patient's the liver liver function that originally sustained damage is unsound, and so vicious cycle that produces again can impairing the liver in the time for the treatment of the liver.Modern medicine study shows; body immunity lowly is to cause the unsound immediate cause of hepatocyte; when carrying out protecting and nourishing liver, effectively strengthen body immunity; build a good living environment to hepatocyte; replenish the nutrient that protects the liver, strengthen the function of detoxification of liver and promote that liver is the effective way of protection nourishing liver function to the drainage of poisonous substance.
The present domestic functional food that is used for protecting and nourishing liver, mainly be that to select the Chinese herbal medicine of medicine-food two-purpose for use with reference to the mechanism of treatment by Chinese herbs hepatopathy be that raw material prepares, so product composition complexity, effective component is indeterminate, majority is that employing property belongs to cold Chinese crude drug, with simple glutamate pyruvate transaminase lowering is main purpose, and similar functional food of the present invention is not seen as yet.
Summary of the invention
The purpose of this invention is to provide a kind of functional food that is used for protecting and nourishing liver, this functional food is a primary raw material through scientific composition, refining forming with Sargassum extract and aminoacid, has the effect of enhancing immunity effect, Detoxication and expansion blood flow.
Solution of the present invention is based on the understanding of protecting and nourishing liver and principle, and to the understanding of protecting and nourishing liver raw material, with reference to modern medicine and pharmacological research achievement, from numerous Sargassum extracts and aminoacid, filter out raw material with multi-functional protecting and nourishing liver effect, scientific composition makes it give full play to the effect of enhancing immunity effect, Detoxication and expansion blood flow.
Active component and the weight content thereof of forming functional food of the present invention are:
Alginate 5～75%
Taurine 10～80%
L-arginine 15～85%.
The preferred weight content of forming the active component of functional food of the present invention is:
Alginate 15～55%
Taurine 20～60%
L-arginase 12 5～65%.
In the above-mentioned active component, described alginate is meant employed alginic acid zinc, calcium alginate, sodium alginate, potassium alginate or alginic acid magnesium in drug additive, food additive and health food nutrient; Described taurine is meant the taurine that extracts or the taurine of synthetic from biology.
The above-mentioned functional food that is used for protecting and nourishing liver by common process, can be made said multiple dosage form on the pharmaceutics, as capsule, tablet, powder, electuary, unguentum or granule.
An important feature of the present invention is that alginate is regulated the immune mechanism of action of liver, the hepatocyte damaged, lose the decomposition and the metabolic function of contratoxin, be a main aspect that causes that various hepatopathys form, the main cause of chronic hepatitis B cell injury is relevant with the caused immunologic derangement of hepatitis B virus.Recent medical research finds that chronic persistent hepatitis and chronic active hepatitis have the phenomenon of cellular immunization and humoral immunization underactivity.Alginate has heat clearing away, softening the hard mass, eliminating stagnation, activating blood circulation to dissipate blood stasis, microcirculation improvement, the function of regulating immunologic function and control hepatic fibrosis.It suppresses on the one hand indirectly, and GPT synthesizes (glutamate pyruvate transaminase) in the hepatocyte, and by alleviating the pathological process of hepatic injury, protection membrane structure and functional integrity reduce the release of GPT on the one hand.By activating intravital T lymphocyte, start the immune system of liver self, impel the liver of damage to recover and hepatocellular regeneration, increase synthesizing of hepatic glycogen, the human body immunity improving function, thus play the effect of protecting and nourishing liver cell.In addition, alginate is a high-purity edible fiber, forms the very high colloid solution of viscosity after the suction swelling, and food paste rises because of viscosity after taking in alginate, thereby the food and extend paste has delayed the process of digesting and assimilating of fats in the holdup time of gastric.Next is to have the activity that suppresses pancreatic lipase, stops fat to be broken down into fatty acid and β-monoglyceride and is absorbed, thereby reduce body to the synthetic of fat and delay the absorption of body to fat, prevents the generation of fatty liver, alleviates burden of liver.
Another one important feature of the present invention is that the taurine in this functional food is the intravital a kind of sulfur-containing amino acid of people and animal, has important function to keeping the humans and animals normal physiological function.Ethanol, synthetic medicament and chemical drugs all can have disrupting biofilm 26S Proteasome Structure and Function in various degree, cause hepatic necrosis, make the interior transaminase of cell be released into blood and cause the active rising of GPT (glutamate pyruvate transaminase).GPT (glutamate pyruvate transaminase) is one of important indicator of reflection liver lysosome stability or degree of injury; CCL4 (carbon tetrachloride) is the hepatocellular chemical substance of damage; inner synthesizing taurine ability improves behind the hepatocyte contact CCL4; taurine can reduce the release of GPT (glutamate pyruvate transaminase), thereby plays the effect of protection nourishing liver cell.Taurine has heat clearing and inflammation relieving, reduces the toxic function of many medicines and other toxic materials, and the liver lysosome membrane is had Stabilization.Taurine can and generate the avirulence material in conjunction with the hypochlorous acid in the leukocyte, reduces the destruction of hypochlorous acid to leukocyte self, thereby improves body immunity.Simultaneously, taurine can be kept cardiac function, makes blood circulation normalization, thereby the allaying tiredness product makes human body produce power effectively.
It is the mechanism of action that the L-arginine expands blood flow that the present invention also has an important feature.The L-arginine is the synthetic nitric oxide production precursor of blood vessel endothelium, synthetic endogenous nitric oxide under the effect of nitric oxide synthetase.Nitric oxide had both participated in various physiological process to liver, participated in many pathological processes again.Nitric oxide role in the hepatic injury due to the different reasons is different, in Mus acute liver damage, liver transplantation, endotoxemia hepatic injury, ischemia-reperfusion hepatic injury and the common bile duct caused by ligature silt gallbladder liver damage process of acute tetrachloro-methane induction, suppressing NO production can obviously increase the lipid peroxidation in the liver and increase the weight of hepatic injury.Nitric oxide production physiological function is as the vasodilation ischemia resisting hepatic injury to be shielded.When the tissue oxygen level was low, the nitric oxide of increase mainly played vasodilative effect, suppresses leukocyte adhesion and gathering, improves little ring of liver and hemorheology situation, alleviates damage to increase tissue perfusion; With regard to its vasodilative effect.When hepatic injury, impaired the most serious because of the hepatocyte around the hypoxic-ischemic central vein, nitric oxide passes through blood vessel dilating, suppresses the hemocyte alluvial, thereby alleviates the degree of hepatocyte hypoxic-ischemic, has flowed the protection work by improving liver blood.
Hepatic injury is that multiple factor causes, and the present invention is that the wherein main pathogeny of basis adopts multiple function raw material to carry out the science compatibility.Alginate has the immune effect of the liver of adjusting; Taurine has the antidotal effect; L-arginine energy vasodilator, the function of blood flow increasing is made up the effect that they can play by certain law, and by certain component proportion, make functional food, make three kinds of raw materials in the process of protecting and nourishing liver, give full play to each self-applying, to reach the purpose of effective protecting and nourishing liver.The present invention proves to have the function of obvious hepatoprotective through the animal function test.
In addition, health food effective component of the present invention is clear and definite, and steady quality is easy to control.It is primary raw material that the present invention selects marine organism extract for use, and component is few, flat flavor, and instant has no side effect.
The present invention is further illustrated below in conjunction with the specific embodiment and contractile studies.
The specific embodiment
The present invention will be described below to enumerate specific embodiment.It is pointed out that embodiment only is used for that the invention will be further described, do not represent protection scope of the present invention, nonessential modification and adjustment that other people prompting according to the present invention is made still belong to protection scope of the present invention.
Embodiment 1
Active component and the weight content thereof of forming functional food of the present invention are:
Alginic acid zinc 75%
Taurine 10%
L-arginine 15%.
Embodiment 2
Active component and the weight content thereof of forming functional food of the present invention are:
Sodium alginate 25%
Taurine 30%
L-arginine 45%.
Embodiment 3
Active component and the weight content thereof of forming functional food of the present invention are:
Calcium alginate 35%
Taurine 40%
L-arginase 12 5%.
Embodiment 4
Active component and the weight content thereof of forming functional food of the present invention are:
Potassium alginate 55%
Taurine 20%
L-arginase 12 5%.
Embodiment 5
Active component and the weight content thereof of forming functional food of the present invention are:
Alginic acid magnesium 15%
Taurine 30%
L-arginine 55%.
The functional food that is used for protecting and nourishing liver of the foregoing description by common process, can be made said multiple dosage form on the pharmaceutics, as capsule, tablet, powder, electuary, unguentum or granule.
The animal function test
The capsule that adopts the foregoing description 1 prescription to make carries out animal function test and evaluation of test result according to the regulation of Ministry of Public Health " health food check and assessment technique standard (2003 editions) ".
1 result of the test
1.1 capsule of the present invention is to the influence of animal subject body weight:
By table 1 as seen, each dosage group and blank group compare, and difference does not have significance meaning (P＞0.05), shows that capsule of the present invention does not have influence to the weight of animals.
Table 1 capsule of the present invention is to the influence of animal subject body weight (x ± s)
1.2 capsule of the present invention is to the influence of animal subject hepatic tissue MDA, TG content:
By seeing Table 2 as seen, ethanol matched group MDA, TG content and blank group relatively raise, and difference has significance meaning (P＜0.05), show the establishment of ethanol liver injury model.Middle and high dosage group MDA, TG content and ethanol matched group relatively reduce, and difference has the significance meaning.Show MDA, the TG positive as a result.
Table 2 capsule of the present invention is to the influence of animal subject hepatic tissue MDA, TG content (x ± s)
Annotate: 1. blank group and ethanol matched group relatively adopt the T check.
2. △, △ △ represent relatively P＜0.05 of ethanol matched group and blank group, P＜0.01.
3. each dosage group and ethanol matched group relatively adopt variance analysis.
4.
*,
*Expression dosage group and ethanol matched group be P＜0.05 relatively, P＜0.01.
1.3 capsule of the present invention is to the influence of animal subject hepatic tissue GSH content:
By seeing Table 3 as seen, ethanol matched group GSH content and blank group relatively reduce, and difference has significance meaning (P＜0.05), show the establishment of ethanol liver injury model.Middle dosage group GSH content and ethanol matched group relatively raise, and difference has highly significant meaning (P＜0.01).Show the GSH positive as a result.
Table 3 capsule of the present invention is to the influence of animal subject hepatic tissue GSH content (x ± s)
Annotate: 1. blank group and ethanol matched group relatively adopt the T check.
2. △ represents relatively P＜0.05 of ethanol matched group and blank group.
3. each dosage group and ethanol matched group relatively adopt variance analysis.
4.
*Expression dosage group and ethanol matched group be P＜0.01 relatively.
1.4 the influence that capsule of the present invention changes the animal subject hepatic pathology:
By seeing Table 4 as seen, the pathology of livers of ethanol matched group and each dosage treated animal is based on hepatocellular degeneration, and diseased region is mainly around lobules of liver.Ethanol matched group and blank group relatively have tangible hepar damnification (hepatic cell fattydegeneration), learn check by statistics, and difference has highly significant meaning (P＜0.05), show the establishment of ethanol liver injury model.High dose group hepatic cell fattydegeneration degree and ethanol matched group relatively alleviate, and difference has significance meaning (P＜0.05).Show the liver of laboratory animal pathological examination positive.
The influence that table 4 capsule of the present invention changes the animal subject hepatic pathology
Annotate: 0 is roughly normal; The I sick cell accounts for 1/4 1 minutes of whole visual field; The II sick cell accounts for 1/2 2 minutes of whole visual field; The III sick cell accounts for 3/4 3 minutes of whole visual field; The IV sick cell accounts for the meter 4 minutes of whole visual field.
1. the liver fat degeneration must be divided into ranked data, adopts rank test.
2. △ △ represents relatively P＜0.01 of ethanol matched group and blank group.
3.
*Expression dosage group and ethanol matched group be P＜0.05 relatively.
2 conclusions:
Give capsule of the present invention every day respectively to SPF level Kunming mouse, dosage is 0.25,0.50,1.00g/kgBW, be equivalent to human body and recommend 5,10,20 times of day dosing, other establishes blank group and ethanol matched group, totally 35 days, each dosage group and ethanol matched group are once irritated stomach with 0.12ml/10g BW dosage and are given 50% ethanol, and the blank group is irritated stomach and given the same dose pure water, and each treated animal fasting is put to death animal and carried out biochemistry and hepatopathy check of science after 12 hours.Given the test agent reduces middle and high dosage group hepatic tissue MDA, TG content as a result; Dosage group hepatic tissue GSH content in the increase, the experimental result positive.Given the test agent high dose group hepatic cell fattydegeneration and ethanol matched group relatively alleviate, and the zoopery hepatic pathology is the positive as a result.According to above-mentioned biochemistry and pathological examination result, judge that according to the criterion of Ministry of Public Health " health food check and assessment technique standard (2003 editions) " capsule of the present invention has the effect of protecting and nourishing liver.
Claims (5)
1, a kind of functional food that is used for protecting and nourishing liver is characterized in that active component and the weight content thereof of forming this functional food are:
Alginate 5～75%
Taurine 10～80%
L-arginine 15～85%.
2, the functional food that is used for protecting and nourishing liver according to claim 1 is characterized in that the weight content of each active component is:
Alginate 15～55%
Taurine 20～60%
L-arginase 12 5～65%.
3, the functional food that is used for protecting and nourishing liver according to claim 1 and 2 is characterized in that described alginate is meant employed alginic acid zinc, calcium alginate, sodium alginate, potassium alginate or alginic acid magnesium in drug additive, food additive and health food nutrient.
4, the functional food that is used for protecting and nourishing liver according to claim 1 and 2 is characterized in that described taurine is meant the taurine that extracts or the taurine of synthetic from biology.
5, the functional food that is used for protecting and nourishing liver according to claim 1 and 2, the dosage form that it is characterized in that described functional food is capsule, tablet, powder, electuary, unguentum or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100286164A CN101306009A (en) | 2008-06-06 | 2008-06-06 | Function food for protecting nourishing the liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100286164A CN101306009A (en) | 2008-06-06 | 2008-06-06 | Function food for protecting nourishing the liver |
Publications (1)
| Publication Number | Publication Date |
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| CN101306009A true CN101306009A (en) | 2008-11-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008100286164A Pending CN101306009A (en) | 2008-06-06 | 2008-06-06 | Function food for protecting nourishing the liver |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973591A (en) * | 2012-11-26 | 2013-03-20 | 合肥博太医药生物技术发展有限公司 | Application of alginic acid in preparing medicament for treating serious hepatitis |
| CN105852114A (en) * | 2016-05-07 | 2016-08-17 | 集美大学 | Lipid lowering and liver protecting functional food |
| CN105996027A (en) * | 2016-05-07 | 2016-10-12 | 集美大学 | Functional food with effects of protecting liver and improving eyesight |
| CN107625932A (en) * | 2017-10-21 | 2018-01-26 | 厦门翼翔缘生物科技有限公司 | A kind of protect liver ferment and preparation method thereof |
| CN107847476A (en) * | 2015-07-13 | 2018-03-27 | 协和发酵生化株式会社 | Containing the arginic tablet of high concentration |
-
2008
- 2008-06-06 CN CNA2008100286164A patent/CN101306009A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973591A (en) * | 2012-11-26 | 2013-03-20 | 合肥博太医药生物技术发展有限公司 | Application of alginic acid in preparing medicament for treating serious hepatitis |
| CN107847476A (en) * | 2015-07-13 | 2018-03-27 | 协和发酵生化株式会社 | Containing the arginic tablet of high concentration |
| CN105852114A (en) * | 2016-05-07 | 2016-08-17 | 集美大学 | Lipid lowering and liver protecting functional food |
| CN105996027A (en) * | 2016-05-07 | 2016-10-12 | 集美大学 | Functional food with effects of protecting liver and improving eyesight |
| CN105996027B (en) * | 2016-05-07 | 2019-05-10 | 集美大学 | A kind of functional food of liver protection and eyesight |
| CN107625932A (en) * | 2017-10-21 | 2018-01-26 | 厦门翼翔缘生物科技有限公司 | A kind of protect liver ferment and preparation method thereof |
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Open date: 20081119 |