CN113040393A

CN113040393A - Nutritional formula for intervening anxiety and sleep disorder

Info

Publication number: CN113040393A
Application number: CN202110348105.6A
Authority: CN
Inventors: 杨继辉; 马仲俊; 陈俊
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-03-31
Filing date: 2021-03-31
Publication date: 2021-06-29

Abstract

The invention relates to a nutritional formula for intervening anxiety and sleep disorder, which comprises spirulina peptide, passion fruit extract, glutamine, ascorbic acid, gamma-aminobutyric acid, embelia nasuta oil or powder and honey. The spirulina peptide and the gamma aminobutyric acid are used as main raw materials, and the component mixture of the plukenetia volubilis linneo oil, the glutamine, the passion fruit extract and the like is added, so that the sleep disorder can be adjusted through nutrient balance adjustment, immunity, digestive tract, metabolism, hormone, liver, cerebral nervous system and the like, and the spirulina peptide and the gamma aminobutyric acid have a good effect of improving clinical symptoms such as difficulty in falling asleep, nighttime dreaminess, easiness in waking at night, poor daytime vigor, dry eyes, discomfort of digestive tract, easiness in waking at early stage and the like.

Description

Nutritional formula for intervening anxiety and sleep disorder

Technical Field

The invention belongs to the technical field of health-care food or food, and particularly relates to a nutritional formula for intervening anxiety and sleep disorder.

Background

Sleep, an essential process of life, is an important link of central nervous system repair, biorhythm maintenance, memory consolidation and body integration, and is an indispensable component for keeping health. Insomnia generally refers to a subjective experience in which a patient does not meet sleep time and/or quality and affects daytime social functioning. Other symptoms are secondary to insomnia, such as difficulty in falling asleep, frequent awakening at night, early awakening, difficulty in getting asleep again after awakening, uncomfortable feeling after awakening, fatigue, too short or too long sleep maintenance time and the like, and the problems are all described in the problem of insomnia caused by co-morbidity of patients suffering from Zhao Wen Qing, Song Li Sheng and anxiety disorder [ J ]. journal of psychiatric medicine, 2016.

The nervous system, the endocrine system and the immune system of the insomnia patients are changed to different degrees, and the inflammatory reaction is over-activated, so that the inflammatory reaction plays an important role in the disease development, and the inflammatory reaction can influence the day-to-day normal behaviors of the patients, such as cognition, emotion and social behaviors thereof; chronic insomnia is a chronic stress that increases cortisol levels, resulting in sleep disturbance. Therefore, sleep disorders can affect the normal functions of the digestive system, the immune system, the metabolic system, the hormone system and the nervous system of the liver and the brain, and can cause the clinical symptoms of difficult sleep, nighttime dreaminess, easy awakening at night, poor daytime vigor, dry eyes, uncomfortable digestive tract, easy early awakening and the like. The above problems are all described in "Leyingxue, Chen Guihai, research progress of blood biological markers of chronic insomnia patients [ J ]. J. J. Neuroimmunology and neurology J. (2018, 025(006):399 one 402").

Researches show that the insomnia people have great relationship with self emotion problem and imbalance of nutrient substances in the body, and how to intervene anxiety and sleep disorder is always a relatively concerned problem in the field of health care.

Disclosure of Invention

Aiming at the problems, the invention provides a formula for intervening anxiety and sleep disorder by regulating the balance of nutrient substances in a human body.

The specific technical scheme is as follows: a nutritional formula for intervening anxiety and sleep disorder comprises spirulina peptide, Passiflora edulis extract, glutamine, ascorbic acid, gamma-aminobutyric acid, Plukenetia volubilis oil or powder, and Mel.

The spirulina peptide can well adjust the liver function, relieve the dryness of eyes, degrade the toxin in the digestive tract, resist inflammation, improve the activity of superoxide dismutase (SOD) in body fluid, well adjust anemia symptoms by organic iron, and well adjust blood sugar, blood pressure and sleep by magnesium, calcium, amino acid and potassium, wherein the calcium can promote the synthesis of 5 hydroxytryptophan;

linolenic acid regulates hormone balance, and vitamins B1, B2, B6 and B12 have metabolism promoting, gastric acid regulating and nerve nourishing effects. A large amount of high-quality plant protein amino acids, vitamins and organic minerals can well improve the balance immunity and synthesize hormone. The nutrient substances in the spirulina peptide are easier to be absorbed by human body, and the allergy rate of the edible spirulina is reduced.

The passion fruit extract has a neuroprotective effect, and researches show that the substances in the passion fruit have a protective effect on glutamic acid-induced HT4 neuronal cell death, mitochondrial depolarization and glutathione consumption, and also have a protective effect on mouse dopamine neurons injected with neurotoxin MTPT;

the effect of passion fruit juice on the weight swimming and fatigue resistance of the mice aged by D-galactose is studied, and 42D of passion fruit juice is continuously infused into the mice aged by the D-galactose, and the results show that compared with the normal group, the mice aged by injecting the passion fruit juice have the advantages of prolonged exhaustion swimming time, increased content of hepatic glycogen and quadriceps muscle glycogen, increased activity of superoxide dismutase (SOD) and reduced content of Malondialdehyde (MAD). The passion fruit juice has a certain anti-fatigue effect on mice aged by D-galactose, a maze experiment is carried out on the mice injected with the passion fruit ethanol extracting solution, compared with a blank group, the passion fruit ethanol extracting solution is found to be more stable to find an outlet, and a study shows that the cycloartane triterpenoid in the passion fruit has an anti-depression effect.

The glutamine can improve mental disorder and epileptic brain function. A nutritional supplement. It can be used for treating digestive organ ulcer (gastric ulcer, duodenal ulcer), and acute and chronic gastritis. Also useful as a brain function improving agent. Repairing digestive tract mucosa and regulating liver: the detoxification of many toxic compounds by the liver depends mainly on glutathione. Glutathione is a main scavenger of toxic oxidants of organisms, has the main functions of protecting biological membranes, nucleic acid and various proteins from being attacked by free radicals, and has very important function in an antioxidant system. Under stress, the production and release of a large number of free radicals can cause lipid peroxidation. The glutamic acid in the glutathione compound is mostly derived from glutamine. Under stress, glutamine level is reduced, so that glutathione synthesis is reduced, and the oxidation resistance of the organism is reduced, thereby forming a vicious circle. The glutamine of gastrointestinal tract disease is the most important nutrient substance for repairing digestive tract, can effectively increase the blood flow volume of intestinal tract and oxygen intake, and keeps the intestinal mucosa intact. Glutamine, which is a raw material for immune cell replication, is an important nutrient for rapidly proliferating cells such as lymphocytes and phagocytes. The lymphocyte and phagocyte contain active substances dependent on glutaminase, can be used in large quantity, and glutamine synthesizes cell nucleic acid, which is an essential substance for lymphocyte proliferation under antigen stimulation, can up-regulate glutathione, improve the quantity and activity of T lymphocyte, CD4+ cell and killer cell, promote the differentiation and proliferation of immunocompetent cell, enhance the nonspecific defense capability of organism, and regulate immunocompetence. The related discovery of the nervous system, glutamine can obviously reduce the cortisol level in serum, and is a very potential heat shock response promoter. The above data are all clearly described in "Wangjingjing, Xiagua sinica, Zhang bright-day glutamine clinical application research progress [ J ] civil military medical science, 2013: 107-.

Ascorbic acid is also called VC, and has the functions of promoting the absorption of iron and detoxifying (after a large amount of vitamin C is supplemented in vivo, the toxic action of heavy metals such as lead, mercury, cadmium, arsenic and the like on organisms can be relieved, the normal discharge of brains can be influenced by the heavy metals in vivo), free radicals can be eliminated (super negative oxygen ions in vivo can be eliminated through the process of gradually supplying electrons to semi-dehydroascorbic acid and dehydroascorbic acid), and the damage of the free radicals to the nervous system is reduced.

Gamma-aminobutyric acid: (1) anxiety relief and excitement suppression: GABA acts as a major inhibitory neurotransmitter in the central nervous system and is involved in the physiological activities of the cerebral circulation. The GABA is supplemented properly, so that anxiety can be relieved, excitation can be inhibited, and the effect of improving sleep is achieved. (2) And (3) metabolism promotion: GABA can increase activity of hexokinase in tricarboxylic acid cycle (TCA), so as to accelerate metabolism of glucose in brain, finally increase blood supply and oxygen supply of brain, and promote sleep. (3) Improving the memory: GABA can inhibit excessive excitation of neuron, improve central nervous system stability, and enhance brain memory function by relieving pressure. (4) And (3) delaying the aging of nerve cells: GABA can increase the activity of glucose phosphatase, participate in tricarboxylic acid circulation in brain, and activate brain cell function.

A large amount of alpha-linolenic acid in the plukenetia volubilis linneo oil or powder belongs to omega-3 series (or n-3 series) fatty acid, (1) the alpha-linolenic acid is directly absorbed mainly by intestinal tracts after entering a human body, is stored in a liver and is conveyed to each part of the body through blood to directly become a structural substance of a cell membrane, and is converted into EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) under the catalysis of enzymes (dehydrogenase and carbon chain elongase), so that the alpha-linolenic acid can be completely absorbed by the body;

(2) the alpha-linolenic acid has inhibition effect on various inflammation mediators and cytokines, and does not bring adverse reaction. The effect of alpha-linolenic acid on lipid inflammatory mediators. When inflammation occurs, AA on cell membranes produces a series of physiologically active lipid mediators, mainly including prostaglandin PGE2 and tetraleukotriene LT4, under the action of cyclooxygenase and lipoxygenase, causing inflammatory reaction. The metabolite EPA of alpha-linolenic acid is an analogue of AA, the prostaglandin PGE3 and penta-leukotriene LT5 produced by competing with the same enzyme line inhibit the production of PGE2 and LT4, and PGE3 and LT5 have little effect on inflammatory activity compared with PGE2 and LT4, so that the alpha-linolenic acid in vivo has good anti-inflammatory effect. The effect of alpha-linolenic acid on peptide inflammatory mediators (cytokines). IL-I beta and TNF-alpha are important peptide inflammatory mediators, and can stimulate the production of collagenase and mediate leukocyte adhesion to endothelial cells so as to activate neutrophils and macrophages to cause inflammatory response. Alpha-linolenic acid can obviously inhibit the production of cytokines, and the mechanism of the alpha-linolenic acid is not clear. It was found that by administering alpha-23 linolenic acid of 56% purity for 4 weeks, the production of IL-I beta and TNF-alpha can be inhibited by about 30% with an increased concentration of leukocyte EPA in vivo. The research results show that the inhibition of the alpha-linolenic acid on inflammatory mediators can judge that the alpha-linolenic acid has a therapeutic effect on inflammatory diseases;

(3) esterifying cholesterol, reducing cholesterol and triglyceride in blood, reducing blood viscosity, and improving blood microcirculation;

(4) alpha-linolenic acid converted docosahexaenoic acid (DHA) is present in large amounts in the cranial nerves and retina and if absent, will affect the normal function of the organ. Can inhibit excitation by improving inflammation blood lipid and microcirculation, and relieve sleep difficulty.

Mel is used as thickener and sweetener.

Of course, some of the chelate in honey can also play the functions of regulating sleep, regulating hormone balance and regulating digestion.

Since sleep disorders can affect the normal functions of the digestive, immune, metabolic, hormonal and hepatic and cerebral nervous systems, it is desirable to improve sleep and its associated symptoms such as: (dry eyes, dyspepsia, inflammatory factors and the like) must be supplemented and balanced with digestive, immune, metabolic, hormonal and liver and brain nerve-related intervention substances.

The passion fruit brass and the gamma aminobutyric acid have the functions of resisting anxiety, depression and inhibiting excitation, and mainly act on related targets of a nervous system to solve the problem of current sleep disorder.

But the intervention factors causing the sleep disorder and the problem of unbalanced related nutrient substances, a plurality of amino acids in the spirulina peptide are important raw materials for synthesizing serotonin and dopamine, the balance of the hormones is closely related to depression, anxiety and the sleep disorder, and trace elements such as magnesium, calcium, potassium, iron and the like can simultaneously participate in the contraction and relaxation of muscles and the transmission of a nervous system, can balance blood sugar (gamma aminobutyric acid has similar functions and is different from a target point), reduce blood fat, increase blood oxygen, reduce blood pressure and inhibit excitation. The glutamine repairs the mucous membrane of the digestive tract, the spirulina peptide can adjust the function of the gastrointestinal tract to excretion, can also reduce intestinal toxin, reduce the intestinal toxin from entering blood, lighten the burden of the liver, promote the synthesis of glutathione, improve the activity of SOD enzyme, is very important for the health of the liver, and simultaneously the health of the liver can influence the health of eyes and greatly improve the symptoms of dry eyes and the like. The spirulina peptide contains limited nutrients, so the material form and dosage of the spirulina must reach a certain amount to effectively adjust the balance of nutrient substances of the body and achieve the intervention effect.

The embelia laeta oil or powder and the glutamine in the technical scheme of the invention have the effect of improving brain functions from different targets, wherein omega-3 in the embelia laeta can also influence cholesterol, reduce blood fat, inhibit platelet aggregation, improve blood circulation, improve heart functions, inhibit excitation and protect eyes to a certain extent.

Glutamine and Plukenetia volubilis oil or powder have anti-inflammatory effect. Glutamine is an important nutrient substance of lymphocytes and phagocytes, and can improve immunity and resist inflammation. Alpha-linolenic acid in the embelia laeta oil or powder has inhibitory effect on various inflammation mediators and cytokines to combat inflammation. The alpha-linolenic acid can only play a good role after being eaten for a long time with proper dosage, and the alpha-linolenic acid are combined to aim at different targets and play a role in improving brain functions and resisting inflammation in a synergistic way from different directions.

Ascorbic acid (VC) promotes iron absorption to increase blood oxygen concentration, resists oxidation to remove free radicals, activates immune cells, and prevents damage to the nervous system by combining the glutamine and the embelia nasi oil or powder to resist inflammation and certain anti-inflammation of the body, and the like to remove free radicals and the like.

Therefore, the formula adopts the spirulina peptide and the gamma aminobutyric acid as main raw materials, and the components of the calamus margaritae oil, the glutamine and the passion fruit extract which are not used for the sleep intervention effect are added, so that the sleep disorder can be adjusted through nutrient balance adjustment, immunity, digestive tract, metabolism, hormone, liver, cerebral nervous system and the like, and the good improvement effect is achieved on the clinical symptoms such as difficulty in falling asleep, nighttime dreaminess, easiness in waking at night, poor daytime vigor, dry eyes, discomfort digestive tract and easiness in waking early and the like.

Further, it is preferable that 1000 parts of algae peptide, 300 parts of passion fruit extract, 300 parts of glutamine 150, 200 parts of ascorbic acid, 250 parts of gamma-aminobutyric acid, 500 parts of embelia nassia oil or powder and 500 parts of honey 300 are mixed.

The spirulina peptide needs a larger dosage because of the relatively lower content and proportion of amino acids and vitamin minerals, so that the spirulina peptide can be used as a basic ingredient to effectively adjust the balance of nutrient substances of the body to achieve the intervention effect by 500 plus 1000 parts from the aspects of the technical effect, the purpose and the economy of food health care.

The passion fruit extract accounts for 150-300 parts from the aspects of technical effect, purpose and economy of food health care.

The amount of the cambogia oil or the cambogia powder is lower (300 parts can be selected) when the cambogia oil or the cambogia powder is used as plant powder particles, and the amount of the pills is higher (500 parts can be selected).

300 parts of honey can achieve the effect of a thickening agent.

Further, 1000 parts of spirulina peptide, 300 parts of passion fruit extract, 300 parts of glutamine, 150 parts of ascorbic acid, 150 parts of gamma-aminobutyric acid, 300 parts of plukenetia volubilis linneo oil or powder and 300 parts of honey are preferably mixed.

Another technical object of the present invention is to provide a formula for a mixture prepared by using a nutritional formula for intervening anxiety and sleep disorders, wherein the mixture can be prepared into a tablet, a powder or a honeyed pill. It is of course possible to prepare a paste, or a solution dissolved in the medium, or the like.

The invention has the beneficial effects that: the spirulina peptide and the gamma aminobutyric acid are used as main raw materials, and the component mixture of the embelia meiliana oil or powder, the glutamine, the passion fruit extract and the like is added, so that the sleep disorder is adjusted through nutrient balance adjustment, immunity, digestive tract, metabolism, hormone, liver, cerebral nervous system and the like, and the spirulina compound preparation has a good effect of improving clinical symptoms such as difficulty in falling asleep, nighttime dreaminess, easiness in waking at night, daytime energy, dry eyes, discomfort of digestive tract, easiness in waking early and the like.

Drawings

FIG. 1 is a graph of the improvement in symptoms in a subject on a 14 day basis using the formulation of the invention.

Fig. 2 is a first raw data record table of the survey.

Fig. 3 is a second original data record table of the present survey.

Detailed Description

In order to make the technical problems and technical solutions solved by the present invention more clearly apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Example 1:

a nutritional formula for intervening anxiety and sleep disorder comprises 500 parts of spirulina peptide, 150 parts of passion fruit extract, 150 parts of glutamine, 200 parts of ascorbic acid, 250 parts of gamma aminobutyric acid, 500 parts of plukenetia volubilis oil and 500 parts of honey.

The mixture can then be prepared into a compressed tablet.

Example 2:

a nutritional formula for intervening anxiety and sleep disorder comprises 1000 parts of spirulina peptide, 300 parts of passion fruit extract, 300 parts of glutamine, 150 parts of ascorbic acid, 150 parts of gamma aminobutyric acid, 300 parts of plukenetia volubilis oil and 300 parts of honey.

The mixture can then be prepared as a powder.

Example 3:

the blend pellets prepared in example 2 above were used to intervene on the panelists as shown in figures 1 to 3.

Basic data: : the subjects were 50, 29 males and 21 females, at age range 25-45 years, with the mean age (36.61 + -4.62).

Clinical symptoms before intervention are shown in table one:

TABLE 1 Pre-intervention general clinical symptoms

Clinical symptoms after intervention are shown in statistics, see table two:

TABLE 2 symptom improvement (%)

As shown in fig. 1, the term statistical analysis of the symptom improvement change within 14 days shows that:

1. symptoms of difficulty falling asleep: the dry prognosis showed the least improvement in symptoms on day 2 (74%), the most improvement in symptoms on days 13 and 14 (96%), and the overall trend was upward in the number of improvement in the symptoms of difficulty falling asleep within 14 days after the intervention treatment was performed, as shown in fig. 1.

2. Symptoms of nighttime dreaminess: the dry prognosis showed the least improvement in symptoms on day 2 (78%), the highest improvement in symptoms on day 14 (98%), and the overall increase in the improvement in nighttime dreaminess symptoms within 14 days after intervention was shown in FIG. 1.

3. Symptoms of easy awakening at night: the dry prognosis shows that the number of people with the symptom improved on the 2 nd day is the least (74%), the number of people with the symptom improved on the 10 th and 13 th days is the highest (98%), and the number of people with the symptom easy to wake up at night in 14 days after the intervention measures are implemented is generally in an increasing trend from figure 1.

4. Daytime symptoms of poor energy: the dry prognosis showed the least improvement in symptoms on day 1 (84%), the highest improvement in symptoms on days 10 and 14 (98%), and the overall trend was upward in the number of people who improved energy symptoms in day 14 after intervention as shown in fig. 1.

5. Dry eye symptoms: the improvement rate of symptoms is minimum (88%) on the 2 nd day after the dry prognosis, the improvement rate of symptoms is maximum (99%) on the 14 th day, and as can be seen from fig. 1, the improvement rate of dry eye symptoms in 14 days after the intervention is performed is on the whole in an increasing trend.

6. Symptoms of improvement of digestive tract (constipation/diarrhea): the dry prognosis showed the least improvement in symptoms on day 1 (58%), the highest improvement in symptoms on day 12 (88%), and as can be seen from fig. 1, the overall trend was upward in the improvement in symptoms of digestive tract (constipation/diarrhea) within 14 after the intervention.

7. Easy early awakening symptom: the dry prognosis shows that the number of people with the least improvement of symptoms (82%) on the 2 nd day and the number of people with the highest improvement of symptoms (98%) on the 14 th day are the highest, and the number of people with the improvement of early-awakening symptoms in 14 days after the intervention is implemented is generally in an ascending trend as shown in fig. 1.

From the above analysis it follows that: after the prepared mixture is adopted, the symptoms of difficult falling asleep, nighttime dreaminess, easy awakening at night, dry eyes and easy early awakening of an investigator are improved by the least number of people on the 2 nd day after intervention; daytime energy and digestive tract improvement (constipation/diarrhea) were all at least improved on day 1 after intervention; except for the symptom of easy wakefulness at night (day 13), improvement of digestive tract (constipation/diarrhea) (day 12), all the other symptoms were improved the highest in 14 days. Generally speaking, the number of people with difficulty in falling asleep, dreaminess at night, easy awakening at night, poor daytime vigor, dry eyes, improvement of digestive tract (constipation/diarrhea), easy early awakening symptoms is rising within 14 after intervention measures are implemented.

The present invention has been described in detail with reference to the specific and preferred embodiments, but it should be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and any modifications, equivalents and the like, which are within the spirit and principle of the present invention, should be included in the scope of the present invention.

Claims

1. A nutritional formula for intervening anxiety sleep disorder, which is characterized in that: comprises spirulina peptide, passion fruit extract, glutamine, ascorbic acid, gamma-aminobutyric acid, Plukenetia volubilis oil or powder, and Mel.

2. The nutritional formula for intervening anxiety sleep disorders according to claim 1, wherein: comprises 1000 parts of spirulina peptide, 300 parts of passion fruit extract, 300 parts of glutamine 150, 200 parts of ascorbic acid, 250 parts of gamma-aminobutyric acid, 500 parts of embelia nasi oil or powder and 500 parts of honey 300.

3. The nutritional formula for intervening anxiety sleep disorders according to claim 1, wherein: comprises 1000 parts of spirulina peptide, 300 parts of passion fruit extract, 300 parts of glutamine, 150 parts of ascorbic acid, 150 parts of gamma-aminobutyric acid, 300 parts of embelia laeta oil or powder and 300 parts of honey.

4. A mixture prepared using the nutritional formula for intervening anxiety sleep disorders according to any one of claims 1-3 wherein: the mixture can be prepared into tablet, powder or honeyed pill.