CN101301201A - Detecting device integrated with light sound ultrasonic excitation and sensor - Google Patents
Detecting device integrated with light sound ultrasonic excitation and sensor Download PDFInfo
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- CN101301201A CN101301201A CNA2008101069738A CN200810106973A CN101301201A CN 101301201 A CN101301201 A CN 101301201A CN A2008101069738 A CNA2008101069738 A CN A2008101069738A CN 200810106973 A CN200810106973 A CN 200810106973A CN 101301201 A CN101301201 A CN 101301201A
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Abstract
The invention provides an optical acoustic ultrasound excitation and induction integrated detection device. An acoustic insulating layer, a sound absorption pad, a miniaturized semiconductor laser tube, a Fourier lens, a cylinder lens, a protection film and an annular multi-ring array sensor are all arranged in casing of the detection device and at same axle wire to form an integrated coaxial confocal structure. The multi-ring array sensor can generate ultrasonic signal, receive ultrasonic echo signal and receive optical acoustic signal by time-sharing excitation to realize optical acoustic ultrasound single or combined detection of A-type dynamic scan. The detection device has advantages of integrating excitation and induction of optical acoustic ultrasound, greatly increasing excitation and induction efficiency optical acoustic ultrasound, effectively reducing laser energy demand, increasing detection depth, and having high measurement sensitivity, simple operation and low cost. The detection device can be widely applied in fields of blood oxygen detection, blood sugar detection, HIFU therapy and effect monitoring, industrial crack detection and so on.
Description
Technical field
The present invention relates to biomedical measurement and technical field of medical instruments, particularly relate to a kind of light sound ultrasonic excitation and sensing integrated checkout gear.
Background technology
Also there are a lot of difficulties in the ultransonic multiparameter combined detection of optoacoustic at present, for example consider the damage threshold of biological tissue, incident laser can not be too strong, again owing to organize strong scattering and the absorption of top layer to light, arrive the light intensity decreasing of deep tissues, so effectively the launching efficiency of raising optoacoustic is a problem that needs solution in a hurry; In addition, optoacoustic detection is based on optoacoustic effect and supersonic sounding is based on piezoelectric effect, there is certain difficulty in the system integration and the miniaturization of two cover different principle.
" Optoacoustic and Ultrasonic Co-Image with a Linear TransducerArray " Opt.Lett.29,1760-1762,2004. reported the optoacoustic ultrasonic in combination formation method that shakes first linear array detector based on 320, but that the detection method of this lateral mode is difficult to be applied to is clinical." Combined ultrasound and optoacoustic system for real-timehigh-contrast vascular imaging in vivo " IEEE Trans.Med.Imaging 24,436-440,2005. reported that based on the optoacoustic ultrasonic in combination formation method of detection mode dorsad having adopted pick off is 64 linear array detector and the laser energy output side optical fiber formulas of shaking unit." Integratedsystem for ultrasonic; photoacoustic and elasticity imaging, " Proc.SPIE, 6147,61470H1-8,2006. have reported the joint imaging method of optoacoustic based on the forward direction detection mode, ultrasonic and elastic modelling quantity.But the scope of application of forward direction detection mode is narrower, and above method all is to adopt linear array detector as transducing part, detection mode is B-scan, light sound ultrasonic excitation and sensing can't realize the coaxial confocal structure, therefore the efficient of photo-acoustic excitation and detection is not high, need more powerful solid state laser that the optoacoustic excitation energy is provided, and the solid state laser of large volume can't realize encouraging the integrated and miniaturization with sensing, actual popularizing application prospect has been subjected to very big restriction.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of light sound ultrasonic excitation and sensing integrated checkout gear, the ultrasonic single or combined detection of optoacoustic can be realized, the detection of blood oxygen, blood sugar test, HIFU treatment and fields such as effect monitoring, industrial flaw detection can be widely used in.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of light sound ultrasonic excitation and sensing integrated checkout gear, top and middle part at shell are provided with the acoustics insulating barrier, center of top at the acoustics insulating barrier is provided with semiconductor laser tube, in the central authorities of acoustics insulating barrier, the below that is positioned at semiconductor laser tube is provided with fourier transform lens; Be provided with the sound absorption pad under the bottom of shell, acoustics insulating barrier, in the central authorities of sound absorption pad, the below that is positioned at fourier transform lens is provided with cylindrical lens, and the bottom surface of cylindrical lens is provided with protecting film; The hollow inner ring sleeve of ring-type multi-ring array pick off is contained in the bottom of cylindrical lens; The center of semiconductor laser tube, fourier transform lens, cylindrical lens, multi-ring array pick off all is positioned on the same axis, and integrated being packaged in the shell constitutes incorporate coaxial confocal structure.Described semiconductor laser tube (1) is the quasiconductor pulsed laser diode, and the quasiconductor pulsed laser diode is operated in one or more wavelength that ultraviolet is selected to the infra-red range.Described semiconductor laser tube, fourier transform lens and cylindrical lens are formed photo-acoustic excitation source and light path lens combination, and light path system can conversion produce focusing or parallel laser beam, passes the hollow internal ring of protecting film and multi-ring array pick off, the detected sample of directive.Planar array that described multi-ring array pick off is a hollow or concavo-convex battle array, each ring of multi-ring array pick off is cut into a * k=2 π, (k=1,2, n) arc of the radian unit of shaking, wherein a is each arc corresponding radian of unit that shakes, and k is the arc of cutting first number that shakes, and each arc unit's 14 electrodes 12 by lead and signal processor that shake are electrically connected.Described multi-ring array pick off adopts piezoelectric, comprises Lithium metaniobate, composite, piezoelectric ceramics or the making of PVDF thin film; Described multi-ring array pick off can the excitation of timesharing ground produce ultrasonic signal, receive ultrasound echo signal and receive photoacoustic signal, realizes the ultrasonic single or combined detection of optoacoustic of A type dynamic scan.
Work process of the present invention is: externally control signal triggers down, the semiconductor laser tube excitation produces pulse laser, Wavelength of Laser, pulsewidth and repetition rate can be selected as required, laser energy is by behind the light path lens combination collimation, sees through protecting film and is radiated and excites the generation photoacoustic signal on the sample; Control signal triggers the multi-ring array pick off simultaneously and surveys photoacoustic signal, realizes exciting and sensing of photoacoustic signal; At the next cycle of control signal, control signal triggers multi-ring array sensor emission ultrasonic signal, begins to receive ultrasound echo signal after the time-delay, realizes exciting and sensing of ultrasonic signal; By optoacoustic data and the ultrasonic echo data that signal and algorithm process collect, can obtain to survey the target value of sample at the ultrasonic A type dynamic scan single or associating of the optoacoustic of depth direction.
The invention has the beneficial effects as follows: this device light harvesting sound is ultransonic to excite and is sensed as one, and photo-acoustic excitation source, light path lens combination and multi-ring array pick off form the coaxial confocal structure; Can realize that the ultrasonic A type dynamic scan single or associating of optoacoustic surveys, can improve greatly that optoacoustic is ultransonic to be excited and sensing efficient, when effectively reducing the laser energy requirement, improves the acoustics insulating barrier investigation depth, measure highly sensitive, and make apparatus structure miniaturization and practicability, be easy to carry, easy and simple to handle, cost is lower.The present invention can be widely used in the detection of blood oxygen, blood sugar test, HIFU treatment and fields such as effect monitoring, industrial flaw detection.
Description of drawings
Fig. 1 is a structural profile sketch map of the present invention.
Fig. 2 is the sketch map that is electrically connected of multi-ring array pick off of the present invention.
Fig. 3 is the structural representation of a ring of multi-ring array pick off of the present invention.
The specific embodiment
The invention will be further described below in conjunction with drawings and Examples.
Embodiment; A kind of light sound ultrasonic excitation and sensing integrated checkout gear, top and middle part at shell 10 are provided with acoustics insulating barrier 9, center of top at acoustics insulating barrier 9 is provided with semiconductor laser tube 1, and in the central authorities of acoustics insulating barrier 9, the below that is positioned at semiconductor laser tube 1 is provided with fourier transform lens 2; Be provided with sound absorption pad 8 under the bottom of shell 10, acoustics insulating barrier 9, in the central authorities of sound absorption pad 8, the below that is positioned at fourier transform lens 2 is provided with cylindrical lens 3, and the bottom surface of cylindrical lens 3 is provided with protecting film 4; The hollow inner ring sleeve of ring-type multi-ring array pick off 7 is contained in the bottom of cylindrical lens 3; Semiconductor laser tube 1, the center of fourier transform lens 2, cylindrical lens 3, multi-ring array pick off 7 all are positioned on the same axis 6, and integrated being packaged in the shell 10 constitutes incorporate coaxial confocal structure.Said elements is integrated to be fixed in the crust of the device 10; Protecting film 4 has printing opacity and water-proof function, can protect inner optics; Acoustics insulating barrier 9 is used to prevent that ultrasonic energy from reaching crust of the device 10 and causing the reflection interference signal, and improves investigation depth when effectively reducing the laser energy requirement.
Multi-ring array pick off 7 is the concavo-convex battle array of hollow, and each ring of multi-ring array pick off 7 is cut into k=16 the homalographic arc unit 14 of shaking, and respectively shaking is provided with spacing 13 between the unit, and each arc corresponding radian 15 of unit that shakes is a=π/8.Each arc unit 14 of shaking is electrically connected by lead 11 electrodes 12 with signal processor.
Multi-ring array pick off 7 adopts piezoelectric ceramics to make, the work centre frequency is 1MHz, the number of ring is 7, be designed to the equally spaced planar rings battle array of the homalographic structure of hollow, ring spacing is not more than half-wavelength, and wherein the velocity of sound is decided to be 1500m/s, and each arc unit 14 of shaking is electrically connected by lead 11 electrodes 12 with signal processor, can realize that the excitation of timesharing ground produces ultrasonic signal, receives ultrasound echo signal and receives photoacoustic signal, can realize the ultrasonic single or combined detection of optoacoustic of a-scan.
Claims (5)
1, light sound ultrasonic excitation and sensing integrated checkout gear, it is characterized in that: top and middle part at shell (10) are provided with acoustics insulating barrier (9), center of top at acoustics insulating barrier (9) is provided with semiconductor laser tube (1), central authorities in acoustics insulating barrier (9), the below that is positioned at semiconductor laser tube (1) is provided with fourier transform lens (2); Be provided with sound absorption pad (8) under the bottom of shell (10), acoustics insulating barrier (9), in the central authorities of sound absorption pad (8), the below that is positioned at fourier transform lens (2) is provided with cylindrical lens (3), and the bottom surface of cylindrical lens (3) is provided with protecting film (4); The hollow inner ring sleeve of ring-type multi-ring array pick off (7) is contained in the bottom of cylindrical lens (3); The center of semiconductor laser tube (1), fourier transform lens (2), cylindrical lens (3), multi-ring array pick off (7) all is positioned on the same axis (6), and integrated being packaged in the shell (10) constitutes incorporate coaxial confocal structure; Multi-ring array pick off (7) can the excitation of timesharing ground produce ultrasonic signal, receive ultrasound echo signal and receive photoacoustic signal, realizes the ultrasonic single or combined detection of optoacoustic of A type dynamic scan.
2, light sound ultrasonic excitation according to claim 1 and sensing integrated checkout gear, it is characterized in that: described semiconductor laser tube (1) is for the quasiconductor pulsed laser diode, and the quasiconductor pulsed laser diode is operated in one or more wavelength that ultraviolet is selected to the infra-red range.
3, light sound ultrasonic excitation according to claim 1 and sensing integrated checkout gear; it is characterized in that: described semiconductor laser tube (1), fourier transform lens (2) and cylindrical lens (3) are formed photo-acoustic excitation source and light path lens combination; light path system can conversion produce focusing or parallel laser beam (5); pass the hollow internal ring of protecting film (4) and multi-ring array pick off (7), the detected sample of directive.
4, light sound ultrasonic excitation according to claim 1 and sensing integrated checkout gear, it is characterized in that: described multi-ring array pick off (7) is the planar array of hollow or concavo-convex battle array, each ring of multi-ring array pick off (7) is cut into a * k=2 π, (k=1,2 ... n) arc of the radian unit of shaking, wherein a is each arc corresponding radian of unit that shakes, k is arc first number that shakes of cutting, and each arc unit 14 of shaking is electrically connected by the electrodes 12 of lead 11 with signal processor.
5, light sound ultrasonic excitation according to claim 1 and sensing integrated checkout gear is characterized in that: described multi-ring array pick off (7) adopts piezoelectric, comprises Lithium metaniobate, composite, piezoelectric ceramics or the making of PVDF thin film.
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| CNB2008101069738A CN100571626C (en) | 2008-07-03 | 2008-07-03 | Light sound ultrasonic excitation and sensing integrated checkout gear |
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| CNB2008101069738A CN100571626C (en) | 2008-07-03 | 2008-07-03 | Light sound ultrasonic excitation and sensing integrated checkout gear |
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| CN102621066A (en) * | 2012-02-26 | 2012-08-01 | 曾吕明 | Small integrated two-dimensional opto-acoustic galvanometer excitation source |
| CN102621068A (en) * | 2012-02-26 | 2012-08-01 | 曾吕明 | Portable real-time opto-acoustic imaging system |
| CN101852774B (en) * | 2010-05-14 | 2012-10-24 | 西安金波检测仪器有限责任公司 | Flaw detection system and flaw detection method |
| CN102854141A (en) * | 2012-08-28 | 2013-01-02 | 曾吕明 | Portable integrated optical resolution type photoacoustic microscope |
| CN103976743A (en) * | 2014-05-27 | 2014-08-13 | 江西科技师范大学 | CMUT (Capacitive Micro-machined Ultrasonic Transducer) annular array based micro-photoacoustic transducer |
| CN104034665A (en) * | 2014-06-06 | 2014-09-10 | 江西科技师范大学 | Handheld food safety detection device and method |
| CN104535656A (en) * | 2014-12-17 | 2015-04-22 | 江苏大学 | All-optical non-contact type composite material plate layer crack damage detection system and method |
| WO2015097251A3 (en) * | 2013-12-23 | 2015-08-13 | Eric Chevalier | Vibrating medical device for minimally invasive procedures |
| CN105232004A (en) * | 2015-11-16 | 2016-01-13 | 华南师范大学 | Opto-acoustic-ultrasonic united imaging device and imaging method for precisely measuring thickness of melanoma |
| CN106473755A (en) * | 2016-11-30 | 2017-03-08 | 江西科技师范大学 | A kind of optical sound head for blood sugar monitoring |
| CN107157491A (en) * | 2017-07-21 | 2017-09-15 | 江西科技师范大学 | Light sound blood sugar detection means and method that a kind of blood vessel is automatically positioned |
| CN107167518A (en) * | 2017-04-19 | 2017-09-15 | 西安交通大学 | Loop laser electromagnetic acoustic focusing probe |
| CN107228904A (en) * | 2017-07-21 | 2017-10-03 | 江西科技师范大学 | A kind of photic ultrasonic non-invasive glucose monitoring device and method |
| DE102016119810A1 (en) * | 2016-10-18 | 2018-04-19 | Hamilton Bonaduz Ag | Layers for the detection of oxygen |
| CN110596009A (en) * | 2019-10-24 | 2019-12-20 | 南昌洋深电子科技有限公司 | High-sensitivity large-area laser ultrasonic imaging method |
| CN110686771A (en) * | 2019-10-11 | 2020-01-14 | 暨南大学 | Photoacoustic effect-based wide-spectrum pulse light detector and detection method |
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| JP4406226B2 (en) * | 2003-07-02 | 2010-01-27 | 株式会社東芝 | Biological information video device |
| CN100446730C (en) * | 2005-12-16 | 2008-12-31 | 华南师范大学 | Photoacoustic imaging and chromatographic imaging method based on acoustic lens and apparatus thereof |
| CN201244025Y (en) * | 2008-07-03 | 2009-05-27 | 刘国栋 | Detecting device integrated with light sound ultrasonic excitation and sensor |
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2008
- 2008-07-03 CN CNB2008101069738A patent/CN100571626C/en not_active Expired - Fee Related
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| CN101852774B (en) * | 2010-05-14 | 2012-10-24 | 西安金波检测仪器有限责任公司 | Flaw detection system and flaw detection method |
| CN102621068A (en) * | 2012-02-26 | 2012-08-01 | 曾吕明 | Portable real-time opto-acoustic imaging system |
| CN102621066A (en) * | 2012-02-26 | 2012-08-01 | 曾吕明 | Small integrated two-dimensional opto-acoustic galvanometer excitation source |
| CN102854141A (en) * | 2012-08-28 | 2013-01-02 | 曾吕明 | Portable integrated optical resolution type photoacoustic microscope |
| WO2015097251A3 (en) * | 2013-12-23 | 2015-08-13 | Eric Chevalier | Vibrating medical device for minimally invasive procedures |
| CN103976743A (en) * | 2014-05-27 | 2014-08-13 | 江西科技师范大学 | CMUT (Capacitive Micro-machined Ultrasonic Transducer) annular array based micro-photoacoustic transducer |
| CN104034665A (en) * | 2014-06-06 | 2014-09-10 | 江西科技师范大学 | Handheld food safety detection device and method |
| CN104535656B (en) * | 2014-12-17 | 2017-10-20 | 江苏大学 | Full optical non-contact plies of composite material splits damage detection system and method |
| CN104535656A (en) * | 2014-12-17 | 2015-04-22 | 江苏大学 | All-optical non-contact type composite material plate layer crack damage detection system and method |
| CN105232004A (en) * | 2015-11-16 | 2016-01-13 | 华南师范大学 | Opto-acoustic-ultrasonic united imaging device and imaging method for precisely measuring thickness of melanoma |
| DE102016119810A1 (en) * | 2016-10-18 | 2018-04-19 | Hamilton Bonaduz Ag | Layers for the detection of oxygen |
| US11630094B2 (en) | 2016-10-18 | 2023-04-18 | Hamilton Bonaduz Ag | Layers for the detection of oxygen |
| CN106473755A (en) * | 2016-11-30 | 2017-03-08 | 江西科技师范大学 | A kind of optical sound head for blood sugar monitoring |
| CN107167518A (en) * | 2017-04-19 | 2017-09-15 | 西安交通大学 | Loop laser electromagnetic acoustic focusing probe |
| CN107157491A (en) * | 2017-07-21 | 2017-09-15 | 江西科技师范大学 | Light sound blood sugar detection means and method that a kind of blood vessel is automatically positioned |
| CN107228904A (en) * | 2017-07-21 | 2017-10-03 | 江西科技师范大学 | A kind of photic ultrasonic non-invasive glucose monitoring device and method |
| CN107157491B (en) * | 2017-07-21 | 2023-04-14 | 江西科技师范大学 | Photoacoustic blood glucose detection device and method for automatically positioning blood vessel |
| CN110686771A (en) * | 2019-10-11 | 2020-01-14 | 暨南大学 | Photoacoustic effect-based wide-spectrum pulse light detector and detection method |
| CN110596009A (en) * | 2019-10-24 | 2019-12-20 | 南昌洋深电子科技有限公司 | High-sensitivity large-area laser ultrasonic imaging method |
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