JP4490386B2 - Component concentration measuring device - Google Patents

Description

  The present invention relates to a noninvasive component concentration measurement apparatus for a human or animal subject.

  With the aging of society, dealing with adult diseases is becoming a major issue. In blood glucose level and other tests, blood collection is necessary, which places a heavy burden on the patient. Therefore, a non-invasive component concentration measurement apparatus that does not collect blood has attracted attention. As a non-invasive component concentration measuring device that has been developed so far, the skin is irradiated with electromagnetic waves and absorbed by blood molecules to be measured, for example, glucose molecules in the case of blood glucose levels, and heated locally. Photoacoustic spectroscopy (hereinafter, “photoacoustic spectroscopy” is abbreviated as “PAS”) that observes sound waves generated from the living body due to thermal expansion has attracted attention.

  FIG. 15 is a diagram showing a configuration example of a conventional blood component concentration measuring apparatus using PAS using an optical pulse as an electromagnetic wave (see, for example, Non-Patent Document 1). In this example, blood glucose, that is, glucose is the measurement target as the blood component. In FIG. 15, a driving circuit 604 supplies a pulsed excitation current to a pulse light source 616, the pulse light source 616 generates a light pulse having a sub-microsecond duration, and the generated light pulse is applied to the subject 610. The Each component inside the subject 610 has a specific light wavelength that produces a photoacoustic effect, and the concentration of the component inside the subject 610 that produces the photoacoustic effect at the wavelength of the light of the irradiated light pulse. An ultrasonic wave with a corresponding intensity is generated. Since the blood component concentration measuring apparatus of FIG. 15 measures the concentration of glucose, the pulsed light source 616 irradiates the light pulse with the wavelength of light that causes the photoacoustic effect of glucose. The generated ultrasonic wave is transmitted to the surface of the subject 610 and detected by the ultrasonic detector 613. The ultrasonic detector 613 converts the detected ultrasonic wave into an electric signal having an amplitude proportional to the intensity.

The waveform of the electrical signal is observed by a waveform observer 620. The waveform observer 620 is triggered by a signal synchronized with the excitation current, the electric signal is displayed at a fixed position on the screen, and the electric signal can be measured by integrating and averaging. By analyzing the amplitude of the electrical signal thus obtained, the glucose concentration inside the subject 610 is measured.
University of Oulu (University of Oulu, Finland) thesis “Pulse photoacoustic technique and glucodesis in human blood and tissue” (IBS 951-42-6690-0, ul./200.

  However, in order to efficiently detect a sound wave, which is a photoacoustic signal generated in a human body, with a sound wave detector, the wave surface of the sound wave needs to be a plane wave instead of a spherical wave. For this reason, the detection distance must be increased as the light irradiation area increases, and the distance and irradiation area between the sound wave detector and the sound wave generation source are limited. For example, when a biological fingertip is used as a subject, the detection distance is short, and thus the irradiation area needs to be reduced.

On the other hand, since the limit value of the laser output that can be irradiated on the skin of a living body is defined by the JIS standard, the size of the photoacoustic signal that can be generated at the irradiation point is also limited. Here, according to JISC6802, when invisible infrared light (wavelength of 0.8 μm or more) is continuously irradiated to the skin, 1 mW per 1 mm ² is the maximum allowable amount. For this reason, the generated photoacoustic signal is weak depending on the portion of the living body irradiated with light, and is easily affected by noise.

  In order to accurately detect ultrasonic waves from the subject, in the conventional blood component concentration measuring apparatus as shown in FIG. 15, an acoustic sensor is brought into direct contact with the subject 610 like the ultrasonic detector 613. However, when the ultrasonic detector 613 is brought into contact with the subject 610, pressure is applied to the contact portion, and there is a problem that the blood volume changes and affects the measurement result of the blood component concentration. Furthermore, when the contact portion is scratched, the ultrasonic detector 613 cannot be brought into contact with the subject 610, and there is a problem that the blood component concentration cannot be measured.

  The present invention has been made to solve the above problems, and an object of the present invention is to provide a component concentration measuring apparatus capable of measuring a blood component concentration of a subject without contact with the subject.

  In order to achieve the above object, the component concentration measuring apparatus according to the present invention includes a detecting means for detecting an ultrasonic wave from reflected light of light irradiated on a subject. Here, the subject is a human or animal to be measured.

  Specific means for solving the problems according to the present invention will be described. The present invention provides a light irradiating means for irradiating a subject with a modulated laser light that is electrically intensity-modulated with a modulation signal of a constant frequency toward the subject, and the inside of the subject generated by the irradiated modulated laser light. Vibration detecting means for detecting ultrasonic waves as vibrations on the surface of the subject, wherein the vibration detecting means irradiates a measuring beam on the surface of the subject. And a light position detecting means for measuring an optical axis position of the reflected light of the measurement beam reflected by the surface of the subject.

  The light irradiation means can irradiate the modulated laser light from a position away from the subject to generate a photoacoustic effect in the subject.

  The measurement beam irradiating means irradiates the surface of the subject with the measurement beam from a position away from the subject, and the optical position detection means reflects on the surface of the subject at a position away from the subject. The reflected light of the measurement beam can be received. The light position detecting means can measure the position where the reflected light is irradiated on the light receiving surface.

  Since the surface of the subject vibrates due to the photoacoustic effect, the reflection angle of the reflected light on the surface of the subject vibrates due to the vibration of the surface of the subject. Further, the reflection angle of the reflected light changes according to the magnitude of vibration of the surface of the subject. That is, the light position detecting means measures the magnitude of vibration of the reflection angle of the reflected light as the amplitude of vibration of the light receiving position of the reflected light.

  If the concentration of the measurement target component of the subject is high, the vibration of the surface of the subject becomes large, so that the fluctuation of the reflection angle of the reflected light becomes large, and the vibration of the light receiving position of the reflected light in the light position detecting means becomes large. Amplitude increases. On the contrary, if the concentration of the measurement target component of the subject is low, the vibration of the surface of the subject is small, so that the variation in the reflection angle of the reflected light is small, and the light receiving position of the reflected light in the light position detecting means The amplitude of vibration becomes small.

  The amplitude data of the light receiving position in the optical position detecting unit of the reflected light with respect to the wavelength of the modulated laser beam that causes a photoacoustic effect on the measurement target component of the subject and the concentration of the measurement target component of the subject are acquired in advance. Thus, the component concentration measuring apparatus can measure the concentration of the measurement target component of the subject from the amplitude of the vibration at the light receiving position of the reflected light.

  Therefore, the present invention provides a component concentration measuring apparatus that can measure the blood component concentration of a subject in a non-contact manner with the subject by providing the light irradiation means and the vibration detecting means at a position away from the subject. can do.

  The vibration detection unit may include an integrated light amount measurement unit as an alternative to the light position detection unit.

  Specifically, the present invention is generated by light irradiation means for irradiating a subject with modulated laser light that is electrically intensity-modulated with a modulation signal of a constant frequency toward the subject, and the irradiated modulated laser light. Vibration detecting means for detecting ultrasonic waves in the subject as vibrations on the surface of the subject, wherein the vibration detecting means irradiates a measurement beam on the surface of the subject. And a measuring beam irradiation unit for measuring the concentration of the light beam, and a measuring unit for measuring the total amount of light received through the pinhole of the reflected light of the measuring beam reflected from the surface of the subject. Device.

  The integrated light quantity measuring means has a pinhole on the light receiving surface, and integrates the light quantity of light passing through the pinhole. The reflection angle of the reflected light reflected by the measurement beam is vibrated by the vibration of the surface of the subject, and the reflected light vibrates on the pinhole. If the amplitude of vibration of the reflected light on the pinhole is large, the integrated light quantity of light passing through the pinhole is reduced. Conversely, if the amplitude of vibration of the reflected light on the pinhole is small, the pinhole is reduced. The accumulated light quantity of light passing through increases.

  By acquiring in advance the integrated light amount data in the integrated light amount measurement means for the wavelength of the modulated laser beam that causes a photoacoustic effect on the measurement target component of the subject and the concentration of the measurement target component of the subject, The component concentration measuring apparatus can measure the concentration of the measurement target component of the subject from the integrated light quantity of the reflected light that has passed through the pinhole.

  Therefore, the present invention provides a component concentration measuring apparatus that can measure the blood component concentration of a subject in a non-contact manner with the subject by providing the light irradiation means and the vibration detecting means at a position away from the subject. can do.

  The vibration detection unit may include a measurement laser oscillator and an interferometer as an alternative to the optical position detection unit.

  Specifically, the present invention is generated by light irradiation means for irradiating a subject with modulated laser light that is electrically intensity-modulated with a modulation signal of a constant frequency toward the subject, and the irradiated modulated laser light. A component concentration measuring apparatus comprising: a vibration detecting unit configured to detect an ultrasonic wave in the subject as a vibration of the surface of the subject, wherein the vibration detecting unit emits a measuring laser beam. And the measurement laser beam from the measurement laser oscillator is bifurcated into a first laser beam and a second laser beam, the surface of the subject is irradiated with the first laser beam, and the second laser beam And an interferometer that measures a phase difference between the first laser beam reflected by the surface of the subject and the first laser beam.

  The interferometer is bifurcated into the first laser beam that irradiates the surface of the subject from a position away from the subject and the second laser beam that serves as a reference, and the subject laser beam. The phase difference between the first laser beam and the second laser beam is measured by causing the reflected light, which is the first laser beam reflected on the surface of the laser beam, to interfere with the second laser beam.

  The surface of the subject vibrates due to a photoacoustic effect, and the phase of the reflected light varies based on the magnitude of the vibration of the surface of the subject. If the vibration of the surface of the subject is large, the phase difference between the reflected light and the second laser light is large. Conversely, if the vibration of the surface of the subject is small, the reflected light and the second laser are large. The phase difference from the light becomes small.

  Phase difference data between the reflected light and the second laser light in the interferometer with respect to the wavelength of the modulated laser light that causes a photoacoustic effect on the measurement target component of the subject and the concentration of the measurement target component of the subject in advance The component concentration measuring apparatus can measure the concentration of the measurement target component of the subject from the phase difference measured by the interferometer.

  Therefore, the present invention provides a component concentration measuring apparatus that can measure the blood component concentration of a subject in a non-contact manner with the subject by providing the light irradiation means and the vibration detecting means at a position away from the subject. can do.

  The component concentration measurement apparatus in which the vibration detection unit includes the measurement beam irradiation unit or the measurement laser oscillator preferably further includes a light reflector on the surface of the subject that vibrates via an ultrasonic matching material.

  By disposing the light reflector having a high reflectivity with respect to the measurement beam or the measurement laser light on the surface of the subject, the light intensity of the reflected light is increased and the accuracy of the component concentration measurement is improved. Can do. Furthermore, an ultrasonic matching material may be interposed between the surface of the subject and the light reflector. Since the ultrasonic matching material matches the acoustic impedance between the subject and the light reflector, vibration attenuation can be prevented. The ultrasonic matching material can efficiently transmit the vibration of the surface of the subject to the light reflector, thereby improving the accuracy of component concentration measurement.

  Therefore, the present invention can provide a component concentration measuring apparatus that can accurately measure the blood component concentration of a subject without contact with the subject.

  The vibration detection unit does not include the measurement beam irradiation unit or the measurement laser oscillator, and uses reflected light obtained by reflecting a part of the modulated laser light from the light irradiation unit on the surface of the subject. The vibration of the subject surface may be measured.

  Specifically, the present invention is generated by light irradiation means for irradiating a subject with modulated laser light that is electrically intensity-modulated with a modulation signal of a constant frequency toward the subject, and the irradiated modulated laser light. Vibration detecting means for detecting ultrasonic waves in the subject as vibrations on the surface of the subject, wherein the vibration detecting means is a surface of the subject out of the modulated laser light. It is a component concentration measuring apparatus characterized by having an optical position detecting means for measuring the position of the optical axis of the reflected light reflected by.

  The surface of the subject vibrates due to a photoacoustic effect, and the reflection angle of the reflected light of the modulated laser light also vibrates due to the vibration of the surface of the subject, similar to the reflected light of the measurement beam. Since the vibration detection unit includes the light position detection unit, the component concentration measurement apparatus can measure the concentration of the measurement target component of the subject from the amplitude of the vibration at the light receiving position of the reflected light in the vibration detection unit.

  Therefore, the present invention provides a component concentration measuring apparatus that can measure the blood component concentration of a subject in a non-contact manner with the subject by providing the light irradiation means and the vibration detecting means at a position away from the subject. can do.

  In addition, reflected light obtained by reflecting a part of the modulated laser light from the light irradiation means on the surface of the subject may be measured by the integrated light quantity measurement means.

  Specifically, the present invention is generated by light irradiation means for irradiating a subject with modulated laser light that is electrically intensity-modulated with a modulation signal of a constant frequency toward the subject, and the irradiated modulated laser light. Vibration detecting means for detecting ultrasonic waves in the subject as vibrations on the surface of the subject, wherein the vibration detecting means is a surface of the subject out of the modulated laser light. A component concentration measuring device comprising an integrated light amount measuring means for measuring an integrated light amount received through a pinhole of reflected light reflected by the light source.

  The integrated light quantity measuring means can measure the vibration of the reflection angle of the reflected light as the integrated light quantity of the light that has passed through the pinhole. That is, the component concentration measuring apparatus can measure the concentration of the measurement target component of the subject from the integrated light amount of the reflected light that has passed through the pinhole.

  Therefore, the present invention provides a component concentration measuring apparatus that can measure the blood component concentration of a subject in a non-contact manner with the subject by providing the light irradiation means and the vibration detecting means at a position away from the subject. can do.

  The modulated laser beam may be branched into two, one being used for the photoacoustic effect and the other being used for measuring the vibration of the surface of the subject.

  Specifically, in the present invention, the first modulated laser is obtained by bifurcating a modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency into a first modulated laser beam and a second modulated laser beam. Light irradiation for irradiating light onto a light reflector disposed on the surface of the subject via an ultrasonic matching material and for irradiating the surface of the subject at a position different from the light reflector with the second modulated laser light And a vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated second modulated laser light as vibrations on the surface of the subject, wherein the vibration The detection means is a component concentration measurement device comprising optical position detection means for measuring the optical axis position of the reflected light of the first modulated laser light reflected by the light reflector.

  The surface of the subject is vibrated by the photoacoustic effect of the second modulated laser light, and the reflected light of the first modulated laser light is also vibrated on the surface of the subject, similarly to the reflected light of the measurement beam. The reflection angle vibrates. Since the vibration detection unit includes the light position detection unit, the component concentration measurement apparatus can measure the concentration of the measurement target component of the subject from the amplitude of the vibration at the light receiving position of the reflected light in the vibration detection unit.

  Furthermore, since the light reflector having a high reflectance with respect to the first modulated laser light is disposed on the surface of the subject, the light intensity of the reflected light is increased. Further, since an ultrasonic matching material is interposed between the surface of the subject and the light reflector, vibration of the surface of the subject can be efficiently transmitted to the light reflector, and the component concentration Measurement accuracy can be improved.

  Therefore, the present invention provides a component concentration measuring apparatus that can measure the blood component concentration of a subject in a non-contact manner with the subject by providing the light irradiation means and the vibration detecting means at a position away from the subject. can do.

  The reflected light of the first modulated laser beam reflected by the light reflector disposed on the surface of the subject may be measured by the integrated light quantity measuring unit.

  Specifically, in the present invention, the first modulated laser is obtained by bifurcating a modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency into a first modulated laser beam and a second modulated laser beam. Light irradiation for irradiating light onto a light reflector disposed on the surface of the subject via an ultrasonic matching material and for irradiating the surface of the subject at a position different from the light reflector with the second modulated laser light And a vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated second modulated laser light as vibrations on the surface of the subject, wherein the vibration The detection means includes an integrated light quantity measuring means for measuring an integrated light quantity received through a pinhole of the reflected light of the first modulated laser light reflected by the light reflector.

  The integrated light quantity measuring means can measure the vibration of the reflection angle of the reflected light as the integrated light quantity of the light that has passed through the pinhole. That is, the component concentration measuring apparatus can measure the concentration of the measurement target component of the subject from the integrated light amount of the reflected light that has passed through the pinhole.

  Therefore, the present invention provides a component concentration measuring apparatus that can measure the blood component concentration of a subject in a non-contact manner with the subject by providing the light irradiation means and the vibration detecting means at a position away from the subject. can do.

  The component concentration measurement apparatus including the vibration detection unit having the optical position detection unit is configured to emit an optical axis position measurement signal of the optical axis position of the reflected light output from the optical position detection unit in the vibration detection unit. It is preferable to perform synchronous detection with the modulation signal of the means.

  By using the modulation signal of the light irradiation means and synchronously detecting the optical axis position measurement signal output from the light position detection means, vibration of the surface of the subject can be detected with high accuracy. .

  Therefore, the present invention can provide a component concentration measuring apparatus that can accurately measure the blood component concentration of a subject without contact with the subject.

  The present invention can provide a component concentration measuring apparatus capable of measuring the blood component concentration of a subject without contact with the subject.

  Embodiments of the present invention will be described with reference to the accompanying drawings. The embodiment described below is an example of the configuration of the present invention, and the present invention is not limited to the following embodiment.

(Embodiment 1)
In the present embodiment, a light irradiating means for irradiating the subject with modulated laser light that is electrically intensity-modulated with a modulation signal having a constant frequency toward the subject, and the inside of the subject generated by the irradiated modulated laser light. And a vibration detecting means for detecting the ultrasonic wave as vibration of the surface of the subject, wherein the vibration detecting means irradiates the measuring beam to the surface of the subject. An apparatus for measuring a concentration of a component, comprising: irradiation means; and optical position detection means for measuring an optical axis position of reflected light of the measurement beam reflected by the surface of the subject.

  A schematic diagram of a component concentration measuring apparatus 201 according to this embodiment is shown in FIG. The component concentration measuring apparatus 201 in FIG. 1 includes light irradiation means 11 and vibration detection means 12. In FIG. 1 and FIGS. 4, 5, 7, 10, 11, 12, 13, and 14 described below, the subject 900 is described as a fingertip of a human body. Is not limited to the fingertips, but may be other parts, for example, the cornea of the eye.

  The light irradiation means 11 includes a light source 13 and an oscillator 18.

  The oscillator 18 outputs a modulation signal E1 having a constant frequency. For example, the frequency may be 100 kHz or more and 10 MHz or less.

  The light source 13 includes a laser light source and a drive circuit. The drive circuit drives the laser light source based on the modulation signal E1, and outputs a modulated laser beam L1 whose intensity is modulated based on the modulation signal E1 from the laser light source. It can be exemplified that the laser light source is a semiconductor laser. In addition, it is desirable that the laser light output from the laser light source has a wavelength that is easily absorbed by the measurement target component of the subject 900. When a semiconductor laser is used as the laser light source, the wavelength of light generated by heating or cooling the semiconductor laser with a heater or a Peltier element can be changed. For example, when the component to be measured is glucose, the wavelength of the laser light is 1608 nm.

  Therefore, the light irradiation unit 11 irradiates the modulated laser beam L1 from the light source 13 based on the modulation signal E1 of the oscillator 18 from a position away from the subject 900 toward the modulated laser irradiation point A on the surface of the subject 900. Can do.

  The vibration detection unit 12 includes a measurement beam irradiation unit 14 and an optical position detection unit 17.

  The measuring beam irradiation means 14 incorporates a measuring beam light source and a collimator.

  The measurement beam light source is a light source that generates light having a wavelength that is easily reflected on the surface of the subject 900. If the subject 900 is a human body, light having a wavelength of 500 nm to 600 nm is likely to be reflected on the skin. Examples of the measurement light source include a visible light laser that generates light having the wavelength and a lamp with a filter that transmits light having the wavelength. On the other hand, the collimator has an optical system in which optical components such as a lens that converts incident light into parallel light are combined.

  The measurement beam irradiation means 14 converts the light output from the measurement beam light source into parallel light by the collimator and irradiates the measurement beam B1.

  The optical position detection means 17 can measure the amplitude of vibration of light incident on the light receiving surface like an element described later. Further, the optical position detecting means 17 is arranged at a position where it can receive the reflected light B2, which is the measurement beam B1 reflected at the measurement point P.

  Therefore, the vibration detection unit 12 irradiates the measurement point P of the subject 900 with the measurement beam B1 from the measurement beam irradiation unit 14 from a position away from the subject 900, and performs measurement at a position away from the subject 900. The amplitude of the reflected light B2 of the beam B1 on the light receiving surface in the light position detecting means 17 can be measured.

  Examples of the optical position detection means 17 include an image pickup element (CCD image sensor) and a position detection element (PSD) described below.

  The CCD image sensor is a two-dimensional array of photodiodes (PD) as a light receiving surface. FIG. 2 shows a conceptual diagram of the structure of the CCD image sensor. The PD 21 transfers the photoelectrically converted charges to the vertical transfer CCD 23 corresponding to each PD through the transfer gate 22 at a fixed timing. The vertical transfer CCD 23 moves the charge from the PD 21 to the horizontal transfer CCD 24. Subsequently, the light receiving position specifying circuit 25 gives a transfer pulse to the horizontal transfer CCD 24 to sequentially read out the charges. The light receiving position specifying circuit 25 can specify the PD 21 irradiated with light from the read charges.

  Since the optical axis position of the reflected light B2 vibrates at the frequency of the modulation signal E1 from the oscillator 18, the CCD image sensor specifies the optical axis position of the instantaneous reflected light B2 when the vibration frequency is too high. Although not possible, the amplitude of vibration can be measured.

  Therefore, the CCD image sensor can measure the amplitude value from the vibration of the optical axis position of the reflected light B2.

  The PSD is a semiconductor element that applies the principle of a PIN photodiode and identifies the position of light irradiated on the light receiving surface continuously. FIG. 3 is a diagram showing the operating principle of PSD. An intrinsic semiconductor layer 32 that generates electron and hole carriers upon incidence of light is formed on an n-type silicon substrate 31, and a p-type semiconductor layer 33 is formed on the intrinsic semiconductor layer 32. Electrodes 34 a and 34 b are formed on both ends of the p-type semiconductor layer 33. A ground electrode 35 is formed on the back surface of the silicon substrate 31. The p-type semiconductor layer 33 between the electrode 34a and the electrode 34b becomes a light receiving surface.

The PSD shown in FIG. 3 operates as described below to identify the light receiving position. When the light C is incident on the light receiving surface of the PSD, carriers are generated in the intrinsic semiconductor layer 32 below the incident position. Of the carriers, holes are absorbed by the p-type semiconductor layer 33 and move to the electrodes 34a and 34b. At this time, the amount D of holes reaching the electrode 34a, the amount E of holes reaching the electrode 34b, the distance Xa from the incident position of the light C to the electrode 34a, and the distance Xb from the incident position of the light C to the electrode 34b Since there is a relationship of Formula (1), the light receiving position of the light C can be specified from the current ratio output from the electrode 34a and the electrode 34b.

  The PSD in FIG. 3 shows a one-dimensional PSD for explanation, but it is preferable to use a two-dimensional PSD as the optical position detection means 17.

  The component concentration measuring apparatus 201 measures the concentration of the measurement target component in the subject 900 as follows. The light irradiation means 11 irradiates the modulated laser beam L 1 toward the modulated laser irradiation point A of the subject 900. Since the modulated laser light L1 reaches the inside of the subject 900, the inside of the subject 900 vibrates at the frequency of the electrical signal output from the oscillator 18 by the photoacoustic effect of the measurement target component. Since the photoacoustic effect is greater as the concentration of the measurement target component is higher, the amount of vibration increases when the concentration of the measurement target component of the subject 900 is higher. Conversely, when the concentration of the measurement target component of the subject 900 is low, the vibration amount is small. The vibration is transmitted to vibrate the surface of the subject 900.

  The measurement beam irradiation means 14 irradiates the measurement point P with the measurement beam B 1 from a position away from the subject 900. In FIG. 1, the measurement point P is shown on the opposite side of the modulated laser irradiation point A, but any surface may be used as the measurement point P because the surface of the subject 900 vibrates.

  The direction in which the reflected light B2 is reflected by the vibration at the measurement point P vibrates at the frequency of the vibration at the measurement point P, that is, the frequency of the modulation signal E1. When the concentration of the measurement target component of the subject 900 is high, the amplitude of the vibration of the reflected light B2 in the optical axis direction increases. Conversely, when the concentration of the measurement target component is low, the amplitude of the vibration of the reflected light B2 in the optical axis direction. Becomes smaller. By acquiring in advance data on the relationship between the concentration of the component to be measured and the amplitude of the vibration of the reflected light B2 measured by the light position detecting means 17, the component concentration measuring apparatus 201 determines the object 900 from the amplitude value. The concentration of the measurement target component can be calculated.

  Therefore, since the component concentration measurement apparatus 201 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without bringing the vibration detection means 12 into contact with the subject 900.

  The light source 13 may have a structure capable of outputting two-wavelength modulated laser light L1. Specifically, the light source 13 receives the second signal branched from the branch circuit by bifurcating the modulation signal E1 into the first signal and the second signal, and converts the phase by 180 °. The laser light source is driven based on the phase shift circuit, the two laser light sources that output laser beams having different wavelengths, and the first signal from the branch circuit and the second signal from the phase shift circuit, respectively. Two drive circuits, and a combining unit that combines the intensity-modulated laser beams from the two laser light sources and outputs the modulated laser beam L1 to the outside.

  Since the light source 13 synthesizes light of two different wavelengths by intensity modulation with electrical signals of the same frequency and opposite phase, it is possible to output modulated laser light L1 in which light of two wavelengths appears alternately. The basic principle of measuring the component concentration with the modulated laser beam L1 in which light of two wavelengths appears alternately will be described below.

  Of the two different wavelengths of light, the wavelength of the first light is set to a wavelength that is significantly different from, for example, the absorbance due to the water that accounts for the majority of the analyte, with the absorbance due to the analyte being measured. The wavelength of light is set to a wavelength that exhibits an absorbance equal to that of water at the wavelength of the first light. The above wavelength setting method will be described with reference to FIG. 16, taking as an example the case of measuring the concentration of glucose in blood.

FIG. 16 shows the absorbance characteristics of water and an aqueous glucose solution at room temperature. In FIG. 16, the vertical axis indicates the absorbance, and the horizontal axis indicates the wavelength of light. In FIG. 16, the solid line indicates the absorbance characteristic of water, and the broken line indicates the absorbance characteristic of the glucose aqueous solution. The wavelength λ ₁ shown in FIG. 16 is a wavelength at which the absorbance due to glucose is significantly different from the absorbance due to water, and the wavelength λ ₂ is a wavelength at which water has the same absorbance as that at λ ₁ . Thus, for example, the wavelength of the first light can be set to λ ₁ and the wavelength of the second light can be set to λ ₂ .

In the following description, as an example, the wavelength of the first light is set to a wavelength λ ₁ where the absorbance of the component to be measured is significantly different from the absorbance of water, and the wavelength of the second light is set to the first light. The case where the wavelength λ ₂ is set to be equal to that at the wavelength λ ₁ will be described.

  Each of the two different wavelengths of light set as described above is intensity-modulated with a signal of the opposite phase at the same frequency and emitted as pulsed light, and the emitted two different wavelengths of light are absorbed by the component of the subject. Then, the generated ultrasonic wave is detected, and the concentration of the component to be measured of the subject is measured from the magnitude of the detected ultrasonic wave. When light of two different wavelengths whose intensity is modulated as described above is emitted, the first ultrasonic wave generated from the subject by the absorption of the first light by both the component to be measured and water, and the second The second ultrasonic wave generated from the subject by absorbing light that occupies most of the subject has the same frequency and an opposite phase. Therefore, the first ultrasonic wave and the second ultrasonic wave are superimposed in the subject, and the ultrasonic wave generated from the subject by absorption of the component to be measured in the first ultrasonic wave as a difference between the ultrasonic waves. Only the size of remains. Therefore, it is possible to measure only the ultrasonic waves generated from the subject by absorbing the first light by the component to be measured by the remaining ultrasonic waves. In the above measurement, rather than measuring the difference between the ultrasonic wave generated by absorption of both the component to be measured and water and the ultrasonic wave generated by water absorption, It is possible to accurately measure ultrasonic waves that are absorbed and generated from the subject.

Furthermore, a method for measuring with high accuracy, excluding the cause of error in component concentration measurement, will be described below. For each of the light of wavelength λ _{1 and} the light of wavelength λ ₂ , the absorption coefficient of water occupying most of the subject is α ₁ ^(w) and α ₂ ^(w) , and the molar absorption of the component to be measured of the subject If the coefficients are α ₁ ^(g) and α ₂ ^(g) , simultaneous equations including the magnitudes s ₁ and s ₂ of the ultrasonic waves generated from the subject by the light of wavelength λ _{1 and} the light of wavelength λ ₂ , respectively. Is expressed by Equation (2).

By solving Equation (2) above, the component concentration M of the subject to be measured can be obtained. Here, C is a coefficient that is difficult to control or predict, that is, the positional relationship between the light irradiation means, the subject and the vibration detection means, the sensitivity of the vibration detection means, the position where the ultrasonic wave is generated by the light in the subject and the vibration detection means. the distance between the specific heat and thermal expansion coefficient of the object, the inside of the subject ultrasound speed, the wavelength lambda ₁ and the light wavelength lambda ₂ of the light modulation frequencies, the components of the absorption coefficient and the subject water It is an unknown constant that depends on the molar absorption coefficient. Further, when C is eliminated by Expression (2), the following Expression (3) is obtained.

Here, the absorption coefficients α ₁ ^(w) and α ₂ ^{(w) of} water occupying most of the subject for each of the light of wavelength λ _{1 and} the light of wavelength λ ₂ are selected to be equal. , Α ₁ ^(w) = α ₂ ^(w) , and if it is further used that s ₁ ≈s ₂ , the component concentration M is expressed by Equation (4).

Substituting α ₁ ^(w) , α ₁ ^(g), and α ₂ ^(g) as known coefficients into the above equation (4), and further by the light of wavelength λ _{1 and} the light of wavelength λ ₂ , respectively. The component concentration M of the subject can be calculated by measuring and substituting the magnitudes s ₁ and s ₂ of the ultrasonic waves generated from the subject. In the above formula (4), rather than separately measuring the _two ultrasonic magnitudes s ₁ and s ₂ , the difference s ₁ -s ₂ is measured, and the ultrasonic magnitude measured separately is measured. Write divided by s ₂ is able to measure the component concentration of the analyte with high accuracy.

That is, first, the light of wavelength λ _{1 and} the light of wavelength λ ₂ are intensity-modulated by modulation signals having opposite phases to each other, combined into one light beam, and emitted, so that the ultrasonic wave generated from the subject is emitted. The difference (s ₁ −s ₂ ) between the ultrasonic waves generated by superimposing the size s ₁ and the ultrasonic size s ₂ on each other is measured. Next, light of wavelength λ ₂ is emitted, and the magnitude s _{2 of the} ultrasonic wave generated from the subject is measured. By calculating (s ₁ -s ₂ ) ÷ s ₂ from (s ₁ -s ₂ ) and s ₂ measured as described above, the component concentration of the measurement target of the subject is increased by Equation (4). It can be measured with high accuracy.

For example, when the component to be measured is glucose, the wavelength λ ₁ is set to 1608 nm, which is a wavelength indicating the characteristic absorption of glucose. When light having a wavelength of 1608 nm is irradiated, not only glucose but also water absorbs light. Therefore, the wavelength λ ₂ is set to 1381 nm, which is a wavelength that absorbs the same amount of light as water absorbs at the wavelength λ ₁ .

  Therefore, the concentration of the measurement target component of the subject 900 can be measured with high accuracy by setting the modulated laser beam L1 to two wavelengths.

  Further, in the present embodiment, the vibration detection unit may detect synchronously the optical axis position measurement signal of the optical axis position of the reflected light output from the optical position detection unit with the modulation signal of the light irradiation unit. Good.

  In the component concentration measuring apparatus 201 of FIG. 1, the optical position detecting means 17 may synchronously detect the reflected light B2 using the modulation signal E2 from the oscillator 18. Since the vibration of the reflected light B2 and the modulation signal E2 of the oscillator 18 have the same frequency, the optical position detection means 17 uses the delay circuit to delay the modulation signal E2, so that the optical position detection means 17 detects the vibration of the reflected light B2 with the modulation signal E2. Synchronous detection can be performed. Since the S / N ratio is improved by synchronously detecting the vibration of the reflected light B2, the optical position detecting means 17 can accurately measure the amplitude value of the vibration of the reflected light B2.

  Therefore, the component concentration measuring apparatus 201 can measure the concentration of the measurement target component of the subject 900 with high accuracy by synchronously detecting the reflected light B2 using the modulation signal E2 from the oscillator 18.

(Embodiment 2)
In the present embodiment, a light reflector may further be provided on the surface of the subject that vibrates via an ultrasonic matching material.

  FIG. 4 shows a schematic diagram of the component concentration measuring apparatus 202 according to the present embodiment. 4 includes a light irradiation unit 11, a vibration detection unit 12, a light reflector 41, and an ultrasonic matching material. 4, the same reference numerals as those used in FIG. 1 indicate the same means, components, signals, or light. The component concentration measuring device 202 synchronously detects the reflected light B2 using the modulation signal E2 from the oscillator 18 as described in the component concentration measuring device 201 of FIG. The difference between the component concentration measuring apparatus 202 and the component concentration measuring apparatus 201 of FIG. 1 is that the light reflecting body 41 and the ultrasonic matching material 42 are further provided.

  The light reflector 41 is made of a material that easily reflects the measurement beam B <b> 1 from the surface of the subject 900. For example, the light reflector 41 may be a mirror, a mirror-like metal plate, or the like. Since the light reflector 41 easily reflects the measurement beam B1, the light intensity of the measurement beam B1 can be reduced, and the measurement beam irradiation means 14 can be downsized, that is, the component concentration measuring device 202 can be downsized. Can do.

  Furthermore, since the light reflector 41 is provided, it is not necessary to use the measurement beam B1 having a wavelength in consideration of the reflectance on the surface of the subject 900. Therefore, a general-purpose small light is used as the measurement beam irradiation means 14. It is possible to reduce the manufacturing cost of the component concentration measuring apparatus 202.

  The ultrasonic matching material 42 can match the acoustic impedance between the subject 900 and the light reflector 41. Since the vibration of the surface of the subject 900 is transmitted to the light reflector 41 without being attenuated, the concentration of the measurement target component of the subject 900 can be measured with high accuracy.

  Therefore, the component concentration measuring apparatus 202 operates in the same manner as the component concentration measuring apparatus 201 of FIG. 1 and can obtain the same effect.

(Embodiment 3)
In the present embodiment, a light irradiating means for irradiating the subject with modulated laser light that is electrically intensity-modulated with a modulation signal having a constant frequency toward the subject, and the inside of the subject generated by the irradiated modulated laser light. And a vibration detecting means for detecting the ultrasonic wave as vibration of the surface of the subject, wherein the vibration detecting means irradiates the measuring beam to the surface of the subject. A component concentration measuring apparatus comprising: an irradiating unit; and an integrated light amount measuring unit that measures an integrated light amount received through a pinhole of reflected light of the measurement beam reflected by the surface of the subject.

  FIG. 5 shows a schematic diagram of the component concentration measuring apparatus 203 according to the present embodiment. The component concentration measuring apparatus 203 in FIG. 5 includes light irradiation means 11 and vibration detection means 52. 5, the same reference numerals as those used in FIG. 1 indicate the same means, components, signals, or light. The difference between the component concentration measuring apparatus 203 and the component concentration measuring apparatus 201 of FIG. 1 is that a vibration detecting means 52 is provided as an alternative to the vibration detecting means 12.

  The vibration detection means 52 includes the measurement beam irradiation means 14, a photodetector 55, and a pinhole 57.

  The photodetector 55 includes a photoelectric conversion element and a peripheral circuit. For example, PD can be exemplified as the photoelectric conversion element. Examples of the peripheral circuit include a circuit that measures the time when the PD receives light or a circuit that measures the integrated light quantity of the received light.

  The pinhole 57 has a hole with a diameter of 0.1 μm or more and 1 μm or less substantially equal to the diameter of the reflected light B2 in the center of the light shielding plate.

  The component concentration measuring device 203 includes the light source 13 and the measurement beam irradiation means 14 as described in the component concentration measuring device 201 of FIG. The pinhole 57 is disposed at a position where the optical axis of the reflected light B2 coincides with the center of the hole of the pinhole 57 when the modulated laser beam L1 is not irradiated, that is, when the surface of the subject 900 is not vibrating. The photodetector 55 is arranged at a position where it can receive light that has passed through the hole of the pinhole 57.

  Therefore, the vibration detection unit 52 irradiates the measurement point P of the subject 900 with the measurement beam B1 from the measurement beam irradiation unit 14 from a position away from the subject 900, and performs measurement at a position away from the subject 900. It is possible to measure the integrated light amount or the light receiving time of the light that the reflected light B2 of the beam B1 has passed through the pinhole 57.

  The component concentration measuring apparatus 203 measures the concentration of the measurement target component in the subject 900 as follows. As described with reference to the component concentration measurement apparatus 201 in FIG. 1, the surface of the subject 900 vibrates due to the modulated laser light L1, and the reflected light B2 vibrates at the frequency of the modulation signal E1 due to the vibration of the measurement point P.

  The relationship between the amount of vibration of the reflected light B2 and the light intensity received by the photodetector 55 is shown in FIG. When there is no vibration of the reflected light B2, since the reflected light B2 always passes through the hole of the pinhole 57, the illuminance of the light received by the photodetector 55 becomes a constant value as shown in FIG. When the reflected light B <b> 2 vibrates, a time occurs when the optical axis B <b> 3 of the reflected light B <b> 2 does not coincide with the center of the pinhole 57. During the time when the optical axis B3 and the center of the hole of the pinhole 57 do not coincide with each other, the illuminance of the reflected light B2 that can pass through the hole of the pinhole 57 decreases. That is, the illuminance of light received by the photodetector 55 varies with the frequency of vibration of the reflected light B2 as shown in FIG. The greater the amplitude of vibration of the reflected light B2, the farther the optical axis of the reflected light B2 is from the center of the hole of the pinhole 57, and the lower the amount of light that the photodetector 55 can receive. When the amplitude of the vibration of the reflected light B2 is larger than a certain level, there is a time during which the reflected light B2 cannot pass through the hole of the pinhole 57. Therefore, as shown in FIG. There is a time during which no light can be received.

  Specifically, when the peripheral circuit is a circuit for measuring the integrated light quantity and the concentration of the measurement target component of the subject 900 is high, the integrated light quantity received by the photodetector 55 decreases. Conversely, when the concentration of the measurement target component is low, the integrated light amount received by the photodetector 55 increases.

  In addition, when the peripheral circuit is a circuit that measures the time when light is received and the concentration of the measurement target component of the subject 900 is high, the time that the photodetector 55 receives light decreases. Conversely, when the concentration of the measurement target component is low, the time for which the photodetector 55 receives light increases. In this case, the amplitude of vibration of the reflected light B2 needs to be so large that the reflected light B2 cannot pass through the hole of the pinhole 57.

  The component concentration measuring device 203 obtains data on the relationship between the concentration of the component to be measured and the integrated light amount or the light receiving time of the light passing through the pinhole 57 measured by the photodetector 55 in advance, so that the component concentration measuring device 203 Alternatively, the concentration of the measurement target component of the subject 900 can be calculated from the light reception time.

  Therefore, since the component concentration measuring device 203 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without bringing the vibration detecting means 52 into contact with the subject 900.

  Further, as described in the component concentration measuring apparatus 201 in FIG. 1, the component concentration measuring apparatus 203 measures the concentration of the measurement target component of the subject 900 with high accuracy by using light of two wavelengths for the modulated laser light L1. be able to.

  Furthermore, in order to increase the reflectance of the measurement beam B1, the light reflector 41 may be disposed on the surface of the subject 900 via the ultrasonic matching material 42 as described in the component concentration measuring apparatus 202 in FIG. .

  Note that the photodetector 55 may synchronously detect light that has passed through the pinhole 57 using the modulation signal E2 from the oscillator 18 as shown in FIG. The component concentration measurement apparatus 203 can measure the concentration of the measurement target component of the subject 900 with high accuracy by synchronously detecting the reflected light B2.

(Embodiment 4)
In the present embodiment, a light irradiating means for irradiating the subject with modulated laser light that is electrically intensity-modulated with a modulation signal having a constant frequency toward the subject, and the inside of the subject generated by the irradiated modulated laser light. And a vibration concentration detecting device for detecting the ultrasonic wave as a vibration of the surface of the subject, wherein the vibration detecting means emits a measurement laser beam and the measurement The measurement laser light from the laser oscillator for use is bifurcated into a first laser light and a second laser light, the surface of the subject is irradiated with the first laser light, and the second laser light and the subject And an interferometer for measuring a phase difference with the first laser beam reflected on the surface of the component concentration measuring apparatus.

  FIG. 7 shows a schematic diagram of the component concentration measuring apparatus 204 according to the present embodiment. The component concentration measuring apparatus 204 in FIG. 7 includes the light irradiation means 11 and the vibration detection means 72. In FIG. 7, the same reference numerals as those used in FIG. 1 indicate the same means, components, signals, or light. The difference between the component concentration measuring apparatus 204 and the component concentration measuring apparatus 201 in FIG. 1 is that a vibration detecting means 72 is provided as an alternative to the vibration detecting means 12.

  The vibration detection means 72 includes a measurement laser oscillator 74 and an interferometer 75.

  The measurement laser oscillator 74 generates light having a wavelength that is easily reflected on the surface of the subject 900. If the subject 900 is a human body, light having a wavelength of 500 nm or more and 600 nm or less is likely to be reflected on the skin, and thus a laser light source that generates light of the wavelength can be exemplified. The measurement laser oscillator 74 couples the measurement laser beam L 7 to the interferometer 75. An optical fiber can be exemplified as means for coupling the measurement laser beam L7 to the interferometer 75.

  The interferometer 75 bifurcates the measurement laser beam L7 from the measurement laser oscillator 74 into a first laser beam and a second laser beam, and uses the first laser beam as an irradiation laser beam S7. A measurement point P is irradiated, and the phase difference between the reflected light R7 reflected from the measurement point P of the subject 900 and the second laser light is measured. In FIG. 7, the irradiation laser light S7 and the reflected light R7 are described with different optical axes, but the optical axes may overlap depending on the type of the interferometer 75. The interferometer 75 includes a plurality of optical systems such as a collimator and a beam splitter, and a photodetector. Examples of the interferometer 75 include a Michelson interferometer and a Mach-Zehnder interferometer.

  FIG. 8 shows an interferometer 75 using a Michelson interferometer, and FIG. 9 shows an interferometer 75 using a Mach-Zehnder interferometer. In each figure, the same reference numerals as those used in FIG. 7 indicate the same means, components, signals, or light.

  8 includes a collimator 81, a beam splitter 83, a reflecting mirror 85, a photodetector 87, and an aperture 89.

  The collimator 81 converts the combined measurement laser light L7 into parallel light L8.

  The beam splitter 83 has a half mirror and branches the parallel light L8 into two. The beam splitter 83 transmits one of the bifurcated parallel light L8 as the reference light D8 that is the second laser light, and refracts the other 90 degrees with respect to the optical axis of the parallel light L8. The reference light D8 reaches the reflecting mirror 85, is reflected, and reaches the beam splitter 83 again.

  On the other hand, the light refracted by the beam splitter 83 has its light diameter determined by the aperture 89, and irradiates the subject 900 as the irradiation laser light S7. The irradiation laser beam S7 is reflected by the subject 900, passes through the aperture 89 again as reflected light R7, and reaches the beam splitter 83. In FIG. 8, the irradiation laser light S7 and the reflected light R7 have the same optical path, and are therefore indicated as H8.

  The reference light D8 and the reflected light R7 that have reached the beam splitter 83 reach the photodetector 87 as interference light G8. Since the phase of the reflected light R7 changes due to the vibration of the surface of the subject 900, the reflected light R7 and the reference light D8 interfere with each other. Specifically, since the phase of the reflected light R7 changes with time depending on the vibration frequency of the surface of the subject 900, that is, the frequency of the ultrasonic wave, the reflected light is proportional to the magnitude of the vibration of the surface of the subject 900. The range of change in phase difference between R7 and reference light D8 is widened. The photodetector 87 measures the phase difference between the reflected light R7 and the reference light D8 as a change in the light intensity of the interference light G8.

  When the Michelson interferometer 75m is used as the interferometer 75, it is desirable to arrange the minute corner cube 80 at the measurement point P of the subject 900 via the ultrasonic matching material 42 described with reference to FIG. The small corner cube 80 is an example of the light reflector 41 described with reference to FIG. The reflected light of the light incident on the small corner cube 80 is emitted in the direction of the incident light. Accordingly, even if the angle between the irradiation laser beam S7 and the surface of the subject 900 is changed by arranging the small corner cube 80, the reflected light R7 returns to the direction of the aperture 89, so that the subject 900 is stably measured. The concentration of the component can be measured with high accuracy.

  The Mach-Zehnder interferometer 75n shown in FIG. 9 includes a collimator 81, a beam splitter 83, a beam splitter 84, an aperture 89, a reflecting mirror 85, and a photodetector 87. 9, the same reference numerals as those used in FIG. 8 indicate the same means, parts, signals, or light. Similar to the Michelson interferometer 75m of FIG. 8, the Mach-Zehnder interferometer 75n irradiates the subject 900 with the irradiation laser light S7. The reflected light R7 reflected by the subject 900 reaches the beam splitter 84, and reaches the photodetector 87 as interference light G8 together with the reference light D8 reflected by the reflecting mirror 85. As described with reference to the Michelson interferometer 75m in FIG. 8, the reflected light R7 and the reference light D8 interfere with each other. The photodetector 87 measures the phase difference between the reflected light R7 and the reference light D8.

  Therefore, the vibration detecting means 72 uses the measurement laser light L7 from the measurement laser oscillator 74 at a position away from the subject 900 and the measurement point P of the subject 900 with the interferometer 75 at a position away from the subject 900. The phase difference between the reflected light R7 and the reference light D8 of the irradiation laser light S7 applied to the laser beam can be measured.

  The component concentration measuring apparatus 204 measures the concentration of the measurement target component in the subject 900 as follows. As described with reference to the component concentration measurement apparatus 201 in FIG. 1, the surface of the subject 900 is vibrated by the modulated laser light L1, and the phase of the irradiation laser light S7 from the interferometer 75 is changed and reflected as reflected light R7. . The interferometer 75 measures the phase difference between the reflected light R7 and the reference light D8.

  Specifically, in the case of a Michelson interferometer or a Mach-Zehnder interferometer, the phase difference increases when the concentration of the measurement target component of the subject 900 is high. Conversely, when the concentration of the measurement target component is low, the phase difference is small.

  By acquiring in advance data on the concentration of the measurement target component and the phase difference measured by the interferometer 75, the component concentration measurement device 204 calculates the concentration of the measurement target component of the subject 900 from the phase difference. be able to.

  Therefore, since the component concentration measuring apparatus 204 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without bringing the vibration detecting means 72 into contact with the subject 900.

  Further, as described in the component concentration measuring apparatus 201 of FIG. 1, the component concentration measuring apparatus 204 measures the concentration of the measurement target component of the subject 900 with high accuracy by using light of two wavelengths for the modulated laser light L1. be able to.

  Furthermore, in order to increase the reflection efficiency of the reflected light R7, the light reflector 41 may be disposed on the surface of the subject 900 via the ultrasonic matching material 42 as described in the component concentration measuring apparatus 202 in FIG.

(Embodiment 5)
In the present embodiment, a light irradiating means for irradiating the subject with modulated laser light that is electrically intensity-modulated with a modulation signal having a constant frequency toward the subject, and the inside of the subject generated by the irradiated modulated laser light. Vibration detecting means for detecting the ultrasonic wave as vibration of the surface of the subject, wherein the vibration detecting means is a reflection of the modulated laser beam reflected by the surface of the subject. It is a component concentration measuring apparatus having an optical position detecting means for measuring the position of the optical axis of light.

  FIG. 10 shows a schematic diagram of the component concentration measuring apparatus 205 according to the present embodiment. 10 includes a light irradiation means 101 and a light position detection means 17 as vibration detection means. 10, the same reference numerals as those used in FIG. 1 indicate the same means, parts, signals, or light. The difference between the component concentration measuring device 205 and the component concentration measuring device 201 of FIG. 1 is that the component concentration measuring device 205 does not include the measurement beam irradiation means 14, and the modulated laser beam L 1 from the light source 13 is reflected by the subject 900. That is, the reflected light B4 is received by the optical position detector 17. The component concentration measuring device 205 synchronously detects the reflected light B4 using the modulation signal E2 from the oscillator 18 as described in the component concentration measuring device 201 in FIG.

  The component concentration measuring apparatus 205 measures the concentration of the measurement target component in the subject 900 as follows. As described with reference to the component concentration measuring apparatus 201 in FIG. 1, the surface of the subject 900 vibrates due to the photoacoustic effect caused by irradiation with the modulated laser light L1. Since part of the modulated laser light L1 is reflected by the surface of the subject 900, the reflected light B4 vibrates at the frequency of the measurement point P, that is, the frequency of the modulation signal E1, in the same direction as the reflected light B2. As described with reference to the component concentration measurement apparatus 201 in FIG. 1, the optical position detection unit 17 receives the reflected light B4 and measures the amplitude of vibration of the reflected light B4 on the light receiving surface of the optical position detection unit 17. By acquiring in advance data on the relationship between the concentration of the measurement target component and the amplitude of the vibration of the reflected light B4, the component concentration measurement device 205 calculates the concentration of the measurement target component of the subject 900 from the amplitude value. be able to.

  Therefore, since the component concentration measuring device 205 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without contacting the vibration detecting means with the subject 900.

  Further, as described in the component concentration measuring apparatus 201 in FIG. 1, the component concentration measuring apparatus 205 measures the concentration of the measurement target component of the subject 900 with high accuracy by using light of two wavelengths for the modulated laser light L1. be able to.

(Embodiment 6)
In the present embodiment, a light irradiating means for irradiating the subject with modulated laser light that is electrically intensity-modulated with a modulation signal having a constant frequency toward the subject, and the inside of the subject generated by the irradiated modulated laser light. Vibration detecting means for detecting the ultrasonic wave as vibration of the surface of the subject, wherein the vibration detecting means is a reflection of the modulated laser beam reflected by the surface of the subject. The component concentration measuring apparatus includes an integrated light amount measuring unit that measures an integrated light amount received through a pinhole of light.

  FIG. 11 shows a schematic diagram of the component concentration measuring apparatus 206 according to this embodiment. The component concentration measuring apparatus 206 in FIG. 11 includes light irradiation means 101 and vibration detection means 112. The vibration detection means 112 includes a photodetector 55 and a pinhole 57. In FIG. 11, the same reference numerals as those used in FIGS. 1 and 5 indicate the same means, components, signals or light. The difference between the component concentration measuring device 206 and the component concentration measuring device 203 in FIG. 5 is that the component concentration measuring device 206 does not include the measurement beam irradiation means 14, and the modulated laser beam L 1 from the light source 13 is reflected by the subject 900. That is, the vibration detecting means 112 receives the reflected light B4. The component concentration measuring device 206 synchronously detects the light that has passed through the pinhole 57 using the modulation signal E2 from the oscillator 18 as described in the component concentration measuring device 201 in FIG.

  The component concentration measuring device 206 measures the concentration of the measurement target component in the subject 900 as follows. As described with reference to the component concentration measuring apparatus 205 in FIG. 10, a part of the modulated laser light L1 is reflected by the surface of the subject 900 to become reflected light B4. As described with reference to the vibration detection means 52 of the component concentration measurement apparatus 203 in FIG. 5, the vibration detection means 112 receives the reflected light B4 that passes through the pinhole 57 and measures the integrated light amount or the light reception time. By acquiring in advance data on the relationship between the concentration of the measurement target component and the integrated light amount or light reception time received by the photodetector 55, the component concentration measurement device 206 can determine the measurement target component of the subject 900 from the amplitude value. Concentration can be calculated.

  Therefore, since the component concentration measuring device 206 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without bringing the vibration detecting means 112 into contact with the subject 900.

(Embodiment 7)
In the present embodiment, a modulated laser beam obtained by electrically modulating the intensity of a laser beam with a modulation signal having a constant frequency is branched into a first modulated laser beam and a second modulated laser beam, and the first modulated laser beam is used as a subject. A light irradiating means for irradiating the surface of the subject with the second modulated laser light at a position different from the light reflector; Vibration detecting means for detecting ultrasonic waves in the subject generated by the second modulated laser light as vibration of the surface of the subject, wherein the vibration detecting means comprises: It is a component concentration measuring apparatus characterized by having an optical position detecting means for measuring the optical axis position of the reflected light of the first modulated laser light reflected by the light reflector.

  FIG. 12 shows a schematic diagram of the component concentration measuring apparatus 207 according to the present embodiment. The component concentration measuring apparatus 207 of FIG. 12 includes a light irradiation means 121 and a light position detection means 17 as a vibration detection means. 12, the same reference numerals as those used in FIGS. 1, 4 and 10 indicate the same means, parts, signals or light. The difference between the component concentration measuring device 207 and the component concentration measuring device 205 in FIG. 10 is that the optical element 123 and the light reflector 41 are arranged in the component concentration measuring device 207. Examples of the optical element 123 include a prism and a beam splitter.

  The light reflector 41 described with reference to the component concentration measuring apparatus 202 in FIG. 4 is disposed on the surface of the subject 900 via the ultrasonic matching material 42. The light reflector 41 is made of a material that easily reflects the first modulated laser light L5 from the surface of the subject 900.

  The optical element 123 splits the modulated laser beam L1 from the light source 13 into a first modulated laser beam L5 and a second modulated laser beam L6. Furthermore, the optical element 123 irradiates the light reflector 41 with the first modulated laser light L5 and irradiates the surface of the subject 900 other than the portion where the light reflector 41 is disposed with the second modulated laser light L6.

  The component concentration measuring device 207 measures the concentration of the measurement target component in the subject 900 as follows. As described with reference to the component concentration measurement apparatus 201 in FIG. 1, the surface of the subject 900 vibrates due to the photoacoustic effect caused by the irradiation with the second modulated laser light L6. The vibration of the surface of the subject 900 causes the light reflector 41 to vibrate via the ultrasonic matching material 42. The first modulated laser light L5 is reflected by the light reflector 41 to become reflected light B6. The direction in which the reflected light B6 is reflected vibrates at the frequency of vibration at the measurement point P, that is, the frequency of the modulation signal E1, in the same manner as the reflected light B2. As described with reference to the component concentration measuring apparatus 201 in FIG. 1, the optical position detector 17 receives the reflected light B6 and measures the amplitude of vibration of the reflected light B6 on the light receiving surface of the optical position detector 17. Therefore, the component concentration measuring apparatus 207 can calculate the concentration of the measurement target component of the subject 900 from the amplitude of the vibration of the reflected light B6 as described in the component concentration measuring apparatus 201 in FIG. The component concentration measuring device 207 in FIG. 12 synchronously detects the reflected light B6 using the modulation signal E2 from the oscillator 18 as described in the component concentration measuring device 201 in FIG.

  Therefore, since the component concentration measuring device 207 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without contacting the vibration detecting means with the subject 900.

  Further, as described in the component concentration measuring apparatus 201 of FIG. 1, the component concentration measuring apparatus 207 measures the concentration of the measurement target component of the subject 900 with high accuracy by using light of two wavelengths for the modulated laser light L1. be able to.

(Embodiment 8)
In the present embodiment, a modulated laser beam obtained by electrically modulating the intensity of a laser beam with a modulation signal having a constant frequency is branched into a first modulated laser beam and a second modulated laser beam, and the first modulated laser beam is used as a subject. A light irradiating means for irradiating the surface of the subject with the second modulated laser light at a position different from the light reflector; Vibration detecting means for detecting ultrasonic waves in the subject generated by the second modulated laser light as vibration of the surface of the subject, wherein the vibration detecting means comprises: The component concentration measuring apparatus includes an integrated light amount measuring unit that measures an integrated light amount received through a pinhole of the reflected light of the first modulated laser light reflected by the light reflector.

  A schematic diagram of the component concentration measuring apparatus 208 according to the present embodiment is shown in FIG. 13 includes a light irradiation unit 121 and a vibration detection unit 112. In FIG. 13, the same reference numerals as those used in FIGS. 1, 4, 5, 11, and 12 indicate the same means, components, signals, or light. The difference between the component concentration measuring device 208 and the component concentration measuring device 206 in FIG. 11 is that the optical element 123 and the light reflector 41 are arranged in the component concentration measuring device 208 as described in the component concentration measuring device 207 in FIG. It is that.

  The component concentration measuring device 208 measures the concentration of the measurement target component in the subject 900 as follows. As described in the component concentration measuring apparatus 207 in FIG. 12, the optical axis of the reflected light B6 vibrates. As described in the vibration detecting means 52 of the component concentration measuring apparatus 203 in FIG. 5, the vibration detecting means 112 receives the reflected light B6 passing through the pinhole 57 and measures the integrated light quantity or the light receiving time. Therefore, the component concentration measuring device 208 can calculate the concentration of the measurement target component of the subject 900 from the integrated light amount or the light receiving time as described in the component concentration measuring device 203 of FIG. The component concentration measuring device 208 in FIG. 13 synchronously detects the reflected light B6 using the modulation signal E2 from the oscillator 18 as described in the component concentration measuring device 201 in FIG.

  Accordingly, since the component concentration measuring device 208 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without contacting the vibration detecting means with the subject 900.

  Further, the component concentration measuring device 207 in FIG. 12 and the component concentration measuring device 208 in FIG. 13 may use light of two wavelengths for the modulated laser light L1 as described in the component concentration measuring device 201 in FIG.

(Embodiment 9)
A schematic diagram of a component concentration measuring apparatus 209 according to this embodiment is shown in FIG. The component concentration measuring apparatus 209 in FIG. 14 includes a light irradiation unit 121 and an interferometer 75 as a vibration detection unit. 14, the same reference numerals as those used in FIGS. 1, 4, 7, 11, 12, and 13 indicate the same means, components, signals, or light. The difference between the component concentration measuring device 209 and the component concentration measuring device 207 in FIG. 12 is that the interferometer 75 described in the component concentration measuring device 204 in FIG. 7 is arranged in the component concentration measuring device 209 as an alternative to the optical position detecting means 17. It has been done.

  The component concentration measuring apparatus 209 measures the concentration of the measurement target component in the subject 900 as follows. The interferometer 75 receives the first modulated laser light L5 emitted from the optical element 123 as the measurement laser light, and irradiates the light reflector 41 with the irradiation laser light S7. The light reflector 41 vibrates as described in the component concentration measuring apparatus 207 in FIG. 12, and the interferometer 75 generates a reflected light R7 and a reference light (not shown) as described in the component concentration measuring apparatus 204 in FIG. Measure the phase difference. Therefore, the component concentration measurement apparatus 209 can calculate the concentration of the measurement target component of the subject 900 from the phase difference measured by the interferometer 75.

  Therefore, since the component concentration measurement apparatus 209 detects vibration using light, the concentration of the measurement target component of the subject 900 can be measured without contacting the vibration detection means with the subject 900.

  The component concentration measuring apparatus of the present invention can be used for daily health management and cosmetic check. Moreover, not only humans but also animals can be used for health management. Furthermore, since the component concentration measuring apparatus of this invention can measure the component density | concentration in a liquid, it can be applied also to the sugar content measurement of a fruit, for example.

It is the schematic of the component concentration measuring apparatus which concerns on one Embodiment of this invention. It is a conceptual diagram of the structure of a CCD image sensor. It is a figure showing the principle of operation of PSD. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is a figure which shows the relationship between the vibration amount of reflected light B2, and the light intensity which the photodetector 55 receives. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is the schematic which shows the structure of a Michelson interferometer. It is the schematic which shows the structure of a Mach-Zehnder interferometer. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is the schematic of the component concentration measuring apparatus which concerns on other embodiment of this invention. It is a figure which shows the structural example of the conventional blood component concentration measuring apparatus. It is the figure which showed the light absorbency characteristic of the water and glucose aqueous solution in normal temperature.

Explanation of symbols

201-209 Component concentration measuring apparatus 11, 101, 121 Light irradiation means 12, 52, 72, 112 Vibration detection means 13 Light source 14 Measurement beam irradiation means 17 Optical position detection means 18 Oscillator 21 PD
22 Transfer gate 23 Vertical transfer CCD
24 Horizontal transfer CCD
25 Light receiving position specifying circuit 31 n-type silicon substrate 32 intrinsic semiconductor layer 33 p-type semiconductor layers 34a and 34b electrode 35 grounding electrode 41 light reflector 42 ultrasonic matching material 55 photodetector 57 pinhole 74 laser oscillator 75 for measurement interference Total 75 m Michelson interferometer 75 n Mach-Zehnder interferometer 80 Minute corner cube 81 Collimator 83, 84 Beam splitter 85 Reflector 87 Photo detector 89 Aperture 123 Optical element 604 Drive circuit 610 Subject 613 Ultrasonic detector 616 Pulse light source 620 Waveform observation Instrument 900 Subject L1 Modulated laser light L5 First modulated laser light L6 Second modulated laser light L7 Measuring laser light B1 Measuring beams B2, B4, B6 Reflected light B3 Reflected light optical axes E1, E2 Modulated signal S7 Irradiation laser Light R7 Reflected light L8 Parallel light H8 Irradiation laser S7 + reflected light R7
D8 Reference light G8 Interference light A Modulated laser irradiation point C Light D, E Hole quantity P Measurement point Xa, Xb Distance

Claims (9)

A light irradiating means for irradiating the subject with a modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency;
Vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated modulated laser light as vibrations on the surface of the subject;
A component concentration measuring device comprising:
The vibration detecting means includes a measuring beam irradiating means for irradiating the surface of the subject with a measuring beam;
Optical position detection means for measuring the optical axis position of the reflected light of the measurement beam reflected by the surface of the subject;
A component concentration measuring apparatus comprising: A light irradiating means for irradiating the subject with a modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency;
Vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated modulated laser light as vibrations on the surface of the subject;
A component concentration measuring device comprising:
The vibration detecting means includes a measuring beam irradiating means for irradiating the surface of the subject with a measuring beam;
Integrated light quantity measuring means for measuring the integrated light quantity received through the pinhole of the reflected light of the measurement beam reflected by the surface of the subject;
A component concentration measuring apparatus comprising: A light irradiating means for irradiating the subject with a modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency;
Vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated modulated laser light as vibrations on the surface of the subject;
A component concentration measuring device comprising:
The vibration detection means includes a measurement laser oscillator that emits measurement laser light, and
The measurement laser beam from the measurement laser oscillator is bifurcated into a first laser beam and a second laser beam, the surface of the subject is irradiated with the first laser beam, and the second laser beam and the second laser beam An interferometer for measuring a phase difference with the first laser beam reflected from the surface of the subject;
A component concentration measuring apparatus comprising:   4. The component concentration measuring apparatus according to claim 1, further comprising a light reflector on the surface of the subject that vibrates via an ultrasonic matching material. A light irradiating means for irradiating the subject with a modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency;
Vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated modulated laser light as vibrations on the surface of the subject;
A component concentration measuring device comprising:
The vibration detecting means includes an optical position detecting means for measuring an optical axis position of reflected light reflected from the surface of the subject in the modulated laser light. A light irradiating means for irradiating the subject with a modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency;
Vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated modulated laser light as vibrations on the surface of the subject;
A component concentration measuring device comprising:
The vibration detecting means includes integrated light quantity measuring means for measuring an integrated light quantity that is received through a pinhole of reflected light reflected from the surface of the subject in the modulated laser light. A modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency is branched into a first modulated laser beam and a second modulated laser beam, and the first modulated laser beam is ultrasonically applied to the surface of the subject. Light irradiation means for irradiating a light reflector disposed through a matching material and irradiating the surface of the subject at a position different from the light reflector with the second modulated laser light;
Vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated second modulated laser light as vibrations on the surface of the subject;
A component concentration measuring device comprising:
The component concentration measuring apparatus according to claim 1, wherein the vibration detecting means includes an optical position detecting means for measuring an optical axis position of the reflected light of the first modulated laser light reflected by the light reflector. A modulated laser beam obtained by electrically modulating the intensity of the laser beam with a modulation signal having a constant frequency is branched into a first modulated laser beam and a second modulated laser beam, and the first modulated laser beam is ultrasonically applied to the surface of the subject. A light irradiation means for irradiating a light reflector disposed through a matching material and irradiating the surface of the subject at a position different from the light reflector with the second modulated laser light;
Vibration detecting means for detecting ultrasonic waves in the subject generated by the irradiated second modulated laser light as vibrations on the surface of the subject;
A component concentration measuring device comprising:
The component concentration measuring apparatus according to claim 1, wherein the vibration detecting unit includes an integrated light amount measuring unit that measures an integrated light amount received through a pinhole of the reflected light of the first modulated laser light reflected by the light reflector. The said vibration detection means carries out synchronous detection of the optical axis position measurement signal of the optical axis position of the said reflected light output from the said optical position detection means with the said modulation signal of the said light irradiation means, The said 1st aspect is characterized by the above-mentioned. 8. The component concentration measuring apparatus according to 5 or 7.

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