CN101288721A - Chinese medicinal composition for treating hypothyroidism and its preparation method - Google Patents
Chinese medicinal composition for treating hypothyroidism and its preparation method Download PDFInfo
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- CN101288721A CN101288721A CNA2008101116512A CN200810111651A CN101288721A CN 101288721 A CN101288721 A CN 101288721A CN A2008101116512 A CNA2008101116512 A CN A2008101116512A CN 200810111651 A CN200810111651 A CN 200810111651A CN 101288721 A CN101288721 A CN 101288721A
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Abstract
The invention relates to a Chinese medicine composite used for treating hypothyroidism. The Chinese medicine composite is made by radix codonopsitis, epimedium powder, cuscuta, pulp of dogwood fruit, cistanche deserticola, Chinese angelica, milk veteh, medlar, radix morindae officinalis, largehead atractylodes rhizome, cimicifuga foetida, glycyrrhiza, bupleurum, cassia twig, radix rehmanniae and/or a carrier acceptable for pharmacy. The invention also relates to a preparation method of the Chinese medicine composite. The Chinese medicine composite used for treating hypothyroidism has the functions of warming kidney to invigorate yang, replenishing Qi, dispelling cold, nourishing yin for moistening dryness and strengthening spleen. The Chinese medicine composite used for treating hypothyroidism can be applicable for protecting against cold, dry skin and olighidria, pale and waxen face and bloated face caused by the hypothyroidism.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of hypothyroidism and preparation method thereof.
Background technology
Hypothyroidism is the synthetic and hyposecretion of thyroxin, or the bad and systemic disease that causes of thyroxin physiological effect.If hypofunction starts from fetus or neonatal period, be called cretinism; The child claims the juvenile form hypothyroidism before starting from sexual development; Start from into the people and claim the adult hypothyroidism.
This disease can be divided into constitutional hypothyroidism, Secondary cases hypothyroidism and three kinds of property hypothyroidism on every side, and its cause of disease is as follows:
One, constitutional hypothyroidism, due to the disease of thyroid own, patients serum TSH all raises.Be mainly seen in: 1. congenital thyroid lacks; 2. atrophy of thyroid gland; 3. diffusivity lymphocytic thyroiditis; 4. subacute thyroiditis; 5. after the destructive treatment of thyroid (radioiodine, operation); 6. thyroid hormone dyssynthesis (congenital enzyme defects, iodine deficiency or excessive iodine); 7. medicine suppresses; 8. wellability infringement (lymph cancer, amyloidosis etc.).
Two, Secondary cases hypothyroidism, patients serum TSH reduces.Be mainly seen in hypophysis disease, pituitary tumor, isolatism TSH shortage; Hypothalamic syndrome, hypothalamic tumors, Isolated TRH deficiency.
Three, property hypothyroidism on every side, rare, be family's hereditary, the function of periphery target tissue picked-up hormone is good, but nucleus inner recipient dysfunction or shortage, so the physiological effect of thyroxin is weakened.
The clinical manifestation of hypothyroidism mainly contains:
One, adult hypothyroidism is more common in middle aged women, and men and women's ratio is 1: 5, the onset concealment, and PD is slow.Classical symptom is as follows:
(1) general performance: be afraid of cold, the xerosis cutis hypohidrosis, slightly thick, yellowing, send out cool, hypotrichosis, withered, fingernail is crisp, crackle is arranged, tired, drowsiness, poor memory, the hypophrenia, bradykinesia, anemia.Weight increase.
(2) unusual facies: face is pale and wax yellow, and puffiness of face is One's eyesight is restrained, and the eyelid pine is swollen, and apathetic expression is wordless, says then hoarseness, tells the speech ambiguity.
(3) cardiovascular system: heart rate is slow, and hear sounds is low, and heart is universality and enlarges, and often with pericardial effusion, cardiac muscle fiber swelling after the prolonged illness is arranged also, and mucus glycoprotein (PAS stained positive) deposition and interstitial fibrosis claim the hypothyroidism cardiomyopathy.Obvious disorders of lipid metabolism can appear in the patient, present hypercholesterolemia, hypertriglyceridemia and high beta-lipoproteinemia, often with atherosclerosis, Incidence of CHD is higher than general crowd, but because of the low metabolic rate of surrounding tissue, cardiac output lowers, myocardium keto consumption reduces, so rare angina pectoris and heart failure.Sometimes blood pressure is higher, but is more common in diastolic pressure.Electrocardiogram is low-voltage, and the T ripple is inverted, the broadening of QRS ripple, and the P-R interval, prolong.
(4) digestive system: patient's loss of appetite, constipation, abdominal distention, even paralytic ileus appears.Patient about half has the completeness achlorhydria.
(5) muscle and articular system: muscle contraction all slowly postpones with lax, often feels myalgia, stiff.Bone metabolism is slow, and bone formation all reduces with absorption.Arthralgia, movable ineffective, tetanic sense is arranged, the postemphasis of catching a cold is just like chronic arthritis.Accidental arthroedema.
(6) hormonal system: impotence, women's menorrhagia, but also amenorrhea of person is not controlled in prolonged illness.Tight upward the gland cortex hormone function is on the low side, and blood and urocortisol reduce.The constitutional hypothyroidism can claim the Schmidt syndrome simultaneously with autoimmunity hypoadrenocorticism and/or type i diabetes sometimes.
Two, gram is ordered sufferer youngster dementia, and appetite is poor, and the feeding difficulty does not have and sucks power, and peace and quiet are cry and screamed less, and are drowsiness, and autokinesis is few, and is of flaccid muscles, pale complexion, and xerosis cutis is sent out cold, slightly thick, and hoarseness is a little less than the tendon reflex.Development delay is arranged.
Three, juvenile form hypothyroidism patient's childhood performance is ordered disease like gram.Big child is shape such as adult type hypothyroidism then, and growth promoter is influenced, the adolescence development delay, and intelligence and school grade are poor.
No matter the hypothyroidism patient of which kind of type works as serious symptom, can not get rational therapy, under a stable condition, and as infecting, cold, operation, anesthesia or can bring out stupor, special myxedema coma when using tranquilizer.The patient has drowsiness earlier, and body temperature does not rise, even is lower than 35﹠amp; Ordm; C, blood pressure drops, hypopnea, heart beating is weak, and tendon reflex disappears and slow, of flaccid muscles, can accompany shock, cardiorenal function depletion and threat to life.
The traditional Chinese medical science thinks that hypothyroidism belongs to categories such as " asthenia ", " deficient ".Innate deficiency is lacked of proper care after one's birth, and the weak or sick mistake for a long time of body constitution is controlled, and factors such as the internal injury of being overworked for a very long period all can cause internal organs hypofunction, insufficiency of generating and transforming QI and blood.Its main pathogenesis is weakened body resistance, and it is dirty to relate to kidney, spleen, the heart three, and the turbid performance of part expectorant is arranged.
Suffer from a deficiency of the kidney, the kidney being the origin of congenital constitution, hypothyroidism starts from period of fetus person, visible with suffer from a deficiency of the kidney in close relations.And its clinical primary symptom is that vigour is short, the spiritlessness and weakness of insufficiency of vital energy and blood, and fear of cold is timid cold etc., is resembling of one deficiency and coldness, and in addition, diseases such as still visible hypomnesis, alopecia, hyposexuality also are the performances of insufficiency of kidney-YANG.Test report factually, all yang deficiency syndrome patients, thyroxine content is on the low side in the serum, the performance that the hypothyroidism patient that also given counterevidence must tool yang deficiency.But the deficiency and coldness sign that hypothyroidism presented is the hyposecretion that comes from thyroxin,, by " deficiency of YIN affecting YANG ", presents the pathological manifestations of " depletion of YIN then sun is difficult to give birth to " so primary disease is the cloudy insufficiency of essence of kidney in fact, and deficiency of the kidney yin is the pathological factor of hypothyroidism inherence.
Insufficiency of the spleen, the spleen being the foundation of acquired constitution, insufficiency of the spleen food ration is few, and diet is inconsiderate, takes the photograph iodine and reduces, and the provisions source will be short the day after tomorrow, more impair the body function performance.And because of suffering from a deficiency of the kidney, the spleen sun also declines, the insufficiency of the spleen and formation vicious cycle of suffering from a deficiency of the kidney.The duty of the main again muscle of spleen, extremity department system blood, according to observations, the hypothyroidism patient has myasthenia person to account for 61%, and with sensory disturbance, numb hand and foot, myalgia, stiff or spasm, this is the hypofunction of " spleen governing muscles ", and has 32%～82% patient to merge in various degree anemia.Simultaneously, the hypothyroidism women often has menoxenia, causes lasting massive blood loss when serious, all is the sign of failure of the spleen to keep the blood flowing within the vessels.
Have a guilty conscience, the hypothyroidism patient is with bradycardia, deep pulse is slow in mainly seeing disease, this is the clinical manifestation of flaccidity of the heart-yang, is because of due to " kidney life can not steam fortune, heart-yang is agitated incapability ", so though sick grass does not just relate to heart, but based on decline of kidney-YANG, flaccidity of the heart-yang, deficiency of heart-YANG and kidney-YANG and the opinion disease of further increasing the weight of clinical yang deficiency.
Expectorant is turbid, and the hypothyroidism patients clinical is main performance with yang deficiency, but myxedema can occur when being in a bad way, and is to be the turbid pathology of expectorant, this expectorant is turbid still come from deficiency of spleen-YANG and kidneyYANG can not transmitting and distributing the fluids, the poly-expectorant that forms.Hypothyroidism patient part can present thyromegaly, " being that the five internal organs blood stasis, foul smell, expectorant stagnate and form ".The phenomenon that lab testing hypothyroidism patient ubiquity serum cholesterol raises from traditional Chinese medical science opinion, is " a turbid fat ", also belongs to the turbid category of expectorant, so primary disease and expectorant are turbid in close relations.
The traditional Chinese medical science adopts warming the kidney to activate YANG, QI invigorating cold relieving, nourshing Yin and drynsessmoistening prescription, this disease of decoction for the treatment that spleen invigorating helps fortune.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of hypothyroidism.
The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.
In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of hypothyroidism, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:
Radix Codonopsis 15-25 part Herba Epimedii 5-15 part Semen Cuscutae 20-25 part
Fructus Corni 10-20 part Herba Cistanches 15-20 part Radix Angelicae Sinensis 20-30 part
Radix Astragali 15-20 part Fructus Lycii 25-35 part Radix Morindae Officinalis 10-15 part
Rhizoma Atractylodis Macrocephalae 10-20 part Rhizoma Cimicifugae 15-20 part Radix Glycyrrhizae 20-30 part
Radix Bupleuri 20-25 part Ramulus Cinnamomi 15-25 part Radix Rehmanniae 10-20 part
Effective ingredient is preferably made by weight by following raw materials according:
23 parts of 11 parts of Semen Cuscutae of 21 parts of Herba Epimedii of Radix Codonopsis
26 parts of 18 parts of Radix Angelicae Sinensis of 16 parts of Herba Cistanchess of Fructus Corni
13 parts of 32 parts of Radix Morindae Officinaliss of 18 portions of Fructus Lyciis of the Radix Astragali
26 parts in 18 portions of Radix Glycyrrhizaes of 16 parts of Rhizoma Cimicifugaes of the Rhizoma Atractylodis Macrocephalae
16 parts in 21 parts of Radix Rehmanniae of 23 parts of Ramulus Cinnamomi of Radix Bupleuri
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
(1) to be broken into impalpable powder standby for Radix Angelicae Sinensis powder;
(2) Semen Cuscutae, Fructus Lycii, Ramulus Cinnamomi are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Codonopsis, Herba Epimedii, Fructus Corni, Herba Cistanches, the Radix Astragali, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cimicifugae, Radix Glycyrrhizae, Radix Bupleuri, the Radix Rehmanniae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder
Make granule, capsule and tablet with pharmaceutically acceptable carrier.
Chinese medicine composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.
Chinese medicine composition of the present invention has warming the kidney to activate YANG, QI invigorating cold relieving, nourshing Yin and drynsessmoistening prescription, spleen invigorating helps effects such as fortune, be used for that hypothyroidism causes be afraid of cold, disease such as xerosis cutis hypohidrosis, face are pale and wax yellow, puffiness of face.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicine composition granule of the present invention
(1) to be ground into impalpable powder standby for Radix Angelicae Sinensis 260g;
(2) Semen Cuscutae 230g, Fructus Lycii 320g, Ramulus Cinnamomi 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Codonopsis 210g, Herba Epimedii 110g, Fructus Corni 160g, Herba Cistanches 180g, Radix Astragali 180g, Radix Morindae Officinalis 130g, Rhizoma Atractylodis Macrocephalae 160g, Rhizoma Cimicifugae 180g, Radix Glycyrrhizae 260g, Radix Bupleuri 230g, Radix Rehmanniae 160g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds lactose 400g, dextrin 400g, mixing sieves, with 72% ethanol wet granulation, drying, pack promptly.
Embodiment 2: Chinese medicine composition capsule of the present invention
(1) to be ground into impalpable powder standby for Radix Angelicae Sinensis 260g;
(2) Semen Cuscutae 230g, Fructus Lycii 320g, Ramulus Cinnamomi 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Codonopsis 210g, Herba Epimedii 110g, Fructus Corni 160g, Herba Cistanches 180g, Radix Astragali 180g, Radix Morindae Officinalis 130g, Rhizoma Atractylodis Macrocephalae 160g, Rhizoma Cimicifugae 180g, Radix Glycyrrhizae 260g, Radix Bupleuri 230g, Radix Rehmanniae 160g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add starch 300g mixing, in the capsulae vacuus of packing into promptly.
Embodiment 3: Chinese medicine composition tablet of the present invention
(1) to be ground into impalpable powder standby for Radix Angelicae Sinensis 260g;
(2) Semen Cuscutae 230g, Fructus Lycii 320g, Ramulus Cinnamomi 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Codonopsis 210g, Herba Epimedii 110g, Fructus Corni 160g, Herba Cistanches 180g, Radix Astragali 180g, Radix Morindae Officinalis 130g, Rhizoma Atractylodis Macrocephalae 160g, Rhizoma Cimicifugae 180g, Radix Glycyrrhizae 260g, Radix Bupleuri 230g, Radix Rehmanniae 160g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add starch 300g, microcrystalline Cellulose 20g and carboxymethylstach sodium 20g are with 70% ethanol wet granulation, tabletting, coating are promptly.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of hypothyroidism is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:
Radix Codonopsis 15-25 part Herba Epimedii 5-15 part Semen Cuscutae 20-25 part
Fructus Corni 10-20 part Herba Cistanches 15-20 part Radix Angelicae Sinensis 20-30 part
Radix Astragali 15-20 part Fructus Lycii 25-35 part Radix Morindae Officinalis 10-15 part
10 20 parts of Rhizoma Cimicifugae 15-20 of Rhizoma Atractylodis Macrocephalae part Radix Glycyrrhizae 20-30 part
Radix Bupleuri 20-25 part Ramulus Cinnamomi 15-25 part Radix Rehmanniae 10-20 part.
2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:
23 parts of 11 parts of Semen Cuscutae of 21 parts of Herba Epimedii of Radix Codonopsis
26 parts of 18 parts of Radix Angelicae Sinensis of 16 parts of Herba Cistanchess of Fructus Corni
13 parts of 32 parts of Radix Morindae Officinaliss of 18 portions of Fructus Lyciis of the Radix Astragali
26 parts in 18 portions of Radix Glycyrrhizaes of 16 parts of Rhizoma Cimicifugaes of the Rhizoma Atractylodis Macrocephalae
16 parts in 21 parts of Radix Rehmanniae of 23 parts of Ramulus Cinnamomi of Radix Bupleuri.
3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.
4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:
(1) to be broken into impalpable powder standby for Radix Angelicae Sinensis powder;
(2) Semen Cuscutae, Fructus Lycii, Ramulus Cinnamomi are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Codonopsis, Herba Epimedii, Fructus Corni, Herba Cistanches, the Radix Astragali, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cimicifugae, Radix Glycyrrhizae, Radix Bupleuri, the Radix Rehmanniae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101116512A CN101288721A (en) | 2008-05-15 | 2008-05-15 | Chinese medicinal composition for treating hypothyroidism and its preparation method |
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| CNA2008101116512A CN101288721A (en) | 2008-05-15 | 2008-05-15 | Chinese medicinal composition for treating hypothyroidism and its preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210782A (en) * | 2011-06-02 | 2011-10-12 | 吴斌 | Compound traditional Chinese medicine for treating glucocorticoid dependence and application thereof |
| CN102119970B (en) * | 2010-01-08 | 2012-12-19 | 北京世纪博康医药科技有限公司 | Chinese medicinal composition for treating myasthenia gravis |
| CN103330907A (en) * | 2013-04-09 | 2013-10-02 | 许祖闪 | Hypothyroidism treatment traditional Chinese medicine composition |
| CN103705861A (en) * | 2014-01-06 | 2014-04-09 | 河南中医学院 | Traditional Chinese medicine for improving deficiency of qi and blood after thyroid cancer surgery |
| CN104587128A (en) * | 2015-01-31 | 2015-05-06 | 季新玲 | Pharmaceutical composition for treating hypothyroidism and application of pharmaceutical composition |
| CN106266945A (en) * | 2016-08-26 | 2017-01-04 | 山东大学齐鲁医院 | One treats hypothyroid Chinese medicine preparation |
-
2008
- 2008-05-15 CN CNA2008101116512A patent/CN101288721A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119970B (en) * | 2010-01-08 | 2012-12-19 | 北京世纪博康医药科技有限公司 | Chinese medicinal composition for treating myasthenia gravis |
| CN102210782A (en) * | 2011-06-02 | 2011-10-12 | 吴斌 | Compound traditional Chinese medicine for treating glucocorticoid dependence and application thereof |
| CN102210782B (en) * | 2011-06-02 | 2013-04-17 | 吴斌 | Compound traditional Chinese medicine for treating glucocorticoid dependence and application thereof |
| CN103330907A (en) * | 2013-04-09 | 2013-10-02 | 许祖闪 | Hypothyroidism treatment traditional Chinese medicine composition |
| CN103330907B (en) * | 2013-04-09 | 2014-08-13 | 许祖闪 | Hypothyroidism treatment traditional Chinese medicine composition |
| CN103705861A (en) * | 2014-01-06 | 2014-04-09 | 河南中医学院 | Traditional Chinese medicine for improving deficiency of qi and blood after thyroid cancer surgery |
| CN103705861B (en) * | 2014-01-06 | 2016-01-27 | 河南中医学院 | A kind of Chinese medicine improving the postoperative deficiency of qi and blood card of thyroid carcinoma |
| CN104587128A (en) * | 2015-01-31 | 2015-05-06 | 季新玲 | Pharmaceutical composition for treating hypothyroidism and application of pharmaceutical composition |
| CN106266945A (en) * | 2016-08-26 | 2017-01-04 | 山东大学齐鲁医院 | One treats hypothyroid Chinese medicine preparation |
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Open date: 20081022 |