CN101264278B - Chinese medicinal composition for treating leukemia and producing method thereof - Google Patents
Chinese medicinal composition for treating leukemia and producing method thereof Download PDFInfo
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- CN101264278B CN101264278B CN2008100443042A CN200810044304A CN101264278B CN 101264278 B CN101264278 B CN 101264278B CN 2008100443042 A CN2008100443042 A CN 2008100443042A CN 200810044304 A CN200810044304 A CN 200810044304A CN 101264278 B CN101264278 B CN 101264278B
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Abstract
The invention discloses a Chinese herbal medicine composition for curing leukaemia, which is characterized in that: the invention is prepared using the components with the following weight proportion: psoralea fruit 2 to 4, pilose antler 2 to 4, tortoise shell 2 to 4, prepared rhizome of rehmanniae 60 to 100, dioscorea opposite thunb 30 to 50, cornus officinalis 30 to 50, cortex mountan 13 to 17, poria cocos 13 to 17, Oriental Waterplantain Rhizome 13 to 17, cassia bark 8 to 12, amomum end 0.1 to 0.4. The Chinese herbal medicine composition has the advantages of few side effects, high therapeutic effects, low product price and 100% effective rate for disease course within a month.
Description
Technical field
The present invention relates to a kind of treatment leukemia medicament, leukemic Chinese medicine composition of especially a kind of treatment and production method thereof.
Background technology
Leukemia is to produce in bone marrow or other hemopoietic tissue and gather a large amount of naiveties and abnormal white cell is the malignant disease of feature.Be more common in child and young crowd, according to the interrelated data introduction, the whole world has more than 1,000 ten thousand patients at present, and China has the anxious bone marrow to be changed of 300,000 patients approximately.Present leukemic treatment mainly relies on chemotherapy, it is also more to treat leukemic medicine, common Western medicine has methotrexate, vincristine, cyclophosphamide, rubidomycin, cytosine arabinoside, tricuspid utmost point ester alkali, interferon etc., the said medicine toxic and side effects is big, as kill and wound, suppress the normal hematopoiesis cell, cause anemia, hemorrhage; Suppress normal immunologic function, body immunity is descended, cause concurrent infection easily, the stimulating gastrointestinal mucosa causes anorexia, feels sick, vomits, and also can influence hepatic and renal function, and increasing by the second tumor incidence rate, these drug doses are big more in addition, can not kill leukaemia in the body fully.Change the bone marrow treatment and cost an arm and a leg, generally want ten thousand yuan of 30-40, the patient is difficult to bear, Chinese medicine is because of showing good effect on leukemia treating, toxic action is low, and few side effects and paid close attention to by people number is 200410023562 disclosed by CH as Chinese patent application
3COOH, the Radix Astragali, the Amaranthusspinosus L. Lay, Radix Ginseng, wild Ganoderma, Rhizoma Curcumae, rhizoma sparganic, Spica Prunellae, NaOH, Hcl, the treatment leukemia medicament compositions that membrane of duck egg is formed has certain effect, but because on this sick pathogeny understanding deviation being arranged, effect has much room for improvement, in addition, Chinese traditional treatment at present mostly is symptomatic treatment, adopt the benefiting QI and nourishing blood method as anemia more, with the treatment of Radix Ginseng nutritious soup plus-minus, the hemorrhage heat-clearing and toxic substances removing that adopts more, the cooling blood for hemostasis treatment, as adding flavor with xijiao Dihuang Tang, the blood stasis stagnation of phlegm adopts the blood circulation promoting and blood stasis dispelling treatment more, and as adding flavor with Gexia Zhuyu Tang, these treatments all can not fundamentally be removed the cause of disease.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of toxic and side effects very little, the curative effect height, leukemic Chinese medicine composition of cheap treatment and production method thereof, purpose of the present invention realizes by following technical proposals.
The present invention is formulated by following component and weight ratio:
Fructus Psoraleae 2-4 Cornu Cervi Pantotrichum 2-4 Carapax et Plastrum Testudinis 2-4
Radix Rehmanniae Preparata 60-100 Rhizoma dioscoreae 30-50 Fructus Corni 30-50
Cortex Moutan 13-17 Poria 13-17 Rhizoma Alismatis 13-17
Cortex Cinnamomi 8-12 Fructus Amomi powder 0.1-0.4.
The present invention also can be formulated by following component and weight ratio:
Fructus Psoraleae 2.5-3.5 Cornu Cervi Pantotrichum 2.5-3.5 Carapax et Plastrum Testudinis 2.5-3.5
Radix Rehmanniae Preparata 70-90 Rhizoma dioscoreae 35-45 Fructus Corni 35-45
Cortex Moutan 14-16 Poria 14-16 Rhizoma Alismatis 14-16
Cortex Cinnamomi 8-10 Fructus Amomi powder 0.2-0.3.
The present invention also can be formulated by following component and weight ratio:
Fructus Psoraleae 3 Cornu Cervi Pantotrichums 3 Carapax et Plastrum Testudiniss 3 Radix Rehmanniaes Preparata 80
Rhizoma dioscoreae 40 Fructus Corni 40 Cortex Moutans 15 Poria 15
Rhizoma Alismatis 15 Cortex Cinnamomis 10 Fructus Amomi powder 0.2.
Manufacture method of the present invention is as follows:
1, Radix Rehmanniae Preparata nine is steamed nine and shine, mixes with Fructus Amomi powder for the first time, and spray a small amount of Chinese liquor (spilling wet get final product) back steaming, steamed behind the gas 20 minutes in the steaming again, taking-up was shone 1-4 hour in the sun, repeatedly after 8 times, 40-80 ℃ of dry for standby;
2, Carapax et Plastrum Testudinis is standby after with edible short system, oily temperature control 180 ℃ with interior be good, treating can be standby when its yellowing is frangible;
3, roguing, Cornu Cervi Pantotrichum peeling hair, Cortex Moutan is removed wooden part, the Poria peeling, the mountain cornel goes seed standby, and Fructus Psoraleae soaks the back stir-fry with Chinese liquor to be done standby;
4, above-mentioned each component is ground into the end, fineness is the 60-100 order, and packing gets final product, or grinds routinely above-mentioned each component into powder pharmaceutical methods altogether and make capsule, tablet or pill, and also pharmaceutical methods is made oral liquid routinely.
The present invention is applicable to treatment acute leukemia, chronic leukemia.
Usage: oral every day 3-4 time, if each 10-20g crude drug is for powder then steep the boiled water clothes, if tablet, capsule, pill are directly oral, if oral liquid then is as the criterion with the oral liquid measure that each 10-20g crude drug is made.
The present invention is through clinical use, and the effect of morbidity in one month is 100%, sees table 1 for details.
Side of the present invention separates: we add Cortex Cinnamomi with LIUWEI DIHUANG WAN or JINGUI SHENQI WAN subtracts Radix Aconiti Lateralis Preparata, add Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Fructus Psoraleae composition again, the treatment kidney yang deficiency, the leukemia that asthenic fire causes outward more is after square medicine changes, the indication that does not possess former side, this side holds concurrently with warming and recuperating the kidney-YANG based on conducting fire back to its origin, and kidney yang is vigorous, just can increase the hemopoietic function of bone marrow, because of kidney governing bones.Radix Rehmanniae Preparata nourishing kidney replenishing essence is main in the side, is aided with the Fructus Corni nourishing the liver and kidney and arresting seminal emission, Rhizoma Dioscoreae tonifying spleen-yin and controlling nocturnal emission with astringent drugs, three medicines share, and to reach the three cloudy also merits of benefit, join the light spleen that oozes of Poria again and wet, to help the strengthening the spleen of Rhizoma Dioscoreae, Rhizoma Alismatis lets out the kidney fire clearly, and the taste of anti-Radix Rehmanniae Preparata is greasy, Cortex Moutan is let out liver-fire clearly, and the temperature of FRUCTUS CORNI PREPARATA, is adjuvant altogether, each medicine share, and the energy enriching yin and nourishing kidney add Cortex Cinnamomi energy conducting fire back to its origin, make outer asthenic fire of getting over get back to the kidney gate of vitality, just can not generate heat, hemorrhage.Deer is the mountain beast, belongs to sun, and Cornu Cervi Pantotrichum is the angle of deer head, all YANG-meridians meeting into the head, and angle ratio head is also high, so kind energy YANG invigorating; Say in " herbal classic is met former " book: " Cornu Cervi is that governor vessel is sent out, and superintends and directs to be the outer wall of kidney, and outer wall was both solid, filled in the kidney qi, and the gate of vitality is fire mutually, unlikely rash action ".So with Cornu Cervi Pantotrichum in order to avoid asthenic fire continues more outer.Testudinis is the aquatic animal of living in the rock cave of sombre humidity, belong to cloudy, the direct kiss the earth of Carapax et Plastrum Testudinis, the sombre gas that absorbs the earth is the heaviest, it distinguishes the flavor of can kidney tonifying the moon, the matter Beijing South Maxpower Technology Co. Ltd floating sun of diving, head of Testudinis Chang Zangxiang abdomen can lead to conception vessel, so Carapax et Plastrum Testudinis is apt to the energy nourishing YIN for suppressing the hyperactive YANG.Cornu Cervi Pantotrichum gets Carapax et Plastrum Testudinis, is tonifying both YIN and YANG, is again the excellent method of YANG invigorating, and their equivalent loading just can not produce the yin or yang excess phenomenon that declines partially, and the efficacy exertion of Cornu Cervi Pantotrichum is got better, and Yin Yangde the moon helps and biochemical infinite.Fructus Psoraleae, hot, bitter, big temperature is gone into kidney channel, can kidney invigorating and YANG supporting." Kaibao Bencao " record: " control five kinds of strain and seven kinds of impairment, the wind cold caused by deficiency, the bone marrow wound loses ".Modern medicine study: Fructus Psoraleae can strengthen the hemopoietic function of bone marrow, illustrates how clever ancients are, just knows that before 900 years it can control " bone marrow hinder lose ".Fructus Psoraleae is also controlled frequent micturition, and the leukaemic is exactly that night urine is many, so add this medicine, suits the medicine to the illness the most, and all medicine compatibilities become conducting fire back to its origin altogether, and warming and recuperating the kidney-YANG rises the white agent of red drop.
The present invention be the inventor through clinical practice for many years and exploration, recognize that leukemia is a kidney yang deficiency, asthenic fire outward more due to, thereby warming and recuperating the kidney-YANG, conducting fire back to its origin is the key point for the treatment of leukemia, practice has also proved inventor's understanding correctness.Dialectical materialism is thought: " human process of cognition is inexhaustible, and anything all can be familiar with ".I believe in dialectical materialism.
The Ming Dynasty cures tame Zhang Jiebin and says: " day big treasured, a ball red sun thus much, the big treasured of people, thus much one expiration and inspiration kidney-Yang ".The importance of the corresponding and yang-energy in the people and the world has been described.
At nature, when rice, Semen Tritici aestivi heading flowering, sunny, will full grains, if meet a run of wet weather, lack sunlight, part or most granule are just not full, and a lot of two cereals are arranged, and also claim recessed shell, people's cases with leukemia and this similar phenomena, at human body,, cause kidney yang deficiency if the moon is contained very much, water wins very much, kidney governing bones, bone marrow has the effect of hemopoietic function, then erythrocyte that produces and hemoglobin with regard to corresponding minimizing, and leukocyte supernormal growth, therefore, leukemia is just answered the conducting fire back to its origin warming and recuperating the kidney-YANG.
Says in the Plain Questions of Huangdi's Internal Classic vital QI of the body connecting with natural QI opinion: " the yang-energy person, if day with day, lose it and then have the allotted portion of life reduced by having or getting more than one deserves and do not cite ".Point out the intravital yang-energy of people, important as day aerial sun, the importance of yang-energy has been described, so the leukaemic, in excess of YIN, the sum total that water wins causes kidney yang deficiency when its function can't normally be brought into play, fire will be got over outward mutually, become kidney fire and soar, that is asthenic fire, because of Zhang Jiebin says: " kidney extreme misery is 12 dirty change sources ".So asthenic fire can be gone to any position of body, goes to lower limb, lower limb just generate heat hot, go to head, head is heating just, goes to trunk, and trunk is heating just, goes to nasal cavity, causes epistaxis, go to gingiva, cause gingival hemorrhage, go to skin, cause subcutaneous purpura etc.
Asthenic fire outward more after, gate of vitality's fire mutually is not enough, the moisture of absorption can not normally fail cloth, and unbridled discharging from urine, so it is many to urinate.Zhang Jingyue is said: " gate of vitality's extreme misery, i.e. 12 dirty change sources, so taste rely it, the richness in Ji granary ".So taste will obtain the stifling of fire from the gater of life, the normal function that competence exertion is digested and assimilated, could produce QI and blood, existing asthenic fire is got over outward, and spleen and stomach function is affected, and QI and blood is difficult to give birth to, at this moment, doctor trained in Western medicine is checked: leukocyte is increased to 100,000-300,000, and erythrocyte, hematochrome and platelet all significantly reduce, and become leukemia.So leukemic pathogenesis is a kidney yang deficiency, asthenic fire is got over outward.Traditional medicine think leukemic heating, hemorrhage be the excessive noxious heat and the hepatic and renal YIN deficiency, I find that in clinical practice neither one is the excessive noxious heat and the hepatic and renal YIN deficiency, more do not have the blood stasis stagnation of phlegm.
The Tang Dynasty, big physician Wang Bing said: " the small person of husband's disease, still people's fire is also met grass and Ruo, wooden and burn, the volt that can wet can go out by water, so attack it against its property gas with discharging the retained water.Sick big very person, still imperial fire also must wet and flame, meets water and burns, and does not know its property, and with the wet discharging the retained water of water, the suitable flare that is enough to is called on day, and end the poor side of thing.Know its property person, the reason of abnormality, is then burnt and is burnt from disappearing by it with fire, and fireworks put out ".The theory of this " conducting fire back to its origin " has very high theory to be worth and realistic meaning, and the square medicine of my treating leukemia just matches with this theory, so can cure leukemia.
The specific embodiment
Embodiment 1, gets the raw materials ready by following component and weight
Fructus Psoraleae 300g Cornu Cervi Pantotrichum 300g Carapax et Plastrum Testudinis 300g
Radix Rehmanniae Preparata 8000g Rhizoma dioscoreae 4000g Fructus Corni 4000g
Cortex Moutan 1500g Poria 1500g Rhizoma Alismatis 1500g
Cortex Cinnamomi 1000g Fructus Amomi powder 20g.
Manufacture method of the present invention is as follows:
1, Radix Rehmanniae Preparata nine is steamed nine and shine, mixes with Fructus Amomi powder for the first time and spray a small amount of Chinese liquor (spilling wet get final product) back steaming, steamed behind the gas 20 minutes in the steaming again, taking-up was shone 1-4 hour in the sun, repeatedly after 8 times, 40-80 ℃ of dry for standby;
2, Carapax et Plastrum Testudinis is standby after with edible short system, oily temperature control 180 ℃ with interior be good, treating can be standby when its yellowing is frangible;
3, roguing, Cornu Cervi Pantotrichum peeling hair, Cortex Moutan is removed wooden part, the Poria peeling, the mountain cornel goes seed standby, and Fructus Psoraleae soaks the back stir-fry with Chinese liquor to be done standby;
4, above-mentioned each component is ground into the end, fineness is the 60-100 order, and packing gets final product, or grinds routinely above-mentioned each component into powder pharmaceutical methods altogether and make capsule, tablet, pill or oral liquid.Present embodiment selects for use branch encapsulated.
Embodiment 2, get the raw materials ready by following component and weight
Fructus Psoraleae 200g Cornu Cervi Pantotrichum 400g Carapax et Plastrum Testudinis 200g
Radix Rehmanniae Preparata 6000g Rhizoma dioscoreae 5000g Fructus Corni 3000g
Cortex Moutan 1700g Poria 1300g Rhizoma Alismatis 1700g
Cortex Cinnamomi 800g Fructus Amomi powder 10g.
Manufacture method is made into tablet with embodiment 1.
Embodiment 3, get the raw materials ready by following component and weight
Fructus Psoraleae 400g Cornu Cervi Pantotrichum 200g Carapax et Plastrum Testudinis 400g
Radix Rehmanniae Preparata 10000g Rhizoma dioscoreae 3000g Fructus Corni 5000g
Cortex Moutan 1300g Poria 1700g Rhizoma Alismatis 1300g
Cortex Cinnamomi 1200g Fructus Amomi powder 40g.
Manufacture method is made into pill with embodiment 1.
Embodiment 4, get the raw materials ready by following component and weight
Fructus Psoraleae 250g Cornu Cervi Pantotrichum 350g Carapax et Plastrum Testudinis 250g
Radix Rehmanniae Preparata 7000g Rhizoma dioscoreae 4500g Fructus Corni 2500g
Cortex Moutan 1600g Poria 1400g Rhizoma Alismatis 1600g
Cortex Cinnamomi 800g Fructus Amomi powder 20g.
Manufacture method is with embodiment 1.
Embodiment 5, get the raw materials ready by following component and weight
Fructus Psoraleae 350g Cornu Cervi Pantotrichum 250g Carapax et Plastrum Testudinis 350g
Radix Rehmanniae Preparata 9000g Rhizoma dioscoreae 3500g Fructus Corni 4500g
Cortex Moutan 1400g Poria 1600g Rhizoma Alismatis 1400g
Cortex Cinnamomi 1000g Fructus Amomi powder 30g.
Manufacture method is with embodiment 1.
Claims (4)
1. treat leukemic Chinese medicine composition for one kind, it is characterized in that by following component and weight ratio formulated:
Fructus Psoraleae 2-4 Cornu Cervi Pantotrichum 2-4 Carapax et Plastrum Testudinis 2-4
Radix Rehmanniae Preparata 60-100 Rhizoma dioscoreae 30-50 Fructus Corni 30-50
Cortex Moutan 13-17 Poria 13-17 Rhizoma Alismatis 13-17
Cortex Cinnamomi 8-12 Fructus Amomi powder 0.1-0.4.
2. the leukemic Chinese medicine composition of a kind of treatment according to claim 1 is characterized in that by following component and weight ratio formulated:
Fructus Psoraleae 2.5-3.5 Cornu Cervi Pantotrichum 2.5-3.5 Carapax et Plastrum Testudinis 2.5-3.5
Radix Rehmanniae Preparata 70-90 Rhizoma dioscoreae 35-45 Fructus Corni 35-45
Cortex Moutan 14-16 Poria 14-16 Rhizoma Alismatis 14-16
Cortex Cinnamomi 8-10 Fructus Amomi powder 0.2-0.3.
3. the leukemic Chinese medicine composition of a kind of treatment according to claim 1 is characterized in that by following component and weight ratio formulated:
Fructus Psoraleae 3 Cornu Cervi Pantotrichums 3 Carapax et Plastrum Testudiniss 3 Radix Rehmanniaes Preparata 80
Rhizoma dioscoreae 40 Fructus Corni 40 Cortex Moutans 15 Poria 15
Rhizoma Alismatis 15 Cortex Cinnamomis 10 Fructus Amomi powder 0.2.
4. the described a kind of production method for the treatment of leukemic Chinese medicine composition of claim 1 is characterized in that, follows these steps to carry out:
(1) Radix Rehmanniae Preparata nine is steamed nine and shine, mixes with Fructus Amomi powder for the first time, and steam after spraying a small amount of Chinese liquor, steamed behind the gas 20 minutes in the steaming again, taking-up was shone 1-4 hour in the sun, repeatedly after 8 times, 40-80 ℃ of dry for standby;
(2) with standby after the edible short system of Carapax et Plastrum Testudinis usefulness, oily temperature control is in 180 ℃, and treating can be standby when its yellowing is frangible;
(3) roguing, Cornu Cervi Pantotrichum peeling hair, Cortex Moutan is removed wooden part, the Poria peeling, the mountain cornel goes seed standby, and Fructus Psoraleae soaks the back stir-fry with Chinese liquor to be done standby;
(4) above-mentioned each component is ground into the end, fineness is the 60-100 order, and packing gets final product, or grinds routinely above-mentioned each component into powder pharmaceutical methods altogether and make capsule, tablet or pill, and also pharmaceutical methods is made oral liquid routinely.
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| CN2008100443042A CN101264278B (en) | 2008-04-24 | 2008-04-24 | Chinese medicinal composition for treating leukemia and producing method thereof |
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| CN2008100443042A CN101264278B (en) | 2008-04-24 | 2008-04-24 | Chinese medicinal composition for treating leukemia and producing method thereof |
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| CN101264278B true CN101264278B (en) | 2011-07-13 |
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| CN101797324B (en) * | 2010-02-24 | 2015-09-02 | 谷铭 | One treats leukemic pharmaceutical composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071582C (en) * | 1992-11-12 | 2001-09-26 | 伍德威股份公司 | Toothed-belt and v-belt means for treadmills |
| CN1260983C (en) * | 2003-06-24 | 2006-06-21 | 中兴通讯股份有限公司 | A method of disaster recovery for home location register (HLR) with zero-time service take-over |
| CN1297766C (en) * | 2000-10-12 | 2007-01-31 | Nok株式会社 | Magnetic fluid seal device |
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2008
- 2008-04-24 CN CN2008100443042A patent/CN101264278B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071582C (en) * | 1992-11-12 | 2001-09-26 | 伍德威股份公司 | Toothed-belt and v-belt means for treadmills |
| CN1297766C (en) * | 2000-10-12 | 2007-01-31 | Nok株式会社 | Magnetic fluid seal device |
| CN1260983C (en) * | 2003-06-24 | 2006-06-21 | 中兴通讯股份有限公司 | A method of disaster recovery for home location register (HLR) with zero-time service take-over |
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