CN101264239A - Externally-applied powdered Chinese medicine for treating chronic sinusitis and nasal polyps and preparation thereof - Google Patents

Abstract

The invention relates to a herbal powder for external application treating chronic sinusitis and nasal polyp and the preparation method; wherein, the primary drugs are magnolia quinquepeta xanthium power composed of xanthium and magnolia quinquepeta, and calyx melon powder composed of clove, small red bean, and bitter clove; the primary drugs have the therapeutic effects of wind-dispelling and dehumidification, stuffy nose relieving, heat-clearing and detoxifying, fester removing and detumescence, phlegm expelling and node dispelling; the secondary drugs are centipeda minima, luffa stem carbon, tulipa edulis, fructus mume carbon, lotus root joint carbon, dog skull carbon, borneol, and menthol; the herbal powder is made of the primary drugs and the secondary drugs through special processing. The herbal powder has the advantages: the herbal powder treats sinusitis and nasal polyp differentially according to the causes and achieves good therapeutic effect; the cure rate is 72.5%, and the total effective rate is 96.1%; the difficulty in curing chronic sinusitis and nasal polyp is broken.

Description

Treatment chronic sinusitis, polypous external Chinese powder medicine and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine for the treatment of sinusitis, specifically, it is a kind of treatment chronic sinusitis, polypous external Chinese powder medicine and preparation method thereof.

Background technology

Sinusitis and nasal polyp all are common chronic refractory diseases.The traditional Chinese medical science is thought: the generation of sinusitis is normal relevant with the diseases caused by exogenous pathogenic factor seasonal pathogen, its wind, cold, wet, all evil lungs of violating of heat, delay and do not go, nose loses that a surname is smooth, breath is come in and gone out and is obstructed and falls ill, or, lifting dereliction of duty strong, turbid damp because of the improper diet and overtiredness impairment of the spleen, deficiency-weakness of spleen-QI, fortune mistake be stranded spleen and evil poison stay for a long time do not remove, stop up resistance nose key arteries and veins arm, QI-blood circulation is not freely fallen ill.Modern medicine is thought: the generation of sinusitis is mainly infected by anaerobic bacillus(cillus anaerobicus) (70～80%) and antibacterial (20%), form myxedema, plumpness, polypoid change, cause hole mouth nasal meatus complex to block, secular bacteriotoxin, enzyme and Dou Kou block that partial pressure of carbon dioxide raises to the hole, partial pressure of oxygen descends and causes ciliary movement to descend, and nasal mucosa local mucous membrane function of immune system descends and falls ill.Nasal polyp is the long-term inflammation because of nasal cavity, nasal sinuses mucosa, causes inflammatory to change and the edema sample vegetation of formation.Therefore, both pathogenesis homophases.In prior art, the traditional Chinese medical science often with Flos Magnoliae Fructus Xanthii powder and Guadi San treatment rhinitis and sinusitis, obtains the curative effect of generally acknowledging in the boundary.But because sinusitis and nasal polyp are pertinacious diseases, traditional Flos Magnoliae Fructus Xanthii powder and Guadi San are difficult to reach the degree, particularly nasal polyp of healing, and the difficulty of healing is bigger, therefore, on traditional prescription basis, also treats in further exploration.

Summary of the invention

The purpose of this invention is to provide a kind of treatment chronic sinusitis of better efficacy, polypous external Chinese powder medicine and preparation method thereof, make its instant effect, cure rate height, relapse rate is low.

Chinese powder medicine of the present invention is made by following raw materials by weight proportions:

Fructus Xanthii 60～90 gram Flos Magnoliaes 60～90 gram Herba Centipedae 90～150 grams

Flos Caryophylli 70～100 gram Semen Phaseolis 250～300 gram Pedicellus Melo charcoals 150～200 grams

Ramulus Luffae charcoal 60～100 Keshan Rhizoma sagittariae sagittifoliaes 30～60 gram carbonized Fructus Mume 60～90 grams

Coupling joint charcoal 90～120 gram dog head bone black 90～120 gram Borneolum Syntheticums 30～60 grams

Mentholum 15～36 grams.

The step of above-mentioned Chinese powder medicine preparation method is as follows:

One, take by weighing Fructus Xanthii 60～90 grams, Flos Magnoliae 60～90 grams, Herba Centipedae 90～150 grams, soaked 7～10 days, pull out and dry in the shade, avoid and tan by the sun, be ground into fine powder with Oleum sesami, stand-by;

Two, take by weighing Semen Phaseoli 250～300 grams, fry to little Huang, be ground into fine powder with slow fire, stand-by;

Three, get an amount of Pedicellus Melo, Ramulus Luffae, Nodus Nelumbinis Rhizomatis respectively, fry respectively and withered and yellowly be ground into fine powder, take by weighing Pedicellus Melo charcoal 150～200 grams, Ramulus Luffae charcoal 60～100 grams and charred Nodus Nelumbinis Rhizomatis 90～120 grams of gained again to the coke color, stand-by;

Four, get an amount of Fructus Mume, to withered and yellow, avoid ironware, be ground into fine powder, take by weighing carbonized Fructus Mume 60～90 grams of gained with watt roasting, stand-by;

Five, get fresh Cranium Canitis, remove the meat on the clean Cranium Canitis, avoid washing, buried wetland shady place 7～14 days takes out the back outwash then, avoids washing, to withered and yellow, is ground into fine powder with old watt of roasting, takes by weighing dog head bone black 90～120 grams of gained, and is stand-by;

Six, take by weighing Pseudobulbus cremastrae seu pleiones 30～60 grams, vinegar is forged shortcake, is ground into fine powder, and is stand-by;

Seven, take by weighing Borneolum Syntheticum 30～60 grams, Mentholum 15～36 grams, Flos Caryophylli 70～100 grams, be ground into fine powder, stand-by;

Eight, with the fine powder mixing and stirring of above each step gained, seal with porcelain or glass drying oven.

This Chinese powder medicine is a principal agent with the Flos Magnoliae Fructus Xanthii powder be made up of Fructus Xanthii, Flos Magnoliae with by the Guadi San that Flos Caryophylli, Semen Phaseoli, Pedicellus Melo are formed, on the basis of their " wind dehumidifying, clearing the nasal passage, heat-clearing and toxic substances removing, the dense detumescence of row, expectorant powder junction loose " curative effects of performance, Herba Centipedae, Ramulus Luffae, Pseudobulbus cremastrae seu pleiones, Fructus Mume, Nodus Nelumbinis Rhizomatis, Cranium Canitis, Borneolum Syntheticum, the Mentholum of having selected to have unique curative effect again are accessory drugs, and make through the special process of preparing Chinese medicine.Wherein Herba Centipedae goes into lung, Liver Channel, and its property liter looses, on reach brains, cold, stuffy nose relieving gas dispels the wind, sharp nine orifices, the skin ulcer of loosing is swollen, and modern pharmacological research shows that it has inhibitory action to various bacillus, strengthen the dispersing wind and cold of principal agent, the effect of clearing the nasal passage with it, simultaneously, the polyp that looses of holding concurrently; The Ramulus Luffae promoting blood circulation to remove obstruction in the collateral cures mainly nasal obstruction, sinusitis with purulent discharge stream juice, strengthens principal agent clearing the nasal passage and mass-dissipating efficacy with it, simultaneously, and convergence nasal cavity sinusitis with purulent discharge flowmeter; Pseudobulbus cremastrae seu pleiones with vinegar calcining can softening the hard mass, promoting blood circulation to remove obstruction in the collateral, improve nasal mucosa surface microcirculation, strengthen the mass-dissipating efficacy of principal agent with its, thereby strengthen polypous therapeutical effect; Carbonized Fructus Mume contains multiple volatile oil, is the principal agent in the flat Nu, strengthens principal agent to polypous therapeutic efficiency with it; Charred Nodus Nelumbinis Rhizomatis can stop blooding, control the nasal sinusitis sinusitis with purulent discharge, calms down the wound surface of nasal cavity with its auxiliary principal agent, convergence nasal cavity sinusitis with purulent discharge stream juice; The dog head bone black can be changed polyp, and the dirt that disappears, and contain the multiple protein chemical compound has the restoration and protection effect to mucosa, strengthens principal agent polypous therapeutic efficiency is repaired the nasal cavity mucosa simultaneously with its; Borneolum Syntheticum, Mentholum are refrigerant, fragrant, clear away heart-fire, logical all keys, saturating network pain relieving, and mucomembranous surface is had the protection repair, strengthen the effect of above-mentioned medication with them.Particularly the carbonization to Pedicellus Melo, Ramulus Luffae, Fructus Mume, Nodus Nelumbinis Rhizomatis, Cranium Canitis is concocted in the side, can make them on the basis of the own former medicine effect of performance, increased the effect of hemostasis, wound repairing again, recovery and the cilium of having strengthened nasal cavity mucosal immunity function transfer, and this point plays an important role to improving cure rate.

This Chinese powder medicine is through inventor's clinical practice for many years, and from treating chronic sinusitis, nasal polyp patient totally 1265 examples between 1993～1996 olympiads altogether, its treatment situation and therapeutic outcome are summarized as follows:

One, clinical data

Treat 1265 examples altogether in the period of 1993～1,996 four, wherein male 572 examples, women 693 examples, at 8～74 years old age, the course of disease did not wait in 1～36 year, and all the patient all has nasal obstruction watery nasal discharge history, the dense tears of the 347 example yellow thickness of stream comprise resorption pus tears, and 996 examples are nasal obstruction obviously, 724 examples have headache, painful area is at most with the forehead, is followed successively by temples, top and occipitalia, and 186 examples have hyposmia or disappearance, 42 examples are with polyp, bilateral polyp 17 examples.

Two, diagnosis and efficacy assessment standard

1, diagnostic criteria

The standard of working out with reference to Society of Ophthalmology of China and Chinese hals,Nasen und Ohrenheilkunde magazine editorial board and hals,Nasen und Ohrenheilkunde diagnostics, and according to clinical symptoms performance is suitably revised and is replenished.The one, observe subjective symptom, as vexed the expanding of typical clinical symptom nasal obstruction, pus tears, headache of sinusitis, olfactory sensation descends, and medical history is no less than 10 months; The 2nd, objective determination middle nasal meatus, olfactory cleft or nasal cavity have purulent secretion; The 3rd, nasal sinuses X film making, CT examination shows the plump or sieve hole of hole mouth nasal meatus complex hypertrophy, sphenoid sinus inflammation or hydrops.Meet abovely at least two, promptly can be diagnosed as sinusitis.

2, criterion of therapeutical effect

The recovery from illness standard: subjective symptom and objective determination recover normal, nasal sinuses X film making, and it is normal that CT recovers substantially; The produce effects standard: subjective symptom and objective determination recover normal, and nasal sinuses X film making and CT do not recover normal: the improvement standard: subjective symptom and objective determination partly recover normally, and nasal sinuses X film making and CT examination do not recover normal; Invalid standard: subjective symptom and objective determination do not change.

Three, Therapeutic Method

Dip in this Chinese powder medicine external plug nose with cotton ball, once a day, continue about 3～5 hours, six days one courses of treatment.One course of treatment of chronic sinusitis the lighter wherein, 2～3 courses of treatment of heavy person; 3～5 courses of treatment of nasal polyp patient.Treat check in back a year, judge its curative effect.

Four, therapeutic outcome

Total treatment number	The recovery from illness number	The produce effects number	Good revolution	Invalid number
					1265 examples	917 examples	228 examples	72 examples	48 examples

Cure rate	Obvious effective rate	Improvement rate	Inefficiency	Total effective rate
					72.5％	18％	5.6％	3.9％	96.1％

Check after 1 year has only 38 example recurrences, and relapse rate is 3%, and nasal polyp is 14 examples in this 38 example, accounts for 36.8% of relapse rate.

This Chinese powder medicine at sinusitis and nasal polyp because of, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs has obtained above-mentioned good curative effect, this mainly has benefited from the process of preparing Chinese medicine of the definite and crude drug uniqueness of medication, has broken the difficulty that chronic sinusitis and nasal polyp are difficult to cure.

The specific embodiment

1, the weight proportion of crude drug of the present invention is as follows:

Fructus Xanthii 60～90 gram Flos Magnoliaes 60～90 gram Herba Centipedae 90～150 grams

Flos Caryophylli 70～100 gram Semen Phaseolis 250～300 gram Pedicellus Melo charcoals 150～200 grams

Ramulus Luffae charcoal 60～100 Keshan Rhizoma sagittariae sagittifoliaes 30～60 gram carbonized Fructus Mume 60～90 grams

Coupling joint charcoal 90～120 gram dog head bone black 90～120 gram Borneolum Syntheticums 30～60 grams

Mentholum 15～36 grams.

The weight proportion of above-mentioned raw materials medicine the best is as follows:

Fructus Xanthii 90 gram Flos Magnoliaes 90 gram Herba Centipedae 140 grams

Flos Caryophylli 90 gram Semen Phaseolis 270 gram Pedicellus Melo charcoals 180 grams

Ramulus Luffae charcoal 80 Keshan Rhizoma sagittariae sagittifoliaes 50 gram carbonized Fructus Mume 75 grams

Coupling joint charcoal 90 gram dog head bone black 100 gram Borneolum Syntheticums 50 grams

Mentholum 20 grams.

2, the preparation method of this Chinese powder medicine

According to the optimum weight proportioning of above-mentioned raw materials medicine, its preparation process is as follows:

(1), get Fructus Xanthii 90 gram, Flos Magnoliae 90 grams, Herba Centipedae 140 grams, soaked 7 days with Oleum sesami, pull out and dry in the shade, avoid and tan by the sun, be ground into fine powder, stand-by;

(2), get Semen Phaseoli 270 gram, fry to little Huang with slow fire, be ground into fine powder, stand-by;

Get an amount of Pedicellus Melo, Ramulus Luffae, Nodus Nelumbinis Rhizomatis, fry respectively and withered and yellowly be ground into fine powder, take by weighing Pedicellus Melo charcoal 180 grams, Ramulus Luffae charcoal 80 grams, charred Nodus Nelumbinis Rhizomatis 90 grams of gained again to the coke color (3), respectively, stand-by;

(4), get an amount of Fructus Mume,, avoid and use ironware to withered and yellow with watt roasting, be ground into fine powder, the carbonized Fructus Mume 75 that takes by weighing gained restrains, and is stand-by;

(5), get fresh Cranium Canitis, remove the meat on the clean Cranium Canitis, avoid washing, buried wetland shady place takes out the back outwash 7 days summers 14 days winters then, avoids washing, to withered and yellow, is ground into fine powder with old watt of roasting, the dog head bone black 100 that takes by weighing gained restrains, and is stand-by;

(6), take by weighing Pseudobulbus cremastrae seu pleiones 50 gram, forge shortcake with vinegar, be ground into fine powder, stand-by;

(7), take by weighing Borneolum Syntheticum 50 gram, Mentholum 20 grams, Flos Caryophylli 90 grams, be ground into fine powder respectively, stand-by;

(8), with the fine powder mixing and stirring of above each step gained, with porcelain or glass drying oven sealing.

Claims (2)

1, a kind of treatment chronic sinusitis, polypous external Chinese powder medicine is characterized in that it is made by following raw materials by weight proportions:

Fructus Xanthii 60～90 gram Flos Magnoliaes 60～90 gram Herba Centipedae 90～150 grams

Flos Caryophylli 70～100 gram Semen Phaseolis 250～300 gram Pedicellus Melo charcoals 150～200 grams

Ramulus Luffae charcoal 60～100 Keshan Rhizoma sagittariae sagittifoliaes 30～60 gram carbonized Fructus Mume 60～90 grams

Coupling joint charcoal 90～120 gram dog head bone black 90～120 gram Borneolum Syntheticums 30～60 grams

Mentholum 15～36 grams.

2, the preparation method of a kind of treatment chronic sinusitis according to claim 1, polypous external Chinese powder medicine, its step is as follows:

(1), take by weighing Fructus Xanthii 60～90 gram, Flos Magnoliae 60～90 grams, Herba Centipedae 90～150 grams, soaked 7～10 days with Oleum sesami, pull out and dry in the shade, avoid and tan by the sun, be ground into fine powder, stand-by;

(2), take by weighing Semen Phaseoli 250～300 gram, fry to little Huang with slow fire, be ground into fine powder, stand-by;

Get an amount of Pedicellus Melo, Ramulus Luffae, Nodus Nelumbinis Rhizomatis, fry respectively and withered and yellowly be ground into fine powder, take by weighing Pedicellus Melo charcoal 150～200 grams, Ramulus Luffae charcoal 60～100 grams and charred Nodus Nelumbinis Rhizomatis 90～120 grams of gained again to the coke color (3), respectively, stand-by;

(4), get an amount of Fructus Mume, to withered and yellow, avoid ironware with watt roasting, be ground into fine powder, take by weighing carbonized Fructus Mume 60～90 grams of gained, stand-by;

(5), get fresh Cranium Canitis, remove the meat on the clean Cranium Canitis, avoid washing, buried wetland shady place 7～14 days takes out the back outwash then, avoids washing, to withered and yellow, is ground into fine powder with old watt of roasting, the dog head bone black 90～120 that takes by weighing gained restrains, and is stand-by;

(6), take by weighing Pseudobulbus cremastrae seu pleiones 30～60 gram, vinegar is forged shortcake, is ground into fine powder, and is stand-by;

(7), take by weighing Borneolum Syntheticum 30～60 gram, Mentholum 15～36 grams, Flos Caryophylli 70～100 grams, be ground into fine powder, stand-by;

(8), with the fine powder mixing and stirring of above each step gained, with porcelain or glass drying oven sealing.