CN101259302B - Intelligent cranial nuclei electric stimulation system - Google Patents
Intelligent cranial nuclei electric stimulation system Download PDFInfo
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- CN101259302B CN101259302B CN2008100176751A CN200810017675A CN101259302B CN 101259302 B CN101259302 B CN 101259302B CN 2008100176751 A CN2008100176751 A CN 2008100176751A CN 200810017675 A CN200810017675 A CN 200810017675A CN 101259302 B CN101259302 B CN 101259302B
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Abstract
The invention relates to an electric stimulus system for an intelligent cranial nerve nuclei mass, which can be used for helping locate the implanted electrode by electrical signals of the feedback electrode peripheral nerve in the process of operation, generates a controllable electrical signal to stimulate a targeted nerve nuclei mass or records, transmits and analyzes the electrical signal of the targeted nerve nuclei mass after the operation so as to automatically adjust the stimulus signal sequence and monitor the change of intracranial pressure. The system is composed of three parts, comprising an implanted part, a radio frequency control part and a power pack in vitro; wherein, the implanted part is composed of six subunits, comprising a stimulus signal generation unit and an information processing unit, a radio frequency communication unit, an intracranial pressure monitoring unit, a neural signal acquisition unit, an electrode and sensor interface and a power supply unit; the radio frequency control unit is mainly composed of five subunits, comprising a radio frequency communication unit, a control unit, an input/output unit, an information processing and analyzing unit and a computer interface; the power pack in vitro mainly consists of two subunits, comprising a coil unit and a high frequency inverter circuit unit.
Description
Technical field
The present invention relates to a kind of novel medical embedded formula device that biomedical engineering field carries out brain deep nerve nucleus functional electric stimulation.Especially, it is a kind of location that helps implant electrode in the operation process by the perineural signal of telecommunication of feedback electrode that is applicable to, postoperative produces the stimulating electrical signal targeting nerve nucleus that can control, or the signal of telecommunication of record, transmission and analysis targeting nerve nucleus, automatically adjust the stimulus signal sequence, and the device of monitoring intracranial pressure variation.
Background technology
Cerebral dysfunction disease is brain kernel group or neural dysfunction and one group of clinical symptom grouping causing, and most patients become without structural disease.Mainly comprise various dyskinetic disorders, the cranial nerve syndrome, epilepsy, psychosis is disliked multiple diseases such as pain.
The onset reason difference of cerebral dysfunction disease, but Therapeutic Method is approximate.Use most often brain deep nerve nucleus electricity irritation at present, it is the effective and efficient manner of treatment cerebral dysfunction disease that grew up in nearly ten years.External designed and invented relevant device, and approval enters clinically, implemented nearly 20,000 example time implant surgeries, all obtained good curative effect.Domestic relevant patent and the report also do not seen, the at present complete dependence on import of such medical treatment device.
Through clinical investigation and experiment for many years, we find that brain depth stimulator as the alternative measure of damaging treatment, has clear superiority, but all many-sides still need to improve.For example:
(1) the brain depth stimulator system does not have the acquisition and recording function, can not implement the accurate location of nerve nucleus, affects the treatment; Lack reliable state of an illness data acquisition, curative effect assessment and feedback control system, can not be used for further investigation disease of brain.
(2) no monitoring intracranial pressure device can't be monitored the recovery situation of postoperative brain.
(3) adopt the disposable battery power supply, service time and intensity are subjected to the restriction of battery electric quantity.Can't select the high-frequency stimulus modelity of the big high voltage of power consumption for a long time, affect the treatment; And must the periodic replacement stimulating apparatus.
(4) stimulator (containing battery) volume is excessive, and the selection of operative site and the orientation problem in the operation process make that the corrective surgery wound surface is excessive, and foreign body sensation also causes secular psychological burden to the patient.
These all bring the unnecessary human body and spiritual misery and damage to the patient, cause the certain economic loss.
Summary of the invention
The object of the present invention is to provide a kind of intelligent cranial nuclei electric stimulation system, this system has the nerve information record, information analysis feedback, functions such as brain kernel group electricity irritation.It can provide the electrical stimulation signal of different frequency, voltage and pulsewidth; Can continue, dynamic acquisition and record electroneurographic signal, be used for the location and the information analysis of implant electrode; Can implement to monitor the variation of intracranial pressure, be used to monitor the recovery situation of postoperative brain; Adopt percutaneous electromagnetic coupling power supply mode, avoid being subjected to the restriction of battery electric quantity, reduced the volume of implant part.
Technical scheme of the present invention is achieved in that
A kind of intelligent cranial nuclei electric stimulation system is made up of implant part, radio frequency control section and external power pack; It is characterized in that, implant part be used for to the brain deep neural carry out that targeting stimulates and dynamically, continuous acquisition physiology and pathological information; The radio frequency control section is used for importing mode of operation into to implant part, the parameter of giving an order, and receive cranium pressure information and the electroneurographic signal that implant part is gathered; External power pack carries out power transfer by the power supply unit of percutaneous electromagnetic coupled and implant part; The distance of external power pack and implant part is no more than 1.5cm, and radio frequency control section and implant part are by the less radio-frequency exchange message;
Described implant part comprises stimulus signal generation and information process unit, the first radio-frequency communication unit, monitoring intracranial pressure unit, nerve signal collecting unit, electrode and sensor interface, first power supply unit, and supporting intracranial pressure sensor on supporting nerve nucleus stimulating electrode and the monitoring intracranial pressure unit on electrode and the sensor interface; The monitoring intracranial pressure unit is connected with electrode and sensor interface respectively with the nerve signal collecting unit, and electrode and sensor interface take place with stimulus signal and the A/D port of information process unit is connected, and be signal digitalized with what collect; Stimulus signal takes place and the A/D port of information process unit is connected with electrode and sensor interface, exports the stimulus signal sequence that produces to electrode; Stimulus signal generation and information process unit are connected with the first radio-frequency communication unit, and wherein first power supply unit receives the energy of external power pack transmission by the percutaneous electromagnetic coupled;
Described stimulus signal takes place and information process unit mainly is made up of single-chip microcomputer MSP430F169, and described radio-frequency communication unit adopts the nRF2401 communication module, and operating frequency is 2.4GHz; Described electrode and sensor interface select two four to select a multi-channel analog permutator, by the control of single-chip microcomputer MSP430F169, realize that counter electrode stimulates the selection in site; If what receive is stimulus parameter,, stimulate brain deep nerve nucleus by electrode and sensor interface then according to parameter generating stimulus signal sequence; If what receive is acquisition parameter,, transport to the radio frequency control section through A/D conversion back repeated transmission then by electrode and corresponding nerve nucleus information of sensor interface collection or intracranial pressure information;
When stimulus modelity, single-chip microcomputer MSP430F169 selects the width of frequency, voltage and the pulse of stimulation according to stimulus parameter, or selects the stimulation site of stimulating electrode, and making stimulates accurate positioning, and stimulus intensity is reasonable;
When drainage pattern, single-chip microcomputer MSP430F169 selects to gather intracranial pressure information or electroneurographic signal according to acquisition parameter;
When gathering intracranial pressure information, the monitoring intracranial pressure unit links to each other with the pressure transducer that is implanted in the skull medial surface, and pressure transducer is converted to the signal of telecommunication with intracranial pressure and exports the monitoring intracranial pressure unit to, through delivering to single-chip microcomputer MSP430F169 after the conversion;
When gathering nerve signal, single-chip microcomputer MSP430F169 will be according to parameter, select the corresponding electrode collection point, through delivering to single-chip microcomputer MSP430F169 after the filtering of nerve signal collecting unit, the amplification, single-chip microcomputer MSP430F169 transfers to the radio frequency control section with the information that collects by the first radio-frequency communication unit again, for its analyzing and processing;
Described radio frequency control section comprises control unit, the second radio-frequency communication unit, input-output unit, information analysis processing unit, computer interface and second power supply unit, wherein, described input-output unit adopts frequency, voltage and the pulsewidth parameter that directly setting or step-by-step movement search adjustment mode are regulated stimulus signal; The I/O mouth of control unit is connected with input-output unit, information analysis processing unit, the second radio-frequency communication unit respectively; The JTAG debug port of control unit is connected with computer interface;
Described external power pack comprises transmission coil, high-frequency inversion and the 3rd power supply unit, and wherein the 3rd power supply unit is connected with high-frequency inversion, and high-frequency inversion is connected with transmission coil by matching capacitance.
Frequency, voltage and pulsewidth parameter that described input-output unit adopts directly setting or step-by-step movement search adjustment mode to regulate stimulus signal.
The dutycycle of described high-frequency inversion generation frequency between 500kHz-1MHz is 50% square wave.
Described transmission coil adopts the coiling of sub-thread snail mode, and and matching capacitance formation oscillation circuit.
Described first power supply unit is made of receiving coil, rectification circuit and voltage-regulating circuit, and receiving coil is connected by matching capacitance with rectification circuit, and rectification circuit is connected with voltage-regulating circuit.
The receiving coil of described first power supply unit adopts multiply and forms oscillation circuit around the mode and the matching capacitance of snail.
The present invention is a kind of novel Wearable brain deep nerve nucleus stimulator.It is fit to cerebral dysfunction disease patient long periods of wear, and can carry out targeting to brain deep nerve nucleus stimulates, and can gather relevant physiological and pathological information dynamically, continuously, by the analyzing and processing to these information, realizes the feedback regulation to stimulus parameter.This system structure is novel, the function uniqueness, and its major technology characteristics are:
(1) can gather EEG signals, realize dynamical feedback adjusting the parameter that stimulates.System can dynamic, successive collection stimulation location nerve nucleus electrophysiology information, after the analyzing and processing, initiatively adjust the electrical stimulation signal parameter, reach the optimization of effect of stimulation.
(2) can detect the variation of intracranial pressure in real time, monitoring patient's recovery situation.
(3) realize the implant part of equipment and the percutaneous power transfer of outside energy supply part, guarantee the stable power-supplying of implant part.
(4) realize the implant part of equipment and the information transmission of external control part, guarantee implant part have good can be handling, the information that guarantees the implant part collection can intactly be transferred to control section and preserve.
(5) system has good bio-compatibility and excellent curative.
Description of drawings
Fig. 1 is a system structure sketch map of the present invention.
Fig. 2 is that sketch map is implanted in operation of the present invention.
Fig. 3 is an operating process of the present invention.
The present invention is described in further detail below in conjunction with accompanying drawing.
The specific embodiment
Shown in Figure 1, the present invention is made up of implant part 1, radio frequency control section 2 and 3 three parts of external power pack.Wherein implant part 1 comprises that stimulus signal takes place and information process unit 4, radio-frequency communication unit 5, intracranial pressure detecting unit 6, nerve signal collecting unit 7, electrode and sensor interface 8 and 9 six subelements formations of power supply unit; Radio frequency control section 2 mainly is made of control unit 10, radio-frequency communication unit 11, input-output unit 12 (containing liquid crystal display and selection key), information analysis processing unit 13, computer interface unit 14 and 15 6 subelements of power supply unit.Externally fed part 3 mainly is made of transmission coil 16, high-frequency inversion 17 and 18 3 subelements of power supply unit.
(1) the main composition and the function of implant part 1
Implant part 1 is a core to stimulate generation and information acquisition unit 4, and this unit mainly is made up of single-chip microcomputer MSP430F169.Radio-frequency communication unit 5 adopts the nRF2401 communication module, and operating frequency is 2.4GHz.Electrode and sensor interface 8 use two four to select a multi-channel analog permutator 4052, by the control of single-chip microcomputer MSP430F169, realize that counter electrode stimulates the selection in site.
Stimulate generation and information acquisition unit 4 input signal, obtain working status parameter from radio frequency control section 2, and select interlock circuit to realize its function by monitoring radio-frequency communication unit 5.If what receive is stimulus parameter,, stimulate brain deep nerve nucleus by electrode and sensor interface 8 then according to parameter generating stimulus signal sequence; If what receive is acquisition parameter, then gather corresponding nerve nucleus information or intracranial pressure information by electrode and sensor interface 8, transport to radio frequency control section 2 through A/D conversion back repeated transmission.
When stimulus modelity, single-chip microcomputer MSP430F169 can select the width of frequency, voltage and the pulse of stimulation according to stimulus parameter, can also select the stimulation site of stimulating electrode, make that the stimulation location is more accurate, stimulus intensity is more reasonable, reaches the purpose that improves therapeutic effect.
When drainage pattern, single-chip microcomputer MSP430F169 can select to gather intracranial pressure information or electroneurographic signal according to acquisition parameter.When gathering intracranial pressure information, monitoring intracranial pressure unit 6 links to each other with the pressure transducer that is implanted in the skull medial surface, and pressure transducer is converted to the signal of telecommunication with intracranial pressure and exports monitoring intracranial pressure unit 6 to, through delivering to single-chip microcomputer MSP430F169 after the conversion.When gathering nerve signal, single-chip microcomputer MSP430F169 will select the corresponding electrode collection point according to parameter, through delivering to MSP430F169 after 7 filtering of nerve signal collecting unit, the amplification.MSP430F169 transfers to radio frequency control section 2 with the information that collects by radio-frequency communication unit 5 again, for its analyzing and processing.
First power supply unit 9 is made up of secondary receiving coil, high-frequency rectification circuit and the voltage-regulating circuit of percutaneous energy transmission system.Secondary coil adopts multiply and increases the efficient of transmission around the mode of dull and stereotyped spiral, and constitutes the LC oscillating circuit with the electric capacity of coupling.High-frequency rectification circuit becomes DC voltage with the voltage commutation of change in oscillation; Voltage-regulating circuit is then according to the suitable voltage of the unitary power requirement output of implant part 1 all functions.
(2) the main composition and the function of radio frequency control section 2
Radio frequency control section 2 is a core with control unit 10, and this control unit 10 mainly is made up of single-chip microcomputer MSP430F149.Single-chip microcomputer MSP430F149 sets the whole system operation pattern by the input parameter that receives input-output unit 12.Information analysis processing unit 13 uses digital signal processor TMS320VC5503 as process chip.Computer interface 14 adopts the TUSB2036 chip as control chip.
When system is in the Information Monitoring pattern, control unit 10 by radio-frequency communication unit 11 to implant part 1 parameter of giving an order, relevant parameter when the classification of selection Information Monitoring and Information Monitoring, and receive the information that is collected by radio-frequency communication unit 11, deliver to the information analysis processing unit 13 in the control section or deliver to computer according to instruction then by computer interface 14.
When system was in manual stimulus modelity, control unit 10 read the stimulus parameter setting of input-output unit 12, controlled the parameter of the stimulus signal sequence of implant parts 1 by radio frequency output unit 11.Simultaneously, manual input mode can change the frequency or the voltage of stimulus signal according to different step values, with searchable suitable stimulus parameter.
When system is in automatic stimulus modelity, system will adopt the mode of time-sharing multiplex to stimulate or Information Monitoring.After control unit 10 is delivered to implant part 1 with running parameter, implant part will be gathered intracranial pressure and nerve information according to setting acquisition parameter, and with information feedback to radio frequency control section 2.Control unit 10 is wherein delivered to information analysis processing unit 13 with the information that collects, and through after the analysis of certain method, adjusts stimulus parameter, returns to implant part 1 again.After implant part 1 stimulates the regular hour according to new stimulus parameter, Information Monitoring once more.
Information analysis processing unit 13 mainly is made of DSP, the scientific and effective nonlinear analysis method of wherein integrated proof.By the information of input is analyzed and is handled, judge the type and the degree of patient's disease, select optimum stimulus parameter.
Input-output unit 12 mainly comprises LCDs and input button, and the interface and the method for man-machine interaction is provided, and has ensured visuality and accuracy that parameter is selected.
(3) the main composition and the function of externally fed part 3
Externally fed part 3 comprises that mainly transmission coil 16 and high-frequency inversion 17 constitute.High-frequency inversion 17 utilizes ZVT-pulse width modulated inverter technology, and improves the form of its transmission coil.PWM on-off control chip is selected the low-power consumption EDM Generator of Adjustable Duty Ratio pwm chip UCC3807-3 of TI company for use, and switching device is selected HF switch pipe IRFU220 for use, and the operating frequency of selection is between 500kHz-1MHz.
Simple transmission coil 16 adopts sub-thread snail pattern, and its area is big than secondary receiving coil, can effectively improve efficiency of transmission.Simple transmission coil and electric capacity coupling form the frequency of oscillation LC oscillation circuit identical with PWM on-off control working frequency of chip.
As shown in Figure 2, the position of the brain deep nuclei close together that the skull distance from top stimulated should be selected in the present invention position of implanting.With the targeting nerve nucleus of supporting nerve nucleus stimulating electrode 23 implantable stimulations of the present invention, intracranial pressure sensor 24 is implanted the skull medial surface, and is connected with the electrode and the sensor interface 8 of implant part 1,19 of the present invention.The transmission coil 16,20 of externally fed part 3 of the present invention is affixed on the coaxial placement of secondary receiving coil of the power supply unit 9 of the outside of head cortex of implant part and implant part 1,19; High-frequency inversion part 17,21 places the ear rear, connects by lead 22 and transmission coil 16,20.
As shown in Figure 3.After opening the switch of externally fed part 3, implant part 1 circuit start standby.Open radio frequency control section 2, behind the adjustment running parameter, by RF remote-controlled implant part 1 work.Can be as required by radio frequency control can part 2 be connected with computer by USB interface, gather the electroneurographic signal and the intracranial pressure signal that need, after using supporting software to write down, analyze and handle, pass the parameter of gained back the radio frequency control section, in order to regulate the stimulus signal sequence of implant part.
An embodiment of system.When using the acquired signal mode of operation, radio frequency control section 2 is transferred to implant part 1 with the signal type of collection and the parameters such as selection of electrode collection point by radio frequency 11, the electrode of implant part 1 and sensor interface 8 are selected the suitable corresponding signal of passage collection, and pass through 5 passbacks of radio-frequency communication unit and give radio frequency control section 2, radio frequency control section 2 can transfer to the signal that collects signal analysis and processing unit 13, or transfers to outer computer through computer interface 14.
Another embodiment of system.When use manually stimulates mode of operation, the parameters such as frequency, voltage and pulsewidth of stimulus signal must manually be set, the parameter when then using stimulated last time by input-output unit 12 as not being provided with.Radio frequency control section 2 transfers to implant part 1 with the parameter that sets, and implant part 1 carries out electricity irritation according to the parameter that obtains.When needs are selected stimulus parameter, can set the initial value and the step value of a certain parameter of selection, after then beginning to stimulate, selected stimulus parameter can change according to the step value of setting, when reaching preferably effect of stimulation, click and determine, can select the stimulus parameter of stimulus parameter this moment for giving tacit consent to.
Another embodiment of system.When use stimulated mode of operation automatically, implant part 1 at first began to gather intracranial pressure and electroneurographic signal (6,7,8), and transfer to radio frequency control section 2, through the analysis of wherein signal analysis and processing unit 13, with selected certain stimulus parameter, this parameter is transmitted back to implant part 1, implant part 1 is gathered intracranial pressure and electroneurographic signal (6,7 after stimulating the regular hour according to this parameter again, 8), and feed back to radio frequency control section 2.By such program, reached the purpose of automatic control stimulus signal sequence.
Claims (5)
1. an intelligent cranial nuclei electric stimulation system is made up of implant part (1), radio frequency control section (2) and external power pack (3); It is characterized in that, implant part (1) be used for to the brain deep neural carry out that targeting stimulates and dynamically, continuous acquisition physiology and pathological information; Radio frequency control section (2) is used for importing mode of operation into to implant part (1), the parameter of giving an order, and receive cranium pressure information and the electroneurographic signal that implant part (1) is gathered; External power pack (3) carries out power transfer by the power supply unit of percutaneous electromagnetic coupled and implant part (1); External power pack (3) is no more than 1.5cm with the distance of implant part (1), and radio frequency control section (2) and implant part (1) are by the less radio-frequency exchange message;
Described implant part (1) comprises that stimulus signal takes place and information process unit (4), the first radio-frequency communication unit (5), monitoring intracranial pressure unit (6), nerve signal collecting unit (7), electrode and sensor interface (8), first power supply unit (9), and electrode and sensor interface (8) are gone up supporting nerve nucleus stimulating electrode (23) and monitoring intracranial pressure unit (6) last supporting intracranial pressure sensor (24); Monitoring intracranial pressure unit (6) is connected with electrode and sensor interface (8) respectively with nerve signal collecting unit (7), electrode and sensor interface (8) take place with stimulus signal and the A/D port of information process unit (4) is connected, and be signal digitalized with what collect; Stimulus signal takes place and the A/D port of information process unit (4) is connected with electrode and sensor interface (8), exports the stimulus signal sequence that produces to electrode; Stimulus signal takes place and information process unit (4) is connected with the first radio-frequency communication unit (5), and wherein first power supply unit (9) receives the energy of external power pack (3) transmission by the percutaneous electromagnetic coupled;
Described stimulus signal takes place and information process unit (4) mainly is made up of single-chip microcomputer MSP430F169, and the described first radio-frequency communication unit (5) adopts the nRF2401 communication module, and operating frequency is 2.4GHz; Described electrode and sensor interface (8) select two four to select a multi-channel analog permutator, by the control of single-chip microcomputer MSP430F169, realize that counter electrode stimulates the selection in site; If what receive is stimulus parameter,, stimulate brain deep nerve nucleus by electrode and sensor interface (8) then according to parameter generating stimulus signal sequence; If what receive is acquisition parameter, then gather corresponding nerve nucleus information or intracranial pressure information by electrode and sensor interface (8), transport to radio frequency control section (2) through A/D conversion back repeated transmission;
When stimulus modelity, single-chip microcomputer MSP430F169 selects the width of frequency, voltage and the pulse of stimulation according to stimulus parameter, or selects the stimulation site of stimulating electrode, and making stimulates accurate positioning, and stimulus intensity is reasonable;
When drainage pattern, single-chip microcomputer MSP430F169 selects to gather intracranial pressure information or electroneurographic signal according to acquisition parameter;
When gathering intracranial pressure information, monitoring intracranial pressure unit (6) links to each other with the pressure transducer that is implanted in the skull medial surface (23), pressure transducer (23) is converted to the signal of telecommunication with intracranial pressure and exports monitoring intracranial pressure unit (6) to, through delivering to single-chip microcomputer MSP430F169 after the conversion;
When gathering nerve signal, single-chip microcomputer MSP430F169 will be according to parameter, select the corresponding electrode collection point, through delivering to single-chip microcomputer MSP430F169 after nerve signal collecting unit (7) filtering, the amplification, single-chip microcomputer MSP430F169 transfers to radio frequency control section (2) with the information that collects by the first radio-frequency communication unit (5) again, for its analyzing and processing;
Described radio frequency control section (2) comprises control unit (10), the second radio-frequency communication unit (11), input-output unit (12), information analysis processing unit (13), computer interface (14) and second power supply unit (15), wherein, described input-output unit (12) adopts frequency, voltage and the pulsewidth parameter that directly setting or step-by-step movement search adjustment mode are regulated stimulus signal; The I/O mouth of control unit (10) is connected with input-output unit (12), information analysis processing unit (13), the second radio-frequency communication unit (11) respectively; The USB interface of control unit (10) is connected with computer interface (14);
Described external power pack (3) comprises transmission coil (16), high-frequency inversion (17) and the 3rd power supply unit (18), wherein, the 3rd power supply unit (18) is connected with high-frequency inversion (17), and high-frequency inversion (17) is connected with transmission coil (16) by matching capacitance.
2. intelligent cranial nuclei electric stimulation system as claimed in claim 1 is characterized in that, the dutycycle of described high-frequency inversion (17) generation frequency between 500kHz-1MHz is 50% square wave.
3. intelligent cranial nuclei electric stimulation system as claimed in claim 1 is characterized in that, described transmission coil (16) adopts the coiling of sub-thread snail mode, and and matching capacitance formation oscillation circuit.
4. intelligent cranial nuclei electric stimulation system as claimed in claim 1, it is characterized in that, described first power supply unit (9) is made of receiving coil, rectification circuit and voltage-regulating circuit, and receiving coil is connected by matching capacitance with rectification circuit, and rectification circuit is connected with voltage-regulating circuit.
5. intelligent cranial nuclei electric stimulation system as claimed in claim 4 is characterized in that, the receiving coil of described first power supply unit (9) adopts multiply and forms oscillation circuit around the mode and the matching capacitance of snail.
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102107044B (en) * | 2010-12-28 | 2013-08-28 | 中国人民解放军第四军医大学唐都医院 | Remote regulation and control method for deep brain stimulator based on 3G (3rd generation) network |
| CN102871663A (en) * | 2012-09-24 | 2013-01-16 | 中山大学 | Physiologic signal collecting system for quadrumana |
| CN103041501B (en) * | 2012-11-09 | 2015-01-07 | 中国人民解放军第三军医大学第三附属医院 | Visual digital nucleus stimulation lesioning instrument |
| CN104623808B (en) * | 2013-11-14 | 2019-02-01 | 先健科技(深圳)有限公司 | Deep brain stimulation system |
| CN104622468B (en) * | 2013-11-14 | 2020-04-07 | 先健科技(深圳)有限公司 | Deep brain stimulation system with external prediction function |
| CN103691058B (en) * | 2013-12-10 | 2015-10-28 | 天津大学 | The deep brain stimulation FPGA experiment porch of parkinson disease basal nuclei-thalamus network |
| CN104013400A (en) * | 2014-05-30 | 2014-09-03 | 西安交通大学 | High-precision low-power-consumption multi-channel brain deep electroneurographic signal wireless collecting system |
| CN104225790B (en) * | 2014-09-19 | 2017-06-16 | 清华大学 | Closed loop neural stimulation system |
| CN107106834B (en) * | 2014-10-03 | 2021-06-11 | 波士顿科学医学有限公司 | Systems and methods for neurostimulation therapy |
| WO2016112401A1 (en) | 2015-01-09 | 2016-07-14 | Axonics Modulation Technologies, Inc. | Attachment devices and associated methods of use with a nerve stimulation charging device |
| CN105030206B (en) * | 2015-02-12 | 2018-12-28 | 中国科学院苏州生物医学工程技术研究所 | The system and method that a kind of pair of brain stimulation target spot is detected and positioned |
| CN104922794B (en) * | 2015-07-07 | 2018-02-02 | 北京品驰医疗设备有限公司 | A kind of position apparatus for evaluating of testing stimulus electrode |
| CN108937874A (en) * | 2017-05-24 | 2018-12-07 | 杭州普惠医疗器械有限公司 | A kind of multi-functional cranium brain monitor system |
| AU2018297323A1 (en) * | 2017-07-07 | 2020-02-20 | The Regents Of The University Of California | Method and system for altering body mass composition using galvanic vestibular stimulation |
| CN110433394B (en) * | 2019-07-17 | 2024-05-10 | 杭州承诺医疗科技有限公司 | Deep brain targeting electric stimulation system based on multichannel independent current trap |
| CN111436923B (en) * | 2020-03-27 | 2022-05-20 | 武汉联影智融医疗科技有限公司 | Puncture path determination device, surgical navigation system, surgical navigation apparatus, and storage medium |
| WO2021223702A1 (en) * | 2020-05-07 | 2021-11-11 | 博睿康科技（常州）股份有限公司 | Cranial nerve regulator |
| CN112603536A (en) * | 2020-12-29 | 2021-04-06 | 北京华科恒生医疗科技有限公司 | Method and system for generating electrode thermal coagulation parameters in three-dimensional model |
| CN116440408B (en) * | 2023-03-17 | 2024-01-09 | 上海杉翎医疗科技有限公司 | Implantable stimulation systems, methods, implantable devices, and storage media |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3757770A (en) * | 1971-02-22 | 1973-09-11 | Bio Tel Western | Physiological pressure sensing and telemetry means employing a diode connected transistor transducer |
| CN1593683A (en) * | 2004-07-09 | 2005-03-16 | 天津大学 | Rechargeable stimulator for deep parts of brain |
-
2008
- 2008-03-10 CN CN2008100176751A patent/CN101259302B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3757770A (en) * | 1971-02-22 | 1973-09-11 | Bio Tel Western | Physiological pressure sensing and telemetry means employing a diode connected transistor transducer |
| CN1593683A (en) * | 2004-07-09 | 2005-03-16 | 天津大学 | Rechargeable stimulator for deep parts of brain |
Non-Patent Citations (1)
| Title |
|---|
| 唐晓琪,Vivian Tang.两项值得期待的短距离技术——RF遥控器和无线充电.http://www.eet-china.com/ARTP_8800499579_617687.HTM.2008,1-3. * |
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