CN104013400A - High-precision low-power-consumption multi-channel brain deep electroneurographic signal wireless collecting system - Google Patents
High-precision low-power-consumption multi-channel brain deep electroneurographic signal wireless collecting system Download PDFInfo
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Abstract
A high-precision low-power-consumption multi-channel brain deep electroneurographic signal wireless collecting system comprises eight-channel brain deep cerebral nuclei electric signal collecting electrodes, any collecting electrode is selected freely by an analog multiway switch to collect brain deep cerebral nuclei electric signals, collected analog signals are directly input into an AD collecting module for preprocessing and A/D conversion, and converted data are stored in a data storage module through an MCU. After data are collected for certain time, the stored data are transmitted to the other MCU through a sending RF wireless transmission module and a receiving RF wireless transmission module, and then the data are transmitted into an upper computer to be displayed and further processed through an USB interface. The brain deep cerebral nuclei electric signals are collected, and an effective cerebral nuclei signal collecting tool is provided for exploring the therapeutic mechanism and action principle of a DBS, and the pathogenesis of the Parkinson's disease, an essential tremor and a series of neurological diseases.
Description
Technical field
The present invention relates to biomedical engineering technology field, particularly a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system.
Background technology
Deep brain stimulation (Deep Brain Stimulation, DBS) be a kind of effectively neuromodulation technology, mainly by implanting micro-brain electrode in specific region, brain deep, produce the stimulus sequence with certain parameter by embedding pulse generator in vivo, change local neuron's flash-over characteristic and alleviate and treat disease.DBS directly changes the activity of brain part with a kind of controlled manner, control symptom that can be permanently effective, and do not cause permanent destruction, and be reversible Therapeutic Method, be also the neurosurgery method of unique permission camera bellows research.At present, DBS is mainly used in treating parkinson disease (Parkinson's Disease, PD) affective disorders such as movement disorder and the depression disease that, chronic pain, essential tremor (Essential Tremor, ET) and myodystonia (Dystonia) etc. cause.According to statistics, these diseases are endangering health, quality of life and even the life of the whole world 5.6 hundred million populations.
Although DBS is more and more extensive in clinical practice, its ultimate principle and mechanism of action are still unclear.DBS affects the electrode cerebral tissue of 2-3mm scope around conventionally, electricity irritation can make peripheral nerve unit and fiber depolarization and activate, also process of depolarization capable of blocking and inactivation, the mechanism of action complexity of this cellular level, may cause that different clinical effectiveness appears in the stimulation of same target spot.The effect that experiment showed, electricity irritation also depends on many factors, comprise basic electrical activity frequency, with distance and the stimulus parameter of stimulating electrode, neuronic form and pericaryon and fiber reacting stimulation.
Therefore, if can collect the neural discharge signal of related neural core group before, during and after DBS, the similarities and differences of contrast electric discharge, so for treatment mechanism and the action principle of exploring DBS, the range of application of expanding DBS has great experiment and clinical effect.In addition, this has important directive significance for exploring such as the pathogenesis of a series of neural class diseases such as parkinson disease, essential tremor.
Although disclosed brain wave acquisition device can gather the faint signal of brain this class of electricity in CN102512109, CN103519807, CN201220428883 and CN201210308665, but for the nerve nucleus signal of telecommunication in brain, the feature of its electric discharge and this class signal of brain electricity have very large difference.Not only amplitude is faint for nerve nucleus discharge signal in brain, and discharge frequency is fast, if want to collect such signal, sample frequency must be more than 2000Hz, and brain wave acquisition frequency is generally hundreds of hertz, and this is and the maximum difference of eeg signal acquisition.Therefore, these disclosed brain wave acquisition devices are not suitable for the collection of brain deep nerve core group discharge signal.In addition, the power consumption of these products and volume are all very large, be not easy to carry and move, and above product is substantially all that the AD conversion chip based on 12 or 24 gathers, due to the precision reason of chip itself, latter several of AD conversion chip is incredible, does not reach desirable required precision.Therefore, in the urgent need to one conversion high accuracy, low-power consumption, little, the portable brain deep nerve of volume core group acquisition system.
Summary of the invention
In order to overcome the defect of above-mentioned prior art, the object of the invention is the collection for the brain deep nerve core group signal of telecommunication, a kind of high-precision low-power consumption wireless transmission brain deep field potential signal picker is provided, for exploring treatment mechanism and the action principle of DBS, and provide effective nerve nucleus signals collecting instrument such as the pathogenesis of a series of neural class diseases such as parkinson disease, essential tremor.
In order to achieve the above object, technical scheme of the present invention is:
A kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system, comprise the acquisition electrode of the 8 passage brain deep nerve core group signals of telecommunication, variable connector, AD acquisition module, data memory module, RF wireless radiofrequency transport module, Liquid Crystal Module, key control module, two Micro-processor MCVs, usb circuit and host computer, analog multichannel switch is selected any one acquisition electrode, brain deep nerve core group discharge signal is gathered, the analogue signal gathering is directly inputted to carries out pretreatment and A/D conversion in AD acquisition module, data after conversion are stored in data memory module by MCU, when gathering after certain hour data, the data of storage are transferred in another one MCU by two RF wireless radiofrequency transport modules of sending and receiving, then by USB interface, transfer of data is shown and further processed in host computer.
Described variable connector adopts 8 tunnels analogy switch chip CD4051 of TI company, and passage switch speed is less than 0.2ms, can select quickly and easily arbitrary acquisition channel to carry out data acquisition.
Described Micro-processor MCV adopts the MSP430F1611 single-chip microcomputer of TI company, it not only has abundant peripheral chip for easy to use, volume is little, the RAM internal storage space of larger 10KB, and the more important thing is the time that its low-power consumption prolongation system is greatly moved.
Described data memory module adopts SD card, SD jig has the features such as cost is low, volume is little, memory space is large, the long-time data that gather of system can be stored in SD card temporarily, the data packing that system can be stored in SD card in the time reaching certain data volume sends to host computer, so that the work efficiency of MCU to be provided.
Described key control module, its major function is the startup of control system and closes, and selects corresponding acquisition channel, starts data acquisition.
Described Liquid Crystal Module, adopts LCD12864 LCDs, shows the selected passage ID while collection, sample frequency, and sample states, in the sampling time, the parameters such as data transmission state, are convenient to user the acquisition state in experimentation are monitored and checked.
Described AD acquisition module adopts the ADS1282 of TI company, it is built-in with bioelectrical signals pre-process circuit, this chip is the high accurate A/D conversion chip of 32, that TI company develops for measuring the faint physiological signals such as brain electricity, electrocardio specially, there is high conversion accuracy, least significant bit can reach below uV rank, what is more important ADS1282 chip internal is provided with filtering and amplifying circuit and programmable amplifier, so just not be used in circuit and design independently signal amplification circuit filter, can greatly simplify the design of circuit.In addition, because brain deep nerve core group discharge signal is very faint, discharge frequency is fast, and background noise is strong, and in order to guarantee to collect the field potential of nerve nucleus in complete brain or the spike potential of cell electric discharge, ADS1282 sample frequency is set to 2000Hz.The RAM that considers MCU is 10KB, and in the time that sample frequency is 2000Hz, system at every turn can continuous sampling 500ms, i.e. the data of 4KB, after these data are stored in SD, can proceed again image data.
Described RF radio frequency transmission module adopts the CC2500 chip of TI company, it is a super low-power consumption, radio receiving transmitting module cheaply, be operated in open ISM (industry, science, the medical science) frequency range in the 2.4GHZ whole world, meet multichannel communication and frequency hopping communications needs, maximum transmission rate reaches 500Kb/s, operational voltage level and MSP430 compatibility, peripheral chip is few, is a low cost, low-power consumption, volume radio frequency chip little and easy to use.The data of system storage in SD card, MCU is shown and further processes with wireless way for transmitting by CC2500 in host computer.
Described usb circuit adopts the TUSB3410 of TI company, and it meets general-purpose serial bus USB 2.0 specifications, supports the data rate of 12Mb/s, is a high performance USB interface device.
Described Micro-processor MCV is coordinated to control to each circuit module, two system core parts of CC2500 that the chip MSP430F1611 single-chip microcomputer that MCU adopts and RF radio frequency transmission module adopt are the low-power chip of TI company, have ensured the low-power consumption of entire system.In addition, the chip integration using is all very high, has greatly reduced the volume of system, therefore, the system that the present invention develops have volume little, be easy to carry, a series of features such as the low and low-power consumption of cost.
One aspect of the present invention adopts high-precision 32 AD conversion chips, sample frequency is 2000Hz, ensure effectively to collect nerve nucleus discharge signal, adopt on the other hand CC2500 radio frequency communication module, the data that gather can be transferred to host computer by wireless transmission method, are convenient to the movement of equipment.Acp chip that this system adopts is all the low-power chip of TI company, and integrated level is high, and cost is low, ensures in the situation of entire system low-power consumption, has reduced R&D costs and has greatly dwindled the volume of system.The present invention is treatment mechanism and the action principle of exploring DBS, and provides effective nerve nucleus signals collecting instrument such as the pathogenesis of a series of neural class diseases such as parkinson disease, essential tremor, has important experimentation and is worth.
Advantage of the present invention is:
1, the designed nerve nucleus discharge signal acquisition system of the present invention have the high and low power consumption of precision, wireless data transmission, multichannel, volume little, be easy to carry and a series of features such as mobile and simple to operate.
2, high accurate A/D acquisition module of the present invention adopts the ADS1282 of TI company, this chip is the high accurate A/D conversion chip of 32, there is high conversion accuracy, least significant bit can reach below uV rank, what is more important ADS1282 chip internal is provided with filtering and amplifying circuit and programmable amplifier, so just not be used in circuit and design independently signal amplification circuit filter, can greatly simplify the design of circuit.
3, the present invention has nerve nucleus signal sampling channel in 8 brains, by analog multichannel switch CD4051, can facilitate and freely select arbitrary passage to carry out data acquisition.
4, transfer of data of the present invention adopts RF wireless radiofrequency transmission means, and when wireless transmission method can be eliminated wire transmission, equipment is not easy to mobile limitation, is convenient to the operation and controlling of equipment; And RF wireless radiofrequency transport module adopts the CC2500 chip of TI company, operational voltage level and MSP430 compatibility, peripheral chip is few, is a low cost, low-power consumption, volume radio frequency chip little and easy to use.
5, in view of the feature of nerve nucleus discharge signal in brain, the frequency acquisition of native system is set as 2000Hz, adopts high-speed data acquisition, can ensure to collect neural field current potential in faint brain.System at every turn can continuous sampling 500ms, i.e. the data of 4KB, and after these data are stored in SD, system is proceeded the continuous acquisition of data, can improve like this work efficiency of system CPU, ensures the long enough continuous sampling time.
6, LCD MODULE of the present invention adopts LCD12864 LCDs, can show the selected passage ID while collection, sample frequency, sample states, in the sampling time, the parameters such as data transmission state, are convenient to user the acquisition state in experimentation are monitored and checked.
Brief description of the drawings
Fig. 1 is electrical block diagram of the present invention.
Fig. 2 is software flow pattern of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in detail.
As shown in Figure 1, a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system, comprise the acquisition electrode of the 8 passage brain deep nerve core group signals of telecommunication, variable connector, AD acquisition module (built-in biological signal of telecommunication preprocessed signal), data memory module, RF wireless radiofrequency transport module, Liquid Crystal Module, key control module, two Micro-processor MCVs, usb circuit and host computer, analog multichannel switch is selected any one acquisition electrode, brain deep nerve core group discharge signal is gathered, the analogue signal gathering is directly inputted to carries out pretreatment and A/D conversion in AD acquisition module, data after conversion are stored in data memory module by MCU, when gathering after certain hour data, the data of storage are transferred in another one MCU by two RF wireless radiofrequency transport modules of sending and receiving, then by USB interface, transfer of data is shown and further processed in host computer.
Described analog multichannel switch adopts 8 tunnels analogy switch chip CD4051 of TI company, and running voltage adopts 3.3V, and passage switch speed is less than 0.2ms, can carry out fast the switching of passage.
Described MCU adopts the MSP430F1611 single-chip microcomputer of TI company, it not only has abundant peripheral chip for easy to use, volume is little, the RAM internal storage space of larger 10KB, and the more important thing is the time that its low-power consumption prolongation system is greatly moved.Supply voltage is 3.3V, adopts SPI communication mode and wireless radio frequency modules and SD to stick into Serial Communication.
Described data memory module adopts SD card, SD jig has the features such as cost is low, volume is little, memory space is large, the long-time data that gather of system can be stored in SD card temporarily, the data packing that system can be stored in SD card in the time reaching certain data volume sends to host computer, so that the work efficiency of MCU to be provided.The SD card parameter that system adopts is:
SD card model: KingSton Micro SD;
Internal memory: 16G;
With microcontroller communication pattern: SPI synchronous serial communication pattern;
The file system adopting: FAT32;
Running voltage: 3.3V;
Work clock: consistent with the clock of single-chip microcomputer;
Message transmission rate: can reach 1MB/s;
Described key control module, its major function is the startup of control system and closes, and selects corresponding acquisition channel, starts data acquisition.
Described LCD MODULE, adopts LCD12864 LCDs, shows the selected passage ID while collection, sample frequency, sample states, sampling time, the parameters such as data transmission state.
Described high accurate A/D acquisition module adopts the ADS1282 of TI company.This chip is the high accurate A/D conversion chip of 32, that TI company develops for measuring the faint physiological signals such as brain electricity, electrocardio specially, there is high conversion accuracy, least significant bit can reach below uV rank, what is more important ADS1282 chip internal is provided with filtering and amplifying circuit and programmable amplifier, so just not be used in circuit and design independently signal amplification circuit filter, can greatly simplify the design of circuit.Running parameter is set to:
Running voltage: 3.3V;
Sample frequency: 2000Hz;
Sampling precision: 32;
Signal to noise ratio: more than 100db;
Inside arranges gain: 1000 times;
Inside arranges passband frequency range: 100Hz-10kHz.
Described RF wireless radiofrequency transport module adopts the CC2500 chip of TI company, it is a super low-power consumption, radio receiving transmitting module cheaply, be operated in open ISM (industry, science, the medical science) frequency range in the 2.4GHZ whole world, meet multichannel communication and frequency hopping communications needs.Maximum transmission rate reaches 500Kb/s, operational voltage level and MSP430 compatibility, and peripheral chip is few, is a low cost, low-power consumption, volume radio frequency chip little and easy to use.The data of system storage in SD card, MCU is shown and further processes with wireless way for transmitting by CC2500 in host computer.Specific works parameter is:
Running voltage: 3.3V;
Working frequency range: 2.4GHz;
Transfer rate: 400Kb/s;
The CC2500 of transmitting terminal is set to sending mode; Receiving terminal CC2500 is set to receptive pattern;
Described usb circuit adopts the TUSB3410 of TI company, and it meets general-purpose serial bus USB 2.0 specifications, supports the data rate of 12Mb/s, is a high performance USB interface device.
Microprocessor MSP430F1611 single-chip microcomputer and two system core parts of radio-frequency (RF) receiving and transmission module CC2500 that each described circuit module is coordinated to control are all the low-power chip of TI company, and this has ensured the low-power consumption of entire system.In addition, the chip integration using is all very high, has greatly reduced the volume of system, therefore, the system that the present invention develops have volume little, be easy to carry, a series of features such as the low and low-power consumption of cost.
Operation principle of the present invention is: select arbitrary acquisition electrode by variable connector, the brain deep nerve core group discharge signal gathering is input in the conversion chip of high-precision AD acquisition module, in conversion chip, carry out the filter and amplification pretreatment of signal, then carry out high precision analogue conversion, after the data of every collection 500ms, data are stored in SD card, if the storage of SD card is full, so just carry out the wireless transmission of data by CC2500 radio frequency chip, and be transferred in host computer and show and further processing by receiving terminal MCU.
As shown in Figure 2, be software flow pattern of the present invention, further illustrate data flow of the present invention and operating process with this.After system start-up, first transmitting terminal and receiving terminal MCU initialize, then be initialization and the configuration of related peripheral chip, mainly comprise the initialization of analog multichannel switch CD4051 and LCDs LCD12864, the initialization of high accurate A/D acquisition module ADS1282 and relevant parameter configuration, it is sending mode that transmitting terminal wireless radio frequency transmission module CC2500 initializes and arrange its pattern, it is receptive pattern that receiving terminal transmitting terminal wireless radio frequency transmission module CC2500 initializes and arrange its pattern, and the initialization of USB interface chip TUSB3410.Now, select by the button in system, can select any passage in 8 acquisition channels to carry out data acquisition, when pressing after " starting to gather " key, system can be carried out the detection of power loss of passage, if selected passage power down detected, will in LCDs, demonstrate so the channel number of power down, until acquisition channel signal is good.
If sampling channel conducting, system will be carried out automatic signals collecting so.Now, on LCDs LCD12864, can show the information such as passage ID, acquisition state, sample frequency of current selection.The every sampling of system 500ms, i.e. the data of 4Kb, will be these compression storing data in SD card, if now detect that SD card also has enough spaces to store the data of next 4KB, system can be carried out the data acquisition of continuous 500ms again so.After SD storage reaches certain amount, system will be sent to the data in SD card in host computer by receiving terminal MCU by wireless radio frequency mode.Now, whether system can detect CC2500 communication good, if there is mistake, now in LCDs, can show corresponding prompting mistake.If wireless telecommunications are good, transmitting terminal MCU is sent to receiving terminal MCU by transmitting terminal CC2500 and receiving terminal CC2500 so, and now receiving terminal MCU is preserved transfer of data and show by usb circuit in host computer.Now, if the not manually operation of halt system, system can be proceeded the collection of data so.
Claims (9)
1. a high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system, it is characterized in that, comprise the acquisition electrode of the 8 passage brain deep nerve core group signals of telecommunication, variable connector, AD acquisition module, data memory module, RF wireless radiofrequency transport module, Liquid Crystal Module, key control module, two Micro-processor MCVs, usb circuit and host computer, analog multichannel switch is selected any one acquisition electrode, brain deep nerve core group discharge signal is gathered, the analogue signal gathering is directly inputted to carries out pretreatment and A/D conversion in AD acquisition module, data after conversion are stored in data memory module by MCU, when gathering after certain hour data, the data of storage are transferred in another one MCU by two RF wireless radiofrequency transport modules of sending and receiving, then by USB interface, transfer of data is shown and further processed in host computer.
2. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, it is characterized in that, described variable connector adopts 8 tunnels analogy switch chip CD4051 of TI company, passage switch speed is less than 0.2ms, selects arbitrary acquisition channel to carry out data acquisition.
3. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, is characterized in that, described Micro-processor MCV adopts the MSP430F1611 single-chip microcomputer of TI company.
4. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, is characterized in that, described data memory module adopts SD card.
5. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, it is characterized in that, described key control module, its major function is the startup of control system and closes, select corresponding acquisition channel, start data acquisition.
6. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, it is characterized in that, described Liquid Crystal Module, adopt LCD12864 LCDs, show the selected passage ID while collection, sample frequency, sample states, sampling time, the parameters such as data transmission state.
7. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, it is characterized in that, described AD acquisition module adopts the ADS1282 of TI company, it is built-in with bioelectrical signals pre-process circuit, and this chip is the high accurate A/D conversion chip of 32, and ADS1282 sample frequency is set to 2000Hz, system at every turn can continuous sampling 500ms, be the data of 4KB, after these data are stored in SD, can proceed again image data.
8. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, it is characterized in that, described RF radio frequency transmission module adopts the CC2500 chip of TI company, the data of system storage in SD card, MCU is shown and further processes with wireless way for transmitting by CC2500 in host computer.
9. a kind of high-precision low-power consumption multichannel brain deep nerve signal of telecommunication wireless acquisition system according to claim 1, it is characterized in that, described usb circuit adopts the TUSB3410 of TI company, it meets general-purpose serial bus USB 2.0 specifications, the data rate of supporting 12Mb/s is a high performance USB interface device.
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| CN107616792A (en) * | 2017-09-15 | 2018-01-23 | 中国科学技术大学 | A kind of brain neural signal acquisition process circuit of ten thousand number of stages passage |
| CN109567796A (en) * | 2018-12-20 | 2019-04-05 | 南京畅享医疗科技有限公司 | A kind of superminiature radio physiological signal collection processing system |
| CN110025889A (en) * | 2018-05-18 | 2019-07-19 | 西安交通大学医学院第二附属医院 | Intelligent blocking system and equipment based on high-frequency electrical stimulation |
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Application publication date: 20140903 |