CN101259115A - 一种治疗糖尿病的口服胰岛素软胶囊及其制备方法 - Google Patents
一种治疗糖尿病的口服胰岛素软胶囊及其制备方法 Download PDFInfo
- Publication number
- CN101259115A CN101259115A CNA2008100152846A CN200810015284A CN101259115A CN 101259115 A CN101259115 A CN 101259115A CN A2008100152846 A CNA2008100152846 A CN A2008100152846A CN 200810015284 A CN200810015284 A CN 200810015284A CN 101259115 A CN101259115 A CN 101259115A
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- Prior art keywords
- insulin
- soft capsule
- solution
- diabetes
- ether
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 108
- 102000004877 Insulin Human genes 0.000 title claims abstract description 54
- 108090001061 Insulin Proteins 0.000 title claims abstract description 54
- 229940125396 insulin Drugs 0.000 title claims abstract description 54
- 239000007901 soft capsule Substances 0.000 title claims abstract description 25
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 239000003094 microcapsule Substances 0.000 claims abstract description 17
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 16
- 229940125395 oral insulin Drugs 0.000 claims abstract description 16
- 239000002502 liposome Substances 0.000 claims abstract description 14
- 239000003921 oil Substances 0.000 claims abstract description 10
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- 239000000499 gel Substances 0.000 claims abstract description 9
- -1 phosphatidyl diglycolamine Chemical compound 0.000 claims abstract description 9
- 108010010803 Gelatin Proteins 0.000 claims abstract description 8
- 239000008273 gelatin Substances 0.000 claims abstract description 8
- 229920000159 gelatin Polymers 0.000 claims abstract description 8
- 235000019322 gelatine Nutrition 0.000 claims abstract description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 8
- 239000004094 surface-active agent Substances 0.000 claims abstract description 7
- 239000000375 suspending agent Substances 0.000 claims abstract description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 4
- 239000008158 vegetable oil Substances 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims description 9
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 8
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 8
- 210000002969 egg yolk Anatomy 0.000 claims description 8
- 229940067606 lecithin Drugs 0.000 claims description 8
- 235000010445 lecithin Nutrition 0.000 claims description 8
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- 239000008347 soybean phospholipid Substances 0.000 claims description 8
- 235000012000 cholesterol Nutrition 0.000 claims description 7
- 238000005253 cladding Methods 0.000 claims description 7
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- 238000010025 steaming Methods 0.000 claims description 7
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 5
- 239000010773 plant oil Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- HVYWMOMLDIMFJA-UHFFFAOYSA-N 3-cholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 HVYWMOMLDIMFJA-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 23
- 239000002552 dosage form Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 229940099352 cholate Drugs 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008100152846A CN101259115B (zh) | 2008-04-18 | 2008-04-18 | 一种治疗糖尿病的口服胰岛素软胶囊及其制备方法 |
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CN2008100152846A CN101259115B (zh) | 2008-04-18 | 2008-04-18 | 一种治疗糖尿病的口服胰岛素软胶囊及其制备方法 |
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CN101259115A true CN101259115A (zh) | 2008-09-10 |
CN101259115B CN101259115B (zh) | 2010-11-24 |
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CN2008100152846A Active CN101259115B (zh) | 2008-04-18 | 2008-04-18 | 一种治疗糖尿病的口服胰岛素软胶囊及其制备方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102144968B (zh) * | 2010-02-08 | 2012-09-26 | 刘树森 | 脂质体包裹胰岛素冻干制剂口服悬液及其制备工艺 |
WO2013040784A1 (zh) * | 2011-09-23 | 2013-03-28 | Fan Shenggang | 胰岛素脂质体冻干粉、口服胰岛素复合制剂及其制备方法与应用 |
CN103720656A (zh) * | 2012-10-15 | 2014-04-16 | 北京大学 | 口服和注射双功效的蛋白质或多肽类药物缓释囊泡及其制备方法 |
CN113575698A (zh) * | 2021-08-03 | 2021-11-02 | 上海健康医学院 | 一种鱼油软胶囊及其制备方法和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1221283C (zh) * | 1999-05-19 | 2005-10-05 | 沈阳药科大学 | 口服胰岛素微粒剂及其制备方法 |
-
2008
- 2008-04-18 CN CN2008100152846A patent/CN101259115B/zh active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102144968B (zh) * | 2010-02-08 | 2012-09-26 | 刘树森 | 脂质体包裹胰岛素冻干制剂口服悬液及其制备工艺 |
WO2013040784A1 (zh) * | 2011-09-23 | 2013-03-28 | Fan Shenggang | 胰岛素脂质体冻干粉、口服胰岛素复合制剂及其制备方法与应用 |
CN103720656A (zh) * | 2012-10-15 | 2014-04-16 | 北京大学 | 口服和注射双功效的蛋白质或多肽类药物缓释囊泡及其制备方法 |
CN113575698A (zh) * | 2021-08-03 | 2021-11-02 | 上海健康医学院 | 一种鱼油软胶囊及其制备方法和应用 |
CN113575698B (zh) * | 2021-08-03 | 2023-12-22 | 上海健康医学院 | 一种鱼油软胶囊及其制备方法和应用 |
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Publication number | Publication date |
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CN101259115B (zh) | 2010-11-24 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Yantai Apoluo Biological Science and Technology Co., Ltd. Assignor: Fan Shenggang Contract record no.: 2011370000517 Denomination of invention: Orally-administered insulin soft capsule for treating diabetes and preparation thereof Granted publication date: 20101124 License type: Exclusive License Open date: 20080910 Record date: 20111209 |
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TR01 | Transfer of patent right |
Effective date of registration: 20190606 Address after: 265716 Longkou Economic Development Zone, Yantai City, Shandong Province Patentee after: Yantai Appollo biological pharmaceutical science and Technology Co Ltd Address before: 265716 Yantai Apollo Biotechnology Co., Ltd. Longkou Economic Development Zone, Shandong Province Patentee before: Fan Shenggang |
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