CN101249169A

CN101249169A - Mongolian medicine for curing hemorrhoid

Info

Publication number: CN101249169A
Application number: CNA2008101038000A
Authority: CN
Inventors: 仲哲; 赵志强; 赵志峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-04-11
Filing date: 2008-04-11
Publication date: 2008-08-27
Anticipated expiration: 2028-04-11
Also published as: CN101249169B

Abstract

The invention relates to a medicine that is a mongolian medicine for treating hemorrhoids. The medicine is made from raw ingredient medicines by weight parts as follows: sophoricoside is 30 to 35 parts, garden burnet is 15 to 20 parts, bitter orange is 15 to 20 parts, scutellaria is 15 to 20 parts, catnip is 15 to 20 parts, coptis is 15 to 20 parts, biota orientalis is 15 to 20 parts, radix saposhinikoviae is 8 to 12 parts, dangguiwei is 12 to 18 parts, and Gentiana macrophylla is 15 to 25 parts. The mongolian medicine which is made by adopting the raw ingredient medicines has the efficacies of detumescence as well as blood stasis removing, regeneration as well as hemostasis, and heat clearing as well as acesodyne; a large number of experiments and clinical application prove that the mongolian medicine has unique therapeutic effect on various types of the hemorrhoids and has the advantages that the course of treatment is short, the cost is low, no toxic and side effects exist, etc., and the application prospect is very considerable.

Description

A kind of mongolian medicine for the treatment of hemorrhoid

Technical field

The present invention relates to a kind of medicine, promptly a kind of mongolian medicine for the treatment of hemorrhoid.

Background technology

Hemorrhoid are a kind of common frdquently encountered diseases, are the venous plexus generation varicoses of anal orifice and rectal intestine bottom and anal mucosa and form a kind of chronic disease of one or more softish veins group projection.The hemorrhoid that have occur in the anus catheter section start, are called internal hemorrhoid.What have occurs near the anus mouth of pipe, is called external hemorrhoid.The anal that also has all has focus outward, claims mixed hemorrhoid.Hemorrhoid often will be followed the patient for a long time in case morbidity just is difficult to cure, the time heavy when light, light anus swelling pain then, heavy then ulceration is bled, very misery.What have also can cancerate, and jeopardizes patient's life.The treatment of hemorrhoid method has multiple, inserts and fumigates, and utilize liquid nitrogen, laser, microwave, electronic equipments that focus is carried out ultralow temperature or superhigh temperature processing etc. as excision, ligation cover bundle, blood stasis injection, external stype.Wherein, the quick result of excision and ultralow temperature or superhigh temperature therapy, but subject range is less, and difficulty is bigger, infects easily, relapse rate is also than higher, and what have also can cause function damage.Ligation cover bundle can make the podex blood circulation be obstructed, and easily produces the congestion edema, difficult defecation.The purpose of blood stasis injection is to cause varicose sclerosis of blood vessels atrophy or withered downright bad and come off,, because the position and the dose of injection are difficult to determine, clinical effectiveness is very unstable, but also can cause the downright bad or infection of surrounding tissue, large-area sclerosis or hemorrhage occurs, formed cicatrix also causes the anal stenosis sequela easily.Therefore, the clinical external stypes that adopt are inserted stifling way relief of symptoms more, carry out expectant treatment.The propaganda of the accidental interior application treatment hemorrhoid of data, but all slow because of taking effect, the course of treatment is long, expense is high, toxic and side effects does not obtain clinical approval greatly.

Summary of the invention

The purpose of this invention is to provide a kind ofly has significant curative effect to hemorrhoid, and instant effect, short treating period, expense is low, toxic and side effects is little oral medicine.

Above-mentioned purpose is realized by following technical scheme: develop a kind of mongolian medicine for the treatment of hemorrhoid, this mongolian medicine is to be made by following bulk drugs: Fructus Sophorae 30-35 part, Radix Sanguisorbae 15-20 part, Fructus Aurantii 15-20 part, Radix Scutellariae 15-20 part, Herba Schizonepetae 15-20 part, Rhizoma Coptidis 15-20 part, Cacumen Platycladi 15-20 part, Cortex Phellodendri 12-18 part, Radix Saposhnikoviae 8-12 part, Radix Angelicae Sinensis 12-18 part, Radix Gentianae Marcrophyllae 15-25 part.

The mongolian medicine of said treatment hemorrhoid is to be made by following bulk drugs: 33.5 parts of the Fructuss Sophorae, 17 parts of Radix Sanguisorbaes, 17 parts of Fructus Aurantiis, 17 parts of Radix Scutellariaes, 17 parts of Herba Schizonepetae, 17 parts of Rhizoma Coptidis, 17 parts of Cacumen Platycladis (stir-fry), 15 parts of Cortex Phellodendris, 10 parts of Radix Saposhnikoviaes, 15 parts of Radix Angelicae Sinensis, 20 parts of Radix Gentianae Marcrophyllae.

The processing method of the mongolian medicine of said treatment hemorrhoid is various crude drug to be ground into fine powder add Mel and become ball.

The mongolian medicine that adopts technique scheme to make, effect with detumescenceization silt, promoting regeneration of the tissue and arresting bleeding, clearing away heat to alleviate pain, can produce unique curative effect to various hemorrhoid by for oral administration, have characteristics such as instant effect, short treating period, expense are low, radical rate height, and do not see any toxic and side effects, application prospect is very considerable.

The specific embodiment

Introduce a kind of embodiment and experimental data below.

Get crude drug Fructus Sophorae 33.5g, Radix Sanguisorbae 17g, Fructus Aurantii 17g, Radix Scutellariae 17g, Herba Schizonepetae 17g, Rhizoma Coptidis 17g, Cacumen Platycladi (stir-fry) 17g, Cortex Phellodendri 15g, Radix Saposhnikoviae 10g, Radix Angelicae Sinensis 15g, Radix Gentianae Marcrophyllae 20g.The crude drug mixed powder is broken to 120 orders, adds equivalent Mel and break into honeyed pill, the 10g/ ball.

Usage: each oral 1 ball, every day 3 times.After meal.0.5-1 hour take.

Prescription analysis: motherland's medical science is summed up as the disease that pathogenic heat or pathogenic fire cause to hemorrhoid, and promptly intenseness of heat is a fire, and fire is poison very, and poison causes carbuncle and bursts.The Mongolian medicine then is classified as the above-mentioned notion of the traditional Chinese medical science " conspicuous according to, red diffusing precious day ", " sticking epidemic disease ", and its performance is called " gluing ", and is close with inflammation notion in the modern medicine.The cause of disease of hemorrhoid is classified as large intestine pathogenic heat bonding, and noxious dampness is assembled, and causes the constipation due to dry stool friction and breaks hemorrhage and cause.Based on above-mentioned theory, the present invention adopts heat clearing away, removing heat from blood, hemostasis to be mark, and the sticking eliminating stagnation dehumidifying that disappears is this therapeutic regimen, takes as the leading factor with mongolian medicine pharmacology knowledge and processing method, through experiment screening for many years, has formed this medicine prescription.The Fructus Sophorae in the side is the fruit of Sophora japonica L., contains the Fructus Sophorae glycoside, can promote blood coagulation, lowers the permeability of blood vessel wall.Have heat clearing away, removing heat from blood, hemostatic effect.Radix Sanguisorbae contains catechu tanninoids, sanguisorbin and retinoid material.Have clearing away heat and cooling blood, hemostasis convergence, the antibiotic effect sticking, reducing swelling and alleviating pain that disappears.Fructus Aurantii contains hesperidin, have dispelling the stagnated QI remove long-pending, the function of painful abdominal mass of disappearing of reducing phlegm.Radix Scutellariae contains baicalin, baicalin, wogonin, sitosterol, wogonoside, neobaicalein etc., has effects such as analgesic, diuresis, antibiotic, antiviral, antifungal, blood vessel dilating.Herba Schizonepetae contains D-menthone and d-limonen, having functions such as the silt of loosing hemostasis sterilization.Rhizoma Coptidis contains berberine, Golden seal, palmatine, worenine, has antibiotic, antiviral, protozoacide, antifungal effect.Cacumen Platycladi contains volatile oil such as juniperic acid, absinthol, has hemostasis, antimicrobial effect.Cortex Phellodendri contains XIAONIE alkali, obacunone, Cortex Phellodendri lactone, shaggy-fruited dittany lactone, has the effect of rushing down kidney fire, clearing away damp-heat, separating sore.Radix Saposhnikoviae contains volatile oil and mannitol, has the effect of delivering diffusing wind, dehumidifying spasmolytic.Radix Angelicae Sinensis, promptly the afterbody of Radix Angelicae Sinensis contains volatile oil, sucrose, vitamin B12 etc., have enrich blood, promoting the circulation of blood, removing blood stasis, intestine moistening, the antibiotic effect such as sticking that disappears.Radix Gentianae Marcrophyllae contains first, second, the third three kinds of Radix Gentianae Macrophyllae alkali, has functions such as diffusing wind dehumidifying, collateral dredging Shujin.As seen, said medicine purify the blood, removing heat from blood and analgesic sticking, the functions such as sterilization detoxification, eliminating dampness and dredging channels of disappearing combine, work along both lines, internal and external application, various in addition drug ratios are proper, the principal and subordinate is orderly, each shows its merit and complements each other, thereby receives good curative effect.

The experiment situation:

One. zoopery:

1. toxicity test

(1) anxious poison test.According to the pertinent regulations of study of tcm new drug, to the median lethal dose(LD 50) (LD of mouse stomach administration ₅₀) carried out test determination, but do not measure LD ₅₀, therefore carried out mtd test.Result: with Cmax (60%), maximum dosage-feeding 200g/Kg day is irritated stomach, be equivalent to pill amount 120g/kg, be equivalent to adult's (pressing 75kg) clinical plan daily dosage (30: 75=0.4g/kg) 150 times, none death of mice in seven days, put to death each internal organs of mice anatomic observation and do not find toxic reaction, administration group and control group mice do not have any difference.

(2) long term toxication.For clinical drug safety, according to the pertinent regulations of country to new drug research, application Wistar rat will be tested medicine and will be set at high, medium and low three dosage, be respectively honeyed pill granule 16g/kg, 8g/kg, 4g/kg.Press 0.4g/kg/ days granules of human dosage and calculate, be 40 times, 20 times and 10 times of human effective dose; Other establishes a matched group, and gastric infusion 90 days, 180 days and the drug withdrawal of part animal were observed the influence to the every physiology of rat, biochemical indicator after 10 days continuously.Experimental result shows: gave the rat continuous oral 180 days with various dose, food-intake and the body weight gain of rat all do not had influence.Hepatic and renal function is not all found the overt toxicity effect.Routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc. be there is no obvious influence, compare no significant difference with matched group between each group.

Two, clinical experiment: since 2002, choose internal hemorrhoid, external hemorrhoid, each 64 example of mixed hemorrhoid patient respectively in medical institutions such as Tongliao, Inner Mongolia city spy health difficult disease institutes, be divided into experimental group and matched group at random, every group 32 example, experimental group adopts the treatment of this medicine, matched group adopts conventional bolt wash thing treatment, two groups of cardinal symptom situations of change of paired observation, experimental data are learned by statistics to handle and are found that the treatment group is to matched group (P＜0.01 that is better than evident in efficacy of cardinal symptom, P＜0.01, P＜0.05).In experiment the patient was divided into for three phases by working standard, it is few that two ends have all appearred in each group, middle many trend, and the first phase patient more than 30%, and the second stage of patient accounts for more than 60%, and three phases were heavily suffered from less than 10%.The general treatment time is: first phase patient 7-10 days.Second phase patient 10-15 days.Three phase patients 15-30 days.The time that reaches the alleviation tolerance with other drug remains basically stable, and we can say that treatment time obviously shortens.Medical expense: dose can be divided into 40 balls, and first phase patient potion gets final product, heavier patient 3-4 agent.As seen cost is very low.

Claims

1. mongolian medicine for the treatment of hemorrhoid, it is characterized in that: this medicine is made by following bulk drugs: Fructus Sophorae 30-35 part, Radix Sanguisorbae 15-20 part, 1520 parts of Fructus Aurantiis, Radix Scutellariae 15-20 part, Herba Schizonepetae 15-20 part, Rhizoma Coptidis 15-20 part, Cacumen Platycladi 15-20 part, Cortex Phellodendri 12-18 part, Radix Saposhnikoviae 8-12 part, Radix Angelicae Sinensis 12-18 part, Radix Gentianae Marcrophyllae 15-25 part.

2. the mongolian medicine of treatment hemorrhoid according to claim 1, it is characterized in that: this medicine is made by following bulk drugs: 33.5 parts of the Fructuss Sophorae, 17 parts of Radix Sanguisorbaes, 17 parts of Fructus Aurantiis, 17 parts of Radix Scutellariaes, 17 parts of Herba Schizonepetae, 17 parts of Rhizoma Coptidis, 17 parts of Cacumen Platycladis (stir-fry), 15 parts of Cortex Phellodendris, 10 parts of Radix Saposhnikoviaes, 15 parts of Radix Angelicae Sinensis, 20 parts of Radix Gentianae Marcrophyllae.

3. the mongolian medicine of treatment hemorrhoid according to claim 1 and 2 is characterized in that: the manufacture method of this medicine is: crude drug is cleaned mix, be crushed to 120 orders again, make honeyed pill.

4. according to the mongolian medicine of claim 2 or 3 described treatment hemorrhoid, it is characterized in that: get crude drug Fructus Sophorae 33.5g, Radix Sanguisorbae 17g, Fructus Aurantii 17g, Radix Scutellariae 17g, Herba Schizonepetae 17g, Rhizoma Coptidis 17g, Cacumen Platycladi (stir-fry) 17g, Cortex Phellodendri 15g, Radix Saposhnikoviae 10g, Radix Angelicae Sinensis 15g, Radix Gentianae Marcrophyllae 20g.The crude drug mixed powder is broken to 120 orders, adds the honeyed pill that equivalent Mel breaks into the 10g/ ball.