CN101242874A - 25－羟基维生素d3用于改善雄性动物生育力的用途 - Google Patents
25－羟基维生素d3用于改善雄性动物生育力的用途 Download PDFInfo
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- CN101242874A CN101242874A CNA2006800300917A CN200680030091A CN101242874A CN 101242874 A CN101242874 A CN 101242874A CN A2006800300917 A CNA2006800300917 A CN A2006800300917A CN 200680030091 A CN200680030091 A CN 200680030091A CN 101242874 A CN101242874 A CN 101242874A
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Abstract
本发明涉及25－羟基维生素D3用于改善动物生育力的用途。更具体地，本发明涉及25－羟基维生素D3用于改善动物(包括男人)中精液质量和/或受胎率的用途。在优选的实施方式中，本发明涉及25－羟基维生素D3用于改善如下动物中雄性的精液质量和/或雌性的受胎率的用途，所述动物例如为牛、狗、猫和马，优选猪。
Description
本发明涉及25-羟基维生素D3用于改善动物生育力的用途。
在本发明的上下文中，动物包括哺乳动物，其例子包括人类。除人类以外，哺乳动物的优选例子是反刍动物和非反刍动物，例如家牛(牛)、如狗和猫的宠物动物、马、骆驼、羊、山羊和猪。
更具体地，本发明涉及25-羟基维生素D3用于改善雄性动物(包括男人)的精液质量的用途。在优选的实施方式中，本发明涉及25-羟基维生素D3用于改善如下动物中精液质量和/或受胎率的用途，所述动物例如为牛、狗、猫和马，优选猪。
基因优异的雄性动物，例如种猪、种马或公牛，非常昂贵，其不仅受到额外的管理和护理，而且被尽可能长时间地保持以使其在牧群或在人工受精中心的作用最大化。现在一些牧场或人工受精中心为雄性育种动物提供最优条件，从而保持其生育力处于高水平，例如将种猪饲养在隧道型通风或空气调节猪圈中。人工受精正被实施，以使雄性动物的作用最大化并最终将其优异的基因遗传给更多的后裔。然而随着雄性动物年龄的增长，精液量、精子运动性和精子数具有逐渐减少的趋势。因此，雌性动物的受孕率和受胎率也逐渐降低。
根据本发明已发现将25-羟基维生素D3给予种猪，改善了种猪的精液质量，并进一步提高了由已服用25-羟基维生素D3种猪受精的猪的受胎率。
因此，一方面，本发明涉及25-羟基维生素D3用于改善精液(例如种猪精液)质量和动物(例如猪)受胎率的用途。另一方面，本发明涉及用于改善动物精液质量和受胎率的方法，所述方法包括，将有效量的25-羟基维生素D3给予雄性动物。
本文中术语“食品”指任何适于人类或动物食用的食物或饲料。食品可以是经制备和包装的人用食物(例如蛋黄酱、沙拉调料、面包或干酪食物)或动物饲料(例如，挤出的或成粒的动物饲料、粗混饲料或宠物食品组合物)。术语“食物”包括固体食物和液体食物，以及饮用液体(诸如饮用水)。本文中术语食料指任何适于人类或动物食用的物质。术语“膳食补充剂”指用于补充人类或动物膳食，以单剂量单位或多剂量单位包装的少量化合物。膳食补充剂通常不会提供显著量的卡路里，但可以包含其它微量营养素(例如维生素或矿物质)。术语“营养补充剂”指含有膳食补充剂以及卡路里源的组合物。在一些实施方式中，营养补充剂是膳食替代剂或补充剂(例如，营养或能量棒或营养饮料或浓缩液)。
为了实现本发明的目的，25-羟基维生素D3适于以补充剂的形式添加到食物中。动物食物可以通过如下方式来补充，将25-羟基维生素D3(例如作为可以Trademark ROVIMIX Hy-D获得的商业配制品)混合到常规食物中，或者首先制备食物组分和25-羟基维生素D3的预混物，随后将预混物与其它食品组分混合。猪的食物可以是任何常规猪饲料。具体地，25-羟基维生素D3可以以配制粉末的形式被添加到含有其它矿物质、维生素、氨基酸和痕量元素的预混物中，其中该预混物被添加到常规动物饲料中，并充分搅拌，从而均匀地分布在动物饲料中。
在本发明猪饲料的制备过程中，将约10mcg/kg至约100mcg/kg的25-羟基维生素D3添加到常规猪饲料中。或者，可以以常规饲料组分为基础，通过将活性成分以较高浓度加入上述饲料组分中来制备饲料预混物，所述浓度例如为约10mg/kg至约100mg/kg 25-羟基维生素D3。如果每1000kg常规饲料中添加1千克上述预混物，那么通过常规食用饲料就能满足动物个体的需要。对于种猪，优选的剂量在约50至约80mcg 25-羟基维生素D3每kg饲料的范围内。
为了实现本发明的目的，以约0.112mcg至约1.120mcg，尤其为约0.560mcg至约0.784mcg每kg个体动物的体重每天的用量适当给予25-羟基维生素D3。因此，25-羟基维生素D3适于以满足上述剂量要求的用量添加到食物中。通常，种猪饲料可以包括约10mcg至约100mcg，尤其为约50mcg至约80mcg的25-羟基维生素D3每kg饲料。
测定服用25-羟基维生素D3后的种猪的总精液量和浓度，精子运动性和精子量以及由该种猪的精液受精的猪的受胎率，将其与食用不含25-羟基维生素D3饲料的种猪所得到数据进行比较，从而可以判定种猪服用25-羟基维生素D3对精液质量的功效。
通常，对于狗，以约0.125mcg至约1mcg每kg个体动物的体重每天的用量适当给予25-羟基维生素D3。通常对于马，以约0.112mcg至约1.120mcg每kg个体动物的体重每天的用量适当给予25-羟基维生素D3。
人类可以以单位剂量的形式服用根据本发明的食物补充剂，所述剂量形式例如为片剂、胶囊、定量的粉末或定量的液体，上述液体如果需要的话可被充二氧化碳气体。而且，本发明的食物补充剂还可以包含常规的惰性和生理学上可接受的载剂、调味剂、着色剂和钙。例如片剂可以采用25-羟基维生素D3进行补充，补充用量使25-羟基维生素D3的日剂量为约5至15mcg每kg体重，其中通常的日剂量为1或2片。
本发明通过如下实施例进一步说明。
实施例1
含有如下表1中所示组分的常规猪饲料采用50至80mcg 25-羟基维生素D3每kg食物来补充。
表1
| 成分 | kg/1000kg |
| 谷物 | 314.94 |
| 谷糠 | 300.00 |
| 大豆粉 | 245.00 |
| 干椰子肉粉 | 100.00 |
| 石灰石 | 14.20 |
| Mono-Dical | 15.60 |
| 盐酸L-赖氨酸 | 0.47 |
| DL-蛋氨酸 | 0.29 |
| NaCl | 5.00 |
| 毒必吸(Toxin binder) | 2.50 |
| 维生素和矿物质预混物*) | 1.00 |
| 氧化锌 | 0.50 |
| 盐酸胆碱 | 0.50 |
| 总量 | 1000.00 |
| *)维生素和矿物质预混物 | |
| 维生素A，IU/kg | 10000 |
| 维生素D3，IU/kg | 1000 |
| 维生素E，IU/kg | 20 |
| 维生素K3，mg/kg | 1 |
| 维生素B1，mg/kg | 2 |
| 维生素B2，mg/kg | 4 |
| 维生素B6，mg/kg | 4 |
| 维生素B12，mg/kg | 0.01 |
| 维生素C，mg/kg | 10 |
| 叶酸，mg/kg | 0.5 |
| 烟酸，mg/kg | 20 |
| 泛酸，mg/kg | 10 |
| 生物素，mg/kg | 0.08 |
| 铁，mg/kg | 100 |
| 锌，mg/kg | 100 |
| 锰，mg/kg | 50 |
| 铜，mg/kg | 10 |
| 碘，mg/kg | 0.5 |
如上详述的饲料采用25-羟基维生素D3通过如下方法进行补充：将50至80mg 25-羟基维生素D3(4至6.4g由DSM Nutritional Products，Kaiseraugst，Switzerland提供的ROVIMIXHy·D1.25％)与其余的饲料部分混合在一起。如果需要可以将所得混合饲料造粒。
实施例2
如实施例1所述制备种猪饲料，不同之处在于，每kg维生素和矿物质预混物中添加约50至80mg 25-羟基维生素D3。
实施例3
如下制备含有25-羟基维生素D3的种猪饲料用预混物：
| 成分 | [％] |
| ROVIMIXHy·D1.25％ | 0.0800 |
| 维生素A 500 | 0.8000 |
| 维生素E 50％ | 8.0000 |
| 维生素D3 500 | 0.0800 |
| 维生素K3 100％MSB/51％ | 0.0800 |
| 维生素B1 98％ | 0.0714 |
| 维生素B2 80％ | 0.1750 |
| 维生素B6 99％ | 0.1212 |
| 维生素B12 0.1％ | 1.0000 |
| 生物素2％ | 0.2000 |
| 叶酸80％ | 0.0227 |
| 尼亚新(Niacin)99.5％ | 0.7035 |
| 泛酸钙98％ | 0.4082 |
| 维生素C | 4.0000 |
| 氯化胆碱60％ | 12.0000 |
| 硫酸铜25％ | 12.8000 |
| 硫酸铁30％ | 10.0000 |
| 氧化锰62％ | 1.6129 |
| 氧化锌76％ | 5.2632 |
| 碳酸钴5％ | 0.0600 |
| 碘酸钙62％ | 0.0323 |
| 亚硒酸钠1％/BMP | 0.8001 |
| BHT 100％ | 2.0000 |
| 载剂组合 | 6.0000 |
| LACANTES S36400-Z | 10.0000 |
| 石灰石 | 23.6895 |
将所有成分小心混合在一起，并将0.5％(5kg/1000kg饲料)这种预混物加入最终饲料中。
或者，还可以将25-羟基维生素D3以1％经稀释预混物的形式加入，所述预混物中含有适当的载剂。上述载剂可以为单独的小麦面粉、小麦粗粉、玉米芯、稻壳、杏壳或碳酸钙，或数种所述载剂的不同混合物。通常的配方为：
成分 [％]
稻壳 64.20
碳酸钙 35.00
ROVIMIXHy·D1.25％ 0.80
将所有成分小心混合在一起，并将0.05％(0.5kg/1000kg饲料)的这种预混物加入最终饲料中。
实施例4
含有以下表2和3中所示组分的常规狗粮(基础饲料)采用10至80mcg 25-羟基维生素D3(ROVIMIXHy·D，1.25％)每kg饲料来补充。
表2：基础狗粮的营养组成(Mera Dog“Brocken”，MERA-TiernahrungGmbH，Marienstraβe 80-84，D-47625Kevelaer-Wetten，Germany)
| 物质 | 含量 |
| 蛋白质，％ | 24 |
| 脂肪，％ | 9.0 |
| 纤维，％ | 3.0 |
| 灰份，％ | 7.0 |
| 钙，％ | 1.3 |
| 磷，％ | 1.0 |
| 钠，％ | 0.4 |
表3：基础狗粮的维生素组成(Mera Dog“Brocken”，MERA-TiernahrungGmbH，Marienstraβe 80-84，D-47625Kevelaer-Wetten，Germany)
| 维生素/kg | 含量 |
| 维生素A，IU | 12000 |
| 维生素D3，IU | 1200 |
| 维生素E，mg | 95 |
| 维生素B1，mg | 3.2 |
| 维生素B2，mg | 5.6 |
| 维生素B6，mg | 3.2 |
| 维生素B12，mcg | 64 |
| 泛酸，mg | 22 |
| 尼亚新(Niacin)，mg | 20 |
| 叶酸，mg | 0.5 |
| 生物素，mcg | 200 |
| 氯化胆碱，mg | 1600 |
实施例5
含有如下表4和5中所示组分的常规马饲料(基础饲料)采用25-羟基维生素D3(ROVIMIXHy·D1.25％)进行补充，补充用量使25-羟基维生素D3的日常剂量为约0.112mcg至约1.120mcg每kg体重。
表4：基础马饲料的营养组成
| 物质 | 含量 |
| 蛋白质，％ | 13.5 |
| 脂肪，％ | 3.6 |
| 纤维，％ | 9.7 |
| 灰份，％ | 5.9 |
| 钙，％ | 1.3 |
| 磷，％ | 0.5 |
| 钠，％ | 0.3 |
表5：基础马饲料的维生素组成
| 维生素/kg | 含量 |
| 维生素A，IU | 36000 |
| 维生素D3，IU | 3000 |
| 维生素E，mg | 1000 |
| 维生素B1，mg | 15 |
| 生物素，mcg | 500 |
实施例6
片剂形式的人用膳食补充剂可以包括25-羟基维生素D3，其包括在维生素配制品的标准化基质组分中。标准基质组分可以包括具有乳化能力的天然多糖树胶，或具有乳化能力的不同天然多糖树胶混合物，而不包含任何蛋白质的混合物。
成分 每片含量
25-羟基维生素D3(晶体) 10-125mcg
基质组分(标准化) 100-400mg
钙盐 0-1000mg
片剂可以通过本领域技术人员公知的常规制片技术来制备和配制。因此，片剂可以通过如下步骤来制备，将膳食补充剂中的所有成分混合、研磨并造粒，然后将颗粒在压片机中压制。
Claims (14)
1.25-羟基维生素D3用于改善动物的精液质量和/或受胎率的用途。
2.如权利要求1所述用于改善宠物精液质量的用途，所述宠物优选狗和猫。
3.如权利要求1所述用于改善马中的种马精液质量的用途。
4.如权利要求1所述用于改善牛中的公牛精液质量的用途。
5.如权利要求1所述用于改善种猪精液质量和母猪受胎率的用途。
6.如权利要求1所述用于改善人类精液质量的用途。
7.如权利要求1至6中任意一项所述的用途，其中，25-羟基维生素D3以膳食补充剂的形式给予。
8.如权利要求7所述的用途，其中，25-羟基维生素D3以使25-羟基维生素D3的给予量为约0.1mcg至约1.2mcg，尤其约0.5mcg至约0.8mcg每kg个体动物的体重每天的用量添加到食物中。
9.如权利要求8所述的用途，其中，25-羟基维生素D3以约10mcg至约100mcg，尤其为约50mcg至约80mcg每kg食物的用量添加到种猪饲料中。
10.一种用于改善雄性精液质量的方法，所述方法包括，将有效量的25-羟基维生素D3给予雄性动物。
11.如权利要求10所述的方法，其中，以约0.1mcg至约1.2mcg，尤其约0.5mcg至约0.8mcg每kg体重每天的用量给予25-羟基维生素D3。
12.如权利要求10所述的方法，其中，25-羟基维生素D3以膳食补充剂的形式给予。
13.一种用于改善种猪精液质量和提高母猪受胎率的方法，所述方法包括，将有效量的25-羟基维生素D3给予种猪。
14.如权利要求13所述的方法，其中以约10mcg至约100mcg，尤其约50mcg至约80mcg每kg个体动物体重每天的用量给予25-羟基维生素D3。
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| EP05017949.8 | 2005-08-18 | ||
| EP05017949 | 2005-08-18 |
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| CN101242874A true CN101242874A (zh) | 2008-08-13 |
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| CNA2006800300917A Pending CN101242874A (zh) | 2005-08-18 | 2006-08-15 | 25－羟基维生素d3用于改善雄性动物生育力的用途 |
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| US (1) | US20100227840A1 (zh) |
| EP (1) | EP1917071B1 (zh) |
| JP (1) | JP5566026B2 (zh) |
| KR (4) | KR20150143872A (zh) |
| CN (1) | CN101242874A (zh) |
| TW (1) | TWI508664B (zh) |
| WO (1) | WO2007020042A1 (zh) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623051B (zh) * | 2009-08-11 | 2012-05-30 | 四川农业大学 | 一种提高猪对繁殖与呼吸综合症抵抗力的饲料添加剂 |
| CN102613407A (zh) * | 2012-03-29 | 2012-08-01 | 张淑二 | 一种改善肉用种公牛精液品质的添加剂预混合饲料 |
| CN102665437A (zh) * | 2009-12-22 | 2012-09-12 | 帝斯曼知识产权资产管理有限公司 | 角黄素和/或25-oh d3用于改善雄禽的繁殖和性能的用途 |
| CN103392670A (zh) * | 2013-08-10 | 2013-11-20 | 内蒙古赛科星繁育生物技术股份有限公司 | 由种公牛体外受精率对种公牛精子体内受胎率的评价方法 |
| CN104431482A (zh) * | 2014-11-28 | 2015-03-25 | 新津邦得科技有限公司 | 妊娠母猪维生素预混合饲料 |
| CN105208878A (zh) * | 2013-03-27 | 2015-12-30 | 帝斯曼知识产权资产管理有限公司 | 25-羟基维生素d3用于增强执行功能的用途 |
| CN107183378A (zh) * | 2017-05-19 | 2017-09-22 | 赣州八维生物科技有限公司 | 羟基蛋氨酸钙和25‑羟基维生素d3在提高猪生长性能和繁殖性能的应用 |
| CN107319150A (zh) * | 2016-04-29 | 2017-11-07 | 广州领鲜生物科技有限公司 | 一种提高种公猪精液品质的配合饲料 |
| CN108720025A (zh) * | 2018-06-08 | 2018-11-02 | 唐飞 | 25-羟基维生素d3在食品中的应用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008043857A2 (en) * | 2006-10-13 | 2008-04-17 | Bioxell Spa | Novel method of treatment of male sub-fertility |
| CN101778636B (zh) * | 2007-08-07 | 2012-11-28 | 帝斯曼知识产权资产管理有限公司 | 25-羟基维生素d3提高哺乳动物中肌肉量的用途 |
| AU2009214052B2 (en) * | 2008-02-13 | 2015-05-07 | Dsm Ip Assets B.V. | Combined use of 25-hydroxy-vitamin D3 and vitamin D3 for improving bone mineral density and for treating osteoporosis |
| CN106214683A (zh) * | 2008-02-13 | 2016-12-14 | 帝斯曼知识产权资产管理有限公司 | 维生素d和25‑羟基维生素d3的组合 |
| CA2865424A1 (en) * | 2011-02-28 | 2012-09-07 | Rigshospitalet Copenhagen University Hospital | Active vitamin d or analogs thereof for use in in vivo or in vitro fertilization |
| WO2015018421A1 (en) * | 2013-08-07 | 2015-02-12 | Rigshospitalet Copenhagen University Hospital | Antibodies, compounds and derivatives thereof for use in the treatment of male infertility |
| DK3244911T3 (da) * | 2015-01-12 | 2019-12-16 | Rigshospitalet Copenhagen Univ Hospital | Fremgangsmåde til bestemmelse af en sandsynlig virkning af en behandling til forbedring af mandlig ufrugtbarhed |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
| US7632518B2 (en) * | 2002-01-15 | 2009-12-15 | Dsm Ip Assets B.V. | 25-hydroxy vitamin D3 compositions |
-
2006
- 2006-08-15 CN CNA2006800300917A patent/CN101242874A/zh active Pending
- 2006-08-15 KR KR1020157034382A patent/KR20150143872A/ko active Search and Examination
- 2006-08-15 WO PCT/EP2006/008032 patent/WO2007020042A1/en active Application Filing
- 2006-08-15 US US12/063,048 patent/US20100227840A1/en not_active Abandoned
- 2006-08-15 KR KR1020147022068A patent/KR20140105873A/ko not_active Application Discontinuation
- 2006-08-15 KR KR1020167034067A patent/KR20160143887A/ko not_active Application Discontinuation
- 2006-08-15 KR KR1020087003656A patent/KR20080039420A/ko active Search and Examination
- 2006-08-15 EP EP06776842.4A patent/EP1917071B1/en active Active
- 2006-08-15 JP JP2008526422A patent/JP5566026B2/ja active Active
- 2006-08-18 TW TW095130507A patent/TWI508664B/zh active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623051B (zh) * | 2009-08-11 | 2012-05-30 | 四川农业大学 | 一种提高猪对繁殖与呼吸综合症抵抗力的饲料添加剂 |
| CN102665437A (zh) * | 2009-12-22 | 2012-09-12 | 帝斯曼知识产权资产管理有限公司 | 角黄素和/或25-oh d3用于改善雄禽的繁殖和性能的用途 |
| CN102613407A (zh) * | 2012-03-29 | 2012-08-01 | 张淑二 | 一种改善肉用种公牛精液品质的添加剂预混合饲料 |
| CN102613407B (zh) * | 2012-03-29 | 2013-11-20 | 张淑二 | 一种改善肉用种公牛精液品质的添加剂预混合饲料 |
| CN105208878A (zh) * | 2013-03-27 | 2015-12-30 | 帝斯曼知识产权资产管理有限公司 | 25-羟基维生素d3用于增强执行功能的用途 |
| CN103392670A (zh) * | 2013-08-10 | 2013-11-20 | 内蒙古赛科星繁育生物技术股份有限公司 | 由种公牛体外受精率对种公牛精子体内受胎率的评价方法 |
| CN104431482A (zh) * | 2014-11-28 | 2015-03-25 | 新津邦得科技有限公司 | 妊娠母猪维生素预混合饲料 |
| CN107319150A (zh) * | 2016-04-29 | 2017-11-07 | 广州领鲜生物科技有限公司 | 一种提高种公猪精液品质的配合饲料 |
| CN107183378A (zh) * | 2017-05-19 | 2017-09-22 | 赣州八维生物科技有限公司 | 羟基蛋氨酸钙和25‑羟基维生素d3在提高猪生长性能和繁殖性能的应用 |
| CN108720025A (zh) * | 2018-06-08 | 2018-11-02 | 唐飞 | 25-羟基维生素d3在食品中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5566026B2 (ja) | 2014-08-06 |
| KR20140105873A (ko) | 2014-09-02 |
| KR20080039420A (ko) | 2008-05-07 |
| KR20160143887A (ko) | 2016-12-14 |
| KR20150143872A (ko) | 2015-12-23 |
| US20100227840A1 (en) | 2010-09-09 |
| TW200800037A (en) | 2008-01-01 |
| EP1917071A1 (en) | 2008-05-07 |
| EP1917071B1 (en) | 2014-01-08 |
| WO2007020042A1 (en) | 2007-02-22 |
| JP2009504699A (ja) | 2009-02-05 |
| TWI508664B (zh) | 2015-11-21 |
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