(3) summary of the invention
The present invention prevents respiratory tract disease in order to provide a kind of, and can strengthen patient's immunity, reduces the Chinese medicine perfume composition that disease relapse infects, and the sachet agent and the fumigant that utilize this Chinese medicine perfume composition to make.
The technical solution used in the present invention is:
A kind of Chinese medicine perfume composition is made up of Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, the Herba Pogostemonis of arbitrary proportion.
Described perfume composition mainly is to utilize its fragrance that distributes, and contains above-mentioned 7 flavor Chinese medicines and gets final product, and its proportioning can be unrestricted.
Cortex Cinnamomi: acrid in the mouth, sweet, extremely hot in nature, function mends that fire is supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation, conducting fire back to its origin.Rhizoma Kaempferiae: acrid in the mouth, warm in nature, function circulation of qi promoting warming middle-JIAO helps digestion pain relieving.Folium Artemisiae Argyi: acrid in the mouth, hardship, warm in nature, function warming the meridian for stopping bleeding, cold expelling regulating menstruation, antiabortive, this product gas fragrance suffering.Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, function is drying damp and strengthening spleen, expelling wind and cold.Rhizoma Acori Graminei: acrid in the mouth, hardship, warm in nature, function have one's ideas straightened out refreshment, removing dampness to restore normal function of the stomach, the mind calming and mentality promoting.Herba Pogostemonis: acrid in the mouth, slightly warm in nature, function removing dampness, preventing or arresting vomiting, expelling summer-heat, this product fragrant odour.The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, function induce sweat cold expelling, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Above-mentioned 7 flavor medicines combinations not only can prevent respiratory tract disease, but enhancing immunity also reduces patient's recurrent infection rate.
Concrete, the Chinese medicine perfume composition can be 1~10: 1~10 by mass ratio: 1~10: 1~10: 1~10: 1~10: 1~10 Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, Herba Pogostemonis are formed.
Preferably, described Chinese medicine perfume composition is 1: 1: 1 by mass ratio: 1: 1: 1: 1 Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, Herba Pogostemonis are formed.
The invention still further relates to the Chinese medicine sachet agent Chinese medicine sachet agent that utilizes described Chinese medicine perfume composition to prepare, described Chinese medicine sachet agent is the sachet that makes with breathable fabric or non-woven fabrics parcel Chinese medicine perfume composition.
The phytoclasts that the Chinese medicine perfume composition is made through pulverizing by Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, Herba Pogostemonis described in the described Chinese medicine sachet agent is formed.
Concrete, the plant powder that the Chinese medicine perfume composition is made through pulverizing by Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, Herba Pogostemonis described in the described Chinese medicine sachet agent is formed, and described powder is 60~100 purpose fine powders.
The invention still further relates to the herbal fumigation agent that utilizes described Chinese medicine perfume composition to prepare.The Aromatic water extracting solution that described herbal fumigation agent is Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, Herba Pogostemonis makes through distillation extraction, the alcohol extract that alcohol extraction makes or the mixed liquor of Aromatic water extracting solution and alcohol extract arbitrary proportion.
Described Aromatic water extracting solution adopts conventional method to make, and among the present invention, the temperature that described Aromatic water extracts is 60~80 ℃, after above-mentioned raw materials can being mixed, in the small-size multifunction extraction pot, extract, be extracted into till the no fragranced, obtain the Aromatic water extract, extraction time is about 1~2 hour usually.
Preferably, described herbal fumigation agent be Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, Herba Pogostemonis Aromatic water extracting solution and 1: 1 mixed liquor of alcohol extract.
Described ethanol extract is prepared by following method: is than 1: 1: 1 with Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, Herba Pogostemonis by matter: 1: 1: 1: 1 mixes, pulverize, cross 20 mesh sieves, with 65% alcohol reflux 2 times, each 0.5~1.5 hour, reclaim under reduced pressure was not to there being the ethanol flavor, and it is 1.05~1.15 that medicinal liquid is concentrated into relative density, filter, filtrate is described ethanol extract.Described aqueous extract and ethanol extract volume ratio are 1: 1.Described reflux, extract, temperature is 60~80 ℃.
Described herbal fumigation agent using method: can place air humidifier to fumigate described herbal fumigation agent.Recommendation is according to 0.5~5ml/m
2Amount calculate after, get corresponding herbal fumigation agent and put into air humidifier and fumigate, morning and afternoon each once, each 0.5~2 hour.
Beneficial effect of the present invention is mainly reflected in: provide a kind of be cocoa prevention respiratory tract disease, again can strengthen patient's immunity, reduce the Chinese medicine perfume composition that disease relapse infects, and the sachet agent and the fumigant that utilize this Chinese medicine perfume composition to make, and preparation method is simple, raw material is easy to get, cost is low, is beneficial to suitability for industrialized production.
(4) specific embodiment
The present invention is described further below in conjunction with specific embodiment, but protection scope of the present invention is not limited in this:
Embodiment 1: the preparation of Chinese medicine sachet agent
Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, each 100 gram of Herba Pogostemonis, pulverizer breaks into coarse powder (20 order), regrind into fine powder (60 order), after the dustless pulverizing mill of cell grade pulverize, make perfume micropowder (in 100 orders),, make (7g/ of sachet agent with the breathable fabric parcel, contain each 1g of every kind of Chinese medicine), can be used for the children's front and wear.
Embodiment 2: the preparation of Chinese medicine sachet agent
Cortex Cinnamomi 10 grams, Rhizoma Kaempferiae 30 grams, Folium Artemisiae Argyi 60 grams, the Radix Angelicae Dahuricae 50 grams, Rhizoma Atractylodis 80 grams, Rhizoma Acori Graminei 20 grams, Herba Pogostemonis 90 grams, pulverizer breaks into coarse powder (60 order), with the breathable fabric parcel, makes sachet agent (20g/), can hang on indoor sealing place.
Embodiment 3: the preparation of Chinese medicine sachet agent
Cortex Cinnamomi 80 grams, Rhizoma Kaempferiae 100 grams, Folium Artemisiae Argyi 90 grams, the Radix Angelicae Dahuricae 100 grams, Rhizoma Atractylodis 10 grams, Rhizoma Acori Graminei 100 grams, Herba Pogostemonis 20 grams, pulverizer breaks into coarse powder (20 order), regrinds into fine powder (60 order), wraps up with non-woven fabrics, make sachet agent (50g/), can hang on the bigger places of flow of the people such as corridor.
Embodiment 4: the preparation of Chinese medicine sachet agent
Cortex Cinnamomi 50 grams, Rhizoma Kaempferiae 80 grams, Folium Artemisiae Argyi 10 grams, the Radix Angelicae Dahuricae 20 grams, Rhizoma Atractylodis 60 grams, Rhizoma Acori Graminei 80 grams, Herba Pogostemonis 50 grams, pulverizer breaks into coarse powder (20 order), regrind into fine powder (60 order), after the dustless pulverizing mill of cell grade pulverize, make perfume micropowder (in 100 orders), with the breathable fabric parcel, make sachet agent (15g/), wear the front that can be used for being grown up.
Embodiment 5: the preparation of Chinese medicine sachet agent
Cortex Cinnamomi 100 grams, Rhizoma Kaempferiae 10 grams, Folium Artemisiae Argyi 100 grams, the Radix Angelicae Dahuricae 60 grams, Rhizoma Atractylodis 50 grams, Rhizoma Acori Graminei 10 grams, Herba Pogostemonis 80 grams, pulverizer breaks into coarse powder (20 order), regrind into fine powder (60 order), after the dustless pulverizing mill of cell grade pulverize, make perfume micropowder (in 100 orders), with the breathable fabric parcel, make sachet agent (7g/), be used for the children's front and wear.
Embodiment 6: herbal fumigation agent preparation
Cortex Cinnamomi, Rhizoma Kaempferiae, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Acori Graminei, each 100 gram of Herba Pogostemonis, pulverizer breaks into coarse powder (20 order), under 60~80 ℃ of temperature conditions, be distilled to no fragranced, obtain the Aromatic water extracting solution, the phytoclasts that to carry Aromatic water again makes ethanol extract with 60~80 ℃ of reflux, extract, of ethanol, ethanol extract be concentrated into no ethanol distinguish the flavor of ethanol extraction, equal-volume mixing Aromatic water extracting solution and ethanol extraction promptly get the herbal fumigation agent.
Embodiment 7: herbal fumigation agent preparation
Cortex Cinnamomi 120 grams, Rhizoma Kaempferiae 10 grams, Folium Artemisiae Argyi 50 grams, the Radix Angelicae Dahuricae 80 grams, Rhizoma Atractylodis 150 grams, Rhizoma Acori Graminei 200 grams, Herba Pogostemonis 100 grams, pulverizer breaks into coarse powder (20 order), under 70~80 ℃ of temperature conditions, be distilled to no fragranced, obtain the Aromatic water extracting solution, to carry the Aromatic water phytoclasts again and make ethanol extract with 60~80 ℃ of reflux, extract, of ethanol, ethanol extract be concentrated into no ethanol distinguish the flavor of ethanol extraction, mixed the Aromatic water extracting solution in 2: 1 by volume and ethanol extraction promptly gets the herbal fumigation agent.
Embodiment 8: herbal fumigation agent preparation
Cortex Cinnamomi 50 grams, Rhizoma Kaempferiae 60 grams, Folium Artemisiae Argyi 30 grams, the Radix Angelicae Dahuricae 20 grams, Rhizoma Atractylodis 40 grams, Rhizoma Acori Graminei 100 grams, Herba Pogostemonis 50 grams, pulverizer breaks into coarse powder (20 order), under 60~80 ℃ of temperature conditions, be distilled to no fragranced, obtain the Aromatic water extracting solution, to carry the Aromatic water phytoclasts again and make ethanol extract with 60~80 ℃ of reflux, extract, of ethanol, ethanol extract be concentrated into no ethanol distinguish the flavor of ethanol extraction, mixed the Aromatic water extracting solution in 1: 2 by volume and ethanol extraction promptly gets the herbal fumigation agent.
Embodiment 9: herbal fumigation agent preparation
Cortex Cinnamomi 10 grams, Rhizoma Kaempferiae 20 grams, Folium Artemisiae Argyi 50 grams, the Radix Angelicae Dahuricae 80 grams, Rhizoma Atractylodis 60 grams, Rhizoma Acori Graminei 80 grams, Herba Pogostemonis 60 grams, pulverizer breaks into coarse powder (20 order), under 70~80 ℃ of temperature conditions, be distilled to no fragranced, obtain the Aromatic water extracting solution, to carry the Aromatic water phytoclasts again and make ethanol extract with 70~80 ℃ of reflux, extract, of ethanol, ethanol extract be concentrated into no ethanol distinguish the flavor of ethanol extraction, mixed the Aromatic water extracting solution in 4: 1 by volume and ethanol extraction promptly gets the herbal fumigation agent.
Embodiment 10: herbal fumigation agent preparation
Cortex Cinnamomi 30 grams, Rhizoma Kaempferiae 50 grams, Folium Artemisiae Argyi 60 grams, the Radix Angelicae Dahuricae 20 grams, Rhizoma Atractylodis 90 grams, Rhizoma Acori Graminei 60 grams, Herba Pogostemonis 100 grams, pulverizer breaks into coarse powder (20 order), under 60~70 ℃ of temperature conditions, be distilled to no fragranced, obtain the Aromatic water extracting solution, to carry the Aromatic water phytoclasts again and make ethanol extract with 60~70 ℃ of reflux, extract, of ethanol, ethanol extract be concentrated into no ethanol distinguish the flavor of ethanol extraction, mixed the Aromatic water extracting solution in 1: 5 by volume and ethanol extraction promptly gets the herbal fumigation agent.
Embodiment 11: the herb fumigation agent reduces patient's recurrent infection
Over surplus in the of nearly ten year, the herbal fumigation agent that my institute will make by embodiment 6~10 with stifling (according to the herbal fumigation agent consumption of embodiment 6~10 methods preparation be respectively 1.0,0.5,1.5,5.0,3.0ml/m
2) method use in the part ward, mainly in oncology, chronic disease patients such as hematology are main, immunologic hypofunction, carry out in the ward that the crowd of easy repeated infection concentrates, find through 600 many cases patients' clinical observation for many years, the incidence rate of ward patient's nosocomial infection of not carrying out herbal fumigation is generally about 7%, generally (the herbal fumigation agent infection rate according to the preparation of embodiment 6~10 methods is followed successively by 2.8% about 3% and take herbal fumigation disinfectant ward patient's nosocomial infection incidence rate, 3.6%, 3.3%, 3.0%, 3.1%), show that herbal fumigation can obviously reduce chronic inpatient's infection rate, effectively reduce patient's nosocomial infection and take place.
Embodiment 12: Chinese medicine sachet agent and herb fumigation agent prevention infantile respiratory tract infection
Nearly two during the last ten years, the sachet agent of making by embodiment 1 and embodiment 5 methods is adopted in the Zhejiang Prov. Hospital of Traditional Chinese Medicine, in the children's of winter-spring season in recurrent respiratory tract infection in every year, wear, clinical observation is found to effectively prevent infantile respiratory tract infection, reduces the flu incidence rate of Children with Recurrent Respiratory Infections winter-spring season.
Carried out the effect comparison research of Chinese medicine sachet agent to respiratory tract infection: selection school that the crowd is dense and kindergarten classroom are as observing the base, with primary school and kindergarten is point of observation, Winter-Spring respiratory tract infection season occurred frequently, utilization embodiment 6 medicine fumigant (1ml/m
2Fumigate in the classroom) and sachet agent (everyone is worn on the front by 1 sachet agent) carry out randomized control study, select laboratory observation class and contrast class at random: primary school of the class of observation 5 (216 people), 5 (168 people) and contrast primary schools of class of kindergarten 5 (209 people), 5 of kindergartens (167 people), relatively the incidence rate of utilization back respiratory tract infection is estimated the effect of traditional Chinese medicine fumigating pastil and sachet agent prevention respiratory tract infection and the difference on effect of different dosage form.The result shows that the infantile common cold incidence rate primary school that uses the herb fumigation agent is 19.3%, kindergarten is 18.5, using the primary school of Chinese medicine sachet agent and the infantile common cold incidence rate of kindergarten is 18.5% (embodiment 1) and 20.4% (embodiment 5), and the infantile common cold incidence rate primary school that does not use the primary school of herb fumigation agent and kindergarten is 76%, kindergarten is 78%, illustrates that Chinese medicine perfume composition of the present invention can effectively prevent the generation of respiratory tract infection.
Embodiment 13: the experiment of herb fumigation agent fungistatic effect
The pathogen of respiratory tract infection is varied, antibacterial, virus, mycoplasma, chlamydia, rickettsia, fungus, spirillum and parasite etc. are arranged, but antibacterial is modal infective pathogen body, account for 80%, the pathogen of at present common respiratory tract infection has Klebsiella Pneumoniae, staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa etc.
Adopt agar dilution to detect and make the minimum inhibitory concentration of herb fumigation agent the respiratory tract infection encountered pathogenic bacteria by embodiment 6~10 methods, as a result display density be 25g/L when above growth to Klebsiella Pneumoniae and staphylococcus aureus all can suppress fully, escherichia coli also there is certain inhibitory action, not obvious to the inhibitory action of Pseudomonas aeruginosa.
Embodiment 14: herb fumigation agent toxicity test
Make the herb fumigation agent by embodiment 6~10 methods mouse toxicity test is shown, per os gastric infusion and after the ultrasonic atomizatio administration is observed day by day, and writes down each treated animal poisoning manifestations and dead animal number to 14 day, and the result shows two kinds of equal LD of medication
50>5000ml/kg (body weight), true border innocuous substance.
Fumigant shows the irritation test of lagophthalmos, splashes into house according to each 2 of the herb fumigation agent stock solutions of embodiment 6~10 methods preparation and exempts from the branch hole conjunctival sac, and opposite side is contrast with the distilled water.Dropping is tried to make behind the thing the passive closed 10s of eye, and behind eye drip 6,24, the reaction (absent lacrimation, hyperemia, water irritation are arranged) of 48h and 4,7 days observer's rabbit conjunctivals, iris and corneas, the reaction integration is 0, belongs to nonirritant.
Embodiment 14: the pharmacodynamics test of herb fumigation agent
The pharmacodynamics test that makes the herb fumigation agent by embodiment 6 methods shows that the herb fumigation agent is respectively with 0.2ml/m
2, 1ml/m
2, 3ml/m
2, 5ml/m
2Variable concentrations, at 60m
2Four classrooms in experimentize, each classroom all is placed on the optional position, classroom respectively with 2 culture dishs, in air, expose 30 minutes after cover lid.With herb fumigation agent morning and afternoon each once, after fumigate in each one hour, other 2 culture dishs are placed on and preceding 2 positions that culture dish is identical exposure cover lid after 30 minutes in air respectively.16 culture dishs in four classrooms are positioned over 37 degree cultivated 24 hours, count bacterium colony after the taking-up respectively.The result is respectively with 0.2ml/m
2The stifling classroom of concentration, clump count is respectively 138,88 before and after the herb fumigation; With 1ml/m
2Clump count is respectively 142,50 before and after the classroom that concentration is stifling, herb fumigation; With 3ml/m
2Clump count is respectively 139,51 before and after the classroom that concentration is stifling, herb fumigation; With 5ml/m
2Clump count is respectively 143,49 before and after the classroom that concentration is stifling, herb fumigation.The stifling valid density of the best that shows the herb fumigation agent is 1ml/m
2
Embodiment 15: the immunologic function that improves the recurrent respiratory tract infection infant
Wear in 60 routine recurrent respiratory tract infection infants by the sachet agent that embodiment 6 methods make, change once weekly, 4 weeks were a course of treatment.Carry out SIgA content in saliva content detection before and after the medication, the result shows that sachet wears preceding SIgA2.41 ± 1.52, and sachet is worn back SIgA4.46 ± 1.81.Prompting: wear the immunologic function that traditional Chinese medicine fumigating pastil sachet can effectively improve the recurrent respiratory tract infection infant.