CN101239019A - 镶嵌高分子材料层的药用橡胶瓶塞及其粘贴成型的方法 - Google Patents
镶嵌高分子材料层的药用橡胶瓶塞及其粘贴成型的方法 Download PDFInfo
- Publication number
- CN101239019A CN101239019A CNA2008100263853A CN200810026385A CN101239019A CN 101239019 A CN101239019 A CN 101239019A CN A2008100263853 A CNA2008100263853 A CN A2008100263853A CN 200810026385 A CN200810026385 A CN 200810026385A CN 101239019 A CN101239019 A CN 101239019A
- Authority
- CN
- China
- Prior art keywords
- material layer
- polymer material
- plug
- rubber
- studded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002861 polymer material Substances 0.000 title claims abstract description 59
- 229920001971 elastomer Polymers 0.000 title claims abstract description 46
- 239000005060 rubber Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 17
- 241001411320 Eriogonum inflatum Species 0.000 title claims description 24
- 238000007493 shaping process Methods 0.000 title claims description 7
- 239000003814 drug Substances 0.000 claims abstract description 22
- 230000003213 activating effect Effects 0.000 claims description 11
- -1 polyethylene Polymers 0.000 claims description 10
- 239000006229 carbon black Substances 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920005549 butyl rubber Polymers 0.000 claims description 4
- 239000003517 fume Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000000465 moulding Methods 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- 239000005025 cast polypropylene Substances 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 3
- 229920005555 halobutyl Polymers 0.000 claims description 3
- 229920003049 isoprene rubber Polymers 0.000 claims description 3
- 239000000395 magnesium oxide Substances 0.000 claims description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 3
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- 229950000845 politef Drugs 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 229960004889 salicylic acid Drugs 0.000 claims description 3
- 229910052717 sulfur Inorganic materials 0.000 claims description 3
- 239000011593 sulfur Substances 0.000 claims description 3
- 238000005987 sulfurization reaction Methods 0.000 claims description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000010215 titanium dioxide Nutrition 0.000 claims description 3
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 claims description 2
- 229960002447 thiram Drugs 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 4
- 230000004888 barrier function Effects 0.000 abstract description 2
- 238000000748 compression moulding Methods 0.000 abstract description 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 238000001467 acupuncture Methods 0.000 description 9
- 235000019241 carbon black Nutrition 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- 239000000693 micelle Substances 0.000 description 3
- 239000013618 particulate matter Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 241000283216 Phocidae Species 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000004299 exfoliation Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 239000012476 oxidizable substance Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 150000003557 thiazoles Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
产品名称 | 镶嵌高分子材料层的药用橡胶瓶塞 | 标准 | YBB00042005 | |
序号 | 检验项目 | 标准规定 | 检验结果 | |
1 | 外观 | 符合标准 | 合格 | |
2 | 鉴别 | 符合标准 | 合格 | |
3 | 针刺落屑(粒) | ≤20 | 0 | |
4 | 穿刺力(N) | Fmax≤80、Fave≤75 | Fmax=43.2Fave=31.6 | |
5 | 密封性与穿刺器保持性 | 保持4h不被拔出,且无渗漏 | 无拔出、无泄漏 | |
6 | 灰分(%) | ≤45 | 44.8 | |
7 | 易挥发性硫化物(μg/20cm2) | ≤50 | 合格 | |
8 | 不溶性微粒(个/ml) | ≥10μm | ≤30 | 5 |
≥25μm | ≤3 | 0.2 | ||
9 | 澄清度(号) | ≤2 | 0.5 | |
颜色(号) | ≤5 | 0.5 | ||
10 | pH变化值 | ≤1.0 | 0.1 | |
11 | 紫外吸收度(220nm-360nm) | ≤0.1 | 0.03 | |
12 | 不挥发物(mg/100ml) | ≤4.0 | 1.1 | |
13 | 易氧化物(ml) | ≤3.0 | 0.7 | |
14 | 重金属(以pb2+计,μg/ml) | ≤1 | 合格 | |
15 | 铵(以铵离子计,μg/ml) | ≤2 | 合格 | |
16 | 锌(以锌离子计,μg/ml) | ≤3 | 合格 | |
17 | 电导率(μs/cm) | ≤40.0 | 5.6 |
18 | 急性全身毒性 | 反应不大于对照组 | 合格 |
19 | 溶血试验 | 溶血率<5% | 合格 |
20 | 热原 | 应符合规定 | 合格 |
产品名称 | 镶嵌高分子材料层的药用橡胶瓶塞 | 标准 | YBB00052005 | |
序号 | 检验项目 | 标准规定 | 检验结果 | |
1 | 外观 | 符合标准 | 合格 | |
2 | 鉴别 | 符合标准 | 合格 | |
3 | 针刺落屑(粒) | ≤5 | 0 | |
4 | 穿刺力(N) | Fmax≤10 | Fmax=2.6 | |
5 | 胶塞与容器密合性 | 亚甲兰溶液不得渗入 | 不渗入 | |
6 | 自密封性 | 亚甲兰溶液不得渗入 | 不渗入 | |
7 | 灰分(%) | ≤50 | 48.8 | |
8 | 易挥发性硫化物(μg/20cm2) | ≤50 | 合格 | |
9 | 不溶性微粒(个/ml) | ≥10μm | ≤60 | 10 |
≥25μm | ≤6 | 0.5 | ||
10 | 澄清度(号) | ≤2 | 1 | |
颜色(号) | ≤5 | 1 | ||
11 | pH变化值 | ≤1.0 | 0.2 | |
12 | 紫外吸收度(220nm-360nm) | ≤0.2 | 0.08 | |
13 | 不挥发物(mg/100ml) | ≤4.0 | 1.1 | |
14 | 易氧化物(ml) | ≤7.0 | 1.0 | |
15 | 重金属(以pb2+计,μg/ml) | ≤1 | 合格 | |
16 | 铵(以铵离子计,μg/ml) | ≤2 | 合格 | |
17 | 锌(以锌离子计,μg/ml) | ≤3 | 合格 | |
18 | 电导率(μs/cm) | ≤40.0 | 5.8 | |
19 | 急性全身毒性 | 反应不大于对照组 | 合格 | |
20 | 溶血试验 | 溶血率<5% | 合格 | |
21 | 热原 | 应符合规定 | 合格 |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100263853A CN101239019B (zh) | 2008-02-20 | 2008-02-20 | 镶嵌高分子材料层的药用橡胶瓶塞及其粘贴成型的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100263853A CN101239019B (zh) | 2008-02-20 | 2008-02-20 | 镶嵌高分子材料层的药用橡胶瓶塞及其粘贴成型的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101239019A true CN101239019A (zh) | 2008-08-13 |
CN101239019B CN101239019B (zh) | 2011-12-28 |
Family
ID=39931039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008100263853A Active CN101239019B (zh) | 2008-02-20 | 2008-02-20 | 镶嵌高分子材料层的药用橡胶瓶塞及其粘贴成型的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101239019B (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101955592A (zh) * | 2010-04-20 | 2011-01-26 | 北京化工大学 | 一种可热塑再加工交联卤化丁基橡胶的制备方法 |
CN101239020B (zh) * | 2008-02-20 | 2011-12-28 | 广东雪龙药用包装材料有限公司 | 镶嵌高分子材料层的药用橡胶瓶塞及其注塑成型的方法 |
CN102408579A (zh) * | 2010-09-25 | 2012-04-11 | 中国科学院化学研究所 | 无锑聚酯薄膜橡胶复合材料及其制备方法与应用 |
CN103271822A (zh) * | 2013-05-22 | 2013-09-04 | 盛州橡塑胶(苏州)有限公司 | 无缝隙覆膜胶塞及其制备方法 |
CN103998349A (zh) * | 2011-09-21 | 2014-08-20 | 通用电气医疗集团股份有限公司 | 对比介质的包装 |
CN111961372A (zh) * | 2020-08-25 | 2020-11-20 | 江苏润德医用材料有限公司 | 用于卤化丁基橡胶塞的涂膜液、涂膜胶塞及二者的制备方法和应用 |
CN115819897A (zh) * | 2022-11-29 | 2023-03-21 | 湖北华强科技股份有限公司 | 一种溴化丁基/聚异戊二烯橡胶垫片及其生产方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1290357B1 (it) * | 1997-02-18 | 1998-10-22 | Enoplastic S P A | Tappo a base di sughero protetto |
CN1133565C (zh) * | 2001-10-18 | 2004-01-07 | 郑秀娣 | 药品瓶塞隔离膜 |
CN100398407C (zh) * | 2005-10-19 | 2008-07-02 | 刘永红 | 复膜胶塞及其制备方法 |
CN2870836Y (zh) * | 2006-01-25 | 2007-02-21 | 谢仁朗 | 药用覆膜胶塞 |
CN101239021B (zh) * | 2008-02-20 | 2011-12-28 | 广东雪龙药用包装材料有限公司 | 镶嵌高分子材料层的药用橡胶瓶塞及其模压成型的方法 |
CN101239020B (zh) * | 2008-02-20 | 2011-12-28 | 广东雪龙药用包装材料有限公司 | 镶嵌高分子材料层的药用橡胶瓶塞及其注塑成型的方法 |
-
2008
- 2008-02-20 CN CN2008100263853A patent/CN101239019B/zh active Active
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101239020B (zh) * | 2008-02-20 | 2011-12-28 | 广东雪龙药用包装材料有限公司 | 镶嵌高分子材料层的药用橡胶瓶塞及其注塑成型的方法 |
CN101955592A (zh) * | 2010-04-20 | 2011-01-26 | 北京化工大学 | 一种可热塑再加工交联卤化丁基橡胶的制备方法 |
CN102408579A (zh) * | 2010-09-25 | 2012-04-11 | 中国科学院化学研究所 | 无锑聚酯薄膜橡胶复合材料及其制备方法与应用 |
CN103998349A (zh) * | 2011-09-21 | 2014-08-20 | 通用电气医疗集团股份有限公司 | 对比介质的包装 |
CN103998349B (zh) * | 2011-09-21 | 2020-01-14 | 通用电气医疗集团股份有限公司 | 对比介质的包装 |
CN103271822A (zh) * | 2013-05-22 | 2013-09-04 | 盛州橡塑胶(苏州)有限公司 | 无缝隙覆膜胶塞及其制备方法 |
CN111961372A (zh) * | 2020-08-25 | 2020-11-20 | 江苏润德医用材料有限公司 | 用于卤化丁基橡胶塞的涂膜液、涂膜胶塞及二者的制备方法和应用 |
CN115819897A (zh) * | 2022-11-29 | 2023-03-21 | 湖北华强科技股份有限公司 | 一种溴化丁基/聚异戊二烯橡胶垫片及其生产方法 |
CN115819897B (zh) * | 2022-11-29 | 2023-11-28 | 湖北华强科技股份有限公司 | 一种溴化丁基/聚异戊二烯橡胶垫片及其生产方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101239019B (zh) | 2011-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101239019B (zh) | 镶嵌高分子材料层的药用橡胶瓶塞及其粘贴成型的方法 | |
CN101239021B (zh) | 镶嵌高分子材料层的药用橡胶瓶塞及其模压成型的方法 | |
CN101239020B (zh) | 镶嵌高分子材料层的药用橡胶瓶塞及其注塑成型的方法 | |
JPS6164253A (ja) | 医療容器用栓体 | |
WO2015006772A8 (en) | Polymeric material for container | |
CN203291228U (zh) | 覆有弹性膜的胶塞 | |
CN102113956B (zh) | 药品包装瓶塞复合膜片及其制作工艺 | |
CN104029911B (zh) | 一种酒坛封装防盗装置 | |
CN2868294Y (zh) | 药用覆膜胶塞 | |
CN202529291U (zh) | 一种防盗环具有折边结构的瓶盖 | |
CN201192463Y (zh) | 一种覆膜胶塞 | |
JP4812236B2 (ja) | 医療用ゴム栓及び医療用容器 | |
CN204249492U (zh) | 一种炸药包装耐穿刺复合膜 | |
CN207242428U (zh) | 一种复合式组合橡胶塞盖 | |
CN210883340U (zh) | 一种适用于无垫片密封的瓶盖 | |
CN208150048U (zh) | 一种容器盖和容器瓶 | |
CN206562064U (zh) | 一种易撕型包装罐 | |
CN2870836Y (zh) | 药用覆膜胶塞 | |
CN206265479U (zh) | 高阻隔的全生物降解复合塑料瓶 | |
CN208360898U (zh) | 加强附着力的预印光油涂层结构 | |
CN202236311U (zh) | 输液用胶塞 | |
CN102743291A (zh) | 无硅化高弹性镀膜药物瓶塞及其制造方法 | |
CN201529269U (zh) | 药塞 | |
CN207174363U (zh) | 一种复合橡胶塞盖 | |
CN208761228U (zh) | 一种自封口包装袋 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: XUELONG MEDICAL PACKING MATERIAL CO., LTD., GUANGD Free format text: FORMER OWNER: XIE RENLANG Effective date: 20111111 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20111111 Address after: 514300 Jinhe Road Industrial Park, Fengshun County, Guangdong Applicant after: Guangzhou Xuelong Pharmaceutical Packaging Materials Corp. Address before: 514300 Guangdong County, Guangdong County, Fengshun Province Applicant before: Xie Renlang |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170606 Address after: 519000 Guangdong province Zhuhai Sanzao Town Spring Garden 1 No. 3 factory Patentee after: Zhuhai Lang Lang Food Co., Ltd. Address before: 514300 Jinhe Road Industrial Park, Fengshun County, Guangdong Patentee before: Guangzhou Xuelong Pharmaceutical Packaging Materials Corp. |