CN101229329A - Indigestion tablet and preparing process thereof - Google Patents
Indigestion tablet and preparing process thereof Download PDFInfo
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- CN101229329A CN101229329A CNA2008100545243A CN200810054524A CN101229329A CN 101229329 A CN101229329 A CN 101229329A CN A2008100545243 A CNA2008100545243 A CN A2008100545243A CN 200810054524 A CN200810054524 A CN 200810054524A CN 101229329 A CN101229329 A CN 101229329A
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Abstract
The invention discloses a tablet of Chinese patent medicine for removing stagnated food and promoting digestion, which solves the problem that the present medicine powder for removing stagnated food and promoting the digestion is difficult to take. The tablet is based on the prescription of the medicine powder for removing stagnated food and promoting the digestion, which is characterized by adding auxiliary materials and preparing according to the following steps: crude drugs of haw, arecanut and pharbitis seed are respectively grounded and decocted to obtain decoction; crude drug of ventriculi galli mucosa is grounded and mixed with malt and medicated leaven, then digeratured by adding water to obtain digeratur solution; the decoction and the digeratur solution are compounded and concentrated in vacuum to obtain the extract of the crude drugs; the auxiliary materials of mannite and powdered sugar are added in the extract of the crude drugs, evenly mixed, dried in a depressed way and milled into fine powder; the auxiliary materials of Gum Acacia, magnesium stearate and French chalk is added in the fine powder; the mixture is evenly mixed and granulated; then cream flavor is added in the substance obtained in the previous step and the mixture is evenly granulated and pressed into tablet, and the tablet for removing stagnated food and promoting digestion is finally obtained. The tablet for removing stagnated food and promoting digestion with obvious effect and convenient taking is the modified product of the present medicine power and is mainly used for curing diseases such as infant spleen-stomach disharmony, poor appetite for food and milk, abdominal mass accumulation, abdominal distension, fatigued limbs, sallow complexion, poor appetite, etc.
Description
Technical field: the invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of production method of indigestion tablet.
Technical background: at present, the Chinese patent medicine eliminate indigestion is dispersed in and is widely used in treating the spleen and stomach in children discord, the breast of stopping eating clinically, gathers diseases such as mass in the abdomen, abdominal flatulence, extremity asthenia, shallow complexion, anorexia.Yet because this powder is full crude drug powder, color, smell and taste are not good enough, therefore are not easy to take very much.
Summary of the invention:
The objective of the invention is, at the problems referred to above, based on the diffusing prescription of eliminate indigestion, a kind of indigestion tablet and manufacturing technique method thereof that its powder is modified as tablet is provided, make the product that obtains therefrom not only have definite curative effect, and color, smell and taste are all good, are convenient to child administration.
Its technical solution comprises:
A kind of indigestion tablet, the crude drug component is loose based on eliminate indigestion and write out a prescription, and it is characterized in that: the crude drug prescription is: Fructus Crataegi (parching to brown) 166.67g, Fructus Hordei Germinatus (stir-fry) 166.67g, Massa Medicata Fermentata (parched with bran) 166.67g, Semen Arecae (stir-fry) 166.67g, Endothelium Corneum Gigeriae Galli (stir-fry) 166.67g, Semen Pharbitidis (stir-fry) 166.67g; Make by adding adjuvant Icing Sugar, mannitol, micropowder silica gel, magnesium stearate, Pulvis Talci and cream flavour, wherein the component compatibility of crude drug extract and adjuvant and percentage by weight prescription is: the crude drug extract is given money as a gift and is counted 10-15%, Icing Sugar 78-73%, mannitol 10%, micropowder silica gel 1%, magnesium stearate 0.5%, Pulvis Talci 0.5%, cream flavour Q.S.
A kind of manufacturing technique method of aforementioned indigestion tablet is characterized in that: press crude drug prescription weighting raw materials, then:
(1) crude drug Fructus Crataegi, Semen Arecae, Semen Pharbitidis pulverize separately are become coarse powder, add 10 times of water gagings and decoct secondary, each 2 hours, get decocting liquid;
(2) the crude drug Endothelium Corneum Gigeriae Galli powder is broken into coarse powder, adds 10 times of water gagings warm macerating secondary in 60-70 ℃ of water-bath with Fructus Hordei Germinatus, Massa Medicata Fermentata, each 2 hours, filter, get warm macerating liquid;
(3) merge decocting liquid and warm macerating liquid, it is 1.3 fluid extract that vacuum concentration becomes 60 ℃ of heat to survey relative densities, must the crude drug extract;
Then, component compatibility and the percentage by weight prescription by its crude drug extract and adjuvant takes by weighing adjuvant again, continues:
(4) in the crude drug extract, add adjuvant mannitol, Icing Sugar, stir, carry out drying under reduced pressure in 60-70 ℃, be ground into fine powder, cross 50 mesh sieves;
(5) add the adjuvant micropowder silica gel, mixing, 70% alcohol granulation, drying adds adjuvant magnesium stearate and Pulvis Talci again, mixing, granulate;
(6) get the part fine powder in addition and mix with cream flavour, again with whole granule mixings, tabletting gets indigestion tablet.
The indigestion tablet that adopts such scheme to make is the remodeling product that eliminate indigestion looses, and the main component of its every medicine: Fructus Crataegi contains multiple organic acid, as Crataegolic acid, citric acid, chlorogenic acid etc.; The starch-containing hydrolytic enzyme of Fructus Hordei Germinatus master, maltase, proteolytic enzyme isoreactivity digestive enzyme; The fatty enzyme of Massa Medicata Fermentata, protease, amylase, saccharase and vitamin B; Semen Arecae contains alkaloid 0.3～0.6%, and main component is an arecoline; Endothelium Corneum Gigeriae Galli contains gastric hormone, several amino acids, vitamin, pepsin and amylase; Semen Pharbitidis contains pharbitin.The function of indigestion tablet cures mainly looses identical with eliminate indigestion.Its associated main pharmacodynamics research: indigestion tablet 3.0g/kg and 6.0g/kg, the difference gastric infusion, the writhing response that mouse peritoneal injection acetic acid is caused has obvious suppression effect (p＜0.01), gastrointestinal promotion motion and gastric emptying to normal mouse also all have obvious facilitation (p＜0.05, p＜0.01); To hyperfunction can the inhibition significantly of mice gastrointestinal peristalsis (p＜0.01) that pilocarpine causes, " insufficiency of the spleen " mice that Radix Et Rhizoma Rhei causes is obviously improved its swimming endurance, prolong swimming time.Indigestion tablet 1.0g/kg and 2.0g/kg give rat oral gavage respectively, can significantly improve the gastric acidity (p＜0.05, p＜0.01) of rat, are dose-effect relationship; Indigestion tablet 1.2g/kg and 2.4g/kg give rat oral gavage respectively, can significantly strengthen pepsin activity (p＜0.01).Show that this product has the effects such as swimming endurance of pain relieving, adjusting gastrointestinal motility, raising pepsin activity, enhancing " insufficiency of the spleen " disease mice.Its acute toxicology research: oral this product of mice (crude drug amount) 60.2g/kg (be equivalent to 3 years old 13kg body weight child consumption per day 6.0g 130.4 times), all are normal in 7 days, do not have dead.The oral maximum tolerated dose 60.2g/kg of mice.Its long term toxicity research: 60 days toxicity tests of the oral this product 20g/kg of rat (high dose), the result shows that this product do not have obviously influence to the behavioral activity of rat, body weight, diet, hemogram, hepatic and renal function etc., internal organs macroscopy and section microscopy are not also seen obvious pathological changes, so think that this product safety is very big.Its preparation stability is investigated, and with the total organic acids is to investigate index, and by indigestion tablet constant temperature accelerated test, the result shows that this product effect duration is 5.9 years, K
25 ℃(hr
-1)=4.8585 * 10
-5The room temperature reserved sample observing, the result shows that 0～38 month this product detects down with relevant items such as drug standard (draft) character by clinical research and production, product quality is basicly stable.Clinical verification: indigestion tablet treatment infantile malnutrition breast food inner product type 100 examples, loose treatment 60 examples in contrast with eliminate indigestion the same period.The result shows that the total obvious effective rate of indigestion tablet is 82%, and total effective rate is 98%, and the diffusing total obvious effective rate of eliminate indigestion is 63.3%, and total effective rate is 93.3%, this shows that the curative effect of indigestion tablet obviously is better than the curative effect that eliminate indigestion looses.Moreover, and clinical hospital is consistent with family numbers of patients to be thought: the indigestion tablet color, smell and taste are all good, and similar toffee can be chewed, taking convenience, and children's is ready to accept, and has solved the problem of medication in children difficulty therefrom, is worthy to be popularized.
The specific embodiment:
Embodiment 1, indigestion tablet.The crude drug component of indigestion tablet is loose based on eliminate indigestion and is write out a prescription, just content is different, and the crude drug prescription of indigestion tablet is specially: Fructus Crataegi (parching to brown) 166.67g, Fructus Hordei Germinatus (stir-fry) 166.67g, Massa Medicata Fermentata (parched with bran) 166.67g, Semen Arecae (stir-fry) 166.67g, Endothelium Corneum Gigeriae Galli (stir-fry) 166.67g, Semen Pharbitidis (stir-fry) 166.67g; Crude drug just can be made tablet by the processing extraction and after adding partial supplementary material, and this adjuvant wherein mainly contains Icing Sugar, mannitol, micropowder silica gel, magnesium stearate, Pulvis Talci and cream flavour etc.Wherein the component compatibility of crude drug extract and adjuvant and percentage by weight prescription is: the crude drug extract is given money as a gift and is counted 10-15%, Icing Sugar 78-73%, mannitol 10%, micropowder silica gel 1%, magnesium stearate 0.5%, Pulvis Talci 0.5%, cream flavour Q.S.Can obtain indigestion tablet according to above-mentioned prescription by certain process.
Embodiment 2, the indigestion tablet production method.
At first, according to crude drug prescription weighting raw materials, wherein Fructus Crataegi (parching to brown) 166.67g, Fructus Hordei Germinatus (stir-fry) 166.67g, Massa Medicata Fermentata (parched with bran) 166.67g, Semen Arecae (stir-fry) 166.67g, Endothelium Corneum Gigeriae Galli (stir-fry) 166.67g, Semen Pharbitidis (stir-fry) 166.67g.Then:
(1) crude drug Fructus Crataegi, Semen Arecae, Semen Pharbitidis pulverize separately are become coarse powder, add 10 times of water gagings and decoct secondary, each 2 hours, get decocting liquid;
(2) the crude drug Endothelium Corneum Gigeriae Galli powder is broken into coarse powder, adds 10 times of water gagings warm macerating secondary in 60-70 ℃ of water-bath with Fructus Hordei Germinatus, Massa Medicata Fermentata, each 2 hours, filter, get warm macerating liquid;
(3) merge decocting liquid and warm macerating liquid, it is 1.3 fluid extract that vacuum concentration becomes 60 ℃ of heat to survey relative densities, must the crude drug extract;
Then, again according to following prescription weighting raw materials extract and adjuvant by weight percentage, wherein: crude drug extract give money as a gift meter 10-15%, Icing Sugar 78-73%, mannitol 10%, micropowder silica gel 1%, magnesium stearate 0.5%, Pulvis Talci 0.5%, cream flavour Q.S.Continue abovementioned steps:
(4) in the crude drug extract, add adjuvant mannitol, Icing Sugar, stir, carry out drying under reduced pressure in 60-70 ℃, be ground into fine powder, cross 50 mesh sieves;
(5) add the adjuvant micropowder silica gel, mixing, 70% alcohol granulation, drying adds adjuvant magnesium stearate and Pulvis Talci again, mixing, granulate;
(6) get the part fine powder in addition and mix,, be pressed into the tablet of every heavy 0.86g at last, promptly get indigestion tablet again with whole granule mixings with an amount of cream flavour.
This medicine is used to treat the spleen and stomach in children discord, the breast of stopping eating, gathers diseases such as mass in the abdomen, abdominal flatulence, extremity asthenia, shallow complexion, anorexia.Its usage and dosage: day clothes 2 times, each 3.Limit is children's's usefulness more than 3 years old.
Claims (2)
1. indigestion tablet, the crude drug component is loose based on eliminate indigestion and write out a prescription, and it is characterized in that: the crude drug prescription is: Fructus Crataegi (parching to brown) 166.67g, Fructus Hordei Germinatus (stir-fry) 166.67g, Massa Medicata Fermentata (parched with bran) 166.67g, Semen Arecae (stir-fry) 166.67g, Endothelium Corneum Gigeriae Galli (stir-fry) 166.67g, Semen Pharbitidis (stir-fry) 166.67g; Make by adding adjuvant Icing Sugar, mannitol, micropowder silica gel, magnesium stearate, Pulvis Talci and cream flavour, wherein the component compatibility of crude drug extract and adjuvant and percentage by weight prescription is: the crude drug extract is given money as a gift and is counted 10-15%, Icing Sugar 78-73%, mannitol 10%, micropowder silica gel 1%, magnesium stearate 0.5%, Pulvis Talci 0.5%, cream flavour Q.S.
2. according to the manufacturing technique method of the described indigestion tablet of claim 1, it is characterized in that: press crude drug prescription weighting raw materials, then:
(1) crude drug Fructus Crataegi, Semen Arecae, Semen Pharbitidis pulverize separately are become coarse powder, add 10 times of water gagings and decoct secondary, each 2 hours, get decocting liquid;
(2) the crude drug Endothelium Corneum Gigeriae Galli powder is broken into coarse powder, adds 10 times of water gagings warm macerating secondary in 60-70 ℃ of water-bath with Fructus Hordei Germinatus, Massa Medicata Fermentata, each 2 hours, filter, get warm macerating liquid;
(3) merge decocting liquid and warm macerating liquid, it is 1.3 fluid extract that vacuum concentration becomes 60 ℃ of heat to survey relative densities, must the crude drug extract;
Then, component compatibility and the percentage by weight prescription by its crude drug extract and adjuvant takes by weighing adjuvant again, continues:
(4) in the crude drug extract, add adjuvant mannitol, Icing Sugar, stir, carry out drying under reduced pressure in 60-70 ℃, be ground into fine powder, cross 50 mesh sieves;
(5) add the adjuvant micropowder silica gel, mixing, 70% alcohol granulation, drying adds adjuvant magnesium stearate and Pulvis Talci again, mixing, granulate;
(6) get the part fine powder in addition and mix with cream flavour, again with whole granule mixings, tabletting gets indigestion tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100545243A CN101229329A (en) | 2008-01-30 | 2008-01-30 | Indigestion tablet and preparing process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100545243A CN101229329A (en) | 2008-01-30 | 2008-01-30 | Indigestion tablet and preparing process thereof |
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| CN101229329A true CN101229329A (en) | 2008-07-30 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370174A (en) * | 2011-10-11 | 2012-03-14 | 苏洋 | Sobering-up healthcare food |
| CN109596768A (en) * | 2018-12-31 | 2019-04-09 | 海南葫芦娃药业集团股份有限公司 | A kind of detection method of Children stasis relieving particle |
| CN109985188A (en) * | 2018-12-31 | 2019-07-09 | 海南葫芦娃药业集团股份有限公司 | A kind of preparation method and products thereof of Children stasis relieving particle |
-
2008
- 2008-01-30 CN CNA2008100545243A patent/CN101229329A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370174A (en) * | 2011-10-11 | 2012-03-14 | 苏洋 | Sobering-up healthcare food |
| CN109596768A (en) * | 2018-12-31 | 2019-04-09 | 海南葫芦娃药业集团股份有限公司 | A kind of detection method of Children stasis relieving particle |
| CN109985188A (en) * | 2018-12-31 | 2019-07-09 | 海南葫芦娃药业集团股份有限公司 | A kind of preparation method and products thereof of Children stasis relieving particle |
| CN109985188B (en) * | 2018-12-31 | 2021-06-11 | 海南葫芦娃药业集团股份有限公司 | Preparation method of infantile indigestion removing granules and product thereof |
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Open date: 20080730 |