CN101229218A - Vanadium compounds for curing diabetes and preparing method thereof - Google Patents
Vanadium compounds for curing diabetes and preparing method thereof Download PDFInfo
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Abstract
The invention relates to a vanadium compound for treating diabetic and the preparation method thereof. The compatible compound mainly comprises: vanadium compound, extract of kudzu root, extract of gingko, vitamins B (VB1, VB2, VB6, VB12, and biotin), propolis, royal jelly, pollen, zinc compound, and chromium compound. According to certain proportion of the compounds, the granules are prepared by adding adequate food-grade ethanol with the ratio of 95 percent, microcrystalline cellulose taking 1.0 to 1.5 percent of the gross weight of the compounds, and 1.0 to 1.5 percent of stearic acid compound, then the granules are dried by 35 to 45 DEG C and settled, and finally a vanadium compound product with the effect of treating diabetic is obtained. The compound product can be made into granule preparation, tablets preparation, and hard capsule preparation or soft capsule preparation. The invention can be widely used for treating and preventing diabetic and complications of diabetic.
Description
Technical field
The present invention relates to treat the medicine and the manufacture method thereof of diabetes, specifically a kind of vanadium compounds and manufacture method thereof.
Background technology
Diabetes are a kind of common metabolic disease, and are higher at the mid-aged population sickness rate, and in recent years, in China's urban population, particularly the sickness rate in the youngster shows a rising trend.Diabetes are to cause beta Cell of islet excreting insulin deficiency and/or surrounding tissue insulin resistant and increasing with the blood glucose level of causing is the metabolic disease group of feature by the different causes of disease, show as abnormal carbohydrate metabolism, lipid metabolism is unusual, protein metabolism reaches multiple complications unusually generation.Hyperglycemia is the main biochemical character of diabetes, its generation and liver and peripheral tissues to utilization minimizing, the glycogen of glucose generate increase relevant.At present, very not clear and definite as yet to the pathogeny of diabetes, though the medicine of more existing different action target spots is used for the treatment of diabetes, can not reach good therapeutic effect sometimes.Lack effective medicine based on the treatment to diabetics at present, therefore, seek the action target spot of new treatment diabetes, the development of new medicine is extremely urgent.
English, beautiful scientist research has a proof with clinical, combination has more good blood sugar reducing function as compound recipes such as biotin (a kind of water soluble vitamin) organic vanadium, selenates, and think that this will become treating diabetes and open up a brand-new approach (Huang Hui, Shen Zhufang " is that target spot exploitation anti-diabetic new drug is paid close attention to GK ", " Chinese Medicine " on November 14th, 2006, total the 3282nd phase).
Research and clinical all proofs, single vanadium preparation has the good effect that prevents and treats diabetes, but take single vanadium preparation three big major defects is arranged.One: easily cause gastrointestinal upset; Its two: the generation and the development of complication such as the microcirculation of control glycosuria that can't be good, cardiovascular and cerebrovascular vessel, neuropathy, liver, kidney; Its three: diabetics owing to strict diet control, body to the absorption of food and take reasons such as medicine, cause the patient to the intake deficiency of some functional components and the storage level wretched insufficiency of body, make to body tissue and can't guarantee the normal metabolic activity of human body.Because of a little, single additional vanadium preparation can not reach the real treatment diabetes of control comprehensively and the complication meaning.
Summary of the invention
The present invention is intended to address the above problem, and provides a kind of toxic and side effects low and can effectively alleviate owing to take the vanadium compounds and the manufacture method thereof of the toxic and side effects that medicine brings to body for a long time.
In order to reach above purpose, vanadium compounds compound compatibility compositions of the present invention mainly comprises: compatibilities such as vfanadium compound, Radix Puerariae extract, Folium Ginkgo extract, vitamin B complex (VB1, VB2, VB6, VB12, biotin), propolis, Lac regis apis, pollen, zinc compound, chromium compound are synthetic, wherein: vfanadium compound is a vanadium picolinate, and zinc compound is that selenium picolinate, chromium compound are chromium picolinate.
Each component is by ratio of weight and the number of copies:
Vanadium picolinate 30-50, Radix Puerariae extract 600-1000,
Folium Ginkgo extract 150-300, vitamin B1 20,
Vitamin B2 10, vitamin B6 1.5,
Vitamin B12 0.02, biotin 1,
Lac regis apis lyophilized powder 600-1000, bee pollen 1500-4000,
Selenium picolinate 200-450, chromium picolinate 3.05-5.05.
Can add propolis in above compositions and other component content are adjusted, each component is by ratio of weight and the number of copies:
Vanadium picolinate 30-50, propolis 600-1400,
Radix Puerariae extract 500-1000, Folium Ginkgo extract 150-300,
Vitamin B1 20, vitamin B2 10,
Vitamin B6 1.5, vitamin B12 0.02,
Biotin 1, Lac regis apis lyophilized powder 600-1000,
Bee pollen 1000-3000, selenium picolinate 200-450,
Chromium picolinate 3.05-5.05.
Can also replace Semen Ginkgo extrac to carry out compatibility with propolis, each component be by ratio of weight and the number of copies:
Vanadium picolinate 30-50, Radix Puerariae extract 300-600,
Propolis 600-1400, vitamin B1 20,
Vitamin B2 10, vitamin B6 1.5,
Vitamin B12 0.02, biotin 1,
Lac regis apis lyophilized powder 600-1000, bee pollen 1350-3700,
Selenium picolinate 200-450, chromium picolinate 3.05-5.05.
The manufacture method of vanadium compounds of the present invention is:
1, system granular preparation method: each compositions is added an amount of 95% food stage ethanol, accounts for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulates after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate. obtain a kind of granular preparation product that is used for the treatment of the vanadium compounds of diabetes, the granular preparation product of making is taken by weighing per 0.5 gram get final product with the lucifuge bag hermetic package.
2, system hard capsule preparation method: each compositions is added an amount of 95% food stage ethanol, accounts for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulates after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate, sieve, divide the capsule of packing into, obtain a kind of hard capsule preparation product that is used for the treatment of the vanadium compounds of diabetes, inspect by ready samples qualified after, the hard capsule preparation product made packed with lucifuge bag or bottle get final product.
3, film-making formulation method: each compositions is added an amount of 95% food stage ethanol, accounts for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulates after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate, sieve, tabletting, obtain a kind of tablet preparation product that is used for the treatment of the vanadium compounds of diabetes, the tablet preparation product made is packed with lucifuge bag or bottle get final product.
4, system soft capsule preparation method: the food stage vegetable oil that each compositions is added the 50-75% that accounts for the above-mentioned composition gross weight, adopt substep emulsifying, detailed process is: prepare and handle described mixed liquor: A as follows, vanadium picolinate, Radix Puerariae extract, Semen Ginkgo extrac and/or propolis, selenium picolinate, chromium picolinate, vegetable oil are mixed, got I liquid at least 20 minutes in 60～75 ℃ of heating and stirring and emulsifying, I liquid is cooled to 30～35 ℃ of temperature naturally; B, the I liquid after the cooling was naturally mixed also stirring and emulsifying at least 5 minutes with vitamin B1, vitamin B2, vitamin B6, vitamin B12, biotin, Lac regis apis lyophilized powder, filter with 100～150 order drainage screens, get the soft capsule core material, fill soft capsule then, obtain a kind of soft capsule preparation product that is used for the treatment of the vanadium compounds of diabetes, the soft capsule preparation product made is packed with lucifuge bag or bottle get final product.
In the present composition, each component has following effect:
A large amount of deep research and clinical proofs, vfanadium compound is effect (Yang Min, Ai Jing, Wang Ning, Du Zhimin, Liu Ping, He Shuzhuan, the Yang Baofeng that significant blood sugar lowering is arranged, " sodium orthovanadate is to the kinase whose influence of type 2 diabetes mellitus rat keto acid " " Chinese Journal of New Drugs " 2004 12 phases,) (people such as Yang Xiaogai, Yang Xiaoda, the chemical fundamentals of vfanadium compound biological effect and prospect in medicine chemical progress, " chemical progress " 2003 14 phases.) wherein 2 foundations comprise: 1. oral effectively; All effective in cure to the type i diabetes patient; 2. action effect is long; Even after the steady back of diabetics glycemic control cut out, its hypoglycemic effect was according to sustainable several weeks or some months.Prove also that simultaneously vfanadium compound is an ILA.
Vanadium can the affecting glucose transhipment.Studies show that in early days vanadium can suppress the Na of diabetes SD jejunum in rats and ileum
+, K
+-atpase activity reduces the absorption of intestinal glucose, thereby improves hyperglycemia state.This especially has meaning for the hyperglycemia state that diabetics improves after the meal.Vanadium not only can increase the expression of GLUT-4, can also activate to make GLUT-1, GLUT-4 be indexed into cell membrane, and the acceleration glucose enters and carries out metabolism (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases) in the cell.
Vanadium can promote carbohydrate metabolism.Vanadium can suppress Ca
2+, Mg
2+The activity of-ATP enzyme makes Ca in the endochylema
2+Concentration improve, carry out carbohydrate metabolism in the cell thereby promote glucose to enter.In glycolytic pathway, phosphofructokinase, hexokinase and pyruvate kinase are 3 important regulatory enzymes of glycolytic pathway, and vanadium can improve the activity of these several enzymes, and induce its mRNA synthetic.Research such as Gupta finds that also vanadium can be regulated tricarboxylic acid cycle; Promote glucose through phosphopentose pathway metabolism (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases).
It is synthetic that vanadium can influence glycogen.Vfanadium compound can make the active rising of pancreatectomy (90%) rat body glycogen synthetase a, the synthetic quantity of glycogen increases in the rat hepatocytes of cultivation, sodium vanadate can make the glycogen synthetase phosphatase level that descends because of glycosuria recover, thereby makes into quantity and active the increasing of enzyme a; It is synthetic that vanadate not only can be urged the cell glycogen, and may identical system (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases) be arranged with insulin.
Vanadium can suppress glyconeogenesis.Vfanadium compound can suppress the activity (being phosphoenolpyruvate carboxykinase, G-6-Pase and 1, the 6-fructose diphosphatase) of 3 kinds of key enzymes in the glyconeogenesis approach, reduces its mRNA level; Also can be by improving 2, the level of 6-fructose diphosphate suppresses 1, the 6-fructose diphosphatase, thus reduce glyconeogenesis, promote glycolysis.In addition, vanadate can also be strengthened the activity of activity of pyruvic acid dehydrogenase system and glucokinase, makes gluconeogenesis reduce (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases).
Vanadium can be protected islet cells.Vanadium to diabetic animal except that hypoglycemic activity is arranged, to the recovery of islets of langerhans morphosis with improve positive role is also arranged; Though give the cellularity that vfanadium compound can not change streptozotocin (STZ) in advance, can protect the sub-fraction B cell to avoid the damage of STZ; Though the normal much less of insulin that the B cell of this part small growth produces has played crucial effect to the recovery and the reverse of diabetes.Studies show that, not the having and can cause damage of high concentration to islet cells, the vanadyl ion can suppress diabetes BALB/c Mus peritoneal macrophages and produce nitric oxide (NO), and this may be the another new mechanism that vanadium has hypoglycemic activity.
Vanadium all has identical usefulness for 1 type with the type 2 diabetes mellitus animal: blood sugar lowering, insulin level, improve carbohydrate tolerance and amount of insulin; But Different Effects is also arranged, and it can increase STZ rat fat synthesizing activity, and suppresses the activity of insulin resistant Animal fat synzyme, helps its antidiabetic effect.What deserves to be mentioned is, concentration and its blood sugar decreasing effect not tangible the closing property of vanadium in slurry and tissue, the power of its hypoglycemic activity depends primarily on vfanadium compound character.A lot of scholars think that vfanadium compound may be by some link behind islets of langerhans receptor or the receptor, and the insulin dependent/non-dependent is given birth to alternative pathway and worked (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 years 02 phases).
Vanadium and diabetic complication. the abnormal carbohydrate metabolism of diabetes causes lipid metabolism unusual usually, and triglyceride, cholesterol, free fatty raise.Vanadium can be regulated the fat metabolism enzyme, and it is unusual to improve lipid metabolism.In addition, research finds that also vanadium has significant prevention and therapeutical effect to the diabetes rat cataract, with degree and the scope that obviously alleviates the diabetes rat lenticular opacity.These effects are for the control of diabetic complication significant (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases).
The clinical observation of vanadium research. clinical research shows that also vanadium has antidiabetic effect: 2 weeks of the vanadic acid sodium of 125mg/d (Na3VO4) treatment or treated for 3 weeks with the vanadium oxysulfate (VOSO4) of 100mg/d after, the daily demand amout of type 1 diabetes patient island element has reduced by 14%, the type 2 diabetes mellitus patient improves the sensitivity of island element, and the effect that can prolong insulin.Continuous 28 weeks of medication, do not see obvious toxic and side effects, and to 1, the type 2 diabetes mellitus patient all has effect.
From vanadium and glycometabolic relation and zoopery and clinical reality, medicine as the treatment diabetes, vfanadium compound will be subjected to extensive concern, and the blood sugar lowering vanadium preparation of exploitation high-efficiency low-toxicity, also must become focus (Koryo brightness, a Li Ling in blood sugar lowering field, " foreign medical science (hygiology fascicle) ", 2007 02 phases).
The effect of zinc and diabetes and complication thereof.Zinc and carbohydrate metabolism.Zinc and carbohydrate metabolism are closely related.But affecting glucose equilibrium process in vivo.Zinc is the cofactor of triphosphoric acid glycerol dehydrogenase, lactic acid dehydrogenase, malic dehydrogenase in the sugar decomposition metabolism.Participate in the oxidation energy supply approach of sugar directly.Simultaneously, zinc also can be assisted the transhipment of glucose on cell membrane.Zinc still is the cofactor (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases) of constituent and lipid and protein metabolism enzyme of many glucose metabolism enzymes.
Zinc and insulin.Synthetic, the secretion of zinc and insulin, storage, degraded, biological activity and antigenicity are relevant.Zinc deficiency can be induced the generation insulin resistant, even diabetes.Insulin is unique hormone of blood sugar lowering in the body, and 2 metallic atom zinc are arranged in its molecular configuration, and the insulin changeableness of zinc deficiency lost efficacy.Active component as superoxide dismutase (SOD); zinc plays crucial effects to the body protective islet cells; it can alleviate the inflammatory reaction of islets of langerhans by antioxidation; suppress macrophage and discharge cytokine; reduce the generation of the diabetes rat serum NO equivalent damage factor, thus the protection B cell.
Zinc can activate protaminase, promotes that proinsulin changes insulin into.During zinc deficiency, protaminase is active in the rat body descends 50%, and the proinsulin of non-activity changes the trend that biologically active insulin is arranged into and descends, thereby causes serum insulin levels to descend.Zinc can also be regulated the level of insulin and receptor, plays an important role in keeping receptor phosphorylation and dephosphorylation level and insulin signaling transduction process.Zinc also can strengthen the adhesion (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 year 02 phase) of insulin to liver plasma membrane simultaneously.
The para-insulin sample effect of zinc.YOshikawa etc. think that zinc not only can keep the activity of insulin, and itself has ILA.Studies show that zinc compound can suppress rat fat cell and discharge free fatty; And can reduce the blood sugar level of KK.Ay mice, correct impaired glucose tolerance; Zinc supplement can reduce the glycolated hemoglobin level of diabetes rat, and corrects the disorders of lipid metabolism (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases) of diabetes rat.
The clinical observation research of zinc.Zinc deficiency reduces with insulin secretion and organizes relevant to the opposing of insulin action.The general zinc deficiency J of diabetics, serum zinc level and blood glucose are remarkable negative correlation, are proportionate with insulin and C peptide.Can improve that the T cell is replied lectins for ZD type 2 diabetes mellitus patient zinc supplement and the activity that do not improve natural killer cell.Zinc can also be corrected the diabetes disorders of lipid metabolism, and accelerated in wounds or ulcer healing have positive effect to the control diabetic complication.Therefore, think and be necessary suitably to replenish zinc (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases) to diabetics.
The effect of chromium and diabetes and complication thereof.Chromium and carbohydrate metabolism.Chromium and carbohydrate metabolism are closely related.Chromium is the essential element of insulin performance blood sugar reducing function, chromium is brought into play its physiological function by combining with nicotinic acid to form GT or form the collaborative insulin of other organo-chromium compounds with aminoacid, its mechanism of action mainly is to form disulfide bond by the Insulin receptor INSR that GTF regulates on insulin and the cell membrane, impels insulin performance maximal biological effect.Chromium also can act on transphosphorylase and the succinate dehydrogenase in the glucose metabolism, increases the utilization of sugar; Promote the expression of glucose transporter (GLUT)-4mRNA, increase glucose transport.
Insulin needs the participation of chromium when playing a role in vivo, and GTF also can only be under the situation that insulin exists, the competence exertion biochemical effect.Chromium bound substances (the low molecular weight chromium-binding substance of the natural low son amount of discovered in recent years, LMwcr) can activate insulin receptor kinase (insulin receptor kinase), under the situation that insulin exists, LMWCr can stimulate kinase activity to increase by 8 times, as chromium is separated from LMWCr, then its effect that increases enzymatic activity disappears; Davis etc. studies show that the outstanding feature of LMWCr is that it can be under the prerequisite that does not increase insulin concentration, promote the activity of insulin, prompting LMWCr has insulin signaling amplification (Koryo brightness, Li Ling at the insulin sensitivity cell, " foreign medical science (hygiology fascicle) ", 2007 02 phases).
Chromium and lipid metabolism.Chromium is not only relevant with carbohydrate metabolism, with lipid metabolism is also closely related experimental rat is lacked the chromium nursing, finds that its blood glucose, cholesterol and triglyceride level increase, and atherosclerotic lesion occurs; If give high chromium feedstuff, then the atherosclerotic lesion incidence rate is very low.Anderson etc. studies show that, the blood sugar level of can make rising for the diabetic mice chromium supplement reduces by 14%～29%, and cholesterol reduces by 35%, and triglyceride reduces by 45%.Then there is not this kind situation that (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases) takes place for the normal mice chromium supplement.
Chromium and protein metabolism.Chromium also has certain influence to protein metabolism.Chromium is synthetic relevant with protein and RNA's, is the essential material of keeping nucleic acid structure and function.Chromium can promote proteinic anabolism by assisting insulin in vivo, and can combine with pyrophosphate, nucleoprotein, methionine, serine etc. in the blood, protein metabolism is played regulating action (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases).
The clinical observation research of chromium.Clinical research shows that chromium supplement is all effective to treating dissimilar diabetes (comprising diabetes that type 1 diabetes, type 2 diabetes mellitus, gestational diabetes and steroid cause etc.).Use the effect of organic chromium better than inorganic chromium, common organic chromium has chromium picolinate, nicotinic acid chromium, Rich chromium yeast etc.Discovery chromium such as Vladeva can be alleviated type 2 diabetes mellitus patient's insulin resistant; Propositions such as Jovanovic replenish the auxiliary treatment that chromium picolinate can be used as the gestational diabetes women; Discovery chromium such as Ravina not only can be treated type 1 diabetes, and the diabetes that steroid is caused are also effective.Chromium plays a role as the collaborative insulin of the active component of GTF, and the metabolism of sugar, fat, protein and nucleic acid is played an important role.Effect is authenticated chromium widely to treatment of diabetes, and additional chromium has become to diabetics appropriate nutrition intervening measure (Koryo brightness, Li Ling, " foreign medical science (hygiology fascicle) ", 2007 02 phases).
Vitamin B complex is the effect positive to the diabetes tool of the transforming factor of enzyme.Vitamin B complex many effects in vivo often all connect each other, their great majority are the transforming factors as metabolic catalyst-enzyme, participate in synthesizing and decomposing and transform (how high mutually of intracellular protein, fat and sugar, " science of vitamin and trace element is used ", publishing house of Shanghai Univ. of Traditional Chinese Medicine, in April, 2003). and diabetes mainly show as abnormal carbohydrate metabolism, lipid metabolism is unusual, the protein lipid metabolism is unusual, therefore, vitamin B has reached the positive effect of complication tool to diabetes.Be embodied in:
Vitamin B1 has another name called thiamine.Thiamine is biological intravital important coenzyme---the main component of cocarboxylase (also being " thiamine pyrophosphate ").Cocarboxylase is one of most important biocatalyzer, and it is a cofactor of keeping metabolic plurality of enzymes system, and therefore, Vitamin B1 deficiency will cause a series of disease such as diabetes to produce.Its most important effect is in the metabolism of sugar, because it is active more to relate to glycometabolic some physiological function in the body, body is just big more to the demand of vitamin B1.
Thereby can keep normal digestive gland secretion and gastrointestinal motility facilitating digestion, vitamin B1 also can act on teleneuron, ethanol neuritis, trimester of pregnancy neuritis etc. there is therapeutic value, (what is high so someone is referred to as " antineuritic vitamin " again, " science of vitamin and trace element is used ", publishing house of Shanghai Univ. of Traditional Chinese Medicine, in April, 2003), therefore, vitamin B1 has reached the positive effect of complication tool to diabetes.
Vitamin B2 has another name called " riboflavin ".Riboflavin promotes the metabolism of nutrition, as the coenzyme composition, function in metabolism and enzyme itself are undivided, these enzymes mainly comprise multiple dehydrogenase system and oxidase system, these enzymes can promote protein, fat and sugar homenergic material removes dehydrogenation and imports oxygen in metabolic process, give off energy simultaneously, they are present in the liver mostly, on histiocytic respiratory chain, play crucial effects, at glucose, fat, play a major role in the metabolism link of protein and other multiple materials, when taking in high protein, how the vitamin B2 requirement (worships " science of vitamin and trace element is used " if can increasing, publishing house of Shanghai Univ. of Traditional Chinese Medicine, in April, 2003), therefore, riboflavin has reached the positive effect of complication tool to diabetes.
Vitamin B6 has another name called " pyridoxin ".Vitamin B6 is the coenzyme of many important enzymes system, pyridoxal 5-phosphate is energy generation, central nervous system activities, hemoglobin is synthetic and glycogen metabolism in necessary coenzyme.It and protein, lipometabolic relation are very close, and the B6 that is deficient in vitamin causes that minicell hangs down hematochrome anemia, nervous system dysfunction (as fainting from fear), fatty liver, seborrheic dermatitis etc.
Vitamin B6 is the important nutritional factors that participates in protein metabolism in the human body, lacks it, and the protein that human body is taken in can't decomposition and inversion be the protein of human body self just, can get knot, many serious diseases such as vomiting.
Vitamin B6 also participates in the metabolism of unsaturated fatty acid, promote that linoleic acid changes the Oleum Arachidis hypogaeae semen tetraenoic acid into, when human body was deficient in vitamin B6, lipid metabolism will reduce, thereby was prone to atherosclerotic lesion, clinical also with it come anti-fatty liver, (what is high to reduce serum cholesterol, " science of vitamin and trace element is used ", publishing house of Shanghai Univ. of Traditional Chinese Medicine, in April, 2003), therefore, vitamin B6 has reached the positive effect of complication tool to diabetes.
Vitamin B12.Vitamin B12 exists with the coenzyme form in vivo, and it exercises many physiological functions in skeleton, nervous tissue and gastrointestinal cell, as increasing the utilization rate of folic acid, promotes synthesizing of protein and nucleic acid etc.Discover the metabolism of the macronutrient in the food, protein, fat and sugar and vitamin B12 close relation.
Vitamin B12 is all play an important role aspect treatment sacred disease, liver and the facial disease (what is high, " science of vitamin and trace element is used ", publishing house of Shanghai Univ. of Traditional Chinese Medicine, in April, 2003).Therefore, vitamin B12 has reached the positive effect of complication tool to diabetes.
Biotin has another name called biotin.Biotin is the micro-growth factor that each living cells all contains, it is the ingredient of necessary carboxylase in protein, fat, the carbohydrate metabolism, participate in the biosynthesis of some aminoacid and long-chain fatty acid directly, participate in becoming oxaloacetic acid and synthesis of glucose process after the acetone acid carboxylation, these carboxylases have its importance in the mammal metabolism.Be to keep the human body normal growth to grow, keep the health institute of skin and bone marrow indispensable (what is high, " science of vitamin and trace element is used ", publishing house of Shanghai Univ. of Traditional Chinese Medicine, in April, 2003).Therefore, biotin has reached the positive effect of complication tool to diabetes.
Radix Puerariae extract is to the effect of diabetes and complication thereof.By extraction, separation and evaluation to the Radix Puerariae main component, find that puerarin has blood sugar lowering, the expansion peripheral blood vessel, particularly effects such as coronary artery dilator blood vessel, anticoagulant, thereby had the treatment diabetes, and improved the peripheral nerve injury due to its microangiopathies and the effect of retinopathy and renal function pathological changes.Source of data: appliance computer retrieval CNK11985-11/2004-11 with Radix Puerariae and diabetes pertinent literature.Term " Radix Puerariae, diabetes ", and qualification document languages are Chinese.Data is selected: data is carried out first trial, include standard in: the 1. active ingredient of Radix Puerariae and effect thereof.2. Radix Puerariae and effective extract thereof the effect in diabetes and complication treatment thereof.Exclusion standard: repeat research, summary class article in the document.Do not get rid of whether the article data has been used at random, contrast and double-blind method.DATA EXTRACTION: collect 314 pieces of pertinent literatures altogether, 16 pieces meet the standard of including in, get rid of 298 pieces, 289 pieces of wherein pure clinical reports, and 9 pieces for repeating report.Information integration: 2 pieces is the composition and the useful effect thereof of Radix Puerariae in 16 pieces of documents; 8 pieces of drug mechanisms that are Radix Puerariae and effective extract thereof to diabetes protopathy; 6 pieces about Radix Puerariae effective extract treatment diabetic complication.Conclusion: the medicine active ingredient of kudzuvine root for treating diabetes and complication thereof mainly is a puerarin, all can treat diabetes and complication thereof in clinical and experiment.
Folium Ginkgo extract is to the effect of diabetes and complication thereof.In addition the Jiang De of Central South University chant, Li Cairui at research pioglitazone and Folium Ginkgo extract (GBE) to diabetic mice retina HIF-1, vegf expression with to the experiment of the influence of retina cell apoptosis, early diagnosis and treatment to diabetic renal papillary necrosis provide theoretical foundation, inquired into expression and the effect thereof of HIF-1 and correlation factor VEGF in the early diabetic retinopathy; Inquired into the protective effect to diabetic renal papillary necrosis of Folium Ginkgo extract and pioglitazone, the result shows that retinal neurons pathological changes and microangiopathies have taken place the early stage NOD mice of diabetes; The early stage retina HIF-1 of diabetes alpha expression increases, and illustrates at the early stage retina generation of diabetes hypoxic-ischemic.The early stage retina HIF-1 of diabetes alpha expression increases with retina VEGF content does not have direct positive correlation.The expression of the early stage retina VEGF of diabetes is increased with multifactor relevant; Pioglitazone may directly suppress the function of HIF-1 and the expression of reducing retina VEGF.Folium Ginkgo extract may be to suppress diabetic mice retinal ischemia anoxia and reduce retina HIF-1 and express.The effect that Folium Ginkgo extract suppresses retina HIF-1 and vegf expression is better than pioglitazone slightly; Apoptosis is the important mechanisms of retinal neurons pathological changes, and it can promote the generation and the development of retinal neurons pathological changes.Pioglitazone and Folium Ginkgo extract have inhibitory action to the diabetic retina apoptosis, the neuron pathological changes of diabetic retina and microangiopathies are had therapeutical effect, and (Jiang De chants, Li Cairui, the doctor of Central South University medicine and pharmacology paper, 2005 05 month 01 daily magazine).Research and clinical all proofs, Folium Ginkgo extract has reached concurrent coronary heart disease to diabetes, angina pectoris, hyperlipemia, neuron and microangiopathies have therapeutical effect.
Propolis is meant by the Apis collection and must processes the extremely strong irregular solids of viscosity, be Apis existence and breed necessary material, deserve to be called the by-product of bee colony, have effect (" traditional Chinese medical science honeybee iatreusiology " Wang Runzhou etc. such as significantly antibiotic, antiviral, antitumor, Shenyang publishing house, July 1 calendar year 2001).Anti-inflammation, adjusting immunity, antioxidation, acceleration organization healing.The auxiliary treatment (Pharmacopoeia of the People's Republic of China, version was an one in 2005, Chemical Industry Press) that is used for hyperlipemia and diabetes.Be embodied in:
1. propolis flavone class, terpenoid substance have the effect that promotes to utilize the synthetic hepatic glycogen of exogenous glucose, and materials such as the catalpol in this class material, pterostibene have the effect of tangible blood sugar lowering.
2. propolis has the good sterilization antiinflammation, and can activating cell, promote tissue regeneration.Take propolis, can not only prevent infecting of pathogenic bacteria pair cell, and cell and the tissue that pathological changes takes place had treatment and repair.Adhere to taking propolis and can recover islet cell function;
3. interior too much free radical of body and lipid oxide and diabetes are closely related, have quite a few diabetes to be caused by free radical and lipid peroxide.Improve diabetes with antioxidant (SOD) rehabilitation efficacy is preferably arranged.Propolis is a kind of very strong Natural antioxidant, and can significantly improve the SOD activity.Take propolis and not only can reduce the injury of radical pair cell, can also prevent and treat multiple complications;
4. diabetic is followed hyperlipidemia mostly, and vessel aging's speed is faster than the normal person, is easy to cause microcirculation disturbance, cerebral thrombosis, heart disease, cardio-cerebrovascular complication.Abundant Flavonoid substances has the effect of good blood fat reducing, the permeability that reduces blood capillary, vessel softening, protection blood vessel in the propolis;
5. materials such as the flavonoid in the propolis, glycoside can strengthen ATPase activity, stimulate body to produce more adenosine triphosphate (ATP), and adenosine triphosphate is the important source of our human body energy, the effect that supplying energy is arranged, regains one's strength;
6. abundant and chemical elements such as the equilibrated calcium of ratio, magnesium, zinc, chromium have Special Significance to diabetes in the propolis.Chromium can activate insulin, improve carbohydrate tolerance; Calcium can influence secretion of insulin and release; Zinc can be kept the 26S Proteasome Structure and Function of insulin; Magnesium participates in the insulin cell function and regulates;
7. the release and the activity of the relevant enzyme with carbohydrate metabolism of propolis scalable system are disturbed the absorption of small intestinal to sugar, make to move behind the post-prandial glycemia peak value and reduce, and are very beneficial for diabetics;
8. propolis suppresses aldose reductase (AR), the activity of a one glucose enzyme (GA), Profilin glycosylation, thereby to anti-diabetic.Because the activation of AR and a large amount of existence can cause the body sorbitol to accumulate in a large number, and sorbitol causes the main cause of diabetic complication just, suppresses AR, just can suppress the generation of sorbitol, thereby suppress complication.Propolis suppresses GA, and the actual glucose that suppresses too much produces, thus blood sugar lowering (" magical propolis therapy ", Liu Fuhai, Chinese agriculture publishing house 2002/01/01).Research and clinical all proofs, propolis two-ways regulation blood glucose, to diabetes and concurrent coronary heart disease, angina pectoris, hyperlipemia, neuron and microangiopathies all have therapeutical effect.Propolis not only rises in vanadium compounds has therapeutical effect to diabetes and complication, but also is the protective agent of vanadium compounds.Contain a large amount of high-quality proteins and the high-activity biological factor in the vanadium compounds, therefore, be easy to cause parasitism, the breeding of antibacterial, make and contain a large amount of high-quality proteins and high-activity biological factor corruption, inactivation in the vanadium compounds, reduce or lose its original effect.But antibiotic anticorrosion, the anti-oxidation characteristics of propolis, showing an invincible might already in food processing and food preservation, it can be protected and contain a large amount of high-quality proteins and the high-activity biological factor in the vanadium compounds, prolongs the application cycle of vanadium compounds.
Lac regis apis contains abundant para-insulin peptide class, mineral element, vitamin, immune protein etc., research and clinical all proofs, and these contained in Lac regis apis materials have good effect to blood glucose metabolism aspect.Vitamin abundant in the Lac regis apis can carry out comprehensive nutrition to the person, can play good balance adjustment effect to body fat metabolism and carbohydrate metabolism, can reduce to obese people's hyperlipidemia, hyperglycemia normally (" traditional Chinese medical science honeybee iatreusiology " Wang Runzhou etc., Shenyang publishing house, July 1 calendar year 2001).Para-insulin sample peptide class is arranged in the Lac regis apis.The Zhou Shaoci of East China Normal University report is taken after the Lac regis apis, and the disease of diabetics begins to relax.This is the fact of making us being difficult to resolve at that time, recently uses the result of radioimmunoassay royal jelly by U.S. scientist and obtains clarification, because royal jelly contains Insulin-Like peptide class, its molecular weight is identical with bovine insulin.And insulin is the specific medicament (" traditional Chinese medical science honeybee iatreusiology " Wang Runzhou etc., Shenyang publishing house, July 1 calendar year 2001) of treatment diabetes.
Lac regis apis treatment diabetes clinically.Comparatively general at present.For example: Workers and Staff Medical College Liaoning Health Department spends beautiful monarch to wait " clinical observation of Lac regis apis treatment type ii diabetes " (1994): with Lac regis apis treatment type ii diabetes 38 examples, obtain satisfactory effect.Man's 32 examples, women 6 examples.Age 38-65 year, average 52 years old.The course of disease 3 months-5 years, average 2.4 years.Fasting glucose 7.1-8.3mmol/L12 example, 8.31-13mmol/L24 example,＞13mmol/L2 example.All in diet control after 2 weeks, symptom does not disappear, and blood glucose and glucose in urine be the changer not.Still continue in the treatment to keep on a diet.Take fresh royal jelly, each 10 milliliters 2 times every day.Serve on 3 months (course of treatment).Result: produce effects 23 examples (60.5%), 12 examples that take a turn for the better (31.3%), invalid 3 examples (7.8%), total effective rate 91.8% (" traditional Chinese medical science honeybee iatreusiology " Wang Runzhou etc., Shenyang publishing house, July 1 calendar year 2001).
Oral fresh royal jelly is sure to the type ii diabetes curative effect, and is consistent with Cong Zheng (1964) experimental result.Its mechanism: promote protein synthesis, diabetics blood glucose is descended, glucose in urine reduces, and improves clinical symptoms.Lac regis apis can impel cell regeneration, and whether can make beta Cell of islet itself recover metabolism normal, its defect repair and the hypoglycemic activity of bringing into normal play treats further to confirm from now on (" traditional Chinese medical science honeybee iatreusiology " Wang Runzhou etc., Shenyang publishing house, July 1 calendar year 2001).
Bee pollen is the more satisfactory auxiliary therapeutical agent of diabetics.Bee pollen is the male plant sexual cell that Apis is gathered, and adds nectar and saliva, the agglomerate that mixes to therebetween through Apis.Main component has: protein 20-30%, amino acid/11 3%, 11 kinds of vitamin, 27 kinds of mineral, multiple enzyme and bioactive substance.Clinical practice proves, pollen has the function of enhancing and stable drug effect, and the patient takes the pollen extraction merely and tucks in or take merely hypoglycemic drug, and its effect can not show a candle to both cooperations and takes significantly (" traditional Chinese medical science honeybee iatreusiology " Wang Runzhou etc., Shenyang publishing house, July 1 calendar year 2001).
The effect of pollen in diabetes control.Bee product treatment diabetes reports such as use pollen are a lot:
1. type ii diabetes is studied.One group of type ii diabetes (NIDM) is 30 of non-insulin-dependent diabetes mellitus patients.Age is at 20-69 between year, average 49.98 years old.Course of disease 1-17, average 8.6 years.Every day three times, obey pollen 10 grams before the meal half an hour, continuous 30 days is a course of treatment.Blood glucose decline 71mg/dl in treatment back drops to 33mg/dl.29 examples (96.7%) evident in efficacy are wherein arranged, invalid 1 example (3.3%).
Beijing Garrison hospital report is treated 30 routine diabeticss with pollen, obeys pollen 30 grams every day, and divide sooner or later and take for 2 times, the treatment through month, the blood glucose 71mg/dl that on average descends, rate of descent is 33%.Learn by statistics and handle, prove the difference highly significant.
2. keep the research of blood sugar level.(1-2) takes the diabetics of pollen for a long time, and clinical symptoms and blood sugar level all maintain normal level substantially.
3. to the research of type i diabetes.To insulin dependent diabetes mellitus (IDDM) is that type i diabetes (IDM) is taked insulin and pollen and usefulness, and collaborative blood sugar reducing function is also arranged.
4. antidiabetic drug comparative observation.Use the yellow ureas person of failing to respond to any medical treatment, use pollen that certain effect is still arranged.
5. foreign study.The slow doctor of U.S.'s speckle (GJBinaing) is in " about pollen " " About pollen " book, writing diabetics has eaten after the pollen, can reduce the injection volume of insulin, also make other patient's minimizing demand (" traditional Chinese medical science honeybee iatreusiology " Wang Runzhou etc. to medicine, Shenyang publishing house, July 1 calendar year 2001).
This vanadium compounds that is used for the treatment of diabetes of the present invention can improve the bioavailability of vfanadium compound, reduces the toxic and side effects of vfanadium compound to human body; And, this compound compatibility composite preparation is compared with single vfanadium compound preparation: have that compatibility is reasonable, effective ingredient is high, bioavailability, control support in conjunction with, irritated rate is low, toxic and side effects is low, to the treatment and the stronger advantages such as specific aim of prevention tool of diabetes and complication thereof, diabetes and complication thereof are controlled the effect of supporting combination, treating both the principal and secondary aspects of a disease thereby reach.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment.
The source of each compositions and standard in the embodiments of the invention:
1, vitamin B1, vitamin B2, vitamin B6, vitamin B12 raw material standard are pressed Pharmacopoeia of the People's Republic of China version execution in 2005; The biotin raw material standard is carried out by " nutrition product company limited company standard is encouraged in Shanghai ", and encouraging into the nutrition product company limited by Shanghai provides;
2, Radix Puerariae extract, Folium Ginkgo extract raw material standard are pressed Pharmacopoeia of the People's Republic of China version execution in 2005, and one Bioisystech Co., Ltd provides by the sky, Xi'an;
3, vanadium picolinate, selenium picolinate, chromium picolinate raw material standard are carried out by " the marine day Fine Chemical Works in Shenyang City put forward company standard ", are provided by the marine day Fine Chemical Works in Shenyang City;
Embodiment 1
Take off the row compositions:
Vanadium picolinate 30g, Radix Puerariae extract 1000g,
Folium Ginkgo extract 150g, vitamin B1 20g,
Vitamin B2 10g, vitamin B6 1.5g,
Vitamin B12 0.02g, biotin 1g,
Lac regis apis lyophilized powder 600g, bee pollen 1500g,
Selenium picolinate 450g, chromium picolinate 3.05g.
And then add an amount of 95% food stage ethanol, account for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulate after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate. obtain a kind of granular preparation product that is used for the treatment of the vanadium compounds of diabetes, inspect by ready samples qualified after, the granular preparation product of making is taken by weighing per 0.5 gram gets final product with lucifuge bag package encapsulation.
Embodiment 2
Take off the row combination:
Vanadium picolinate 50g, Radix Puerariae extract 600g,
Folium Ginkgo extract 300g, vitamin B1 20g,
Vitamin B2 10g, vitamin B6 1.5g,
Vitamin B12 0.02g, biotin 1g,
Lac regis apis lyophilized powder 1000g, bee pollen 4000g,
Selenium picolinate 200g, chromium picolinate 5.05g.
And then add an amount of 95% food stage ethanol, account for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulate after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate, sieve, divide the capsule of packing into, obtain a kind of hard capsule preparation product that is used for the treatment of the vanadium compounds of diabetes, inspect by ready samples qualified after, the hard capsule preparation product made packed with lucifuge bag or bottle get final product.
Embodiment 3
Take off the row compositions:
Vanadium picolinate 40g, Radix Puerariae extract 800g,
Folium Ginkgo extract 225g, vitamin B1 20g,
Vitamin B2 10g, vitamin B6 1.5g,
Vitamin B1 20.02g, biotin 1g,
Lac regis apis lyophilized powder 800g, bee pollen 2750g,
Selenium picolinate 325g, chromium picolinate 4.05g.
Manufacture method by above two embodiment can make granular preparation or hard capsule preparation respectively.
Embodiment 4
Present embodiment is different from above embodiment part and is also to comprise propolis, takes off the row compositions:
Vanadium picolinate 30g, propolis 600g,
Radix Puerariae extract 1000g, Folium Ginkgo extract 300g,
Vitamin B1 20g, vitamin B2 10g,
Vitamin B6 1.5g, vitamin B12 0.02g,
Biotin 1g, Lac regis apis lyophilized powder 600g,
Bee pollen 3000g, selenium picolinate 200g,
Chromium picolinate 3.05g.
And then add an amount of 95% food stage ethanol, account for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulate after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate, sieve, tabletting, obtain a kind of tablet preparation product that is used for the treatment of the vanadium compounds of diabetes, inspect by ready samples qualified after, the tablet preparation product made packed with lucifuge bag or bottle get final product.
Embodiment 5
Take off the row compositions:
Vanadium picolinate 50g, propolis 1400g,
Radix Puerariae extract 500g, Folium Ginkgo extract 150g,
Vitamin B1 20, vitamin B2 10,
Vitamin B6 1.5, vitamin B12 0.02,
Biotin 1, Lac regis apis lyophilized powder 1000g,
Bee pollen 1000g, selenium picolinate 450g,
Chromium picolinate 5.05g.
This practical example is adopted as the soft capsule preparation method of making, and each compositions is added the food stage vegetable oil, adopts substep emulsifying, and concrete preparation steps is:
A, vanadium picolinate, Radix Puerariae extract, propolis, Folium Ginkgo extract, selenium picolinate, chromium picolinate and the vegetable oil that accounts for the 50-75% of above-mentioned composition gross weight are mixed, got I liquid at least 20 minutes in 60～75 ℃ of heating and stirring and emulsifying, I liquid is cooled to 30～35 ℃ of temperature naturally;
B, the I liquid after the cooling was naturally mixed also stirring and emulsifying at least 5 minutes with vitamin B1, vitamin B2, vitamin B6, vitamin B12, biotin, Lac regis apis lyophilized powder, filter with 100～150 order drainage screens, get the soft capsule core material, fill soft capsule then, obtain a kind of soft capsule preparation product that is used for the treatment of the vanadium compounds of diabetes, the soft capsule preparation product made is packed with lucifuge bag or bottle get final product.
Embodiment 6
Take off the row compositions:
Vanadium picolinate 40g, propolis 1000g,
Radix Puerariae extract 750, Folium Ginkgo extract 225g,
Vitamin B1 20g, vitamin B2 10g,
Vitamin B6 1.5g, vitamin B12 0.02g,
Biotin 1g, Lac regis apis lyophilized powder 800g,
Bee pollen 2000g, selenium picolinate 325g,
Chromium picolinate 4.05g.
Manufacture method by above each embodiment can make granular preparation, tablet preparation, hard capsule preparation or soft capsule preparation respectively.
Embodiment 7
Present embodiment is different from above embodiment part and is to replace Folium Ginkgo extract with propolis, takes off the row compositions:
Vanadium picolinate 30g, Radix Puerariae extract 600g,
Propolis 600g, vitamin B1 20g,
Vitamin B2 10g, vitamin B6 1.5g,
Vitamin B12 0.02g, biotin 1g,
Lac regis apis lyophilized powder 1000g, bee pollen 1350g,
Selenium picolinate 200g, chromium picolinate 5.05g.
Preparation method is the same.
Embodiment 8
Take off the row compositions:
Vanadium picolinate 50g, Radix Puerariae extract 300g,
Propolis 1400g, vitamin B1 20g,
Vitamin B2 10g, vitamin B6 1.5g,
Vitamin B12 0.02g, biotin 1g,
Lac regis apis lyophilized powder 600g, bee pollen 3700g,
Selenium picolinate 450g, chromium picolinate 3.05g.
Preparation method is the same.
Embodiment 9
Take off the row compositions:
Vanadium picolinate 40g, Radix Puerariae extract 450g,
Propolis 1000g, vitamin B1 20g,
Vitamin B2 10g, vitamin B6 1.5g,
Vitamin B12 0.02g, biotin 1g,
Lac regis apis lyophilized powder 800g, bee pollen 2525g,
Selenium picolinate 325g, chromium picolinate 4.05g.
Preparation method is the same.
Be the concrete application example of vanadium compounds of the present invention below:
Case one: king x is bright, the man, and 43 years old, Shenzhen people, type ii diabetes, medical history 7 years, the beginning, effect was undesirable always with treatments such as xx blood-sugar reducing tea, the x that quenches one's thirst, beautiful x health, and the impermanence of blood glucose height has thirsty, insomnia, constipation, symptom such as weak.In October, 2007 is when taking beautiful x health, add the vanadium compounds sheet, 3 times/day, 1/time, thirsty after five days, insomnia, constipation, symptom such as weak are clearly better, and fasting glucose is reduced to 6.1mmol/L from 9.14mmol/L, the blood glucose fall reaches 33%, glucose in urine is also by before taking +++reduce to+, rose in the 6th day and to begin to withdraw beautiful x health, follow up a case by regular visits to 2 months fasting glucose and be stabilized between the 5.2mmol/L to 6.3mmol/L always.
Case two: Lee x duckweed, the woman, 57 years old, people from Guangzhou, type ii diabetes, hypertension, angina pectoris, fat, year surplus the medical history 10, main stating: uncomfortable in chest, feeling of fullness in the head, insomnia, dreaminess, symptom such as weak, fasting glucose 13.5mmol/L on inspection, glucose in urine +++, blood pressure 175/105mmHg, T-CHOL, triglyceride all is higher than normal range, begin in March, 2007 on former treatment basis, to add the vanadium compounds sheet, 3 times/day, 1/time, played blood glucose in second day, blood pressure begins steady decline, breakfast post-prandial glycemia 7.5mmol/L after seven days, glucose in urine+, blood pressure 130/90mmHg progressively deducts former medicine for treatment subsequently under expert's guidance, Ahau cuts out former medicine for treatment fully and only takes the vanadium compounds sheet, fasting glucose is reduced to 6.7mmol/L, blood pressure is reduced to 136/88mmHg, and is uncomfortable in chest, feeling of fullness in the head, insomnia, dreaminess, symptom such as weak is clearly better; Fasting glucose 6.3mmolL, blood pressure 135/86mmHg on inspection after three months, T-CHOL, triglyceride also by former high reduce to normal.
Case three: yellow x is flat, 43 years old, Bao'an, Shenzhen civil servant, because operating pressure is big, life less stable, before 5 years, be diagnosed as diabetes, the highest 21.7mmol/L of blood glucose, glucose in urine ++ ++, through in, western medical treatment do not see and is clearly better, often insomnia, weak, symptom such as pruritus from head to foot, blood glucose always between 11.5mmol/L to 14.8mmol/L repeatedly.In JIUYUE, 2007 begins to change clothes vanadium compounds sheet, and blood sugar recovery normally reaches 6.3mmol/L after 15 days, continues to take again, and existing blood glucose has been stabilized in 5.3-5.7mmol/L, and sleep obviously improves, skin pruritus no longer.
This vanadium compounds that is used for the treatment of diabetes of the present invention can be widely used in the treatment and the prevention of diabetes and complication thereof.
Claims (10)
1. a vanadium compounds that is used for the treatment of diabetes is characterized in that, the each component weight ratio is:
Vanadium picolinate 30-50, Radix Puerariae extract 600-1000,
Folium Ginkgo extract 150-300, vitamin B1 20,
Vitamin B2 10, vitamin B6 1.5,
Vitamin B1 20.02, biotin 1,
Lac regis apis lyophilized powder 600-1000, bee pollen 1500-4000,
Selenium picolinate 200-450, chromium picolinate 3.05-5.05.
2. the vanadium compounds of treatment diabetes according to claim 1 is characterized in that, the each component weight ratio is:
Vanadium picolinate 40, Radix Puerariae extract 800,
Folium Ginkgo extract 225, vitamin B1 20,
Vitamin B2 10, vitamin B6 1.5,
Vitamin B12 0.02, biotin 1,
Lac regis apis lyophilized powder 800, bee pollen 2750,
Selenium picolinate 325, chromium picolinate 4.05.
3. a vanadium compounds that is used for the treatment of diabetes is characterized in that, the each component weight ratio is:
Vanadium picolinate 30-50, propolis 600-1400,
Radix Puerariae extract 500-1000, Folium Ginkgo extract 150-300,
Vitamin B1 20, vitamin B2 10,
Vitamin B6 1.5, vitamin B12 0.02,
Biotin 1, Lac regis apis lyophilized powder 600-1000,
Bee pollen 1000-3000, selenium picolinate 200-450,
Chromium picolinate 3.05-5.05.
4. the vanadium compounds that is used for the treatment of diabetes according to claim 3 is characterized in that, the each component weight ratio is:
Vanadium picolinate 40, propolis 1000,
Radix Puerariae extract 750, Folium Ginkgo extract 225,
Vitamin B1 20, vitamin B2 10,
Vitamin B6 1.5, vitamin B12 0.02,
Biotin 1, Lac regis apis lyophilized powder 800,
Bee pollen 2000, selenium picolinate 325,
Chromium picolinate 4.05.
5. a vanadium compounds that is used for the treatment of diabetes is characterized in that, the each component weight ratio is:
Vanadium picolinate 30-50, Radix Puerariae extract 300-600,
Propolis 600-1400, vitamin B1 20,
Vitamin B2 10, vitamin B6 1.5,
Vitamin B12 0.02, biotin 1,
Lac regis apis lyophilized powder 600-1000, bee pollen 1350-3700,
Selenium picolinate 200-450, chromium picolinate 3.05-5.05.
6. the vanadium compounds that is used for the treatment of diabetes according to claim 5 is characterized in that, the each component weight ratio is:
Vanadium picolinate 40, Radix Puerariae extract 450,
Propolis 1000, vitamin B1 20,
Vitamin B2 10, vitamin B6 1.5,
Vitamin B12 0.02, biotin 1,
Lac regis apis lyophilized powder 800, bee pollen 2525,
Selenium picolinate 325, chromium picolinate 4.05.
7. manufacture method that is used for the treatment of the vanadium compounds of diabetes, it is characterized in that: each compositions is added an amount of 95% food stage ethanol, accounts for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulates after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate. obtain a kind of granular preparation product that is used for the treatment of the vanadium compounds of diabetes, the granular preparation product of making is taken by weighing per 0.5 gram lucifuge bag hermetic package.
8. manufacture method that is used for the treatment of the vanadium compounds of diabetes, it is characterized in that: each compositions is added an amount of 95% food stage ethanol, accounts for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulates after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate, sieve, divide the capsule of packing into, obtain a kind of hard capsule preparation product that is used for the treatment of the vanadium compounds of diabetes, inspect by ready samples qualified after, the hard capsule preparation product made is packed with lucifuge bag or bottle.
9. manufacture method that is used for the treatment of the vanadium compounds of diabetes, it is characterized in that: each compositions is added an amount of 95% food stage ethanol, accounts for the 1.0-1.5% microcrystalline Cellulose of above-mentioned composition gross weight, granulates after accounting for the 1.0-1.5% stearic acid enzymes mixing and stirring of above-mentioned composition gross weight, 35-45 ℃ of drying, granulate, sieve, tabletting, obtain a kind of tablet preparation product that is used for the treatment of the vanadium compounds of diabetes, the tablet preparation product of making is packed with lucifuge bag or bottle.
10. manufacture method that is used for the treatment of the vanadium compounds of diabetes, it is characterized in that: the food stage vegetable oil that each compositions is added the 50-75% that accounts for the above-mentioned composition gross weight, adopt substep emulsifying, detailed process is: prepare and handle described mixed liquor: A as follows, vanadium picolinate, Radix Puerariae extract, Semen Ginkgo extrac and/or propolis, selenium picolinate, chromium picolinate, vegetable oil are mixed, got I liquid at least 20 minutes in 60～75 ℃ of heating and stirring and emulsifying, I liquid is cooled to 30～35 ℃ of temperature naturally; B, the I liquid after the cooling was naturally mixed also stirring and emulsifying at least 5 minutes with vitamin B1, vitamin B2, vitamin B6, vitamin B12, biotin, Lac regis apis lyophilized powder, filter with 100～150 order drainage screens, get the soft capsule core material, fill soft capsule then, obtain a kind of soft capsule preparation product that is used for the treatment of the vanadium compounds of diabetes, the soft capsule preparation product of making is packed with lucifuge bag or bottle.
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| WO2012131689A1 (en) | 2011-03-25 | 2012-10-04 | Chaudhuri Mihir K | Insulin mimetic active comprising oxodiperoxo vanadates and a pharamaceutical composition obtained thereof |
| CN107412334A (en) * | 2017-09-06 | 2017-12-01 | 湖北厚品生物科技有限公司 | Compound control sugar mixture and its manufacture method |
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| WO2012131689A1 (en) | 2011-03-25 | 2012-10-04 | Chaudhuri Mihir K | Insulin mimetic active comprising oxodiperoxo vanadates and a pharamaceutical composition obtained thereof |
| CN107412334A (en) * | 2017-09-06 | 2017-12-01 | 湖北厚品生物科技有限公司 | Compound control sugar mixture and its manufacture method |
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