CN101209317A - Medicinal composition with sobering-up and liver-protecting action - Google Patents
Medicinal composition with sobering-up and liver-protecting action Download PDFInfo
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- CN101209317A CN101209317A CNA2006101704623A CN200610170462A CN101209317A CN 101209317 A CN101209317 A CN 101209317A CN A2006101704623 A CNA2006101704623 A CN A2006101704623A CN 200610170462 A CN200610170462 A CN 200610170462A CN 101209317 A CN101209317 A CN 101209317A
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a pharmaceutical composition with the effects of relieving alcoholism and protecting the liver, and the composition is composed of cape jasmine fruit, common floweringquince fruit, flos puerariae, raisin tree seed and grape seed. The invention can effectively prevent being drunk when the invention is taken before drinking. The invention has good improvement effect for headache, dizziness and vomit symptoms which are caused by excessive drinking. The invention can improve the abnormal metabolism of the liver which is caused by alcohol. The invention can be made into the drugs or health care foods, foods and health care supplies with the effects of relieving alcoholism and protecting the liver.
Description
Technical field
Princepia utilis oil skin protection provided by the invention and hair products have the good maintenance skin and the effect of hair.The present invention relates to that a kind of tool relieves the effect of alcohol, the pharmaceutical composition of hepatoprotective effect, compositions is made up of Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae), Semen Vitis viniferae, for the excessive headache that causes in back of drinking, dizziness, feel sick, symptoms of emesis has good improvement effect.Take before the wine, can be effectively anti-intoxication.
Background technology
Wine is prejudicial to human health.Drink for a long time and can cause alcohol user's brain injury, personality being irritable and getting angry easily, the concurrent sick change of hepar damnification.And liver is important detoxifcation organ, can decomposition be arranged to a certain amount of ethanol (in the wine important harmful substance) under the normal condition, but behind long-term or the heavy drinking, liver is obviously not enough to the capacity of decomposition of ethanol.Simultaneously, the excretory metabolic enzyme of liver relatively lags behind again in the absorption of ethanol, therefore, before ethanol is decomposed fully, liver and brain are caused damage, the ability of relieving the effect of alcohol of the liver that sustains damage simultaneously is affected, therefore, for the crowd of long-term heavy drinking, the ability of relieving the effect of alcohol that relies on liver separately is not enough, also to rely on external material to remove ethanol, reduce the harm of ethanol human body.
Drinking of wine originates from the Shang dynasty, and along with socio-cultural development, spirits culture has also obtained bigger development.In the modern society, wine is used as a kind of important media in the social life, extensive use; Wine also is the important beverage that friend gets together; It also is a kind of important beverage of alleviation work mental pressure.The wine industry also is the important ring in the national food industrial chain simultaneously,, be the important source of state tax revenue.Therefore, the total ban alcoholic beverage circulates on market and realizes than difficult.
The object of the present invention is to provide a kind ofly improve the dizziness, the headache that cause after drinking with volume of treatment, feel sick, vomiting, gastric malaise symptoms, and drink for a long time alcoholic liver injury that causes, the pharmaceutical composition of fatty liver, safeguard the crowd's that drinks health.And also should go to hospital to carry out Comprehensive Treatment for alcoholism and more serious hepatic injury.
Summary of the invention
Compositions provided by the invention is through years of researches and screening, and tries out in animal and human group, and the preferable compositions that obtains is at last formed and corresponding weight ratio, and carried out the preparation research of combination dosage form, and relevant pharmacology, clinical grinding.
Compositions composed as follows:
1. pharmaceutical composition is made by the raw material of following weight ratio:
Fructus Gardeniae 1-6 Fructus Chaenomelis 1-5 Flos puerariae lobatae 1-5 Semen Hoveniae (Fructus Hoveniae) 1-5 Semen Vitis viniferae 0.5-3
2. to prepare extract with water extracting method, compositions is mixed and made into following weight ratio by extract raw material respectively:
Fructus Gardeniae 1-5 extract Fructus Chaenomelis extract 1-5 Flos puerariae lobatae extract 1-5
Semen Hoveniae extract (Fructus Hoveniae extract) 1-5 Semen Vitis viniferae extract 0.5-3
3. water extracted after raw material mixed, the preparation compositions.
4. raw material is mixed with compositions after also can pulverizing.
Wherein in the Semen Vitis viniferae main effective ingredient should be procyanidin compounds, so the Semen Vitis viniferae raw material can replace with commercially available procyanidin compounds.
Wherein in the Semen Vitis viniferae main effective ingredient should be procyanidin compounds, so Semen Vitis viniferae extract can replace with commercially available procyanidin compounds.
7. compositions can add adjuvant, excipient, additive according to dosage form and taste needs in preparation process.
8. the product made of compositions can be any type of product that bromatology is accepted.
9. the dosage form made of compositions mainly is a peroral dosage form, can be: oral liquid, tablet, capsule, granule, pill, powder, teabag, beverage etc.
10. the product made of compositions has effects of relieving alcoholism and protecting liver, and can declare becomes medicine, health food, food, health product.
Embodiment:
Embodiment 1: the preparation of capsule
Get Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae), Semen Vitis viniferae (weight ratio is 2: 5: 1: 1: 0.5), after being mixed in proportion, extract 2 times with 10 times of water gagings, each 1 hour, extracting solution was concentrated, dry, and the extract that obtains adds dextrin and starch (ratio of extract-dextrin-starch is 6: 2: 2), ethanol with 80% is granulated, dry, granulate incapsulate, promptly.
Embodiment 2: the preparation of powder
Get Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae), Semen Vitis viniferae, cross 120 mesh sieves, mix homogeneously (weight ratio is 1: 1: 5: 3: 3) behind the pulverize separately.
Embodiment 3: the preparation of teabag
Get Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae), Semen Vitis viniferae, cross 20 mesh sieves after the coarse pulverization respectively, mix homogeneously (weight ratio is 3: 4: 2: 5: 2), pack, sterilization, promptly.
Embodiment 4: the preparation of pill
Get Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae) and use water extraction respectively, extracting solution drying respectively obtains extract, crosses 80 mesh sieves; Other gets Semen Vitis viniferae, and 80 mesh sieves are crossed in coarse pulverization.Extract mixes with Semen Vitis viniferae, and weight ratio is 3: 2: 2: 5: 3), with the Mel mixing of new refining, pill, sterilization, promptly.
Embodiment 5: the preparation of granule
Get Fructus Gardeniae, Fructus Chaenomelis, Semen Hoveniae (Fructus Hoveniae), Flos puerariae lobatae and mix that (weight ratio is 4: 2: 4: 4), merge water extraction, cross 120 mesh sieves behind the concentrate drying.Other gets commercially available procyanidin and extract powder mix homogeneously (weight ratio 1: 2), with the Mel mixed pelletization of new refining, is pressed into the square shape or directly with granule encapsulation, sterilization promptly.
Embodiment 6: the preparation of beverage
Get Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae), Semen Vitis viniferae (weight ratio is 4: 3: 3: 2: 2), use water extraction, extracting liquid filtering concentrates, as concentrated solution.Concentrated solution adds the pure water synthetic beverage, and the concentrated solution volume accounts for 8%, adds sucrose 2%, seasoning, and sterilization, promptly.
Embodiment 7: the preparation of oral liquid
Get Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae), Semen Vitis viniferae (weight ratio is 2: 3: 3: 4: 1), use water extraction, extracting liquid filtering concentrates, sterilization, promptly.
Embodiment 8: the preparation of tablet
Get Fructus Gardeniae, Fructus Chaenomelis, Flos puerariae lobatae, Semen Hoveniae extract (Fructus Hoveniae extract), mix (weight ratio is 3: 1: 3: 5: 0.5) with commercially available procyanidin, pulverize, cross 120 mesh sieves, add adjuvant (contract methyl starch and dextrin, weight ratio are 2: 1), adjuvant weight accounts for 35% of gross weight, makes tablet, promptly.
Experimental example:
Composition therefor is a made tablet among the embodiment 8 in the experimental example, and pulverize is to call the administration group in the following text.
Experimental example 1: the drunk prevention experiment of mice
Experiment material: the administration component is high, medium and low dosage group, and compositions with water dissolution, is mixed with debita spissitudo (pressing the preparation of table 1 dosage).Commercially available Erguotou wine (56 degree, Red Star brewery in Beijing produces, and is mixed with the solution for standby of spirituosity 45%).
Grouping: get 50 of Kunming kind white mice, the male and female dual-purpose, body weight 18-20g is divided into 5 groups at random, 10 every group, is set at blank group respectively, model group, high, medium and low dosage group.
Method: blank group is only irritated stomach feedwater 0.4ml/ every day, and all the other are respectively organized and to wine 0.4ml/ only irritate stomach every day, and model group is given preceding 1 hour of wine every day, irritates stomach feedwater 0.2ml; Each administration group is given preceding 1 hour of wine, all gastric infusion 0.4ml (compound concentration sees Table 1) every day.Stomach feedwater 0.4ml is irritated in preceding 1 hour of blank group feedwater.
Carried out continuously 10, and in the time of the 8th, 9,10 day, mice is carried out righting reflex experiment respectively, and observe the number of elements of righting reflex loss occurring for behind the ethanol mice in 1 hour, righting reflex loss can be thought animal drunk (drunk), 5 observed results of accumulative total, its drunk rate.
The drunk prevention experiment of table 1 mice
The result: experimental result shows that each administration group and model group compare, and drunk rate obviously reduces, and shows that it has the drunk effect of good preventing.
Experimental example 2: to the influence of the rat fat Developmental and Metabolic Disorder due to the ethanol
Experiment material: the administration component is the high and low dose group, and compositions with water dissolution, is mixed with debita spissitudo (pressing the preparation of table 2 dosage).Commercially available Erguotou wine (56 degree, commercially available Beijing Red Star strong, colourless liquor distilled from sorghum).
Animal grouping: grouping: get 40 of wister rats, body weight is 130-170g, is divided into 4 groups at random, i.e. normal control group, and model control group, administration component are the high and low dose group, 10 every group.
Method: feedwater normal control group every day, and be beverage with the tap water, feed with normal diet; All the other are respectively organized and irritate stomach at 10 o'clock in morning every day and give wine 1 time, are 15ml/kg to capacity for liquor, and feedstuff is that Semen Maydis powder adds the high lipid food that Adeps Sus domestica (20%) and cholesterol (0.5%) are made.
The administration group is irritated stomach to 1 hour after drinking administration 15ml/kg every day.
The fasting between every day 8:00-10:00 of all each treated animals, after giving the group administration, each group provides corresponding feedstuff, each group was raised 50 days with said method, got the broken end blood sampling on the 51st day, with the centrifugal 15min of 3000r/min, get upper serum, press the test kit description and measure TC, HDL-C, LDL-C, TG, T
3, T
4Value the results are shown in Table 2, table 3.
The influence of the Serum TC of fatty liver, HDL-C, LDL-C due to the table 2 pair ethanol (x ± s)
△ compares P＜0.05 with the normal control group; * compare P＜0.05 with model control group
Rat blood serum TG, the T of fatty liver due to the table 3 pair ethanol
3, T
4Influence (x ± s)
△ compares P＜0.05 with the normal control group; * compare P＜0.05 with model control group
Experimental result shows that serum TC content: the normal control group is compared significant difference (P＜0.05) with model group; Model group is compared significant difference (P＜0.05) with the administration group;
Serum HDL-C content: matched group is compared significant difference (P＜0.05) with model group, and the administration group is compared significant difference (P＜0.05) with model group.
Serum LDL-C content: matched group is compared significant difference (P＜0.05) with model group, and the administration group is compared difference not remarkable (P＞0.05) with model group, but the LDL-C of administration group has reduction trend.
Experimental example 3: to ethanol headache, dizziness, vomiting crowd's effect
Case is selected: select easily headache (frequency of drinking height, on average weekly more than the secondary, nearest five all headaches of drinking) person 185 people in the crowd that drinks for a long time, age 30-60 year, women 7 people, male 178 people.
Therapeutic Method: take two after drinking, with own control, drinking amount identical with the amount that occurs malaise symptoms in the past (being insobriety).The observation back 1 hour symptom variation of taking medicine.
Curative effect determinate standard:
The effect of 1 pair of headache symptom:
Produce effects: no headache symptom.
Effectively: the headache degree alleviates, and the headache time shortens.
Invalid: headache as before.
The result: what insobriety often produced the headache transference cure has 93 people, women 5 people wherein, and after taking, produce effects 77 people, effective 14 people.Calculate thus, obvious effective rate is 83.0%, and effective percentage is 97.8%.
The effect of 2 pairs of dizzy symptoms
Produce effects: do not have dizzy symptom.
Effectively: close dizzy alleviating.
Invalid: as to close and swoon as before.
The result: what insobriety often produced the headache transference cure has 179 people, women 7 people wherein, and after taking, produce effects 170 people, effective 9 people.Calculate thus, obvious effective rate is 95.0%, and effective percentage is 100%.
The effect of 3 pairs of symptoms of emesis
Since drink after, human body can produce the self-defence vomiting, mostly occur when drinking or after drinking soon, favourable to alleviating alcoholism.And symptoms of emesis appearred later in the part crowd at 1 hour after drinking, and at this moment most ethanol have absorbed or entered lower digestive tract, and ethanol is less in the vomitus, and vomiting at this moment all has adverse effect to jingler's sleep and stomach.Therefore, require the drunk person in drinking or in 1 hour after drinking,, take medicine again after just having told earlier if any the vomiting sense.
Effectively: no longer include the vomiting sense.
Invalid: as to still have vomiting.。
The result: insobriety often produces 33 people that have of head vomiting, women 1 people wherein, and after taking, effective 28 people.Calculate thus, effective percentage is 60.6％。
In addition, all experimenters all react, take the tablet that compositions provided by the present invention makes after, second day no any malaise symptoms after drinking.
Claims (10)
1. pharmaceutical composition with effects of relieving alcoholism and protecting liver, it is characterized in that: this pharmaceutical composition is made by the raw material of following weight ratio:
Fructus Gardeniae 1-6 Fructus Chaenomelis 1-5 Flos puerariae lobatae 1-5 Semen Hoveniae (Fructus Hoveniae) 1-5 Semen Vitis viniferae 0.5-3.
2. pharmaceutical composition according to claim 1 is characterized in that: to prepare extract with water extracting method, compositions is mixed and made into following weight ratio by extract raw material respectively:
Fructus Gardeniae 1-5 extract Fructus Chaenomelis extract 1-5 Flos puerariae lobatae extract 1-5
Semen Hoveniae extract (Fructus Hoveniae extract) 1-5 Semen Vitis viniferae extract 0.5-3.
3. pharmaceutical composition according to claim 1 is characterized in that: be mixed with compositions after the raw material pulverizing.
4. pharmaceutical composition according to claim 1 is characterized in that, raw material mixes the back water and extracts, the preparation compositions.
5. the described pharmaceutical composition of wanting of claim 1 is characterized in that; Semen Vitis viniferae replaces with commercially available procyanidin compounds.
6. the described pharmaceutical composition of wanting of claim 2, it is characterized in that: Semen Vitis viniferae replaces with commercially available procyanidin compounds.
7. the described pharmaceutical composition of claim 1 is characterized in that adding adjuvant, excipient, additive in preparation process.
8. the described pharmaceutical composition of claim 1 is characterized in that any type of product that food prepared therefrom is accepted.
9. the described pharmaceutical composition of claim 1 is characterized in that being prepared into following peroral dosage form: oral liquid, tablet, capsule, granule, pill, powder, teabag, beverage.
10. the described pharmaceutical composition of claim 1 has the purposes aspect the medicine, health food, food, health product of effects of relieving alcoholism and protecting liver in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101704623A CN101209317B (en) | 2006-12-29 | 2006-12-29 | Medicinal composition with sobering-up and liver-protecting action |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101704623A CN101209317B (en) | 2006-12-29 | 2006-12-29 | Medicinal composition with sobering-up and liver-protecting action |
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| Publication Number | Publication Date |
|---|---|
| CN101209317A true CN101209317A (en) | 2008-07-02 |
| CN101209317B CN101209317B (en) | 2011-07-20 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972326A (en) * | 2010-10-20 | 2011-02-16 | 黎秋萍 | Medicinal preparation for relieving alcohol toxin |
| CN117482152A (en) * | 2022-07-26 | 2024-02-02 | 西南民族大学 | Composition for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1765379A (en) * | 2004-10-29 | 2006-05-03 | 桂林工学院 | Chinese herbal alcohol-neutralize healthy product and its preparation method |
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2006
- 2006-12-29 CN CN2006101704623A patent/CN101209317B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972326A (en) * | 2010-10-20 | 2011-02-16 | 黎秋萍 | Medicinal preparation for relieving alcohol toxin |
| CN101972326B (en) * | 2010-10-20 | 2012-05-30 | 黎秋萍 | Medicinal preparation for relieving alcohol toxin |
| CN117482152A (en) * | 2022-07-26 | 2024-02-02 | 西南民族大学 | Composition for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof |
| CN117482152B (en) * | 2022-07-26 | 2024-09-17 | 西南民族大学 | Composition for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN101209317B (en) | 2011-07-20 |
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Effective date of registration: 20180312 Address after: 100024 Liangxiang High Education Park, Fangshan District, Beijing, Liangxiang campus of Beijing University of Chinese Medicine Patentee after: Passing the moxibustion medicine (Beijing) Technology Co., Ltd. Address before: No. 1404, No. 8, Jiulong Mountain home, No. 31, Guang Canal Road, Chaoyang District, Beijing Patentee before: Li Qiang |
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